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Volumn 38, Issue 2, 2009, Pages 315-332

Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulcer: Looking to the Future

Author keywords

Aspirin; CINOD; COX 2 inhibitors; Cyclooxygenase; Hydrogen sulfide; Naproxen; Nitric oxide

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ANTIINFLAMMATORY AGENT; ARTHROTEC; ATB 429; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; ESOMEPRAZOLE PLUS NAPROXEN; ETORICOXIB; FLURBIPROFEN; FLURBIPROFEN 4 NITROXYBUTYL ESTER; HYDROGEN SULFIDE; IBUPROFEN; KETOPROFEN; LANSOPRAZOLE PLUS NAPROXEN; LUMIRACOXIB; NAPROXEN; NAPROXEN PLUS OMEPRAZOLE; NCX 4015; NITRIC OXIDE; NITRONAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PARECOXIB; PN 100; PN 200; PN 400; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTON PUMP INHIBITOR; ROFECOXIB; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; VALDECOXIB;

EID: 65549113804     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gtc.2009.03.001     Document Type: Review
Times cited : (27)

References (53)
  • 1
    • 0033577982 scopus 로고    scopus 로고
    • Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
    • Wolfe M.M., Lichtenstein D.R., and Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340 (1999) 1888-1899
    • (1999) N Engl J Med , vol.340 , pp. 1888-1899
    • Wolfe, M.M.1    Lichtenstein, D.R.2    Singh, G.3
  • 2
    • 0242690224 scopus 로고    scopus 로고
    • COX-2 and beyond: approaches to prostaglandin inhibition in human disease
    • FitzGerald G.A. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat Rev Drug Discov 2 (2003) 879-890
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 879-890
    • FitzGerald, G.A.1
  • 3
    • 0035833502 scopus 로고    scopus 로고
    • The coxibs, selective inhibitors of cyclooxygenase-2
    • FitzGerald G.A., and Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 345 (2001) 433-442
    • (2001) N Engl J Med , vol.345 , pp. 433-442
    • FitzGerald, G.A.1    Patrono, C.2
  • 4
    • 0029953816 scopus 로고    scopus 로고
    • The cellular and molecular basis of gastric mucosal defense
    • Wallace J.L., and Granger D.N. The cellular and molecular basis of gastric mucosal defense. FASEB J 10 (1996) 731-740
    • (1996) FASEB J , vol.10 , pp. 731-740
    • Wallace, J.L.1    Granger, D.N.2
  • 5
    • 25644452810 scopus 로고    scopus 로고
    • A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal anti-inflammatory drug use
    • Lanas A., Perez-Aisa M.A., Feu F., et al. A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal anti-inflammatory drug use. Am J Gastroenterol 100 (2005) 1685-1693
    • (2005) Am J Gastroenterol , vol.100 , pp. 1685-1693
    • Lanas, A.1    Perez-Aisa, M.A.2    Feu, F.3
  • 6
    • 33845457204 scopus 로고    scopus 로고
    • Risk of upper gastrointestinal ulcer bleeding associated with selective COX-2 inhibitors, traditional non-aspirin NSAIDs, aspirin, and combinations
    • [May 10, 2006, E-pub ahead of print]
    • Lanas A., García Rodríguez L.A., Arroyo M.T., et al. Risk of upper gastrointestinal ulcer bleeding associated with selective COX-2 inhibitors, traditional non-aspirin NSAIDs, aspirin, and combinations. [May 10, 2006, E-pub ahead of print]. Gut 55 (2006) 1731-1738
    • (2006) Gut , vol.55 , pp. 1731-1738
    • Lanas, A.1    García Rodríguez, L.A.2    Arroyo, M.T.3
  • 7
    • 34248576685 scopus 로고    scopus 로고
    • Coxibs and non-selective NSAIDs in the gastrointestinal setting: what should patients and physicians do
    • Lazzaroni M., Battocchia A., and Bianchi Porro G. Coxibs and non-selective NSAIDs in the gastrointestinal setting: what should patients and physicians do. Dig Liver Dis 39 (2007) 589-596
    • (2007) Dig Liver Dis , vol.39 , pp. 589-596
    • Lazzaroni, M.1    Battocchia, A.2    Bianchi Porro, G.3
  • 8
    • 0029162250 scopus 로고
    • Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial
    • Silverstein F.E., Graham D.Y., Senior J.R., et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 123 (1995) 241-249
    • (1995) Ann Intern Med , vol.123 , pp. 241-249
    • Silverstein, F.E.1    Graham, D.Y.2    Senior, J.R.3
  • 9
    • 0032510378 scopus 로고    scopus 로고
    • Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group
    • Hawkey C.J., Karrasch J.A., Szczepanski L., et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med 338 (1998) 727-734
    • (1998) N Engl J Med , vol.338 , pp. 727-734
    • Hawkey, C.J.1    Karrasch, J.A.2    Szczepanski, L.3
  • 10
    • 0032510315 scopus 로고    scopus 로고
    • A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group
    • Yeomans N.D., Tulassay Z., Juhasz L., et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med 338 (1998) 719-726
    • (1998) N Engl J Med , vol.338 , pp. 719-726
    • Yeomans, N.D.1    Tulassay, Z.2    Juhasz, L.3
  • 11
    • 1942544570 scopus 로고    scopus 로고
    • NO-aspirin: mechanism of action and gastrointestinal safety
    • S9-19
    • Fiorucci S., and Del Soldato P. NO-aspirin: mechanism of action and gastrointestinal safety. Dig Liver Dis 35 Suppl 2 (2003) S9-19
    • (2003) Dig Liver Dis , vol.35 , Issue.SUPPL. 2
    • Fiorucci, S.1    Del Soldato, P.2
  • 12
    • 0036562261 scopus 로고    scopus 로고
    • Potential cardioprotective actions of nitric oxide-releasing aspirin
    • Wallace J.L., Ignarro L.J., and Fiorucci S. Potential cardioprotective actions of nitric oxide-releasing aspirin. Nat Rev Drug Discov 1 (2002) 375-382
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 375-382
    • Wallace, J.L.1    Ignarro, L.J.2    Fiorucci, S.3
  • 13
    • 33744496549 scopus 로고    scopus 로고
    • NO-NSAIDs: from inflammatory mediators to clinical readouts
    • Fiorucci S., and Antonelli E. NO-NSAIDs: from inflammatory mediators to clinical readouts. Inflamm Allergy Drug Targets 5 (2006) 121-131
    • (2006) Inflamm Allergy Drug Targets , vol.5 , pp. 121-131
    • Fiorucci, S.1    Antonelli, E.2
  • 15
    • 33846184714 scopus 로고    scopus 로고
    • Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulphide-releasing diclofenac derivative in the rat
    • Wallace J.L., Caliendo G., Santagada V., et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulphide-releasing diclofenac derivative in the rat. Gastroenterology 132 (2007) 261-271
    • (2007) Gastroenterology , vol.132 , pp. 261-271
    • Wallace, J.L.1    Caliendo, G.2    Santagada, V.3
  • 16
    • 33846798044 scopus 로고    scopus 로고
    • Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative
    • Li L., Rossoni G., Sparatore A., et al. Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radic Biol Med 42 (2007) 706-719
    • (2007) Free Radic Biol Med , vol.42 , pp. 706-719
    • Li, L.1    Rossoni, G.2    Sparatore, A.3
  • 17
    • 33745920516 scopus 로고    scopus 로고
    • The emerging roles of hydrogen sulphide in the gastrointestinal tract and liver
    • Fiorucci S., Distrutti E., Cirino G., et al. The emerging roles of hydrogen sulphide in the gastrointestinal tract and liver. Gastroenterology 131 (2006) 259-271
    • (2006) Gastroenterology , vol.131 , pp. 259-271
    • Fiorucci, S.1    Distrutti, E.2    Cirino, G.3
  • 18
    • 2342496237 scopus 로고    scopus 로고
    • The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial
    • Bias P., Buchner A., Klesser B., et al. The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial. Am J Gastroenterol 99 4 (2004 Apr) 611-618
    • (2004) Am J Gastroenterol , vol.99 , Issue.4 , pp. 611-618
    • Bias, P.1    Buchner, A.2    Klesser, B.3
  • 19
    • 0036828285 scopus 로고    scopus 로고
    • Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage
    • Fiorucci S., de Lima Jr. O.M., Mencarelli A., et al. Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. Gastroenterology 123 (2002) 1598-1606
    • (2002) Gastroenterology , vol.123 , pp. 1598-1606
    • Fiorucci, S.1    de Lima Jr., O.M.2    Mencarelli, A.3
  • 20
    • 19744380776 scopus 로고    scopus 로고
    • Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
    • Bresalier R.S., Sandler R.S., Quan H., et al. Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 352 (2005) 1092-1102
    • (2005) N Engl J Med , vol.352 , pp. 1092-1102
    • Bresalier, R.S.1    Sandler, R.S.2    Quan, H.3
  • 21
    • 0034707105 scopus 로고    scopus 로고
    • VIGOR Study Group. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group
    • Bombardier C., Laine L., Reicin A., et al. VIGOR Study Group. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 343 (2000) 1520-1528
    • (2000) N Engl J Med , vol.343 , pp. 1520-1528
    • Bombardier, C.1    Laine, L.2    Reicin, A.3
  • 22
    • 0034644396 scopus 로고    scopus 로고
    • Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study
    • Silverstein F.E., Faich G., Goldstein J.L., et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 284 (2000) 1247-1255
    • (2000) JAMA , vol.284 , pp. 1247-1255
    • Silverstein, F.E.1    Faich, G.2    Goldstein, J.L.3
  • 23
    • 4344661128 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial
    • Schnitzer T.J., Burmester G.R., Mysler E., et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet 364 (2004) 665-674
    • (2004) Lancet , vol.364 , pp. 665-674
    • Schnitzer, T.J.1    Burmester, G.R.2    Mysler, E.3
  • 24
    • 4344578073 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial
    • Farkouh M.E., Kirshner H., Harrington R.A., et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. Lancet 364 (2004) 675-684
    • (2004) Lancet , vol.364 , pp. 675-684
    • Farkouh, M.E.1    Kirshner, H.2    Harrington, R.A.3
  • 25
    • 14944371100 scopus 로고    scopus 로고
    • Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery
    • Nussmeier N.A., Whelton A.A., Brown M.T., et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 352 (2005) 1081-1091
    • (2005) N Engl J Med , vol.352 , pp. 1081-1091
    • Nussmeier, N.A.1    Whelton, A.A.2    Brown, M.T.3
  • 26
    • 18344368896 scopus 로고    scopus 로고
    • Risk of hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control study
    • Johnsen S.P., Larsson H., Tarone R.E., et al. Risk of hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control study. Arch Intern Med 165 (2005) 978-984
    • (2005) Arch Intern Med , vol.165 , pp. 978-984
    • Johnsen, S.P.1    Larsson, H.2    Tarone, R.E.3
  • 27
    • 9944262983 scopus 로고    scopus 로고
    • Risk of cardiovascular events and rofecoxib: cumulative meta-analysis
    • Juni P., Nartey L., Reichenbach S., et al. Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364 (2004) 2021-2029
    • (2004) Lancet , vol.364 , pp. 2021-2029
    • Juni, P.1    Nartey, L.2    Reichenbach, S.3
  • 28
    • 0037308335 scopus 로고    scopus 로고
    • Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use
    • Laine L., Connors L.G., Reicin A., et al. Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use. Gastroenterology 124 2 (2003) 288-292
    • (2003) Gastroenterology , vol.124 , Issue.2 , pp. 288-292
    • Laine, L.1    Connors, L.G.2    Reicin, A.3
  • 29
    • 13544272038 scopus 로고    scopus 로고
    • Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo
    • 10.1016/S1542-3565(04)00619-6
    • Goldstein J.L., Eisen G.M., Lewis B., et al. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 3 (2005) 133-141 10.1016/S1542-3565(04)00619-6
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 133-141
    • Goldstein, J.L.1    Eisen, G.M.2    Lewis, B.3
  • 30
    • 0042233664 scopus 로고    scopus 로고
    • A magic bullet for mucosal protection and aspirin is the trigger!
    • Wallace J.L., and Fiorucci S. A magic bullet for mucosal protection and aspirin is the trigger!. Trends Pharmacol Sci 24 7 (2003) 323-326
    • (2003) Trends Pharmacol Sci , vol.24 , Issue.7 , pp. 323-326
    • Wallace, J.L.1    Fiorucci, S.2
  • 31
    • 0038718727 scopus 로고    scopus 로고
    • Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    • Fiorucci S., Distrutti E., de Lima O.M., et al. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J 17 (2003) 1171-1173
    • (2003) FASEB J , vol.17 , pp. 1171-1173
    • Fiorucci, S.1    Distrutti, E.2    de Lima, O.M.3
  • 32
    • 0141479985 scopus 로고    scopus 로고
    • Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa
    • Fiorucci S., Santucci L., Wallace J.L., et al. Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa. Proc Natl Acad Sci U S A 100 (2003) 10937-10941
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10937-10941
    • Fiorucci, S.1    Santucci, L.2    Wallace, J.L.3
  • 33
    • 33750689471 scopus 로고    scopus 로고
    • Shattuck lecture. Nitric oxide and cyclic GMP in cell signaling and drug development
    • Murad F. Shattuck lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med 355 19 (2006) 2003-2011
    • (2006) N Engl J Med , vol.355 , Issue.19 , pp. 2003-2011
    • Murad, F.1
  • 34
    • 0025078185 scopus 로고
    • Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process
    • Wallace J.L., Keenan C.M., and Granger D.N. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Phys 259 (1990) G462-G467
    • (1990) Am J Phys , vol.259
    • Wallace, J.L.1    Keenan, C.M.2    Granger, D.N.3
  • 35
    • 0028967384 scopus 로고
    • Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats
    • Santucci L., Fiorucci S., Di Matteo F.M., et al. Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology 108 2 (1995) 393-401
    • (1995) Gastroenterology , vol.108 , Issue.2 , pp. 393-401
    • Santucci, L.1    Fiorucci, S.2    Di Matteo, F.M.3
  • 36
    • 0028307948 scopus 로고
    • A diclofenac derivative without ulcerogenic properties
    • Wallace J.L., Reuter B., Cicala C., et al. A diclofenac derivative without ulcerogenic properties. Eur J Pharmacol 257 (1994) 249-255
    • (1994) Eur J Pharmacol , vol.257 , pp. 249-255
    • Wallace, J.L.1    Reuter, B.2    Cicala, C.3
  • 37
    • 0028182409 scopus 로고
    • Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat
    • Wallace J.L., Reuter B., Cicala C., et al. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 107 (1994) 173-179
    • (1994) Gastroenterology , vol.107 , pp. 173-179
    • Wallace, J.L.1    Reuter, B.2    Cicala, C.3
  • 38
    • 33847619273 scopus 로고    scopus 로고
    • Cyclo-oxygenase (COX) inhibiting nitric oxide donating (CINODs) drugs: a review of their current status
    • Stefano F., and Distrutti E. Cyclo-oxygenase (COX) inhibiting nitric oxide donating (CINODs) drugs: a review of their current status. Curr Top Med Chem 7 3 (2007) 277-282
    • (2007) Curr Top Med Chem , vol.7 , Issue.3 , pp. 277-282
    • Stefano, F.1    Distrutti, E.2
  • 39
    • 10044244823 scopus 로고    scopus 로고
    • Nitric oxide (NO)-releasing naproxen (HCT-3012[(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection
    • Fiorucci S., Di Lorenzo A., Renga B., et al. Nitric oxide (NO)-releasing naproxen (HCT-3012[(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. J Pharmacol Exp Ther 311 3 (2004) 1264-1271
    • (2004) J Pharmacol Exp Ther , vol.311 , Issue.3 , pp. 1264-1271
    • Fiorucci, S.1    Di Lorenzo, A.2    Renga, B.3
  • 40
    • 0032907875 scopus 로고    scopus 로고
    • Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats
    • Fiorucci S., Antonelli E., Santucci L., et al. Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Gastroenterology 116 (1999) 1089-1106
    • (1999) Gastroenterology , vol.116 , pp. 1089-1106
    • Fiorucci, S.1    Antonelli, E.2    Santucci, L.3
  • 41
    • 0037373349 scopus 로고    scopus 로고
    • Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study
    • Fiorucci S., Santucci L., Gresele P., et al. Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. Gastroenterology 124 (2003) 600
    • (2003) Gastroenterology , vol.124 , pp. 600
    • Fiorucci, S.1    Santucci, L.2    Gresele, P.3
  • 42
    • 3142736598 scopus 로고    scopus 로고
    • Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs
    • Fiorucci S., Mencarelli A., Distrutti E., et al. Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs. J Immunol 173 (2004) 874-882
    • (2004) J Immunol , vol.173 , pp. 874-882
    • Fiorucci, S.1    Mencarelli, A.2    Distrutti, E.3
  • 43
    • 0242329755 scopus 로고    scopus 로고
    • Gastrointestinal safety of AZD3582, a cyclooxygenase inhibiting nitric oxide donator: proof of concept study in humans
    • Hawkey C., Jones J.I., Atherton C.T., et al. Gastrointestinal safety of AZD3582, a cyclooxygenase inhibiting nitric oxide donator: proof of concept study in humans. Gut 52 (2003) 1537-1542
    • (2003) Gut , vol.52 , pp. 1537-1542
    • Hawkey, C.1    Jones, J.I.2    Atherton, C.T.3
  • 44
    • 33745238041 scopus 로고    scopus 로고
    • Nitronaproxen: AZD 3582, HCT 3012, Naproxen Nitroxybutylester, NO-Naproxen
    • Nitronaproxen: AZD 3582, HCT 3012, Naproxen Nitroxybutylester, NO-Naproxen. Drugs R D 7 4 (2006) 262-266
    • (2006) Drugs R D , vol.7 , Issue.4 , pp. 262-266
  • 46
    • 19144373563 scopus 로고    scopus 로고
    • Renal effects of the cyclooxygenase-inhibiting nitric oxide donator AZD3582 compared with rofecoxib and naproxen during normal and low sodium intake
    • Huledal G., Jonzon B., Malmenas M., et al. Renal effects of the cyclooxygenase-inhibiting nitric oxide donator AZD3582 compared with rofecoxib and naproxen during normal and low sodium intake. Clin Pharmacol Ther 77 (2005) 437-450
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 437-450
    • Huledal, G.1    Jonzon, B.2    Malmenas, M.3
  • 47
    • 29144446030 scopus 로고    scopus 로고
    • Comparison of the COX-inhibiting nitric oxide donator AZD3582 and rofecoxib in treating the signs and symptoms of Osteoarthritis of the knee
    • Schnitzer T.J., Kivitz A.J., Lipetz R.S., et al. Comparison of the COX-inhibiting nitric oxide donator AZD3582 and rofecoxib in treating the signs and symptoms of Osteoarthritis of the knee. Arthritis Rheum 53 (2005) 827-837
    • (2005) Arthritis Rheum , vol.53 , pp. 827-837
    • Schnitzer, T.J.1    Kivitz, A.J.2    Lipetz, R.S.3
  • 48
    • 0036845556 scopus 로고    scopus 로고
    • 2S be the third endogenous gaseous transmitter?
    • 2S be the third endogenous gaseous transmitter?. FASEB J 16 (2002) 1792-1798
    • (2002) FASEB J , vol.16 , pp. 1792-1798
    • Wang, R.1
  • 49
    • 34249777260 scopus 로고    scopus 로고
    • Sulfide, the first inorganic substrate for human cells
    • Goubern M., Andriamihaja M., Nubel T., et al. Sulfide, the first inorganic substrate for human cells. FASEB J 21 (2007) 1699-1706
    • (2007) FASEB J , vol.21 , pp. 1699-1706
    • Goubern, M.1    Andriamihaja, M.2    Nubel, T.3
  • 50
    • 29244467154 scopus 로고    scopus 로고
    • Evidence that hydrogen sulphide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels
    • Distrutti E., Sediari L., Mencarelli A., et al. Evidence that hydrogen sulphide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels. J Pharmacol Exp Ther 316 (2006) 325-335
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 325-335
    • Distrutti, E.1    Sediari, L.2    Mencarelli, A.3
  • 51
    • 33748987100 scopus 로고    scopus 로고
    • 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1, 2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulphide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity
    • Distrutti E., Sediari L., Mencarelli A., et al. 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1, 2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulphide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity. J Pharmacol Exp Ther 319 (2006) 447-458
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 447-458
    • Distrutti, E.1    Sediari, L.2    Mencarelli, A.3
  • 52
    • 33845602529 scopus 로고    scopus 로고
    • Hydrogen sulphide is an endogenous modulator of leukocyte-mediated inflammation
    • Zanardo R.C., Brancaleone V., Distrutti E., et al. Hydrogen sulphide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J 20 (2006) 2118-2120
    • (2006) FASEB J , vol.20 , pp. 2118-2120
    • Zanardo, R.C.1    Brancaleone, V.2    Distrutti, E.3
  • 53
    • 34247209138 scopus 로고    scopus 로고
    • Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis
    • Fiorucci S., Orlandi S., Mencarelli A., et al. Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. Br J Pharmacol 150 (2007) 996-1002
    • (2007) Br J Pharmacol , vol.150 , pp. 996-1002
    • Fiorucci, S.1    Orlandi, S.2    Mencarelli, A.3


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