Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6548-6562

  Sheriff, Steven ^a   Beno, Brett R ^a   Zhai, Weixu ^a   Kostich, Walter A ^a   McDonnell, Patricia A ^a   Kish, Kevin ^a   Goldfarb, Valentina ^a   Gao, Mian ^a   Kiefer, Susan E ^a   Yanchunas, Joseph ^a   Huang, Yanling ^a   Shi, Shuhao ^a   Zhu, Shirong ^a   Dzierba, Carolyn ^a   Bronson, Joanne ^a   MacOr, John E ^a   Appiah, Kingsley K ^a   Westphal, Ryan S ^a   O'Connell, Jonathan ^a   Gerritz, Samuel W ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; LIGAND; PHOSPHATASE; PROLINE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; RECEPTOR PROTEIN TYROSINE PHOSPHATASE GAMMA; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; LIGAND BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 5; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 80053893337     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2003766     Document Type: Article

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