Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 14, 2004, Pages 3639-3643

  Galanakis, Dimitrios ^a   Kourounakis, Angeliki P ^b   Tsiakitzis, Karyophyllis C ^a   Doulgkeris, Christos ^a   Rekka, Eleni A ^a   Gavalas, Antonios ^a   Kravaritou, Constantina ^a   Charitos, Christos ^a   Kourounakis, Panos N ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Amide conjugate; Antiinflammatory; Antioxidant; DPPH; Gastrointestinal toxicity; Hypolipidemic; L Cysteine; Lipid peroxidation; Neurodegenerative disease; Ulcer

Indexed keywords

ANTILIPEMIC AGENT; CYSTEINE ETHYL ESTER; DICLOFENAC; FLUFENAMIC ACID; HYPOCHOLESTEROLEMIC AGENT; IBUPROFEN; INDOMETACIN; KETOPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; TOLFENAMIC ACID;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DIGESTIVE SYSTEM ULCER; DRUG EFFECT; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; HUMAN; MELENA; NONHUMAN; PAW EDEMA;

AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CHOLESTEROL; CYSTEINE; DRUG EVALUATION; GASTROINTESTINAL DISEASES; LIPOPROTEINS, LDL; MICE; RATS; TRIGLYCERIDES;

EID: 2942598058     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.025     Document Type: Article

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