Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells

Journal of Cellular Biochemistry

Volumn 104, Issue 4, 2008, Pages 1181-1191

  Wang, Xiao Ming ^a   Li, Jiao ^a   Feng, Xiao Cheng ^a   Wang, Qiong ^a   Guan, Dong Yin ^a   Shen, Zong Hou ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cdc2; Cdc25C; Cell cycle arrest; Chk1; Lithium

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; ATR PROTEIN; CAFFEINE; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 1; HYDROXYUREA; INOSITOL MONOPHOSPHATASE; LITHIUM; PHOSPHATASE; PROTEIN KINASE INHIBITOR; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; SB 218078; SERINE; SMALL INTERFERING RNA; TYROSINE;

ARTICLE; BIPOLAR DISORDER; CANCER CELL; CANCER PREVENTION; CANCER THERAPY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CYCLIN B; G2 PHASE; HUMANS; LITHIUM; PHOSPHORYLATION; PROTEIN KINASES;

ATAXIA TELANGIECTASIA;

EID: 46949094761     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21693     Document Type: Article

References (38)

1. Bartek J, Lukas J. 2003. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3:421-429.
2. Bertoni F, Codegoni AM, Furlan D, Tibiletti MG, Capella C, Broggini M. 1999. CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers. Genes Chromosomes Cancer 26:176-180.
3. Boggs DR, Joyce RA. 1983. The hematopoietic effects of lithium. Semin Hematol 20:129-138.
4. Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ, Jr. 2001. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411:102-107.
5. Chen RW, Chuang DM. 1999. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J Biol Chem 274:6039-6042.
6. Cohen Y, Chetrit A, Cohen Y, Sirota P, Modan B. 1998. Cancer morbidity in psychiatric patients: Influence of lithium carbonate treatment. Med Oncol 15:32-36.
7. Diehl JA, Cheng M, Roussel MF, Sherr CJ. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499-3511.
8. Ding Z, Parchment RE, LoRusso PM, Zhou JY, Li J, Lawrence TS, Sun Y, Wu GS. 2001. The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways. Clin Cancer Res 7:3336-3342.
9. Eymin B, Claverie P, Salon C, Brambilla C, Brambilla E, Gazzeri S. 2006. p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation. Cell Cycle 5:759-765.
10. Gao H, Jin S, Song Y, Fu M, Wang M, Liu Z, Wu M, Zhan Q. 2005. B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest. J Biol Chem 280:10988-10996.
11. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. 1991. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67:197-211.
12. Hallcher LM, Sherman WR. 1980. The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem 255: 10896-10901.
13. Hedgepeth CM, Conrad LJ, Zhang J, Huang HC, Lee VM, Klein PS. 1997. Activation of the Wnt signaling pathway: A molecular mechanism for lithium action. Dev Biol 185:82-91.
14. Huot J, Nosal G, Radoucu-Thomas S. 1972. Effects of lithium chloride on normal and neoplastic cells in vitro. Experientia 28:456-457.
15. Kao KR, Elinson RP. 1998. The legacy of lithium effects on development. Biol Cell 90:585-589.
16. Karlsson-Rosenthal C, Millar JB. 2006. Cdc25: Mechanisms of checkpoint inhibition and recovery. Trends Cell Biol 16:285-292.
17. Khanna KK. 2000. Cancer risk and the ATM gene: A continuing debate. J Natl Cancer Inst 92:795-802.
18. Klein PS, Melton DA. 1996. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93:8455-8459.
19. Kulikov R, Boehme KA, Blattner C. 2005. Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Mol Cell Biol 25:7170-7180.
20. Liu F, Stanton JJ, Wu Z, Piwnica-Worms H. 1997. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol 17:571-583.
21. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ. 2000. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 14:1448-1459.
22. Mao CD, Hoang P, DiCorleto PE. 2001. Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells. J Biol Chem 276:26180-26188.
23. Ng CP, Lee HC, Ho CW, Arooz T, Siu WY, Lau A, Poon RY. 2004. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J Biol Chem 279:8808-8819.
24. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 36:617-656.
25. Ohteki T, Parsons M, Zakarian A, Jones RG, Nguyen LT, Woodgett JR, Ohashi PS. 2000. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med 192:99-104.
26. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H. 1997. Mitotic and G2 checkpoint control: Regulation of 14- 3-3protein binding by phosphorylation of Cdc25C on serine-216. Science 277:1501-1505.
27. Phiel CJ, Klein PS. 2001. Molecular targets of lithium action. Annu Rev Pharmacol Toxicol 41:789-813.
28. Rossig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeier S. 2002. Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 277:9684-9689.
29. Ryves WJ, Harwood AJ. 2001. Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 280:720-725.
30. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. 2004. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85.
31. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT. 1999. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382.
32. Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, Brown KD, Zhang L, Baskaran R. 2004. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J Biol Chem 279:25813-25822.
33. Sinha D, Wang Z, Ruchalski KL, Levine JS, Krishnan S, Lieberthal W, Schwartz JH, Borkan SC. 2005. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. Am J Physiol Renal Physiol 288:F703-F713.
34. Smits VA, Essers MA, Loomans DS, Klompmaker R, Rijksen G, Medema RH. 1999. Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation. FEBS Lett 457:23-27.
35. Stewart ZA, Westfall MD, Pietenpol JA. 2003. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci 24:135-149.
36. Taylor WR, Stark GR. 2001. Regulation of the G2/M transition by p53. Oncogene 20:1803-1815.
37. Watanabe N, Broome M, Hunter T. 1995. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J 14:1878-1891.
38. Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. 2002. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 30:285-289.