Synthesis and cytotoxic activity of lipophilic sulphonamide derivatives of the benzo[b]thiophene 1,1-dioxide

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 5, 2004, Pages 963-968

  Villar, R ^a   Encio, I ^a   Migliaccio, M ^a   Gil, M J ^a   Martinez Merino, V ^a  

^a PUBLIC UNIVERSITY OF NAVARRE   (Spain)

Author keywords

Benzo b thiophenesulphonamide 1,1 dioxide derivatives; Cytotoxic activity; Lipophilicity; Structure activity relationships; Synthesis

Indexed keywords

3 METHYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; DOXORUBICIN; ETHYL 4 (6 BENZO[B]THIOPHENESULFONAMIDO 1,1 DIOXIDE)BUTYRATE; ETHYL 5 (6 BENZO[B]THIOPHENESULFONAMIDO 1,1 DIOXIDE)VALERATE; N (2 METHOXY)ETHYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N (3 CHLORO)PHENYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N (3 METHOXY)PHENYL 5 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N (4 HYDROXY)BUTYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N (4 METHOXY)PHENYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N BENZYL 5 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N BENZYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N BUTYL 5 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N BUTYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N CYCLOPROPYLMETHYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N ETHYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; N HEXYL 6 BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; SULFONAMIDE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIPOPHILICITY; LUNG FIBROBLAST; MEASUREMENT; STRUCTURE ANALYSIS; TUMOR CELL LINE;

EID: 1342343129     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.12.012     Document Type: Article

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