SCOPUS 정보 검색 플랫폼

ChemMedChem

Volumn 7, Issue 2, 2012, Pages 194-203

A Decade of the Human Genome Sequence-How Does the Medicinal Chemist Benefit?

(2) Brunschweiger, Andreas a Hall, Jonathan a

a ETH ZURICH (Switzerland)

Author keywords

Drug discovery; Drug targets; Human genome; Protein superfamilies; Structural genomics

Indexed keywords

CANDESARTAN; G PROTEIN COUPLED RECEPTOR; HISTONE DEACETYLASE; HISTONE DEMETHYLASE; KINOME; MF 438; MK 8245; MOCETINOSTAT; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUTLIN 3; OLAPARIB; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEASOME; PROTEIN TYROSINE PHOSPHATASE; PROTEOME; QUIZARTINIB; RG 2833; SEROTONIN ANTAGONIST; SUNITINIB; TOFACITINIB; TRANSPORTOME; TUBASTATIN; UNCLASSIFIED DRUG; VELIPARIB; VEMURAFENIB; VORINOSTAT; XAV 939;

CHEMISTRY; COMPUTER ANALYSIS; DRUG RESEARCH; DRUG TARGETING; EPIGENETICS; GENE SEQUENCE; GENETIC IDENTIFICATION; GENOME ANALYSIS; GENOMICS; HUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURAL GENOMICS; UBIQUITINATION;

COMPUTER-AIDED DESIGN; DRUG DISCOVERY; GENOME, HUMAN; GENOMICS; HISTONE DEACETYLASES; HISTONE DEMETHYLASES; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASES; PROTEIN TYROSINE PHOSPHATASES; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84856406638 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100498 Document Type: Review

Times cited : (16)

References (112)

1
- 2042437650
- E. S. Lander, L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, K. Dewar, M. Doyle, W. FitzHugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland, L. Kann, J. Lehoczky, R. LeVine, P. McEwan, K. McKernan, etal., Nature 2001, 409, 860-921.
- (2001) Nature , vol.409 , pp. 860-921
- Lander, E.S.¹ Linton, L.M.² Birren, B.³ Nusbaum, C.⁴ Zody, M.C.⁵ Baldwin, J.⁶ Devon, K.⁷ Dewar, K.⁸ Doyle, M.⁹ FitzHugh, W.¹⁰ Funke, R.¹¹ Gage, D.¹² Harris, K.¹³ Heaford, A.¹⁴ Howland, J.¹⁵ Kann, L.¹⁶ Lehoczky, J.¹⁷ LeVine, R.¹⁸ McEwan, P.¹⁹ McKernan, K.²⁰ more..

2
- 0035895505
- J. C. Venter, M. D. Adams, E. W. Myers, P. W. Li, R. J. Mural, G. G. Sutton, H. O. Smith, M. Yandell, C. A. Evans, R. A. Holt, J. D. Gocayne, P. Amanatides, R. M. Ballew, D. H. Huson, J. RussoWortman, Q. Zhang, C. D. Kodira, X. H. Zheng, L. Chen, M. Skupski, etal., Science 2001, 291, 1304-1351.
- (2001) Science , vol.291 , pp. 1304-1351
- Venter, J.C.¹ Adams, M.D.² Myers, E.W.³ Li, P.W.⁴ Mural, R.J.⁵ Sutton, G.G.⁶ Smith, H.O.⁷ Yandell, M.⁸ Evans, C.A.⁹ Holt, R.A.¹⁰ Gocayne, J.D.¹¹ Amanatides, P.¹² Ballew, R.M.¹³ Huson, D.H.¹⁴ RussoWortman, J.¹⁵ Zhang, Q.¹⁶ Kodira, C.D.¹⁷ Zheng, X.H.¹⁸ Chen, L.¹⁹ Skupski, M.²⁰ more..

3
- 17544377194
- C. Debouck, B. Metcalf, Annu. Rev. Pharmacol. Toxicol. 2000, 40, 193-207.
- (2000) Annu. Rev. Pharmacol. Toxicol. , vol.40 , pp. 193-207
- Debouck, C.¹ Metcalf, B.²

4
- 0034571571
- P. N. Goodfellow, Novartis Found. Symp. 2000, 229, 131-132.
- (2000) Novartis Found. Symp. , vol.229 , pp. 131-132
- Goodfellow, P.N.¹

5
- 78649694445
- J. Hall, P. Dennler, S. Haller, A. Pratsinis, K. Sauberli, H. Towbin, K. Walther, J. Woytschak, Nat. Rev. Drug Discovery 2010, 9, 988-989.
- (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 988-989
- Hall, J.¹ Dennler, P.² Haller, S.³ Pratsinis, A.⁴ Sauberli, K.⁵ Towbin, H.⁶ Walther, K.⁷ Woytschak, J.⁸

6
- 79961007572
- M. Rask-Andersen, M. SaellmanAlmen, H. B. Schioeth, Nat. Rev. Drug Discovery 2011, 10, 579-590.
- (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 579-590
- Rask-Andersen, M.¹ SaellmanAlmen, M.² Schioeth, H.B.³

7
- 38549146894
- D-D.
- R. D. Finn, J. Tate, J. Mistry, P. C. Coggill, S. J. Sammut, H.-R. Hotz, G. Ceric, K. Forslund, S. R. Eddy, E. L. L. Sonnhammer, A. Bateman, Nucleic Acids Res. 2008, 36, D281-D288.
- (2008) Nucleic Acids Res. , vol.36 , pp. 281-288
- Finn, R.D.¹ Tate, J.² Mistry, J.³ Coggill, P.C.⁴ Sammut, S.J.⁵ Hotz, H.-R.⁶ Ceric, G.⁷ Forslund, K.⁸ Eddy, S.R.⁹ Sonnhammer, E.L.L.¹⁰ Bateman, A.¹¹

8
- 9144257886
- D-D.
- A. Bateman, L. Coin, R. Durbin, R. D. Finn, V. Hollich, S. Griffiths-Jones, A. Khanna, Marshall, Mhairi, S. Moxon, E. L. L. Sonnhammer, D. J. Studholme, C. Yeats, S. R. Eddy, Nucleic Acids Res. 2004, 32, D138-D141.
- (2004) Nucleic Acids Res. , vol.32 , pp. 138-141
- Bateman, A.¹ Coin, L.² Durbin, R.³ Finn, R.D.⁴ Hollich, V.⁵ Griffiths-Jones, S.⁶ Khanna, A.⁷ Marshall⁸ Mhairi⁹ Moxon, S.¹⁰ Sonnhammer, E.L.L.¹¹ Studholme, D.J.¹² Yeats, C.¹³ Eddy, S.R.¹⁴

9
- 0035415863
- P. R. Caron, M. D. Mullican, R. D. Mashal, K. P. Wilson, M. S. Su, M. A. Murcko, Curr. Opin. Chem. Biol. 2001, 5, 464-470.
- (2001) Curr. Opin. Chem. Biol. , vol.5 , pp. 464-470
- Caron, P.R.¹ Mullican, M.D.² Mashal, R.D.³ Wilson, K.P.⁴ Su, M.S.⁵ Murcko, M.A.⁶

10
- 1542268206
- C. G. Wermuth, J. Med. Chem. 2004, 47, 1303-1314.
- (2004) J. Med. Chem. , vol.47 , pp. 1303-1314
- Wermuth, C.G.¹

11
- 0035986718
- C. W. Goulding, M. Apostol, D. H. Anderson, H. S. Gill, C. V. Smith, M. R. Kuo, J. K. Yang, G. S. Waldo, S. W. Suh, R. Chauhan, A. Kale, N. Bachhawat, S. C. Mande, J. M. Johnston, J. S. Lott, E. N. Baker, V. L. Arcus, D. Leys, K. J. McLean, A. W. Munro, J. Berendzen, V. Sharma, M. S. Park, D. Eisenberg, J. Sacchettini, T. Alber, B. Rupp, W. Jacobs, Jr., T. C. Terwilliger, Curr. Drug Targets: Infect. Disord. 2002, 2, 121-141.
- (2002) Curr. Drug Targets: Infect. Disord. , vol.2 , pp. 121-141
- Goulding, C.W.¹ Apostol, M.² Anderson, D.H.³ Gill, H.S.⁴ Smith, C.V.⁵ Kuo, M.R.⁶ Yang, J.K.⁷ Waldo, G.S.⁸ Suh, S.W.⁹ Chauhan, R.¹⁰ Kale, A.¹¹ Bachhawat, N.¹² Mande, S.C.¹³ Johnston, J.M.¹⁴ Lott, J.S.¹⁵ Baker, E.N.¹⁶ Arcus, V.L.¹⁷ Leys, D.¹⁸ McLean, K.J.¹⁹ Munro, A.W.²⁰ more..

12
- 77952555814
- J. Weigelt, Exp. Cell Res. 2010, 316, 1332-1338.
- (2010) Exp. Cell Res. , vol.316 , pp. 1332-1338
- Weigelt, J.¹

13
- 40849141980
- J. Weigelt, L. D. B. McBroom-Cerajewski, M. Schapira, Y. Zhao, C. H. Arrowsmith, Curr. Opin. Chem. Biol. 2008, 12, 32-39.
- (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 32-39
- Weigelt, J.¹ McBroom-Cerajewski, L.D.B.² Schapira, M.³ Zhao, Y.⁴ Arrowsmith, C.H.⁵

14
- 31144467558
- J.-M. Chandonia, S. E. Brenner, Science 2006, 311, 347-351.
- (2006) Science , vol.311 , pp. 347-351
- Chandonia, J.-M.¹ Brenner, S.E.²

15
- 84856380948
- Press release from the Structural Genomics Consortium (SGC), September 27
- Press release from the Structural Genomics Consortium (SGC), September 27, 2010.
- (2010)

16
- 0034878886
- E. Jacoby, Quant. Struct.-Act. Relat. 2001, 20, 115-123.
- (2001) Quant. Struct.-Act. Relat. , vol.20 , pp. 115-123
- Jacoby, E.¹

17
- 23944454816
- A. Evers, G. Hessler, H. Matter, T. Klabunde, J. Med. Chem. 2005, 48, 5448-65.
- (2005) J. Med. Chem. , vol.48 , pp. 5448-5465
- Evers, A.¹ Hessler, G.² Matter, H.³ Klabunde, T.⁴

18
- 80051988079
- M. Bieler, R. Heilker, H. Köppen, G. Schneider, J. Chem. Inf. Model. 2011, 51, 1897-1905.
- (2011) J. Chem. Inf. Model. , vol.51 , pp. 1897-1905
- Bieler, M.¹ Heilker, R.² Köppen, H.³ Schneider, G.⁴

19
- 34548317031
- D. Rognan, Br. J. Pharmacol. 2007, 152, 38-52.
- (2007) Br. J. Pharmacol. , vol.152 , pp. 38-52
- Rognan, D.¹

20
- 1842532337
- M. Bredel, E. Jacoby, Nat. Rev. Genet. 2004, 5, 262-275.
- (2004) Nat. Rev. Genet. , vol.5 , pp. 262-275
- Bredel, M.¹ Jacoby, E.²

21
- 0037024360
- S. Takeda, S. Kadowaki, T. Haga, H. Takaesu, S. Mitaku, FEBS Lett. 2002, 520, 97-101.
- (2002) FEBS Lett. , vol.520 , pp. 97-101
- Takeda, S.¹ Kadowaki, S.² Haga, T.³ Takaesu, H.⁴ Mitaku, S.⁵

22
- 30144441512
- J.-S. Surgand, J. Rodrigo, E. Kellenberger, D. Rognan, Proteins Struct. Funct. Bioinf. 2006, 62, 509-538.
- (2006) Proteins Struct. Funct. Bioinf. , vol.62 , pp. 509-538
- Surgand, J.-S.¹ Rodrigo, J.² Kellenberger, E.³ Rognan, D.⁴

23
- 22944479010
- T. M. Frimurer, T. Ulven, C. E. Elling, L.-O. Gerlach, E. Kostenis, T. Hoegberg, Bioorg. Med. Chem. Lett. 2005, 15, 3707-3712.
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3707-3712
- Frimurer, T.M.¹ Ulven, T.² Elling, C.E.³ Gerlach, L.-O.⁴ Kostenis, E.⁵ Hoegberg, T.⁶

24
- 33750978443
- T. Ulven, J.-M. Receveur, M. Grimstrup, O. Rist, T. M. Frimurer, L.-O. Gerlach, J. M. Mathiesen, E. Kostenis, L. Uller, T. Hoegberg, J. Med. Chem. 2006, 49, 6638-6641.
- (2006) J. Med. Chem. , vol.49 , pp. 6638-6641
- Ulven, T.¹ Receveur, J.-M.² Grimstrup, M.³ Rist, O.⁴ Frimurer, T.M.⁵ Gerlach, L.-O.⁶ Mathiesen, J.M.⁷ Kostenis, E.⁸ Uller, L.⁹ Hoegberg, T.¹⁰

25
- 37049020280
- R. E. Martin, L. G. Green, W. Guba, N. Kratochwil, A. Christ, J. Med. Chem. 2007, 50, 6291-6294.
- (2007) J. Med. Chem. , vol.50 , pp. 6291-6294
- Martin, R.E.¹ Green, L.G.² Guba, W.³ Kratochwil, N.⁴ Christ, A.⁵

26
- 37049017628
- W. Guba, L. G. Green, R. E. Martin, O. Roche, N. Kratochwil, H. Mauser, C. Bissantz, A. Christ, M. Stahl, J. Med. Chem. 2007, 50, 6295-6298.
- (2007) J. Med. Chem. , vol.50 , pp. 6295-6298
- Guba, W.¹ Green, L.G.² Martin, R.E.³ Roche, O.⁴ Kratochwil, N.⁵ Mauser, H.⁶ Bissantz, C.⁷ Christ, A.⁸ Stahl, M.⁹

27
- 65649104052
- T. Klabunde, C. Giegerich, A. Evers, J. Med. Chem. 2009, 52, 2923-32.
- (2009) J. Med. Chem. , vol.52 , pp. 2923-2932
- Klabunde, T.¹ Giegerich, C.² Evers, A.³

28
- 0037032835
- 1933-1934.
- G. Manning, D. B. Whyte, R. Martinez, T. Hunter, S. Sudarsanam, Science 2002, 298, 1912-1916, 1933-1934.
- (2002) Science , vol.298 , pp. 1912-1916
- Manning, G.¹ Whyte, D.B.² Martinez, R.³ Hunter, T.⁴ Sudarsanam, S.⁵

29
- 0034254249
- M. C. Heinrich, D. J. Griffith, B. J. Druker, C. L. Wait, K. A. Ott, A. J. Zigler, Blood 2000, 96, 925-932.
- (2000) Blood , vol.96 , pp. 925-932
- Heinrich, M.C.¹ Griffith, D.J.² Druker, B.J.³ Wait, C.L.⁴ Ott, K.A.⁵ Zigler, A.J.⁶

30
- 79551610758
- T. Force, K. L. Kolaja, Nat. Rev. Drug Discovery 2011, 10, 111-126.
- (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 111-126
- Force, T.¹ Kolaja, K.L.²

31
- 33746845181
- R. Kerkelä, L. Grazette, R. Yacobi, C. Iliescu, R. Patten, C. Beahm, B. Walters, S. Shevtsov, S. Pesant, F. J. Clubb, A. Rosenzweig, R. N. Salomon, R. A. VanEtten, J. Alroy, J.-B. Durand, T. Force, Nat. Med. 2006, 12, 908-916.
- (2006) Nat. Med. , vol.12 , pp. 908-916
- Kerkelä, R.¹ Grazette, L.² Yacobi, R.³ Iliescu, C.⁴ Patten, R.⁵ Beahm, C.⁶ Walters, B.⁷ Shevtsov, S.⁸ Pesant, S.⁹ Clubb, F.J.¹⁰ Rosenzweig, A.¹¹ Salomon, R.N.¹² VanEtten, R.A.¹³ Alroy, J.¹⁴ Durand, J.-B.¹⁵ Force, T.¹⁶

32
- 1542358841
- M. Vieth, R. E. Higgs, D. H. Robertson, M. Shapiro, E. A. Gragg, H. Hemmerle, Biochim. Biophys. Acta Proteins Proteomics 2004, 1697, 243-257.
- (2004) Biochim. Biophys. Acta Proteins Proteomics , vol.1697 , pp. 243-257
- Vieth, M.¹ Higgs, R.E.² Robertson, D.H.³ Shapiro, M.⁴ Gragg, E.A.⁵ Hemmerle, H.⁶

33
- 34247350792
- O. Fedorov, M. Sundstroem, B. Marsden, S. Knapp, Drug Discovery Today 2007, 12, 365-372.
- (2007) Drug Discovery Today , vol.12 , pp. 365-372
- Fedorov, O.¹ Sundstroem, M.² Marsden, B.³ Knapp, S.⁴

34
- 19744365702
- M. A. Fabian, W. H. Biggs, D. K. Treiber, C. E. Atteridge, M. D. Azimioara, M. G. Benedetti, T. A. Carter, P. Ciceri, P. T. Edeen, M. Floyd, J. M. Ford, M. Galvin, J. L. Gerlach, R. M. Grotzfeld, S. Herrgard, D. E. Insko, M. A. Insko, A. G. Lai, J. M. Lélias, S. A. Mehta, Z. V. Milanov, A. M. Velasco, L. M. Wodicka, H. K. Patel, P. P. Zarrinkar, D. J. Lockhart, Nat. Biotechnol. 2005, 23, 329-336.
- (2005) Nat. Biotechnol. , vol.23 , pp. 329-336
- Fabian, M.A.¹ Biggs, W.H.² Treiber, D.K.³ Atteridge, C.E.⁴ Azimioara, M.D.⁵ Benedetti, M.G.⁶ Carter, T.A.⁷ Ciceri, P.⁸ Edeen, P.T.⁹ Floyd, M.¹⁰ Ford, J.M.¹¹ Galvin, M.¹² Gerlach, J.L.¹³ Grotzfeld, R.M.¹⁴ Herrgard, S.¹⁵ Insko, D.E.¹⁶ Insko, M.A.¹⁷ Lai, A.G.¹⁸ Lélias, J.M.¹⁹ Mehta, S.A.²⁰ more..

35
- 42949150113
- D. M. Goldstein, N. S. Gray, P. P. Zarrinkar, Nat. Rev. Drug Discovery 2008, 7, 391-397.
- (2008) Nat. Rev. Drug Discovery , vol.7 , pp. 391-397
- Goldstein, D.M.¹ Gray, N.S.² Zarrinkar, P.P.³

36
- 68349146253
- H. K. Patel, R. M. Grotzfeld, A. G. Lai, S. A. Mehta, Z. V. Milanov, Q. Chao, K. G. Sprankle, T. A. Carter, A. M. Velasco, M. A. Fabian, J. James, D. K. Treiber, D. J. Lockhart, P. P. Zarrinkar, S. S. Bhagwat, Bioorg. Med. Chem. Lett. 2009, 19, 5182-5185.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5182-5185
- Patel, H.K.¹ Grotzfeld, R.M.² Lai, A.G.³ Mehta, S.A.⁴ Milanov, Z.V.⁵ Chao, Q.⁶ Sprankle, K.G.⁷ Carter, T.A.⁸ Velasco, A.M.⁹ Fabian, M.A.¹⁰ James, J.¹¹ Treiber, D.K.¹² Lockhart, D.J.¹³ Zarrinkar, P.P.¹⁴ Bhagwat, S.S.¹⁵

37
- 72249087752
- Q. Chao, K. G. Sprankle, R. M. Grotzfeld, A. G. Lai, T. A. Carter, A. M. Velasco, R. N. Gunawardane, M. D. Cramer, M. F. Gardner, J. James, J. James, P. P. Zarrinkar, H. K. Patel, S. S. Bhagwat, J. Med. Chem. 2009, 52, 7808-7816.
- (2009) J. Med. Chem. , vol.52 , pp. 7808-7816
- Chao, Q.¹ Sprankle, K.G.² Grotzfeld, R.M.³ Lai, A.G.⁴ Carter, T.A.⁵ Velasco, A.M.⁶ Gunawardane, R.N.⁷ Cramer, M.D.⁸ Gardner, M.F.⁹ James, J.¹⁰ James, J.¹¹ Zarrinkar, P.P.¹² Patel, H.K.¹³ Bhagwat, S.S.¹⁴

38
- 70449475105
- P. P. Zarrinkar, R. N. Gunawardane, M. D. Cramer, M. F. Gardner, D. Brigham, B. Belli, M. W. Karaman, K. W. Pratz, G. Pallares, Q. Chao, K. G. Sprankle, H. K. Patel, M. Levis, R. C. Armstrong, J. James, S. S. Bhagwat, Blood 2009, 114, 2984-2992.
- (2009) Blood , vol.114 , pp. 2984-2992
- Zarrinkar, P.P.¹ Gunawardane, R.N.² Cramer, M.D.³ Gardner, M.F.⁴ Brigham, D.⁵ Belli, B.⁶ Karaman, M.W.⁷ Pratz, K.W.⁸ Pallares, G.⁹ Chao, Q.¹⁰ Sprankle, K.G.¹¹ Patel, H.K.¹² Levis, M.¹³ Armstrong, R.C.¹⁴ James, J.¹⁵ Bhagwat, S.S.¹⁶

39
- 80052713073
- S. Knapper, Expert Opin. Invest. Drugs 2011, 20, 1377-1395.
- (2011) Expert Opin. Invest. Drugs , vol.20 , pp. 1377-1395
- Knapper, S.¹

40
- 84873062703
- Efficacy Study for AC220 to Treat Acute Myeloid Leukemia (AML) (ACE), Ambit Biosciences Corp. (San Diego, USA); ClinicalTrials.gov (US National Institutes of Health), ID: NCT00989261.
- Efficacy Study for AC220 to Treat Acute Myeloid Leukemia (AML) (ACE), Ambit Biosciences Corp. (San Diego, USA); ClinicalTrials.gov (US National Institutes of Health), ID: NCT00989261.

41
- 18444374405
- H. Davies, G. H. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, etal., Nature 2002, 417, 949-954.
- (2002) Nature , vol.417 , pp. 949-954
- Davies, H.¹ Bignell, G.H.² Cox, C.³ Stephens, P.⁴ Edkins, S.⁵ Clegg, S.⁶ Teague, J.⁷ Woffendin, H.⁸ Garnett, M.J.⁹ Bottomley, W.¹⁰ Davis, N.¹¹ Dicks, E.¹² Ewing, R.¹³ Floyd, Y.¹⁴ Gray, K.¹⁵ Hall, S.¹⁶ Hawes, R.¹⁷ Hughes, J.¹⁸ Kosmidou, V.¹⁹ Menzies, A.²⁰ more..

42
- 42949149240
- J. Tsai, J. T. Lee, W. Wang, J. Zhang, H. Cho, S. Mamo, R. Bremer, S. Gillette, J. Kong, N. K. Haass, K. Sproesser, L. Li, K. S. M. Smalley, D. Fong, Y.-L. Zhu, A. Marimuthu, H. Nguyen, B. Lam, J. Liu, I. Cheung, etal., Proc. Natl. Acad. Sci. USA 2008, 105, 3041-3046.
- (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3041-3046
- Tsai, J.¹ Lee, J.T.² Wang, W.³ Zhang, J.⁴ Cho, H.⁵ Mamo, S.⁶ Bremer, R.⁷ Gillette, S.⁸ Kong, J.⁹ Haass, N.K.¹⁰ Sproesser, K.¹¹ Li, L.¹² Smalley, K.S.M.¹³ Fong, D.¹⁴ Zhu, Y.-L.¹⁵ Marimuthu, A.¹⁶ Nguyen, H.¹⁷ Lam, B.¹⁸ Liu, J.¹⁹ Cheung, I.²⁰ more..

43
- 77956513286
- G. Bollag, P. Hirth, J. Tsai, J. Zhang, P. N. Ibrahim, H. Cho, W. Spevak, C. Zhang, Y. Zhang, G. Habets, E. A. Burton, B. Wong, G. Tsang, B. L. West, B. Powell, R. Shellooe, A. Marimuthu, H. Nguyen, K. Y. J. Zhang, etal., Nature 2010, 467, 596-599.
- (2010) Nature , vol.467 , pp. 596-599
- Bollag, G.¹ Hirth, P.² Tsai, J.³ Zhang, J.⁴ Ibrahim, P.N.⁵ Cho, H.⁶ Spevak, W.⁷ Zhang, C.⁸ Zhang, Y.⁹ Habets, G.¹⁰ Burton, E.A.¹¹ Wong, B.¹² Tsang, G.¹³ West, B.L.¹⁴ Powell, B.¹⁵ Shellooe, R.¹⁶ Marimuthu, A.¹⁷ Nguyen, H.¹⁸ Zhang, K.Y.J.¹⁹

44
- 77954531991
- J. S. Fridman, P. A. Scherle, R. Collins, T. C. Burn, Y. Li, J. Li, M. B. Covington, B. Thomas, P. Collier, M. F. Favata, X. Wen, J. Shi, R. McGee, P. J. Haley, S. Shepard, J. D. Rodgers, S. Yeleswaram, G. Hollis, R. C. Newton, B. Metcalf, S. M. Friedman, K. Vaddi, J. Immunol. 2010, 184, 5298-5307.
- (2010) J. Immunol. , vol.184 , pp. 5298-5307
- Fridman, J.S.¹ Scherle, P.A.² Collins, R.³ Burn, T.C.⁴ Li, Y.⁵ Li, J.⁶ Covington, M.B.⁷ Thomas, B.⁸ Collier, P.⁹ Favata, M.F.¹⁰ Wen, X.¹¹ Shi, J.¹² McGee, R.¹³ Haley, P.J.¹⁴ Shepard, S.¹⁵ Rodgers, J.D.¹⁶ Yeleswaram, S.¹⁷ Hollis, G.¹⁸ Newton, R.C.¹⁹ Metcalf, B.²⁰ Friedman, S.M.²¹ Vaddi, K.²² more..

45
- 34547849752
- P. R. Pine, B. Chang, N. Schoettler, M. L. Banquerigo, S. Wang, A. Lau, F. Zhao, E. B. Grossbard, D. G. Payan, E. Brahn, Clin. Immunol. 2007, 124, 244-57.
- (2007) Clin. Immunol. , vol.124 , pp. 244-257
- Pine, P.R.¹ Chang, B.² Schoettler, N.³ Banquerigo, M.L.⁴ Wang, S.⁵ Lau, A.⁶ Zhao, F.⁷ Grossbard, E.B.⁸ Payan, D.G.⁹ Brahn, E.¹⁰

46
- 79960245571
- K. Garber, Nat. Biotechnol. 2011, 29, 467-468.
- (2011) Nat. Biotechnol. , vol.29 , pp. 467-468
- Garber, K.¹

47
- 38049018155
- M. W. Karaman, S. Herrgard, D. K. Treiber, P. Gallant, C. E. Atteridge, B. T. Campbell, K. W. Chan, P. Ciceri, M. I. Davis, P. T. Edeen, R. Faraoni, M. Floyd, J. P. Hunt, D. J. Lockhart, Z. V. Milanov, M. J. Morrison, G. Pallares, H. K. Patel, S. Pritchard, L. M. Wodicka, P. P. Zarrinkar, Nat. Biotechnol. 2008, 26, 127-132.
- (2008) Nat. Biotechnol. , vol.26 , pp. 127-132
- Karaman, M.W.¹ Herrgard, S.² Treiber, D.K.³ Gallant, P.⁴ Atteridge, C.E.⁵ Campbell, B.T.⁶ Chan, K.W.⁷ Ciceri, P.⁸ Davis, M.I.⁹ Edeen, P.T.¹⁰ Faraoni, R.¹¹ Floyd, M.¹² Hunt, J.P.¹³ Lockhart, D.J.¹⁴ Milanov, Z.V.¹⁵ Morrison, M.J.¹⁶ Pallares, G.¹⁷ Patel, H.K.¹⁸ Pritchard, S.¹⁹ Wodicka, L.M.²⁰ Zarrinkar, P.P.²¹ more..

48
- 78650362917
- M. E. Flanagan, T. A. Blumenkopf, W. H. Brissette, M. F. Brown, J. M. Casavant, S.-P. Chang, J. L. Doty, E. A. Elliott, M. B. Fisher, M. Hines, C. Kent, E. M. Kudlacz, B. M. Lillie, K. S. Magnuson, S. P. McCurdy, M. J. Munchhof, B. D. Perry, P. S. Sawyer, T. J. Strelevitz, C. Subramanyam, J. Sun, D. A. Whipple, P. S. Changelian, J. Med. Chem. 2010, 53, 8468-8484.
- (2010) J. Med. Chem. , vol.53 , pp. 8468-8484
- Flanagan, M.E.¹ Blumenkopf, T.A.² Brissette, W.H.³ Brown, M.F.⁴ Casavant, J.M.⁵ Chang, S.-P.⁶ Doty, J.L.⁷ Elliott, E.A.⁸ Fisher, M.B.⁹ Hines, M.¹⁰ Kent, C.¹¹ Kudlacz, E.M.¹² Lillie, B.M.¹³ Magnuson, K.S.¹⁴ McCurdy, S.P.¹⁵ Munchhof, M.J.¹⁶ Perry, B.D.¹⁷ Sawyer, P.S.¹⁸ Strelevitz, T.J.¹⁹ Subramanyam, C.²⁰ more..

49
- 33750299450
- N. K. Tonks, Nat. Rev. Mol. Cell Biol. 2006, 7, 833-846.
- (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 833-846
- Tonks, N.K.¹

50
- 2942581416
- A. Alonso, J. Sasin, N. Bottini, I. Friedberg, I. Friedberg, A. Osterman, A. Godzik, T. Hunter, J. Dixon, T. Mustelin, Cell 2004, 117, 699-711.
- (2004) Cell , vol.117 , pp. 699-711
- Alonso, A.¹ Sasin, J.² Bottini, N.³ Friedberg, I.⁴ Friedberg, I.⁵ Osterman, A.⁶ Godzik, A.⁷ Hunter, T.⁸ Dixon, J.⁹ Mustelin, T.¹⁰

51
- 34247362854
- S. Zhang, Z.-Y. Zhang, Drug Discovery Today 2007, 12, 373-381.
- (2007) Drug Discovery Today , vol.12 , pp. 373-381
- Zhang, S.¹ Zhang, Z.-Y.²

52
- 0030769147
- K. E. You-Ten, E. S. Muise, A. Itie, E. Michaliszyn, J. Wagner, S. Jothy, W. S. Lapp, M. L. Tremblay, J. Exp. Med. 1997, 186, 683-93.
- (1997) J. Exp. Med. , vol.186 , pp. 683-693
- You-Ten, K.E.¹ Muise, E.S.² Itie, A.³ Michaliszyn, E.⁴ Wagner, J.⁵ Jothy, S.⁶ Lapp, W.S.⁷ Tremblay, M.L.⁸

53
- 33144482200
- L. Tautz, M. Pellecchia, T. Mustelin, Expert Opin. Ther. Targets 2006, 10, 157-177.
- (2006) Expert Opin. Ther. Targets , vol.10 , pp. 157-177
- Tautz, L.¹ Pellecchia, M.² Mustelin, T.³

54
- 0034785827
- J. N. Andersen, O. H. Mortensen, G. H. Peters, P. G. Drake, L. F. Iversen, O. H. Olsen, P. G. Jansen, H. S. Andersen, N. K. Tonks, N. P. H. Møller, Mol. Cell Biol. 2001, 21, 7117-7136.
- (2001) Mol. Cell Biol. , vol.21 , pp. 7117-7136
- Andersen, J.N.¹ Mortensen, O.H.² Peters, G.H.³ Drake, P.G.⁴ Iversen, L.F.⁵ Olsen, O.H.⁶ Jansen, P.G.⁷ Andersen, H.S.⁸ Tonks, N.K.⁹ Møller, N.P.H.¹⁰

55
- 58249138122
- A. J. Barr, E. Ugochukwu, W. H. Lee, O. N. F. King, P. Filippakopoulos, I. Alfano, P. Savitsky, N. A. Burgess-Brown, S. Muller, S. Knapp, Cell 2009, 136, 352-363.
- (2009) Cell , vol.136 , pp. 352-363
- Barr, A.J.¹ Ugochukwu, E.² Lee, W.H.³ King, O.N.F.⁴ Filippakopoulos, P.⁵ Alfano, I.⁶ Savitsky, P.⁷ Burgess-Brown, N.A.⁸ Muller, S.⁹ Knapp, S.¹⁰

56
- 72149132031
- S. Wu, M. Bottini, R. C. Rickert, T. Mustelin, L. Tautz, ChemMedChem 2009, 4, 440-444.
- (2009) ChemMedChem , vol.4 , pp. 440-444
- Wu, S.¹ Bottini, M.² Rickert, R.C.³ Mustelin, T.⁴ Tautz, L.⁵

57
- 80053893337
- S. Sheriff, B. R. Beno, W. Zhai, W. A. Kostich, P. A. McDonnell, K. Kish, V. Goldfarb, M. Gao, S. E. Kiefer, J. Yanchunas, Y. Huang, S. Shi, S. Zhu, C. Dzierba, J. Bronson, J. E. Macor, K. K. Appiah, R. S. Westphal, J. O'Connell, S. W. Gerritz, J. Med. Chem. 2011, 54, 6548-6562.
- (2011) J. Med. Chem. , vol.54 , pp. 6548-6562
- Sheriff, S.¹ Beno, B.R.² Zhai, W.³ Kostich, W.A.⁴ McDonnell, P.A.⁵ Kish, K.⁶ Goldfarb, V.⁷ Gao, M.⁸ Kiefer, S.E.⁹ Yanchunas, J.¹⁰ Huang, Y.¹¹ Shi, S.¹² Zhu, S.¹³ Dzierba, C.¹⁴ Bronson, J.¹⁵ Macor, J.E.¹⁶ Appiah, K.K.¹⁷ Westphal, R.S.¹⁸ O'Connell, J.¹⁹ Gerritz, S.W.²⁰ more..

58
- 79751497953
- J. W. Ellisen, Cancer Cell 2011, 19, 165-167.
- (2011) Cancer Cell , vol.19 , pp. 165-167
- Ellisen, J.W.¹

59
- 38449088040
- P. O. Hassa, M. O. Hottiger, Front. Biosci. 2008, 13, 3046-3082.
- (2008) Front. Biosci. , vol.13 , pp. 3046-3082
- Hassa, P.O.¹ Hottiger, M.O.²

60
- 0023475837
- B. W. Cherney, O. W. McBride, D. Chen, H. Alkhatib, K. Bhatia, P. Hensley, M. E. Smulson, Proc. Natl. Acad. Sci. USA 1987, 84, 8370-4.
- (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8370-8374
- Cherney, B.W.¹ McBride, O.W.² Chen, D.³ Alkhatib, H.⁴ Bhatia, K.⁵ Hensley, P.⁶ Smulson, M.E.⁷

61
- 77951023118
- M. O. Hottiger, P. O. Hassa, B. Luescher, H. Schueler, F. Koch-Nolte, Trends Biochem. Sci. 2010, 35, 208-219.
- (2010) Trends Biochem. Sci. , vol.35 , pp. 208-219
- Hottiger, M.O.¹ Hassa, P.O.² Luescher, B.³ Schueler, H.⁴ Koch-Nolte, F.⁵

62
- 70349695861
- S.-M. A. Huang, Y. M. Mishina, S. Liu, A. Cheung, F. Stegmeier, G. A. Michaud, O. Charlat, E. Wiellette, Y. Zhang, S. Wiessner, M. Hild, X. Shi, C. J. Wilson, C. Mickanin, V. Myer, A. Fazal, R. Tomlinson, F. Serluca, W. Shao, H. Cheng, M. Shultz, C. Rau, etal., Nature 2009, 461, 614-620.
- (2009) Nature , vol.461 , pp. 614-620
- Huang, S.-M.A.¹ Mishina, Y.M.² Liu, S.³ Cheung, A.⁴ Stegmeier, F.⁵ Michaud, G.A.⁶ Charlat, O.⁷ Wiellette, E.⁸ Zhang, Y.⁹ Wiessner, S.¹⁰ Hild, M.¹¹ Shi, X.¹² Wilson, C.J.¹³ Mickanin, C.¹⁴ Myer, V.¹⁵ Fazal, A.¹⁶ Tomlinson, R.¹⁷ Serluca, F.¹⁸ Shao, W.¹⁹ Cheng, H.²⁰ Shultz, M.²¹ Rau, C.²² more..

63
- 76749153013
- T. Karlberg, M. Hammarstrom, P. Schutz, L. Svensson, H. Schuler, Biochemistry 2010, 49, 1056-1058.
- (2010) Biochemistry , vol.49 , pp. 1056-1058
- Karlberg, T.¹ Hammarstrom, M.² Schutz, P.³ Svensson, L.⁴ Schuler, H.⁵

64
- 42749090879
- L. Lehtioe, R. Collins, S. vandenBerg, A. Johansson, L.-G. Dahlgren, M. Hammarstroem, T. Helleday, L. Holmberg-Schiavone, T. Karlberg, J. Weigelt, J. Mol. Biol. 2008, 379, 136-145.
- (2008) J. Mol. Biol. , vol.379 , pp. 136-145
- Lehtioe, L.¹ Collins, R.² vandenBerg, S.³ Johansson, A.⁴ Dahlgren, L.-G.⁵ Hammarstroem, M.⁶ Helleday, T.⁷ Holmberg-Schiavone, L.⁸ Karlberg, T.⁹ Weigelt, J.¹⁰

65
- 77954709179
- T. Karlberg, N. Markova, I. Johansson, M. Hammarstrom, P. Schutz, J. Weigelt, H. Schuler, J. Med. Chem. 2010, 53, 5352-5355.
- (2010) J. Med. Chem. , vol.53 , pp. 5352-5355
- Karlberg, T.¹ Markova, N.² Johansson, I.³ Hammarstrom, M.⁴ Schutz, P.⁵ Weigelt, J.⁶ Schuler, H.⁷

66
- 33747455678
- R. J. Klose, E. M. Kallin, Y. Zhang, Nat. Rev. Genet. 2006, 7, 715-727.
- (2006) Nat. Rev. Genet. , vol.7 , pp. 715-727
- Klose, R.J.¹ Kallin, E.M.² Zhang, Y.³

67
- 43249102851
- P. A. C. Cloos, J. Christensen, K. Agger, K. Helin, Genes Dev. 2008, 22, 1115-1140.
- (2008) Genes Dev. , vol.22 , pp. 1115-1140
- Cloos, P.A.C.¹ Christensen, J.² Agger, K.³ Helin, K.⁴

68
- 33749576106
- J. Schneider, A. Shilatifard, ACS Chem. Biol. 2006, 1, 75-81.
- (2006) ACS Chem. Biol. , vol.1 , pp. 75-81
- Schneider, J.¹ Shilatifard, A.²

69
- 11144332565
- Y. Shi, F. Lan, C. Matson, P. Mulligan, J. R. Whetstine, P. A. Cole, R. A. Casero, Y. Shi, Cell 2004, 119, 941-953.
- (2004) Cell , vol.119 , pp. 941-953
- Shi, Y.¹ Lan, F.² Matson, C.³ Mulligan, P.⁴ Whetstine, J.R.⁵ Cole, P.A.⁶ Casero, R.A.⁷ Shi, Y.⁸

70
- 32844454603
- Y. Tsukada, J. Fang, H. Erdjument-Bromage, M. E. Warren, C. H. Borchers, P. Tempst, Y. Zhang, Nature 2006, 439, 811-816.
- (2006) Nature , vol.439 , pp. 811-816
- Tsukada, Y.¹ Fang, J.² Erdjument-Bromage, H.³ Warren, M.E.⁴ Borchers, C.H.⁵ Tempst, P.⁶ Zhang, Y.⁷

71
- 34447133035
- S. S. Ng, K. L. Kavanagh, M. A. McDonough, D. Butler, E. S. Pilka, B. M. R. Lienard, J. E. Bray, P. Savitsky, O. Gileadi, F. vonDelft, N. R. Rose, J. Offer, J. C. Scheinost, T. Borowski, M. Sundstrom, C. J. Schofield, U. Oppermann, Nature 2007, 448, 87-91.
- (2007) Nature , vol.448 , pp. 87-91
- Ng, S.S.¹ Kavanagh, K.L.² McDonough, M.A.³ Butler, D.⁴ Pilka, E.S.⁵ Lienard, B.M.R.⁶ Bray, J.E.⁷ Savitsky, P.⁸ Gileadi, O.⁹ vonDelft, F.¹⁰ Rose, N.R.¹¹ Offer, J.¹² Scheinost, J.C.¹³ Borowski, T.¹⁴ Sundstrom, M.¹⁵ Schofield, C.J.¹⁶ Oppermann, U.¹⁷

72
- 56749151276
- N. R. Rose, S. S. Ng, J. Mecinovic, B. M. R. Lienard, S. H. Bello, Z. Sun, M. A. McDonough, U. Oppermann, C. J. Schofield, J. Med. Chem. 2008, 51, 7053-6.
- (2008) J. Med. Chem. , vol.51 , pp. 7053-7056
- Rose, N.R.¹ Ng, S.S.² Mecinovic, J.³ Lienard, B.M.R.⁴ Bello, S.H.⁵ Sun, Z.⁶ McDonough, M.A.⁷ Oppermann, U.⁸ Schofield, C.J.⁹

73
- 77649224314
- N. R. Rose, E. C. Y. Woon, G. L. Kingham, O. N. F. King, J. Mecinovic, I. J. Clifton S. S. Ng, J. Talib-Hardy, U. Oppermann, M. A. McDonough, C. J. Schofield, J. Med. Chem. 2010, 53, 1810-8.
- (2010) J. Med. Chem. , vol.53 , pp. 1810-1818
- Rose, N.R.¹ Woon, E.C.Y.² Kingham, G.L.³ King, O.N.F.⁴ Mecinovic, J.⁵ Ng, I.J.C.S.S.⁶ Talib-Hardy, J.⁷ Oppermann, U.⁸ McDonough, M.A.⁹ Schofield, C.J.¹⁰

74
- 77955345001
- S. Hamada, T. Suzuki, K. Mino, K. Koseki, F. Oehme, I. Flamme, H. Ozasa, Y. Itoh, D. Ogasawara, H. Komaarashi, A. Kato, H. Tsumoto, H. Nakagawa, M. Hasegawa, R. Sasaki, T. Mizukami, N. Miyata, J. Med. Chem. 2010, 53, 5629-5638.
- (2010) J. Med. Chem. , vol.53 , pp. 5629-5638
- Hamada, S.¹ Suzuki, T.² Mino, K.³ Koseki, K.⁴ Oehme, F.⁵ Flamme, I.⁶ Ozasa, H.⁷ Itoh, Y.⁸ Ogasawara, D.⁹ Komaarashi, H.¹⁰ Kato, A.¹¹ Tsumoto, H.¹² Nakagawa, H.¹³ Hasegawa, M.¹⁴ Sasaki, R.¹⁵ Mizukami, T.¹⁶ Miyata, N.¹⁷

75
- 79959204866
- X.-L. Luo, Y.-X. Liu, S. Kubicek, J. Myllyharju, A. Tumber, S. Ng, K. H. Che, J. Podoll, T. D. Heightman, U. Oppermann, S. L. Schreiber, X. Wang, J. Am. Chem. Soc. 2011, 133, 9451-9456.
- (2011) J. Am. Chem. Soc. , vol.133 , pp. 9451-9456
- Luo, X.-L.¹ Liu, Y.-X.² Kubicek, S.³ Myllyharju, J.⁴ Tumber, A.⁵ Ng, S.⁶ Che, K.H.⁷ Podoll, J.⁸ Heightman, T.D.⁹ Oppermann, U.¹⁰ Schreiber, S.L.¹¹ Wang, X.¹²

76
- 0029932598
- J. Taunton, C. A. Hassig, S. L. Schreiber, Science 1996, 272, 408-11.
- (1996) Science , vol.272 , pp. 408-411
- Taunton, J.¹ Hassig, C.A.² Schreiber, S.L.³

77
- 0029850458
- W.-M. Yang, C. Inouye, Y. Zeng, D. Bearss, E. Seto, Proc. Natl. Acad. Sci. USA 1996, 93, 12845-12850.
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12845-12850
- Yang, W.-M.¹ Inouye, C.² Zeng, Y.³ Bearss, D.⁴ Seto, E.⁵

78
- 0033964223
- H.-Y. Kao, M. Downes, P. Ordentlich, R. M. Evans, Genes Dev. 2000, 14, 55-66.
- (2000) Genes Dev. , vol.14 , pp. 55-66
- Kao, H.-Y.¹ Downes, M.² Ordentlich, P.³ Evans, R.M.⁴

79
- 0030834976
- W.-M. Yang, Y.-L. Yao, J.-M. Sun, J. R. Davie, E. Seto, J. Biol. Chem. 1997, 272, 28001-28007.
- (1997) J. Biol. Chem. , vol.272 , pp. 28001-28007
- Yang, W.-M.¹ Yao, Y.-L.² Sun, J.-M.³ Davie, J.R.⁴ Seto, E.⁵

80
- 0033609055
- C. M. Grozinger, C. A. Hassig, S. L. Schreiber, Proc. Natl. Acad. Sci. USA 1999, 96, 4868-4873.
- (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4868-4873
- Grozinger, C.M.¹ Hassig, C.A.² Schreiber, S.L.³

81
- 0034663486
- J. J. Buggy, M. L. Sideris, P. Mak, D. D. Lorimer, B. McIntosh, J. M. Clark, Biochem. J. 2000, 350, 199-205.
- (2000) Biochem. J. , vol.350 , pp. 199-205
- Buggy, J.J.¹ Sideris, M.L.² Mak, P.³ Lorimer, D.D.⁴ McIntosh, B.⁵ Clark, J.M.⁶

82
- 0035845539
- X. Zhou, P. A. Marks, R. A. Rifkind, V. M. Richon, Proc. Natl. Acad. Sci. USA 2001, 98, 10572-10577.
- (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10572-10577
- Zhou, X.¹ Marks, P.A.² Rifkind, R.A.³ Richon, V.M.⁴

83
- 0037016696
- H.-Y. Kao, C.-H. Lee, A. Komarov, C. C. Han, R. M. Evans, J. Biol. Chem. 2002, 277, 187-193.
- (2002) J. Biol. Chem. , vol.277 , pp. 187-193
- Kao, H.-Y.¹ Lee, C.-H.² Komarov, A.³ Han, C.C.⁴ Evans, R.M.⁵

84
- 0037067696
- L. Gao, M. A. Cueto, F. Asselbergs, P. Atadja, J. Biol. Chem. 2002, 277, 25748-25755.
- (2002) J. Biol. Chem. , vol.277 , pp. 25748-25755
- Gao, L.¹ Cueto, M.A.² Asselbergs, F.³ Atadja, P.⁴

85
- 77949886046
- J. S. Kerr, S. Galloway, A. Lagrutta, M. Armstrong, T. Miller, V. M. Richon, P. A. Andrews, Int. J. Toxicol. 2010, 29, 3-19.
- (2010) Int. J. Toxicol. , vol.29 , pp. 3-19
- Kerr, J.S.¹ Galloway, S.² Lagrutta, A.³ Armstrong, M.⁴ Miller, T.⁵ Richon, V.M.⁶ Andrews, P.A.⁷

86
- 49249116407
- S. Marsoni, G. Damia, G. Camboni, Epigenetics 2008, 3, 164-71.
- (2008) Epigenetics , vol.3 , pp. 164-171
- Marsoni, S.¹ Damia, G.² Camboni, G.³

87
- 42249084230
- M. Fournel, C. Bonfils, Y. Hou, T. P. Yan, M.-C. Trachy-Bourget, A. Kalita, J. Liu, A.-H. Lu, N. Z. Zhou, M.-F. Robert, J. Gillespie, J. J. Wang, H. Ste-Croix, J. Rahil, S. Lefebvre, O. Moradei, D. Delorme, A. R. MacLeod, J. M. Besterman, J. Zi, Mol. Cancer Ther. 2008, 7, 759-768.
- (2008) Mol. Cancer Ther. , vol.7 , pp. 759-768
- Fournel, M.¹ Bonfils, C.² Hou, Y.³ Yan, T.P.⁴ Trachy-Bourget, M.-C.⁵ Kalita, A.⁶ Liu, J.⁷ Lu, A.-H.⁸ Zhou, N.Z.⁹ Robert, M.-F.¹⁰ Gillespie, J.¹¹ Wang, J.J.¹² Ste-Croix, H.¹³ Rahil, J.¹⁴ Lefebvre, S.¹⁵ Moradei, O.¹⁶ Delorme, D.¹⁷ MacLeod, A.R.¹⁸ Besterman, J.M.¹⁹ Zi, J.²⁰ more..

88
- 79955803337
- Y. Boumber, A. Younes, G. Garcia-Manero, Expert Opin. Invest. Drugs 2011, 20, 823-829.
- (2011) Expert Opin. Invest. Drugs , vol.20 , pp. 823-829
- Boumber, Y.¹ Younes, A.² Garcia-Manero, G.³

89
- 67349227787
- S. Balasubramanian, E. Verner, J. J. Buggy, Cancer Lett. 2009, 280, 211-221.
- (2009) Cancer Lett. , vol.280 , pp. 211-221
- Balasubramanian, S.¹ Verner, E.² Buggy, J.J.³

90
- 65449166411
- R. Ficner, Curr. Top. Med. Chem. 2009, 9, 235-240.
- (2009) Curr. Top. Med. Chem. , vol.9 , pp. 235-240
- Ficner, R.¹

91
- 3142562372
- J. R. Somoza, R. J. Skene, B. A. Katz, C. Mol, J. D. Ho, A. J. Jennings, C. Luong, A. Arvai, J. J. Buggy, E. Chi, J. Tang, B. C. Sang, E. Verner, R. Wynands, E. M. Leahy, D. R. Dougan, G. Snell, M. Navre, M. W. Knuth, R. V. Swanson, D. E. Mcree, L. W. Tari, Structure 2004, 12, 1325-1334.
- (2004) Structure , vol.12 , pp. 1325-1334
- Somoza, J.R.¹ Skene, R.J.² Katz, B.A.³ Mol, C.⁴ Ho, J.D.⁵ Jennings, A.J.⁶ Luong, C.⁷ Arvai, A.⁸ Buggy, J.J.⁹ Chi, E.¹⁰ Tang, J.¹¹ Sang, B.C.¹² Verner, E.¹³ Wynands, R.¹⁴ Leahy, E.M.¹⁵ Dougan, D.R.¹⁶ Snell, G.¹⁷ Navre, M.¹⁸ Knuth, M.W.¹⁹ Swanson, R.V.²⁰ Mcree, D.E.²¹ Tari, L.W.²² more..

92
- 45549095066
- A. Schuetz, J. Min, A. Allali-Hassani, M. Schapira, M. Shuen, P. Loppnau, R. Mazitschek, N. P. Kwiatkowski, T. A. Lewis, R. L. Maglathin, T. H. McLean, A. Bochkarev, A. N. Plotnikov, M. Vedadi, C. H. Arrowsmith, J. Biol. Chem. 2008, 283, 11355-11363.
- (2008) J. Biol. Chem. , vol.283 , pp. 11355-11363
- Schuetz, A.¹ Min, J.² Allali-Hassani, A.³ Schapira, M.⁴ Shuen, M.⁵ Loppnau, P.⁶ Mazitschek, R.⁷ Kwiatkowski, N.P.⁸ Lewis, T.A.⁹ Maglathin, R.L.¹⁰ McLean, T.H.¹¹ Bochkarev, A.¹² Plotnikov, A.N.¹³ Vedadi, M.¹⁴ Arrowsmith, C.H.¹⁵

93
- 55549094833
- M. J. Bottomley, P. LoSurdo, P. DiGiovine, A. Cirillo, R. Scarpelli, F. Ferrigno, P. Jones, P. Neddermann, R. DeFrancesco, C. Steinkuehler, P Gallinari, A. Carf, J. Biol. Chem. 2008, 283, 26694-26704.
- (2008) J. Biol. Chem. , vol.283 , pp. 26694-26704
- Bottomley, M.J.¹ LoSurdo, P.² DiGiovine, P.³ Cirillo, A.⁴ Scarpelli, R.⁵ Ferrigno, F.⁶ Jones, P.⁷ Neddermann, P.⁸ DeFrancesco, R.⁹ Steinkuehler, C.¹⁰ Gallinari, P.¹¹ Carf, A.¹²

94
- 77952530173
- e.
- M. Rai, E. Soragni, C. J. Chou, G. Barnes, S. Jones, J. R. Rusche, J. M. Gottesfeld, M. Pandolfo, PLoS One 2010, 5, e8825.
- (2010) PLoS One , vol.5 , pp. 8825
- Rai, M.¹ Soragni, E.² Chou, C.J.³ Barnes, G.⁴ Jones, S.⁵ Rusche, J.R.⁶ Gottesfeld, J.M.⁷ Pandolfo, M.⁸

95
- 84873065550
- FDA Grants Orphan Drug Status to RG-2833 in Friedreich's Ataxia, Thomson Reuters Drug News, May 26, 2010
- FDA Grants Orphan Drug Status to RG-2833 in Friedreich's Ataxia, Thomson Reuters Drug News, May 26, 2010.

96
- 77955355838
- K. V. Butler, J. Kalin, C. Brochier, G. Vistoli, B. Langley, A. P. Kozikowski, J. Am. Chem. Soc. 2010, 132, 10842-10846.
- (2010) J. Am. Chem. Soc. , vol.132 , pp. 10842-10846
- Butler, K.V.¹ Kalin, J.² Brochier, C.³ Vistoli, G.⁴ Langley, B.⁵ Kozikowski, A.P.⁶

97
- 79961168180
- C. D'Ydewalle, J. Krishnan, D. M. Chiheb, P. VanDamme, J. Irobi, A. P. Kozikowski, P. VandenBerghe, V. Timmerman, W. Robberecht, L. VanDenBosch, Nat. Med. 2011, 17, 968-974.
- (2011) Nat. Med. , vol.17 , pp. 968-974
- D'Ydewalle, C.¹ Krishnan, J.² Chiheb, D.M.³ VanDamme, P.⁴ Irobi, J.⁵ Kozikowski, A.P.⁶ VandenBerghe, P.⁷ Timmerman, V.⁸ Robberecht, W.⁹ VanDenBosch, L.¹⁰

98
- 79251473377
- P. Cohen, M. Tcherpakov, Cell 2010, 143, 686-693.
- (2010) Cell , vol.143 , pp. 686-693
- Cohen, P.¹ Tcherpakov, M.²

99
- 33745674468
- G. Nalepa, M. Rolfe, J. WadeHarper, Nat. Rev. Drug Discovery 2006, 5, 596-613.
- (2006) Nat. Rev. Drug Discovery , vol.5 , pp. 596-613
- Nalepa, G.¹ Rolfe, M.² WadeHarper, J.³

100
- 76449094879
- F. Colland, Biochem. Soc. Trans. 2010, 38, 137-143.
- (2010) Biochem. Soc. Trans. , vol.38 , pp. 137-143
- Colland, F.¹

101
- 10744221485
- L. T. Vassilev, B. T. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, N. Kong, U. Kammlott, C. Lukacs, C. Klein, N. Fotouhi, E. A. Liu, Science 2004, 303, 844-848.
- (2004) Science , vol.303 , pp. 844-848
- Vassilev, L.T.¹ Vu, B.T.² Graves, B.³ Carvajal, D.⁴ Podlaski, F.⁵ Filipovic, Z.⁶ Kong, N.⁷ Kammlott, U.⁸ Lukacs, C.⁹ Klein, C.¹⁰ Fotouhi, N.¹¹ Liu, E.A.¹²

102
- 84873075578
- A Study of RO5045337 [RG7112] in Patients with Advanced Solid Tumors, Hoffmann-La Roche (Basel, Switzerland); ClinicalTrials.gov (US National Institutes of Health), ID: NCT00559533.
- A Study of RO5045337 [RG7112] in Patients with Advanced Solid Tumors, Hoffmann-La Roche (Basel, Switzerland); ClinicalTrials.gov (US National Institutes of Health), ID: NCT00559533.

103
- 79959656754
- D. F. Ceccarelli, X. Tang" B. Pelletier, S. Orlicky, W. Xie, V. Plantevin, D. Neculai, Y.-C. Chou, A. Ogunjimi, A. Al-Hakim, X. Varelas, J. Koszela, G. A. Wasney, M. Vedadi, S. Dhe-Paganon, S. Cox, S. Xu, A. Lopez-Girona, F. Mercurio, J. Wrana, D. Durocher, S. Meloche, D. R. Webb, M. Tyers, F. Sicher, Cell 2011, 145, 1075-1087.
- (2011) Cell , vol.145 , pp. 1075-1087
- Ceccarelli, D.F.¹ Pelletier, X.T.B.² Orlicky, S.³ Xie, W.⁴ Plantevin, V.⁵ Neculai, D.⁶ Chou, Y.-C.⁷ Ogunjimi, A.⁸ Al-Hakim, A.⁹ Varelas, X.¹⁰ Koszela, J.¹¹ Wasney, G.A.¹² Vedadi, M.¹³ Dhe-Paganon, S.¹⁴ Cox, S.¹⁵ Xu, S.¹⁶ Lopez-Girona, A.¹⁷ Mercurio, F.¹⁸ Wrana, J.¹⁹ Durocher, D.²⁰ more..

104
- 78650113602
- J. G. Marblestone, K. G. S. Kumar, M. J. Eddins, C. A. Leach, D. E. Sterner, M. R. Mattern, B. Nicholson, J. Biomol. Screening 2010, 15, 1220-1228.
- (2010) J. Biomol. Screening , vol.15 , pp. 1220-1228
- Marblestone, J.G.¹ Kumar, K.G.S.² Eddins, M.J.³ Leach, C.A.⁴ Sterner, D.E.⁵ Mattern, M.R.⁶ Nicholson, B.⁷

105
- 44349098667
- B. Nicholson, C. A. Leach, S. J. Goldenberg, D. M. Francis, M. P. Kodrasov, X. Tian, J. Shanks, D. E. Sterner, A. Bernal, M. R. Mattern, K. D. Wilkinson, T. F. Butt, Protein Sci. 2008, 17, 1035-1043.
- (2008) Protein Sci. , vol.17 , pp. 1035-1043
- Nicholson, B.¹ Leach, C.A.² Goldenberg, S.J.³ Francis, D.M.⁴ Kodrasov, M.P.⁵ Tian, X.⁶ Shanks, J.⁷ Sterner, D.E.⁸ Bernal, A.⁹ Mattern, M.R.¹⁰ Wilkinson, K.D.¹¹ Butt, T.F.¹²

106
- 77649216536
- K. M. Giacomini, S.-M. Huang, D. J. Tweedie, L. Z. Benet, K. L. R. Brouwer, X. Chu, A. Dahlin, R. Evers, V. Fischer, K. M. Hillgren, K. A. Hoffmaster, T. Ishikawa, D. Keppler, R. B. Kim, S. A. Lee, M. Niemi, J. W. Polli, Y. Sugiyama, P. W. Swaan, J. A. Ware, S. H. Wright, S. W. Yee, M. J. Zamek-Gliszczynski, L. Zhang, Nat. Rev. Drug Discovery 2010, 9, 215-236.
- (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 215-236
- Giacomini, K.M.¹ Huang, S.-M.² Tweedie, D.J.³ Benet, L.Z.⁴ Brouwer, K.L.R.⁵ Chu, X.⁶ Dahlin, A.⁷ Evers, R.⁸ Fischer, V.⁹ Hillgren, K.M.¹⁰ Hoffmaster, K.A.¹¹ Ishikawa, T.¹² Keppler, D.¹³ Kim, R.B.¹⁴ Lee, S.A.¹⁵ Niemi, M.¹⁶ Polli, J.W.¹⁷ Sugiyama, Y.¹⁸ Swaan, P.W.¹⁹ Ware, J.A.²⁰ more..

107
- 79960632377
- R. M. Oballa, L. Belair, C. W. Black, K. Bleasby, C. C. Chan, C. Desroches, X. Du, R. Gordon, J. Guay, S. Guiral, M. J. Hafey, E. Hamelin, Z. Huang, B. Kennedy, N. Lachance, F. Landry, C. S. Li, J. Mancini, D. Normandin, A. Pocai, etal., J. Med. Chem. 2011, 54, 5082-5096.
- (2011) J. Med. Chem. , vol.54 , pp. 5082-5096
- Oballa, R.M.¹ Belair, L.² Black, C.W.³ Bleasby, K.⁴ Chan, C.C.⁵ Desroches, C.⁶ Du, X.⁷ Gordon, R.⁸ Guay, J.⁹ Guiral, S.¹⁰ Hafey, M.J.¹¹ Hamelin, E.¹² Huang, Z.¹³ Kennedy, B.¹⁴ Lachance, N.¹⁵ Landry, F.¹⁶ Li, C.S.¹⁷ Mancini, J.¹⁸ Normandin, D.¹⁹ Pocai, A.²⁰ more..

108
- 77952426387
- J. M. Brown, L. L. Rudel, Curr. Opin. Lipidol. 2010, 21, 192-197.
- (2010) Curr. Opin. Lipidol. , vol.21 , pp. 192-197
- Brown, J.M.¹ Rudel, L.L.²

109
- 72249113143
- S. Léger, C. W. Black, D. Deschenes, D. Denis, S. Dolman, J.-P. Falgueyret, M. Gagnon, S. Guiral, Z. Huang, J. Guay, Y. Leblanc, C.-S. Li, F. Massé, R. Oballa, Bioorg. Med. Chem. Lett. 2010, 20, 499-502.
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 499-502
- Léger, S.¹ Black, C.W.² Deschenes, D.³ Denis, D.⁴ Dolman, S.⁵ Falgueyret, J.-P.⁶ Gagnon, M.⁷ Guiral, S.⁸ Huang, Z.⁹ Guay, J.¹⁰ Leblanc, Y.¹¹ Li, C.-S.¹² Massé, F.¹³ Oballa, R.¹⁴

110
- 43949101389
- J.-P. Garnier, Harv. Bus. Rev. 2008, 86, 68-76.
- (2008) Harv. Bus. Rev. , vol.86 , pp. 68-76
- Garnier, J.-P.¹

111
- 77950412216
- The Human Genome at Ten (Editorial)
- The Human Genome at Ten (Editorial): Nature 2010, 464, 649-650.
- (2010) Nature , vol.464 , pp. 649-650

112
- 84954223299
- Eds.: H. Kubinyi, G. Müller), Wiley-VCH, Weinheim
- Chemogenomics in Drug Discovery-A Medicinal Chemistry Perspective, (Eds.: H. Kubinyi, G. Müller), Wiley-VCH, Weinheim, 2004.
- (2004) Chemogenomics in Drug Discovery-A Medicinal Chemistry Perspective

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.