5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis

Investigational New Drugs

Volumn 29, Issue 5, 2011, Pages 786-799

  Xu, Danqing ^a   Cao, Ji ^a   Qian, Shijing ^a   Li, Lin ^a   Hu, Chunqi ^b   Weng, Qinjie ^a   Lou, Jianshu ^a   Zhu, Difeng ^a   Zhu, Hong ^a   Hu, Yongzhou ^b   He, Qiaojun ^a   Yang, Bo ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; DNA damage; G 2 arrest; MDR; Topo II inhibitor

Indexed keywords

4 BETA [[4 (PYRROLIDIN 1 YLMETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 EPIPODOPHYLLOTOXIN; 5 K; ANTINEOPLASTIC AGENT; ATM PROTEIN; ATR PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; DNA TOPOISOMERASE (ATP HYDROLYSING); EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE; GLYCOPROTEIN P; UNCLASSIFIED DRUG; 4 ((4 (PYRROLIDIN 1 YLMETHYL)PHENYL)AMINO) 4' O DEMETHYL 4 EPIPODOPHYLLOTOXIN; 4-((4-(PYRROLIDIN-1-YLMETHYL)PHENYL)AMINO)-4'-O-DEMETHYL-4-EPIPODOPHYLLOTOXIN; CAFFEINE; CASPASE; CELL CYCLE PROTEIN; DNA; DRUG DERIVATIVE; GYRASE INHIBITOR; PODOPHYLLOTOXIN; PROTEIN BCL 2; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL ACTIVITY; CELL CYCLE ARREST; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; COLORECTAL CARCINOMA; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME REPRESSION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MALE; MITOCHONDRION; MITOSIS; MOLECULAR DOCKING; MOLECULAR MECHANICS; MOUSE; MOUTH SQUAMOUS CELL CARCINOMA; MULTIDRUG RESISTANCE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTE; PROMYELOCYTIC LEUKEMIA; PROSTATE TUMOR; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; FEMALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NEOPLASM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CAFFEINE; CASPASES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HERPES SIMPLEX VIRUS PROTEIN VMW65; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; PODOPHYLLOTOXIN; PROTO-ONCOGENE PROTEINS C-BCL-2; TOPOISOMERASE II INHIBITORS;

EID: 84856071983     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9423-5     Document Type: Article

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