Mutant presenilin 2 increases β-secretase activity through reactive oxygen species-dependent activation of extracellular signal-regulated kinase

Journal of Neuropathology and Experimental Neurology

Volumn 71, Issue 2, 2012, Pages 130-139

  Park, Mi Hee ^a   Choi, Dong Young ^a   Jin, Hae Won ^a   Yoo, Hwan Soo ^a   Han, Jin Yi ^a   Oh, Ki Wan ^a   Han, Sang Bae ^a   Hwang, Dae Yeun ^b   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

secretase; Alzheimer disease; Amyloid ; ERK; Neurons; Presenilin 2; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; BETA SECRETASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; PRESENILIN 2; REACTIVE OXYGEN METABOLITE; UO 126;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NERVE CELL CULTURE; NEUROPATHOLOGY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SENILE PLAQUE; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOPRECIPITATION; LIPID PEROXIDATION; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; PEPTIDE FRAGMENTS; PRESENILIN-2; REACTIVE OXYGEN SPECIES;

EID: 84856060315     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3182432967     Document Type: Article

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