Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism

Neuroscience Letters

Volumn 436, Issue 1, 2008, Pages 77-80

  Dehvari, Nodi ^a   Isacsson, Ola ^a   Winblad, Bengt ^a   Cedazo Minguez, Angel ^a   Cowburn, Richard F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alzheimer's disease; Extracellular regulated kinase; Phospholipase C; Presenilin; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; AMYLOID PRECURSOR PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL DIBUTYRATE; PHOSPHOLIPASE C; PRESENILIN; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; PROTEIN KINASE C DELTA; PROTEIN KINASE C GAMMA; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; PRESENILINS; PROTEIN KINASE C-ALPHA; SIGNAL TRANSDUCTION; TYPE C PHOSPHOLIPASES;

EID: 41749103541     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.02.063     Document Type: Article

References (28)

1. Alkon D.L., Sun M.K., and Nelson T.J. PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease. Trends Pharmacol. Sci. 28 (2007) 51-60
2. Bae Y.S., Lee T.G., Park J.C., Hur J.H., Kim Y., Heo K., Kwak J.Y., Suh P.G., and Ryu S.H. Identification of a compound that directly stimulates phospholipase C activity. Mol. Pharmacol. 63 (2003) 1043-1050
3. Cedazo-Minguez A., Popescu B.O., Ankarcrona M., Nishimura T., and Cowburn R.F. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations. J. Biol. Chem. 277 (2002) 36646-36655
4. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., and Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398 (1999) 518-522
5. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., and Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391 (1998) 387-390
6. Dehvari N., Cedazo-Minguez A., Isacsson O., Nilsson T., Winblad B., Karlstrom H., Benedikz E., and Cowburn R.F. Presenilin dependence of phospholipase C and protein kinase C signaling. J. Neurochem. 102 (2007) 848-857
7. Deng G., Pike C.J., and Cotman C.W. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397 (1996) 50-54
8. Dumanchin C., Czech C., Campion D., Cuif M.H., Poyot T., Martin C., Charbonnier F., Goud B., Pradier L., and Frebourg T. Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum. Mol. Genet. 8 (1999) 1263-1269
9. Ferrer I., Blanco R., Carmona M., and Puig B. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. J. Neural Transm. 108 (2001) 1397-1415
10. Georgakopoulos A., Marambaud P., Efthimiopoulos S., Shioi J., Cui W., Li H.C., Schutte M., Gordon R., Holstein G.R., Martinelli G., Mehta P., Friedrich Jr. V.L., and Robakis N.K. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol. Cell. 4 (1999) 893-902
11. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Xie J., Robinson N., Martin G.M., and Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport 8 (1996) 379-383
12. Guo Q., Sopher B.L., Furukawa K., Pham D.G., Robinson N., Martin G.M., and Mattson M.P. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17 (1997) 4212-4222
13. Kang D.E., Yoon I.S., Repetto E., Busse T., Yermian N., Ie L., and Koo E.H. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signalling. J. Biol. Chem. 280 (2005) 31537-31547
14. Kim M.Y., Park J.H., Choi E.J., and Park H.S. Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway. Biochem. Biophys. Res. Commun. 332 (2005) 609-613
15. Levy-Lahad E., Wasco W., Poorkaj P., Romano D.M., Oshima J., Pettingell W.H., Yu C.E., Jondro P.D., Schmidt S.D., Wang K., Crowley A.C., Fu Y., Guenette S.Y., Galas D., Nemens E., Wijsman E.M., Bird T.D., Schellenberg G.D., and Tanzi R.E. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269 (1995) 973-977
16. Nishimura M., Yu G., Levesque G., Zhang D.M., Ruel L., Chen F., Milman P., Holmes E., Liang Y., Kawarai T., Jo E., Supala A., Rogaeva E., Xu D.M., Janus C., Levesque L., Bi Q., Duthie M., Rozmahel R., Mattila K., Lannfelt L., Westaway D., Mount H.T., Woodgett J., Fraser P.E., and St George-Hyslop P. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nat. Med. 5 (1999) 164-169
17. Parks A.L., and Curtis D. Presenilin diversifies its portfolio. Trends Genet. 23 (2007) 140-150
18. Perry G., Roder H., Nunomura A., Takeda A., Friedlich A.L., Zhu X., Raina A.K., Holbrook N., Siedlak S.L., Harris P.L., and Smith M.A. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport 10 (1999) 2411-2415
19. Popescu B.O., Cedazo-Minguez A., Benedikz E., Nishimura T., Winblad B., Ankarcrona M., and Cowburn R.F. Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction. J. Biol. Chem. 279 (2004) 6455-6464
20. Rebecchi M.J., and Pentyala S.N. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80 (2000) 1291-1335
21. Repetto E., Yoon I.S., Zheng H., and Kang D.E. Presenilin-1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J. Biol. Chem. 282 (2007) 31504-31516
22. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., Da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., and St George-Hyslop P.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 (1995) 754-760
23. Trojanowski J.Q., Mawal-Dewan M., Schmidt M.L., Martin J., and Lee V.M. Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites. Brain Res. 618 (1993) 333-337
24. Troppmair J., Bruder J.T., Munoz H., Lloyd P.A., Kyriakis J., Banerjee P., Avruch J., and Rapp U.R. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J. Biol. Chem. 269 (1994) 7030-7035
25. Zhang Z., Nadeau P., Song W., Donoviel D., Yuan M., Bernstein A., and Yankner B.A. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat. Cell. Biol. 2 (2000) 463-465
26. Zhang Y.W., Wang R., Liu Q., Zhang H., Liao F.F., and Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 10613-10618
27. Zhou J., Liyanage U., Medina M., Ho C., Simmons A.D., Lovett M., and Kosik K.S. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 8 (1997) 2085-2090
28. Zhu X., Castellani R.J., Takeda A., Nunomura A., Atwood C.S., Perry G., and Smith M.A. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech. Ageing Dev. 123 (2001) 39-46