-
1
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
2
-
-
0034641980
-
Apoptosis in development
-
Meier P, Finch A, Evan G (2000) Apoptosis in development. Nature 407:796-801
-
(2000)
Nature
, vol.407
, pp. 796-801
-
-
Meier, P.1
Finch, A.2
Evan, G.3
-
3
-
-
0038171513
-
Overview: Apoptotic signaling pathways in the immune system
-
DOI 10.1034/j.1600-065X.2003.00045.x
-
Green DR (2003) Overview: apoptotic signaling pathways in the immune system. Immunol Rev 193:5-9 (Pubitemid 36688034)
-
(2003)
Immunological Reviews
, vol.193
, pp. 5-9
-
-
Green, D.R.1
-
4
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
5
-
-
0026504147
-
Social controls on cell survival and cell death
-
Raff MC (1992) Social controls on cell survival and cell death. Nature 356:397-400
-
(1992)
Nature
, vol.356
, pp. 397-400
-
-
Raff, M.C.1
-
6
-
-
0842281645
-
Cell death: Critical control points
-
DOI 10.1016/S0092-8674(04)00046-7
-
Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219 (Pubitemid 38167313)
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
7
-
-
0034068601
-
Mitochondrial control of cell death
-
DOI 10.1038/74994
-
Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513-519 (Pubitemid 30305900)
-
(2000)
Nature Medicine
, vol.6
, Issue.5
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
8
-
-
0035936797
-
The TNF and TNF receptor superfamilies: Integrating mammalian biology
-
DOI 10.1016/S0092-8674(01)00237-9
-
Locksley RM, Killeen N, Lenardo MJ (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487-501 (Pubitemid 32201945)
-
(2001)
Cell
, vol.104
, Issue.4
, pp. 487-501
-
-
Locksley, R.M.1
Killeen, N.2
Lenardo, M.J.3
-
9
-
-
0347601880
-
A decade of caspases
-
DOI 10.1038/sj.onc.1207107
-
Degterev A, Boyce M, Yuan J (2003) A decade of caspases. Oncogene 22:8543-8567 (Pubitemid 38028527)
-
(2003)
Oncogene
, vol.22
, Issue.53
, pp. 8543-8567
-
-
Degterev, A.1
Boyce, M.2
Yuan, J.3
-
10
-
-
0030892234
-
Apoptosis by death factor
-
DOI 10.1016/S0092-8674(00)81874-7
-
Nagata S (1997) Apoptosis by death factor. Cell 88:355-365 (Pubitemid 27131377)
-
(1997)
Cell
, vol.88
, Issue.3
, pp. 355-365
-
-
Nagata, S.1
-
11
-
-
70349694386
-
Membranebound Fas ligand only is essential for Fas-induced apoptosis
-
O'Reilly L, Tai L, Lee L et al (2009) Membranebound Fas ligand only is essential for Fas-induced apoptosis. Nature 461:659-663
-
(2009)
Nature
, vol.461
, pp. 659-663
-
-
O'reilly, L.1
Tai, L.2
Lee, L.3
-
12
-
-
0036162436
-
The molecular architecture of the TNF superfamily
-
DOI 10.1016/S0968-0004(01)01995-8, PII S0968000401019958
-
Bodmer JL, Schneider P, Tschopp J (2002) The molecular architecture of the TNF superfamily. Trends Biochem Sci 27:19-26 (Pubitemid 34131621)
-
(2002)
Trends in Biochemical Sciences
, vol.27
, Issue.1
, pp. 19-26
-
-
Bodmer, J.-L.1
Schneider, P.2
Tschopp, J.3
-
13
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-989
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'leary, D.D.3
Tessier-Lavigne, M.4
-
14
-
-
0001203366
-
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor
-
Wu GS, Burns TF, Zhan Y et al (1999) Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res 59:2770-2775 (Pubitemid 29283105)
-
(1999)
Cancer Research
, vol.59
, Issue.12
, pp. 2770-2775
-
-
Wu, G.S.1
Burns, T.F.2
Zhan, Y.3
Alnemri, E.S.4
El-Deiry, W.S.5
-
15
-
-
62849093368
-
Death receptor signal transducers: Nodes of coordination in immune signaling networks
-
Wilson NS, Dixit V, Ashkenazi A (2009) Death receptor signal transducers: nodes of coordination in immune signaling networks. Nature Immunol 10:348-355
-
(2009)
Nature Immunol
, vol.10
, pp. 348-355
-
-
Wilson, N.S.1
Dixit, V.2
Ashkenazi, A.3
-
16
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
DOI 10.1016/1074-7613(95)90057-8
-
Wiley SR, Schooley K, Smolak PJ et al (1995) Identifi cation and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673-682 (Pubitemid 26091143)
-
(1995)
Immunity
, vol.3
, Issue.6
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
Din, W.S.4
Huang, C.-P.5
Nicholl, J.K.6
Sutherland, G.R.7
Smith, T.D.8
Rauch, C.9
Smith, C.A.10
Goodwin, R.G.11
-
17
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
DOI 10.1074/jbc.271.22.12687
-
Pitti RM, Marsters SA, Ruppert S et al (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271:12687-12690 (Pubitemid 26175834)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.22
, pp. 12687-12690
-
-
Pitti, R.M.1
Marsters, S.A.2
Ruppert, S.3
Donahue, C.J.4
Moore, A.5
Ashkenazi, A.6
-
18
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi A, Pai RC, Fong S et al (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104:155-162
-
(1999)
J Clin Invest
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
-
19
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
DOI 10.1038/5517
-
Walczak H, Miller RE, Ariail K et al (1999) Tumoricidal activity of tumor necrosis factorrelated apoptosis-inducing ligand in vivo. Nat Med 5:157-163 (Pubitemid 29068521)
-
(1999)
Nature Medicine
, vol.5
, Issue.2
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
Gliniak, B.4
Griffith, T.S.5
Kubin, M.6
Chin, W.7
Jones, J.8
Woodward, A.9
Le, T.10
Smith, C.11
Smolak, P.12
Goodwin, R.G.13
Rauch, C.T.14
Schuh, J.C.L.15
Lynch, D.H.16
-
21
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
DOI 10.1126/science.276.5309.111
-
Pan G, O'Rourke K, Chinnaiyan AM et al (1997) The receptor for the cytotoxic ligand TRAIL. Science 276:111-113 (Pubitemid 27161256)
-
(1997)
Science
, vol.276
, Issue.5309
, pp. 111-113
-
-
Pan, G.1
O'Rourke, K.2
Chinnaiyan, A.M.3
Gentz, R.4
Ebner, R.5
Ni, J.6
Dixit, V.M.7
-
22
-
-
0030707811
-
Characterization of two receptors for TRAIL
-
DOI 10.1016/S0014-5793(97)01231-3, PII S0014579397012313
-
Schneider P, Bodmer JL, Thome M et al (1997) Characterization of two receptors for TRAIL. FEBS Lett 416:329-334 (Pubitemid 27475391)
-
(1997)
FEBS Letters
, vol.416
, Issue.3
, pp. 329-334
-
-
Schneider, P.1
Bodmer, J.-L.2
Thome, M.3
Hofmann, K.4
Holler, N.5
Tschopp, J.6
-
23
-
-
0030770614
-
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
-
DOI 10.1074/jbc.272.41.25417
-
MacFarlane M, Ahmad M, Srinivasula SM et al (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem 272:25417-25420 (Pubitemid 27438841)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.41
, pp. 25417-25420
-
-
MacFarlane, M.1
Ahmad, M.2
Srinivasula, S.M.3
Fernandes-Alnemri, T.4
Cohen, G.M.5
Alnemri, E.S.6
-
24
-
-
0030792712
-
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
-
DOI 10.1126/science.277.5327.818
-
Sheridan JP, Marsters SA, Pitti RM et al (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277:818-821 (Pubitemid 27366733)
-
(1997)
Science
, vol.277
, Issue.5327
, pp. 818-821
-
-
Sheridan, J.P.1
Marsters, S.A.2
Pitti, R.M.3
Gurney, A.4
Skubatch, M.5
Baldwin, D.6
Ramakrishnan, L.7
Gray, C.L.8
Baker, K.9
Wood, W.I.10
Goddard, A.D.11
Godowski, P.12
Ashkenazi, A.13
-
25
-
-
0030880548
-
TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL
-
DOI 10.1093/emboj/16.17.5386
-
Walczak H, Degli-Esposti MA, Johnson RS et al (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J 16:5386-5397 (Pubitemid 27380146)
-
(1997)
EMBO Journal
, vol.16
, Issue.17
, pp. 5386-5397
-
-
Walczak, H.1
Degli-Esposti, M.A.2
Johnson, R.S.3
Smolak, P.J.4
Waugh, J.Y.5
Boiani, N.6
Timour, M.S.7
Gerhart, M.J.8
Schooley, K.A.9
Smith, C.A.10
Goodwin, R.G.11
Rauch, C.T.12
-
26
-
-
0030869432
-
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
-
DOI 10.1084/jem.186.7.1165
-
Degli-Esposti MA, Smolak PJ, Walczak H et al (1997) Cloning and characterization of TRAILR3, a novel member of the emerging TRAIL receptor family. J Exp Med 186:1165-1170 (Pubitemid 27441160)
-
(1997)
Journal of Experimental Medicine
, vol.186
, Issue.7
, pp. 1165-1170
-
-
Degli-Esposti, M.A.1
Smolak, P.J.2
Walczak, H.3
Waugh, J.4
Huang, C.-P.5
DuBose, R.F.6
Goodwin, R.G.7
Smith, C.A.8
-
27
-
-
7344233085
-
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
-
DOI 10.1074/jbc.273.23.14363
-
Emery JG, McDonnell P, Burke MB et al (1998) Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 273:14363-14367 (Pubitemid 28319153)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.23
, pp. 14363-14367
-
-
Emery, J.G.1
McDonnell, P.2
Burke, M.B.3
Deen, K.C.4
Lyn, S.5
Silverman, C.6
Dul, E.7
Appelbaum, E.R.8
Eichman, C.9
DiPrinzio, R.10
Dodds, R.A.11
James, I.E.12
Rosenberg, M.13
Lee, J.C.14
Young, P.R.15
-
28
-
-
0034733682
-
A domain in TNF receptors that mediates ligand-independent receptor assembty and signaling
-
DOI 10.1126/science.288.5475.2351
-
Chan FK, Chun HJ, Zheng L et al (2000) A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288:2351-2354 (Pubitemid 30448156)
-
(2000)
Science
, vol.288
, Issue.5475
, pp. 2351-2354
-
-
Chan, F.K.-M.1
Chun, H.J.2
Zheng, L.3
Siegel, R.M.4
Bui, K.L.5
Lenardo, M.J.6
-
29
-
-
0033935490
-
Coordinated regulation of two TRAIL-R2/KILLER/DR5 mRNA isoforms by DNA damaging agents, serum and 17β-estradiol in human breast cancer cells
-
DOI 10.1023/A:1006432201432
-
Wang TT, Jeng J (2000) Coordinated regulation of two TRAIL-R2/KILLER/DR5 Mrna isoforms by DNA damaging agents, serum and 17beta-estradiol in human breast cancer cells. Breast Cancer Res Treat 61:87-96 (Pubitemid 30440553)
-
(2000)
Breast Cancer Research and Treatment
, vol.61
, Issue.1
, pp. 87-96
-
-
Wang, T.T.Y.1
Jeng, J.2
-
30
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
DOI 10.1128/MCB.00520-06
-
Merino D, Lalaoui N, Morizot A et al (2006) Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol 26:7046-7055 (Pubitemid 44477684)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.19
, pp. 7046-7055
-
-
Merino, D.1
Lalaoui, N.2
Morizot, A.3
Schneider, P.4
Solary, E.5
Micheau, O.6
-
31
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
DOI 10.1016/S0092-8674(00)81569-X
-
Lacey DL, Timms E, Tan HL et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176 (Pubitemid 28180851)
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.-L.3
Kelley, M.J.4
Dunstan, C.R.5
Burgess, T.6
Elliott, R.7
Colombero, A.8
Elliott, G.9
Scully, S.10
Hsu, H.11
Sullivan, J.12
Hawkins, N.13
Davy, E.14
Capparelli, C.15
Eli, A.16
Qian, Y.-X.17
Kaufman, S.18
Sarosi, I.19
Shalhoub, V.20
Senaldi, G.21
Guo, J.22
Delaney, J.23
Boyle, W.J.24
more..
-
32
-
-
0036467427
-
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
-
Cretney E, Takeda K, Yagita H et al (2002) Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing liganddefi cient mice. J Immunol 168:1356-1361 (Pubitemid 34094506)
-
(2002)
Journal of Immunology
, vol.168
, Issue.3
, pp. 1356-1361
-
-
Cretney, E.1
Takeda, K.2
Yagita, H.3
Glaccum, M.4
Peschon, J.J.5
Smyth, M.J.6
-
33
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
DOI 10.1038/91000
-
Ichikawa K, Liu W, Zhao L et al (2001) Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7:954-960 (Pubitemid 32756434)
-
(2001)
Nature Medicine
, vol.7
, Issue.8
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
Wang, Z.4
Liu, D.5
Ohtsuka, T.6
Zhang, H.7
Mountz, J.D.8
Koopman, W.J.9
Kimberly, R.P.10
Zhou, T.11
-
34
-
-
62749084512
-
Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling
-
2 p following 192
-
Rossin A, Derouet M, Abdel-Sater F, Hueber AO (2009) Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling. Biochem J 419:185-192, 2 p following 192
-
(2009)
Biochem J
, vol.419
, pp. 185-192
-
-
Rossin, A.1
Derouet, M.2
Abdel-Sater, F.3
Hueber, A.O.4
-
35
-
-
33746472380
-
Nitrosylcobalamin promotes cell death via S nitrosylation of Apo2L/TRAIL receptor DR4
-
DOI 10.1128/MCB.00199-06
-
Tang Z, Bauer JA, Morrison B, Lindner DJ (2006) Nitrosylcobalamin promotes cell death via S nitrosylation of Apo2L/TRAIL receptor DR4. Mol Cell Biol 26:5588-5594 (Pubitemid 44134317)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.15
, pp. 5588-5594
-
-
Tang, Z.1
Bauer, J.A.2
Morrison, B.3
Lindner, D.J.4
-
36
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
DOI 10.1038/nm1627, PII NM1627
-
Wagner KW, Punnoose EA, Januario T et al (2007) Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 13:1070-1077 (Pubitemid 47517508)
-
(2007)
Nature Medicine
, vol.13
, Issue.9
, pp. 1070-1077
-
-
Wagner, K.W.1
Punnoose, E.A.2
Januario, T.3
Lawrence, D.A.4
Pitti, R.M.5
Lancaster, K.6
Lee, D.7
Von Goetz, M.8
Yee, S.F.9
Totpal, K.10
Huw, L.11
Katta, V.12
Cavet, G.13
Hymowitz, S.G.14
Amler, L.15
Ashkenazi, A.16
-
37
-
-
10344260656
-
TRAIL-R as a negative regulator of innate immune cell responses
-
DOI 10.1016/j.immuni.2004.11.008, PII S1074761304003474
-
Diehl GE, Yue HH, Hsieh K et al (2004) TRAIL-R as a negative regulator of innate immune cell responses. Immunity 21:877-889 (Pubitemid 39626676)
-
(2004)
Immunity
, vol.21
, Issue.6
, pp. 877-889
-
-
Diehl, G.E.1
Yue, H.H.2
Hsieh, K.3
Kuang, A.A.4
Ho, M.5
Morici, L.A.6
Lenz, L.L.7
Cado, D.8
Riley, L.W.9
Winoto, A.10
-
38
-
-
0037338951
-
-/- mice
-
DOI 10.1038/ni894
-
Lamhamedi-Cherradi SE, Zheng SJ, Maguschak KA et al (2003) Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/-mice. Nat Immunol 4:255-260 (Pubitemid 36322135)
-
(2003)
Nature Immunology
, vol.4
, Issue.3
, pp. 255-260
-
-
Lamhamedi-Cherradi, S.-E.1
Zheng, S.-J.2
Maguschak, K.A.3
Peschon, J.4
Chen, Y.H.5
-
39
-
-
38149122326
-
TRAIL-R defi ciency in mice enhances lymph node metastasis without affecting primary tumor development
-
Grosse-Wilde A, Voloshanenko O, Bailey SL et al (2008) TRAIL-R defi ciency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 118:100-110
-
(2008)
J Clin Invest
, vol.118
, pp. 100-110
-
-
Grosse-Wilde, A.1
Voloshanenko, O.2
Bailey, S.L.3
-
40
-
-
0035137696
-
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
-
DOI 10.1038/83416
-
Takeda K, Hayakawa Y, Smyth MJ et al (2001) Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 7:94-100 (Pubitemid 32095647)
-
(2001)
Nature Medicine
, vol.7
, Issue.1
, pp. 94-100
-
-
Takeda, K.1
Hayakawa, Y.2
Smyth, M.J.3
Kayagaki, N.4
Yamaguchi, N.5
Kakuta, S.6
Iwakura, Y.7
Yagita, H.8
Okumura, K.9
-
41
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick MR, Weigand MA, Rieser E et al (2000) FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12:599-609
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
-
42
-
-
77956170550
-
New insights into apoptosis signaling by Apo2L/TRAIL
-
Gonzalvez F, Ashkenazi A (2010) New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29:4752-4765
-
(2010)
Oncogene
, vol.29
, pp. 4752-4765
-
-
Gonzalvez, F.1
Ashkenazi, A.2
-
43
-
-
0033547350
-
TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells
-
Yamada H, Tada-Oikawa S, Uchida A, Kawanishi S (1999) TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells. Biochem Biophys Res Commun 265:130-133
-
(1999)
Biochem Biophys Res Commun
, vol.265
, pp. 130-133
-
-
Yamada, H.1
Tada-Oikawa, S.2
Uchida, A.3
Kawanishi, S.4
-
44
-
-
0036131142
-
Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
-
DOI 10.1038/nm0302-274
-
LeBlanc H, Lawrence D, Varfolomeev E et al (2002) Tumor-cell resistance to death receptorinduced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. Nat Med 8:274-281 (Pubitemid 34250106)
-
(2002)
Nature Medicine
, vol.8
, Issue.3
, pp. 274-281
-
-
LeBlanc, H.1
Lawrence, D.2
Varfolomeev, E.3
Totpal, K.4
Morlan, J.5
Schow, P.6
Fong, S.7
Schwall, R.8
Sinicropi, D.9
Ashkenazi, A.10
-
45
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X, Budihardjo I, Zou H et al (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490 (Pubitemid 28391864)
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
46
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
DOI 10.1038/40657
-
Irmler M, Thome M, Hahne M et al (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388:190-195 (Pubitemid 27297457)
-
(1997)
Nature
, vol.388
, Issue.6638
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
Bodmer, J.-L.7
Schroter, M.8
Burns, K.9
Mattmann, C.10
Rimoldi, D.11
French, L.E.12
Tschopp, J.13
-
47
-
-
0037015675
-
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
-
DOI 10.1038/sj.onc.1205853
-
MacFarlane M, Harper N, Snowden RT et al (2002) Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 21:6809-6818 (Pubitemid 35221923)
-
(2002)
Oncogene
, vol.21
, Issue.44
, pp. 6809-6818
-
-
MacFarlane, M.1
Harper, N.2
Snowden, T.R.3
Dyer, M.J.S.4
Barnett, G.A.5
Pringle, J.H.6
Cohen, G.M.7
-
48
-
-
0034959128
-
Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different FLIP isoforms
-
DOI 10.1046/j.1365-3083.2001.00941.x
-
Djerbi M, Darreh-Shori T, Zhivotovsky B, Grandien A (2001) Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different fl ip isoforms. Scan J Immunol 54:180-189 (Pubitemid 32592344)
-
(2001)
Scandinavian Journal of Immunology
, vol.54
, Issue.1-2
, pp. 180-189
-
-
Djerbi, M.1
Darreh-Shori, T.2
Zhivotovsky, B.3
Grandien, A.4
-
49
-
-
17644378775
-
R, a new regulator of death receptor-induced apoptosis
-
DOI 10.1074/jbc.M414425200
-
Golks A, Brenner D, Fritsch C et al (2005) c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem 280:14507-14513 (Pubitemid 40562792)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.15
, pp. 14507-14513
-
-
Golks, A.1
Brenner, D.2
Fritsch, C.3
Krammer, P.H.4
Lavrik, I.N.5
-
50
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
-
DOI 10.1074/jbc.M206882200
-
Micheau O, Thome M, Schneider P et al (2002) The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 277:45162-45171 (Pubitemid 36159119)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.47
, pp. 45162-45171
-
-
Micheau, O.1
Thome, M.2
Schneider, P.3
Holler, N.4
Tschopp, J.5
Nicholson, D.W.6
Briand, C.7
Grutter, M.G.8
-
51
-
-
54949132875
-
Bcl-2 family proteins and cancer
-
Yip KW, Reed JC (2008) Bcl-2 family proteins and cancer. Oncogene 27:6398-6406
-
(2008)
Oncogene
, vol.27
, pp. 6398-6406
-
-
Yip, K.W.1
Reed, J.C.2
-
52
-
-
0037067678
-
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells
-
DOI 10.1074/jbc.M202946200
-
Xiao C, Yang BF, Asadi N et al (2002) Tumor necrosis factor-related apoptosis-inducing ligandinduced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J Biol Chem 277:25020-25025 (Pubitemid 34951805)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.28
, pp. 25020-25025
-
-
Xiao, C.1
Yang, B.F.2
Asadi, N.3
Beguinot, F.4
Hao, C.5
-
53
-
-
33749004024
-
Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells
-
DOI 10.1158/0008-5472.CAN-06-0808
-
Palacios C, Yerbes R, Lopez-Rivas A (2006) Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells. Cancer Res 66:8858-8869 (Pubitemid 44449204)
-
(2006)
Cancer Research
, vol.66
, Issue.17
, pp. 8858-8869
-
-
Palacios, C.1
Yerbes, R.2
Lopez-Rivas, A.3
-
54
-
-
21444446872
-
Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis
-
DOI 10.1074/jbc.M413962200
-
Sharp DA, Lawrence DA, Ashkenazi A (2005) Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. J Biol Chem 280:19401-19409 (Pubitemid 41379648)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.19
, pp. 19401-19409
-
-
Sharp, D.A.1
Lawrence, D.A.2
Ashkenazi, A.3
-
55
-
-
78650741412
-
Cellular FLIP(L) plays a survival role and regulates morphogenesis in breast epithelial cells
-
Yerbes R, Palacios C, Reginato MJ, Lopez-Rivas A (2011) Cellular FLIP(L) plays a survival role and regulates morphogenesis in breast epithelial cells. Biochim Biophys Acta 1813:168-178
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 168-178
-
-
Yerbes, R.1
Palacios, C.2
Reginato, M.J.3
Lopez-Rivas, A.4
-
56
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z, Li Y, Pitti R et al (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137:721-735
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
Li, Y.2
Pitti, R.3
-
57
-
-
34547123570
-
Lipid rafts and nonrafts mediate tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic and nonapoptotic signals in non-small cell lung carcinoma cells
-
DOI 10.1158/0008-5472.CAN-06-3896
-
Song JH, Tse MC, Bellail A et al (2007) Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res 67:6946-6955 (Pubitemid 47105542)
-
(2007)
Cancer Research
, vol.67
, Issue.14
, pp. 6946-6955
-
-
Song, J.H.1
Tse, M.C.L.2
Bellail, A.3
Phuphanich, S.4
Khuri, F.5
Kneteman, N.M.6
Hao, C.7
-
58
-
-
34250331231
-
Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
-
DOI 10.1074/jbc.M700438200
-
Kohlhaas SL, Craxton A, Sun XM et al (2007) Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. J Biol Chem 282:12831-12841 (Pubitemid 47100635)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.17
, pp. 12831-12841
-
-
Kohlhaas, S.L.1
Craxton, A.2
Sun, X.-M.3
Pinkoski, M.J.4
Cohen, G.M.5
-
59
-
-
56949098754
-
Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells
-
Zhao X, Liu Y, Ma Q et al (2009) Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun 378:21-26
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 21-26
-
-
Zhao, X.1
Liu, Y.2
Ma, Q.3
-
60
-
-
33750370438
-
Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis
-
DOI 10.1128/MCB.00257-06
-
Jin Z, El-Deiry WS (2006) Distinct signaling pathways in TRAIL- versus tumor necrosis factorinduced apoptosis. Mol Cell Biol 26:8136-8148 (Pubitemid 44631011)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.21
, pp. 8136-8148
-
-
Jin, Z.1
El-Deiry, W.S.2
-
61
-
-
28844441555
-
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
-
DOI 10.1074/jbc.M509560200
-
Varfolomeev E, Maecker H, Sharp D et al (2005) Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factorrelated apoptosis-inducing ligand. J Biol Chem 280:40599-40608 (Pubitemid 41780550)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.49
, pp. 40599-40608
-
-
Varfolomeev, E.1
Maecker, H.2
Sharp, D.3
Lawrence, D.4
Renz, M.5
Vucic, D.6
Ashkenazi, A.7
-
62
-
-
56249123994
-
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells
-
Secchiero P, Melloni E, Corallini F et al (2008) Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Stem Cells 26:2955-2963
-
(2008)
Stem Cells
, vol.26
, pp. 2955-2963
-
-
Secchiero, P.1
Melloni, E.2
Corallini, F.3
-
63
-
-
0038339094
-
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-κB
-
DOI 10.1038/sj.onc.1206520
-
Ehrhardt H, Fulda S, Schmid I et al (2003) TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 22:3842-3852 (Pubitemid 36819657)
-
(2003)
Oncogene
, vol.22
, Issue.25
, pp. 3842-3852
-
-
Ehrhardt, H.1
Fulda, S.2
Schmid, I.3
Hiscott, J.4
Debatin, K.-M.5
Jeremias, I.6
-
65
-
-
33846429218
-
TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions
-
DOI 10.1158/0008-5472.CAN-06-1610
-
Meurette O, Rebillard A, Huc L et al (2007) TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. Cancer Res 67:218-226 (Pubitemid 46142778)
-
(2007)
Cancer Research
, vol.67
, Issue.1
, pp. 218-226
-
-
Meurette, O.1
Rebillard, A.2
Huc, L.3
Le Moigne, G.4
Merino, D.5
Micheau, O.6
Lagadic-Gossmann, D.7
Dimanche-Boitrel, M.-T.8
-
66
-
-
0035911242
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon γ-dependent natural killer cell protection from tumor metastasis
-
DOI 10.1084/jem.193.6.661
-
Smyth MJ, Cretney E, Takeda K et al (2001) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gammadependent natural killer cell protection from tumor metastasis. J Exp Med 193:661-670 (Pubitemid 32524460)
-
(2001)
Journal of Experimental Medicine
, vol.193
, Issue.6
, pp. 661-670
-
-
Smyth, M.J.1
Cretney, E.2
Takeda, K.3
Wiltrout, R.H.4
Sedger, L.M.5
Kayagaki, N.6
Yagita, H.7
Okumura, K.8
-
67
-
-
27144489394
-
Cutting edge: TRAIL deficiency accelerates hematological malignancies
-
Zerafa N, Westwood JA, Cretney E et al (2005) Cutting edge: TRAIL defi ciency accelerates hematological malignancies. J Immunol 175:5586-5590 (Pubitemid 41508035)
-
(2005)
Journal of Immunology
, vol.175
, Issue.9
, pp. 5586-5590
-
-
Zerafa, N.1
Westwood, J.A.2
Cretney, E.3
Mitchell, S.4
Waring, P.5
Iezzi, M.6
Smyth, M.J.7
-
68
-
-
11844305926
-
Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice [3]
-
DOI 10.1038/sj.cdd.4401523
-
Yue HH, Diehl GE, Winoto A (2005) Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 12:94-97 (Pubitemid 40090033)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.1
, pp. 94-97
-
-
Yue, H.H.1
Diehl, G.E.2
Winoto, A.3
-
69
-
-
67649300721
-
Genes that mediate breast cancer metastasis to the brain
-
Bos PD, Zhang XH, Nadal C et al (2009) Genes that mediate breast cancer metastasis to the brain. Nature 459:1005-1009
-
(2009)
Nature
, vol.459
, pp. 1005-1009
-
-
Bos, P.D.1
Zhang, X.H.2
Nadal, C.3
-
70
-
-
52649109068
-
The TRAIL apoptotic pathway in cancer onset, progression and therapy
-
Johnstone RW, Frew AJ, Smyth MJ (2008) The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer 8:782-798
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 782-798
-
-
Johnstone, R.W.1
Frew, A.J.2
Smyth, M.J.3
-
71
-
-
0001130662
-
Alterations of the DR5/TRAIL receptor 2 gene in nonsmall cell lung cancers
-
Lee SH, Shin MS, Kim HS et al (1999) Alterations of the DR5/TRAIL receptor 2 gene in nonsmall cell lung cancers. Cancer Res 59:5683-5686
-
(1999)
Cancer Res
, vol.59
, pp. 5683-5686
-
-
Lee, S.H.1
Shin, M.S.2
Kim, H.S.3
-
72
-
-
0035394722
-
Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers
-
Shin MS, Kim HS, Lee SH et al (2001) Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers. Cancer Res 61:4942-4946
-
(2001)
Cancer Res
, vol.61
, pp. 4942-4946
-
-
Shin, M.S.1
Kim, H.S.2
Lee, S.H.3
-
73
-
-
34548695886
-
TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma
-
DOI 10.1016/j.ijrobp.2007.03.057, PII S0360301607006529
-
Sanlioglu AD, Korcum AF, Pestereli E et al (2007) TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma. Int J Radiat Oncol Biol Phys 69:716-723 (Pubitemid 47418395)
-
(2007)
International Journal of Radiation Oncology Biology Physics
, vol.69
, Issue.3
, pp. 716-723
-
-
Sanlioglu, A.D.1
Korcum, A.F.2
Pestereli, E.3
Erdogan, G.4
Karaveli, S.5
Savas, B.6
Griffith, T.S.7
Sanlioglu, S.8
-
74
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence D, Shahrokh Z, Marsters S et al (2001) Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 7:383-385
-
(2001)
Nat Med
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
-
75
-
-
57049155399
-
Directing cancer cells to selfdestruct with pro-apoptotic receptor agonists
-
Ashkenazi A (2008) Directing cancer cells to selfdestruct with pro-apoptotic receptor agonists. Nat Rev Drug Discov 7:1001-1012
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 1001-1012
-
-
Ashkenazi, A.1
-
76
-
-
77956414973
-
Phase i dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
-
Herbst RS, Eckhardt SG, Kurzrock R et al (2010) Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol 28:2839-2846
-
(2010)
J Clin Oncol
, vol.28
, pp. 2839-2846
-
-
Herbst, R.S.1
Eckhardt, S.G.2
Kurzrock, R.3
-
77
-
-
10744220151
-
Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
-
DOI 10.1084/jem.20031457
-
Takeda K, Yamaguchi N, Akiba H et al (2004) Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med 199:437-448 (Pubitemid 38233828)
-
(2004)
Journal of Experimental Medicine
, vol.199
, Issue.4
, pp. 437-448
-
-
Takeda, K.1
Yamaguchi, N.2
Akiba, H.3
Kojima, Y.4
Hayakawa, Y.5
Tanner, J.E.6
Sayers, T.J.7
Seki, N.8
Okumura, K.9
Yagita, H.10
Smyth, M.J.11
-
78
-
-
78651466506
-
An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells
-
Wilson NS, Yang B, Yang A et al (2011) An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell 19:101-113
-
(2011)
Cancer Cell
, vol.19
, pp. 101-113
-
-
Wilson, N.S.1
Yang, B.2
Yang, A.3
-
79
-
-
29244477848
-
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction
-
DOI 10.1158/0008-5472.CAN-05-1724
-
Eramo A, Pallini R, Lotti F et al (2005) Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Cancer Res 65:11469-11477 (Pubitemid 41821704)
-
(2005)
Cancer Research
, vol.65
, Issue.24
, pp. 11469-11477
-
-
Eramo, A.1
Pallini, R.2
Lotti, F.3
Sette, G.4
Patti, M.5
Bartucci, M.6
Ricci-Vitiani, L.7
Signore, M.8
Stassi, G.9
Larocca, L.M.10
Crino, L.11
Peschle, C.12
De Maria, R.13
-
80
-
-
33947368690
-
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window
-
DOI 10.1002/hep.21555
-
Koschny R, Ganten TM, Sykora J et al (2007) TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 45:649-658 (Pubitemid 46450616)
-
(2007)
Hepatology
, vol.45
, Issue.3
, pp. 649-658
-
-
Koschny, R.1
Ganten, T.M.2
Sykora, J.3
Haas, T.L.4
Sprick, M.R.5
Kolb, A.6
Stremmel, W.7
Walczak, H.8
-
81
-
-
0035291880
-
Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
-
Nguyen T, Zhang XD, Hersey P (2001) Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Clin Cancer Res 7:966s-973s (Pubitemid 33600952)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.11 SUPPL.
-
-
Nguyen, T.1
Zhang, X.D.2
Hersey, P.3
-
82
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
Wu GS, Burns TF, McDonald ER 3rd et al (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 17:141-143
-
(1997)
Nat Genet
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
Burns, T.F.2
McDonald III, E.R.3
-
83
-
-
0034551746
-
Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells
-
Wen J, Ramadevi N, Nguyen D et al (2000) Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. Blood 96:3900-3906
-
(2000)
Blood
, vol.96
, pp. 3900-3906
-
-
Wen, J.1
Ramadevi, N.2
Nguyen, D.3
-
84
-
-
45649084324
-
Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
-
Greco FA, Bonomi P, Crawford J et al (2008) Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 61:82-90
-
(2008)
Lung Cancer
, vol.61
, pp. 82-90
-
-
Greco, F.A.1
Bonomi, P.2
Crawford, J.3
-
85
-
-
71749102407
-
TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies
-
Holoch PA, Griffi th TS (2009) TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. Eur J Pharmacol 625:63-72
-
(2009)
Eur J Pharmacol
, vol.625
, pp. 63-72
-
-
Holoch, P.A.1
Griffith, T.S.2
-
86
-
-
37149035841
-
A phase 1b safety and pharmacokinetic (PK) study of recombinant human APO2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma
-
Yee L, Fanale M, Dimick K et al (2007) A phase 1b safety and pharmacokinetic (PK) study of recombinant human APO2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma. J Clin Oncol 25:8078
-
(2007)
J Clin Oncol
, vol.25
, pp. 8078
-
-
Yee, L.1
Fanale, M.2
Dimick, K.3
-
87
-
-
77951894266
-
Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer
-
Soria JC, Smit E, Khayat D et al (2010) Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer. J Clin Oncol 28:1527-1533
-
(2010)
J Clin Oncol
, vol.28
, pp. 1527-1533
-
-
Soria, J.C.1
Smit, E.2
Khayat, D.3
-
88
-
-
33845809820
-
APO2L/TRAIL pharmacokinetics in a phase 1a trial in advanced cancer and lymphoma
-
Ling J, Herbst RS, Mendelson DS et al (2006) APO2L/TRAIL pharmacokinetics in a phase 1a trial in advanced cancer and lymphoma. J Clin Oncol 24:3047
-
(2006)
J Clin Oncol
, vol.24
, pp. 3047
-
-
Ling, J.1
Herbst, R.S.2
Mendelson, D.S.3
-
89
-
-
52649109485
-
Application of phamacodynamic assays in a phase 1a trial of APO2L/TRAIL in patients with advanced tumors
-
Pan Y, Xu R, Peach M et al (2007) Application of phamacodynamic assays in a phase 1a trial of APO2L/TRAIL in patients with advanced tumors. J Clin Oncol 25:3535
-
(2007)
J Clin Oncol
, vol.25
, pp. 3535
-
-
Pan, Y.1
Xu, R.2
Peach, M.3
-
90
-
-
34248187996
-
Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
-
DOI 10.1200/JCO.2006.08.8898
-
Tolcher AW, Mita M, Meropol NJ et al (2007) Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 25:1390-1395 (Pubitemid 46706887)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.11
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
Von Mehren, M.4
Patnaik, A.5
Padavic, K.6
Hill, M.7
Mays, T.8
McCoy, T.9
Fox, N.L.10
Halpern, W.11
Corey, A.12
Cohen, R.B.13
-
93
-
-
72449141229
-
Phase i and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors
-
Wakelee HA, Patnaik A, Sikic BI et al (2010) Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann Oncol 21:376-381
-
(2010)
Ann Oncol
, vol.21
, pp. 376-381
-
-
Wakelee, H.A.1
Patnaik, A.2
Sikic, B.I.3
-
94
-
-
45749105225
-
First-inhuman study of AMG655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors
-
LoRusso P, Hong D, Heath E et al (2007) First-inhuman study of AMG655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. J Clin Oncol 25:3534
-
(2007)
J Clin Oncol
, vol.25
, pp. 3534
-
-
Lorusso, P.1
Hong, D.2
Heath, E.3
-
95
-
-
47949092316
-
Apomab: An agonist monoclonal antibody directed against death receptor 5/TRAIL-receptor 2 for use in the treatment of solid tumors
-
Camidge DR (2008) Apomab: an agonist monoclonal antibody directed against death receptor 5/TRAIL-receptor 2 for use in the treatment of solid tumors. Exp Opin Biol Ther 8:1167-1176
-
(2008)
Exp Opin Biol Ther
, vol.8
, pp. 1167-1176
-
-
Camidge, D.R.1
-
96
-
-
55949100658
-
A phase 1 study of CS-1008 administered weekly to patients with advanced solid tumors or lymphomas
-
Saleh MN, Percent I, Wood TE et al (2008) A phase 1 study of CS-1008 administered weekly to patients with advanced solid tumors or lymphomas. J Clin Oncol 26:3537
-
(2008)
J Clin Oncol
, vol.26
, pp. 3537
-
-
Saleh, M.N.1
Percent, I.2
Wood, T.E.3
-
97
-
-
72449150359
-
Phase 1b study of recombinant human APO2L/TRAIL plus irinotecan and cetuximab or FOLFIRI in metastatic colorectal cancer (mCRC) patients: Preliminary results
-
Yee L, Burris HA, Kozloff M et al (2009) Phase 1b study of recombinant human APO2L/TRAIL plus irinotecan and cetuximab or FOLFIRI in metastatic colorectal cancer (mCRC) patients: preliminary results. J Clin Oncol 27: 4129
-
(2009)
J Clin Oncol
, vol.27
, pp. 4129
-
-
Yee, L.1
Burris, H.A.2
Kozloff, M.3
-
98
-
-
69949110775
-
Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: A phase i study
-
Mom CH, Verweij J, Oldenhuis CN et al (2009) Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: a phase I study. Clin Cancer Res 15:5584-5590
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5584-5590
-
-
Mom, C.H.1
Verweij, J.2
Oldenhuis, C.N.3
-
99
-
-
70349318434
-
Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: Results of a phase i and pharmacokinetic study
-
Leong S, Cohen RB, Gustafson DL et al (2009) Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study. J Clin Oncol 27:4413-4421
-
(2009)
J Clin Oncol
, vol.27
, pp. 4413-4421
-
-
Leong, S.1
Cohen, R.B.2
Gustafson, D.L.3
-
100
-
-
45749137688
-
A phase 1b study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI
-
Sikic BI, Wakelee HA, von Mehren M et al (2007) A phase 1b study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI. J Clin Oncol 25:14006
-
(2007)
J Clin Oncol
, vol.25
, pp. 14006
-
-
Sikic, B.I.1
Wakelee, H.A.2
Von Mehren, M.3
-
101
-
-
75749156293
-
Safety and effi cacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC)
-
Paz-Ares L, Sánchez Torres JM, Diaz-Padilla I et al (2009) Safety and effi cacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 27:19048
-
(2009)
J Clin Oncol
, vol.27
, pp. 19048
-
-
Paz-Ares, L.1
Sánchez Torres, J.M.2
Diaz-Padilla, I.3
-
102
-
-
77949745021
-
2 open-label study of AMG 655 in combination with doxorubicin for the first-line treatment of patients with locally advanced or metastatic, unresectable soft tissue sarcoma
-
London
-
Blay J-Y, Chawla S, Demetri GD et al (2008) 2 open-label study of AMG 655 in combination with doxorubicin for the first-line treatment of patients with locally advanced or metastatic, unresectable soft tissue sarcoma. CTOS 14th Annual Meeting, London, p 34845
-
(2008)
CTOS 14th Annual Meeting
, pp. 34845
-
-
Blay, J.-Y.1
Chawla, S.2
Demetri, G.D.3
-
103
-
-
72449176627
-
Safety and effi cacy of AMG 655 plus modifi ed FOLFOX6 and bevacizumab for the first-line treatment of patients with metastatic colorectal cancer
-
Saltz L, Infante J, Schwartzberg L et al (2009) Safety and effi cacy of AMG 655 plus modifi ed FOLFOX6 and bevacizumab for the first-line treatment of patients with metastatic colorectal cancer. J Clin Oncol 27:4079
-
(2009)
J Clin Oncol
, vol.27
, pp. 4079
-
-
Saltz, L.1
Infante, J.2
Schwartzberg, L.3
-
104
-
-
68649085369
-
A phase 1b study to evaluate the safety and effi cacy of AMG 655 in combination with gemcitabine in patients with metastatic pancreatic cancer
-
Kindler HL, Garbo L, Stephenson J et al (2009) A phase 1b study to evaluate the safety and effi cacy of AMG 655 in combination with gemcitabine in patients with metastatic pancreatic cancer. J Clin Oncol 27:4501
-
(2009)
J Clin Oncol
, vol.27
, pp. 4501
-
-
Kindler, H.L.1
Garbo, L.2
Stephenson, J.3
-
105
-
-
72449138830
-
A phase 1b/2 trial of AMG 655 and panitumumab for the treatment of metastatic colorectal cancer: Safety results
-
Rougier P, Infante J, Van Laethem J et al (2009) A phase 1b/2 trial of AMG 655 and panitumumab for the treatment of metastatic colorectal cancer: safety results. J Clin Oncol 27:4130
-
(2009)
J Clin Oncol
, vol.27
, pp. 4130
-
-
Rougier, P.1
Infante, J.2
Van Laethem, J.3
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