Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation

Cellular and Molecular Life Sciences

Volumn 65, Issue 17, 2008, Pages 2763-2775

  Chen, T ^a   Wong, Y S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Melanoma; Mitochondria; p53; Reactive oxygen species; Selenium; Selenocystine

Indexed keywords

CASPASE; CASPASE INHIBITOR; DEATH RECEPTOR; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SELENOCYSTEINE; SERINE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG UPTAKE; ENZYME ACTIVATION; GENE CONTROL; GENE SILENCING; HUMAN; HUMAN CELL; MELANOMA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CYSTINE; DNA DAMAGE; HUMANS; MALE; MELANOMA; MICE; MICE, NUDE; MITOCHONDRIA; ORGANOSELENIUM COMPOUNDS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 51349139834     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8329-2     Document Type: Article

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