Myofibroblasts in the infarct area: Concepts and challenges

Microscopy and Microanalysis

Volumn 18, Issue 1, 2012, Pages 35-49

  Daskalopoulos, Evangelos P ^a   Janssen, Ben J A ^a   Blankesteijn, W Matthijs ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

cardiac remodeling; fibroblast; fibrosis; heart; heart failure; myocardial infarction; myofibroblast

Indexed keywords

COLLAGEN;

ANIMAL; CONFERENCE PAPER; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; HEART FAILURE; HEART INFARCTION; HUMAN; METABOLISM; MOUSE; MYOFIBROBLAST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; WOUND HEALING;

ANIMALS; COLLAGEN; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBROSIS; HEART FAILURE; HUMANS; MICE; MYOCARDIAL INFARCTION; MYOFIBROBLASTS; RATS; WOUND HEALING;

EID: 84855998104     PISSN: 14319276     EISSN: 14358115     Source Type: Journal    
DOI: 10.1017/S143192761101227X     Document Type: Conference Paper

References (146)

1. Aisagbonhi, O., Rai, M., Ryzhov, S., Atria, N., Feoktistov, I. & Hatzopoulos, A.K. (2011). Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-tomesenchymal transition. Dis Model Mech 4(4), 469-483.
2. Akasaka, T. (2010). What can we expect in PCI in patients with chronic coronary artery disease. Indication of PCI for angiographically significant coronary artery stenosis without objective evidence of myocardial ischemia (Con). Circ J 75(1), 211-217; discussion 210.
3. Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K. & Kawabata, M. (1999). c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem 274(49), 35269-35277. (Pubitemid 129509586)
4. Banerjee, I., Fuseler, J.W., Intwala, A.R. & Baudino, T.A. (2009). IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart. Am J Physiol Heart Circ Physiol 296(5), H1694-H1704.
5. Baudino, T.A., Carver, W., Giles, W. & Borg, T.K. (2006). Cardiac fibroblasts: Friend or foe? Am J Physiol Heart Circ Physiol 291(3), H1015-H1026. (Pubitemid 44343642)
6. Baum, J. & Duffy, H.S. (2011). Fibroblasts andmyofibroblasts:What are we talking about? J Cardiovasc Pharmacol 57(4), 376-379.
7. Bellini, A. & Mattoli, S. (2007). The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 87(9), 858-870. (Pubitemid 47267815)
8. Beltrami, C.A., Finato, N., Rocco, M., Feruglio, G.A., Puricelli, C., Cigola, E., Quaini, F., Sonnenblick, E.H., Olivetti, G. & Anversa, P. (1994). Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 89(1), 151-163. (Pubitemid 24026485)
9. Blankesteijn, W.M., Essers-Janssen, Y.P., Verluyten, M.J., Daemen, M.J. & Smits, J.F. (1997). A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. Nat Med 3(5), 541-544. (Pubitemid 27198652)
10. Blankesteijn, W.M., van de Schans, V.A., ter Horst, P. & Smits, J.F. (2008). The Wnt/frizzled/GSK-3 beta pathway: A novel therapeutic target for cardiac hypertrophy. Trends Pharmacol Sci 29(4), 175-180.
11. Brilla, C.G., Maisch, B., Zhou, G. & Weber, K.T. (1995). Hormonal regulation of cardiac fibroblast function. Eur Heart J 16(Suppl C), 45-50.
12. Brilla, C.G., Zhou, G., Matsubara, L. & Weber, K.T. (1994). Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone. J Mol Cell Cardiol 26(7), 809-820. (Pubitemid 24223231)
13. Bui, A.L., Horwich, T.B. & Fonarow, G.C. (2011). Epidemiology and risk profile of heart failure. Nat Rev Cardiol 8(1), 30-41.
14. Buja, L.M. & Vela, D. (2008). Cardiomyocyte death and renewal in the normal and diseased heart. Cardiovasc Pathol 17(6), 349-374.
15. Bujak, M. & Frangogiannis, N.G. (2007). The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 74(2), 184-195. (Pubitemid 46517504)
16. Bujak, M., Ren, G., Kweon, H.J., Dobaczewski, M., Reddy, A., Taffet, G., Wang, X.F. & Frangogiannis, N.G. (2007). Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation 116(19), 2127-2138. (Pubitemid 350060350)
17. Camelliti, P., Borg, T.K. & Kohl, P. (2005). Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res 65(1), 40-51. (Pubitemid 40038477)
18. Campbell, J. & Hilleman, D. (2010). Recombinant peptides in thrombolysis. Semin Thromb Hemost 36(5), 529-536.
19. Carthy, J.M., Garmaroudi, F.S., Luo, Z. & McManus, B.M. (2011). Wnt3a induces myofibroblast differentiation by upregulating TGF-beta signaling through SMAD2 in a beta-catenindependent manner. PLoS One 6(5), e19809.
20. Cave, A.C., Brewer, A.C., Narayanapanicker, A., Ray, R., Grieve, D.J., Walker, S. & Shah, A.M. (2006). NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal 8(5-6), 691-728. (Pubitemid 44043102)
21. Cleutjens, J.P., Blankesteijn, W.M., Daemen, M.J. & Smits, J.F. (1999). The infarcted myocardium: Simply dead tissue, or a lively target for therapeutic interventions. Cardiovasc Res 44(2), 232-241. (Pubitemid 29474084)
22. Cleutjens, J.P., Verluyten, M.J., Smiths, J.F. & Daemen, M.J. (1995). Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol 147(2), 325-338.
23. Cortez, D.M., Feldman, M.D., Mummidi, S., Valente, A.J., Steffensen, B., Vincenti, M., Barnes, J.L. & Chandrasekar, B. (2007). IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation. Am J Physiol Heart Circ Physiol 293(6), H3356-H3365. (Pubitemid 350230876)
24. Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P.J., Ariyan, S., Dikalov, S. & Sorescu, D. (2005). NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 97(9), 900-907. (Pubitemid 41552675)
25. Cunnington, R.H., Wang, B., Ghavami, S., Bathe, K.L., Rattan, S.G. & Dixon, I.M. (2011). Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility. Am J Physiol Cell Physiol 300(1), C176-C186.
26. Dewald, O., Ren, G., Duerr, G.D., Zoerlein, M., Klemm, C., Gersch, C., Tincey, S., Michael, L.H., Entman, M.L. & Frangogiannis, N.G. (2004). Of mice and dogs: Species specific differences in the inflammatory response following myocardial infarction. Am J Pathol 164(2), 665-677. (Pubitemid 38364680)
27. Diaz-Flores, L., Gutierrez, R., Madrid, J.F., Varela, H., Valladares, F., Acosta, E., Martin-Vasallo, P. & Diaz-Flores, L., Jr. (2009). Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 24(7), 909-969.
28. Dickson, M.C., Martin, J.S., Cousins, F.M., Kulkarni, A.B., Karlsson, S. & Akhurst, R.J. (1995). Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121(6), 1845-1854.
29. Dixon, I.M. (2010). The soluble interleukin 6 receptor takes its place in the pantheon of interleukin 6 signaling proteins: Phenoconversion of cardiac fibroblasts to myofibroblasts. Hypertension 56(2), 193-195.
30. Dobaczewski, M., Bujak, M., Li, N., Gonzalez-Quesada, C., Mendoza, L.H., Wang, X.F. & Frangogiannis, N.G. (2010). Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res 107(3), 418-428.
31. Dobaczewski, M., Bujak, M., Zymek, P., Ren, G., Entman, M.L. & Frangogiannis, N.G. (2006). Extracellular matrix remodeling in canine and mouse myocardial infarcts. Cell Tissue Res 324(3), 475-488. (Pubitemid 43673489)
32. Dobaczewski, M., Chen, W. & Frangogiannis, N.G. (2011). Transforming growth factor (TGF)-beta signaling in cardiac remodeling. J Mol Cell Cardiol 51(4), 600-606.
33. Duisters, R.F., Tijsen, A.J., Schroen, B., Leenders, J.J., Lentink, V., van der Made, I., Herias, V., van Leeuwen, R.E., Schellings, M.W., Barenbrug, P., Maessen, J.G., Heymans, S., Pinto, Y.M. & Creemers, E.E. (2009). miR-133 and miR-30 regulate connective tissue growth factor: Implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 104(2), 170-178, 176p following 178.
34. Ellmers, L.J., Scott, N.J., Medicherla, S., Pilbrow, A.P., Bridgman, P.G., Yandle, T.G., Richards, A.M., Protter, A.A. & Cameron, V.A. (2008). Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology 149(11), 5828-5834.
35. Fix, C., Bingham, K. & Carver, W. (2011). Effects of interleukin-18 on cardiac fibroblast function and gene expression. Cytokine 53(1), 19-28.
36. Fomovsky, G.M. & Holmes, J.W. (2010). Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat. Am J Physiol Heart Circ Physiol 298(1), H221-H228.
37. Fomovsky, G.M., Thomopoulos, S. & Holmes, J.W. (2010). Contribution of extracellular matrix to the mechanical properties of the heart. J Mol Cell Cardiol 48(3), 490-496.
38. Frangogiannis, N.G. (2006). Targeting the inflammatory response in healing myocardial infarcts. Curr Med Chem 13(16), 1877-1893.
39. Frantz, S., Bauersachs, J. & Ertl, G. (2009). Post-infarct remodelling: Contribution of wound healing and inflammation. Cardiovasc Res 81(3), 474-481.
40. Frantz, S., Hu, K., Adamek, A., Wolf, J., Sallam, A., Maier, S.K., Lonning, S., Ling, H., Ertl, G. & Bauersachs, J. (2008). Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction. Basic Res Cardiol 103(5), 485-492.
41. Freed, D.H., Borowiec, A.M., Angelovska, T. & Dixon, I.M. (2003). Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: Integration of multiple signaling pathways. Cardiovasc Res 60(2), 365-375. (Pubitemid 37412370)
42. Freed, D.H., Cunnington, R.H., Dangerfield, A.L., Sutton, J.S. & Dixon, I.M. (2005). Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovasc Res 65(4), 782-792. (Pubitemid 40249724)
43. Fries, K.M., Blieden, T., Looney, R.J., Sempowski, G.D., Silvera, M.R., Willis, R.A. & Phipps, R.P. (1994). Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol 72(3), 283-292. (Pubitemid 24275206)
44. Gabbiani, G., Ryan, G.B. & Majne, G. (1971). Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27(5), 549-550.
45. Ge, Y., Bagnall, A., Stricklett, P.K., Webb, D., Kotelevtsev, Y. & Kohan, D.E. (2008). Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention. Am J Physiol Renal Physiol 295(6), F1635-F1640.
46. Grossman, J. & Frishman, W.H. (2010). Relaxin: A new approach for the treatment of acute congestive heart failure. Cardiol Rev 18(6), 305-312.
47. Guarda, E., Katwa, L.C., Myers, P.R., Tyagi, S.C. & Weber, K.T. (1993). Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc Res 27(12), 2130-2134. (Pubitemid 24034724)
48. Gurantz, D., Cowling, R.T., Varki, N., Frikovsky, E., Moore, C.D. & Greenberg, B.H. (2005). IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart. J Mol Cell Cardiol 38(3), 505-515. (Pubitemid 40331941)
49. He, W., Zhang, L., Ni, A., Zhang, Z., Mirotsou, M., Mao, L., Pratt, R.E. & Dzau, V.J. (2010). Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci USA 107(49), 21110-21115.
50. Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T.R., Horowitz, J.C., Pennathur, S., Martinez, F.J. & Thannickal, V.J. (2009). NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med 15(9), 1077-1081.
51. Hinz, B. (2007). Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 127(3), 526-537.
52. Hinz, B., Celetta, G., Tomasek, J.J., Gabbiani, G. & Chaponnier, C. (2001). Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.Mol Biol Cell 12(9), 2730-2741. (Pubitemid 33051938)
53. Hinz, B. & Gabbiani, G. (2003). Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotechnol 14(5), 538-546. (Pubitemid 37298041)
54. Holmes, J.W., Borg, T.K. & Covell, J.W. (2005). Structure and mechanics of healing myocardial infarcts. Annu Rev Biomed Eng 7, 223-253. (Pubitemid 41170188)
55. Holmes, J.W., Nunez, J.A. & Covell, J.W. (1997). Functional implications of myocardial scar structure. Am J Physiol 272(5 Pt 2), H2123-H2130.
56. Husse, B., Briest, W., Homagk, L., Isenberg, G. & Gekle, M. (2007). Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts. Am J Physiol Regul Integr Comp Physiol 293(5), R1898-R1907. (Pubitemid 350085665)
57. Hyde, A., Blondel, B., Matter, A., Cheneval, J.P., Filloux, B. & Girardier, L. (1969). Homo- and heterocellular junctions in cell cultures: An electrophysiological and morphological study. Prog Brain Res 31, 283-311.
58. Katwa, L.C. (2003). Cardiac myofibroblasts isolated from the site of myocardial infarction express endothelin de novo. Am J Physiol Heart Circ Physiol 285(3), H1132-H1139. (Pubitemid 37048169)
59. Katwa, L.C., Campbell, S.E., Tyagi, S.C., Lee, S.J., Cicila, G.T. & Weber, K.T. (1997). Cultured myofibroblasts generate angiotensin peptides de novo. J Mol Cell Cardiol 29(5), 1375-1386. (Pubitemid 27259651)
60. Kim, S. & Iwao, H. (2000). Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 52(1), 11-34. (Pubitemid 30127593)
61. Kober, L., Torp-Pedersen, C., Carlsen, J.E., Bagger, H., Eliasen, P., Lyngborg, K., Videbaek, J., Cole, D.S., Auclert, L. & Pauly, N.C. (1995).A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. N Engl J Med 333(25), 1670-1676. (Pubitemid 26001955)
62. Konstam, M.A., Kramer, D.G., Patel, A.R., Maron, M.S. & Udelson, J.E. (2011). Left ventricular remodeling in heart failure: Current concepts in clinical significance and assessment. JACC Cardiovasc Imaging 4(1), 98-108.
63. Krishnamurthy, P., Rajasingh, J., Lambers, E., Qin, G., Losordo, D.W. & Kishore, R. (2009). IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 104(2), e9-e18.
64. Laeremans, H., Hackeng, T.M., van Zandvoort, M.A., Thijssen, V.L., Janssen, B.J., Ottenheijm, H.C., Smits, J.F. & Blankesteijn, W.M. (2011). Blocking of frizzled signaling with a homologous peptide fragment of Wnt3a/Wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction. Circulation 124(15), 1626-1635.
65. Laeremans, H., Rensen, S.S., Ottenheijm, H.C., Smits, J.F. & Blankesteijn, W.M. (2010). Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts. Cardiovasc Res 87(3), 514-523.
66. Leask, A. & Abraham, D.J. (2004). TGF-beta signaling and the fibrotic response. FASEB J 18(7), 816-827.
67. Lefkowitz, R.J., Rockman, H.A. & Koch, W.J. (2000). Catecholamines, cardiac beta-adrenergic receptors, and heart failure. Circulation 101(14), 1634-1637. (Pubitemid 30196619)
68. Lenga, Y., Koh, A., Perera, A.S., McCulloch, C.A., Sodek, J. & Zohar, R. (2008). Osteopontin expression is required for myofibroblast differentiation. Circ Res 102(3), 319-327. (Pubitemid 351271652)
69. Lijnen, P.J., Petrov, V.V. & Fagard, R.H. (2001). Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors. J Renin Angiotensin Aldosterone Syst 2(2), 117-122. (Pubitemid 33686750)
70. Manabe, R., Ohe, N., Maeda, T., Fukuda, T. & Sekiguchi, K. (1997). Modulation of cell-adhesive activity of fibronectin by the alternatively spliced EDA segment. J Cell Biol 139(1), 295-307. (Pubitemid 27444099)
71. Matsui, Y., Morimoto, J. & Uede, T. (2010). Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction. World J Biol Chem 1(5), 69-80.
72. McKelvie, R.S., Yusuf, S., Pericak, D., Avezum, A., Burns, R.J., Probstfield, J., Tsuyuki, R.T., White, M., Rouleau, J., Latini, R., Maggioni, A., Young, J. & Pogue, J. (1999). Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. Circulation 100(10), 1056-1064. (Pubitemid 29416231)
73. McMahon, J.A. & McMahon, A.P. (1989). Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene. Development 107(3), 643-650. (Pubitemid 20006102)
74. McMurray, J.J., Ostergren, J., Swedberg, K., Granger, C.B., Held, P., Michelson, E.L., Olofsson, B., Yusuf, S. & Pfeffer, M.A. (2003). Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM Added trial. Lancet 362(9386), 767-771. (Pubitemid 37093916)
75. McMurray, J.J. & Pfeffer, M.A. (2005). Heart failure. Lancet 365(9474), 1877-1889. (Pubitemid 40744967)
76. Melchior-Becker, A., Dai, G., Ding, Z., Schafer, L., Schrader, J., Young, M.F. & Fischer, J.W. (2011). Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J Biol Chem 286(19), 17365-17375.
77. Melendez, G.C., McLarty, J.L., Levick, S.P., Du, Y., Janicki, J.S. & Brower, G.L. (2010). Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension 56(2), 225-231.
78. Meran, S. & Steadman, R. (2011). Fibroblasts and myofibroblasts in renal fibrosis. Int J Exp Pathol 92(3), 158-167.
79. Meszaros, J.G., Gonzalez, A.M., Endo-Mochizuki, Y., Villegas, S., Villarreal, F. & Brunton, L.L. (2000). Identification of G protein-coupled signaling pathways in cardiac fibroblasts: Cross talk between G(q) and G(s). Am J Physiol Cell Physiol 278(1), C154-C162. (Pubitemid 30101906)
80. Minnaard-Huiban, M., Hermans, J.J., Essen, H., Bitsch, N. & Smits, J.F. (2008). Comparison of the effects of intrapericardial and intravenous aldosterone infusions on left ventricular fibrosis in rats. Eur J Heart Fail 10(12), 1166-1171.
81. Nag, A.C. (1980). Study of non-muscle cells of the adult mammalian heart: A fine structural analysis and distribution. Cytobios 28(109), 41-61. (Pubitemid 11219342)
82. Nahrendorf, M., Pittet, M.J. & Swirski, F.K. (2010). Monocytes: Protagonists of infarct inflammation and repair after myocardial infarction. Circulation 121(22), 2437-2445.
83. Neumann, S., Huse, K., Semrau, R., Diegeler, A., Gebhardt, R., Buniatian, G.H. & Scholz, G.H. (2002). Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitro. Hypertension 39(3), 756-760. (Pubitemid 34252870)
84. Nusse, R. & Varmus, H.E. (1982). Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31(1), 99-109.
85. Olivetti, G., Melissari, M., Balbi, T., Quaini, F., Sonnenblick, E.H. & Anversa, P. (1994). Myocyte nuclear and possible cellular hyperplasia contribute to ventricular remodeling in the hypertrophic senescent heart in humans. J Am Coll Cardiol 24(1), 140-149. (Pubitemid 24202789)
86. Owan, T.E., Hodge, D.O., Herges, R.M., Jacobsen, S.J., Roger, V.L. & Redfield, M.M. (2006). Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3), 251-259. (Pubitemid 44079340)
87. Palmer, J.N., Hartogensis, W.E., Patten, M., Fortuin, F.D. & Long, C.S. (1995). Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture. J Clin Invest 95(6), 2555-2564.
88. Pellman, J., Lyon, R.C. & Sheikh, F. (2010). Extracellular matrix remodeling in a trial fibrosis: Mechanisms and implications in a trial fibrillation. J Mol Cell Cardiol 48(3), 461-467.
89. Pfeffer, M.A., McMurray, J.J., Velazquez, E.J., Rouleau, J.L., Kober, L., Maggioni, A.P., Solomon, S.D., Swedberg, K., Van de Werf, F., White, H., Leimberger, J.D., Henis, M., Edwards, S., Zelenkofske, S., Sellers, M.A. & Califf, R.M. (2003). Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 349(20), 1893-1906. (Pubitemid 37409706)
90. Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Bittman, R., Hurley, S., Kleiman, J. & Gatlin, M. (2003). Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348(14), 1309-1321. (Pubitemid 36384098)
91. Pitt, B., Zannad, F., Remme, W.J., Cody, R., Castaigne, A., Perez, A., Palensky, J. & Wittes, J. (1999). The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341(10), 709-717. (Pubitemid 29407370)
92. Ponta, H., Sherman, L. & Herrlich, P.A. (2003). CD44: From adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 4(1), 33-45. (Pubitemid 36077255)
93. Porter, K.E. & Turner, N.A. (2009). Cardiac fibroblasts: At the heart of myocardial remodeling. Pharmacol Ther 123(2), 255-278.
94. Porter, K.E., Turner, N.A., O'Regan, D.J. & Ball, S.G. (2004a). Tumor necrosis factor alpha induces human a trial myofibroblast proliferation, invasion and MMP-9 secretion: Inhibition by simvastatin. Cardiovasc Res 64(3), 507-515. (Pubitemid 39505429)
95. Porter, K.E., Turner, N.A., O'Regan, D.J., Balmforth, A.J. & Ball, S.G. (2004b). Simvastatin reduces human a trial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovasc Res 61(4), 745-755. (Pubitemid 38249473)
96. Post, S.R., Hammond, H.K. & Insel, P.A. (1999). Beta-adrenergic receptors and receptor signaling in heart failure. Annu Rev Pharmacol Toxicol 39, 343-360. (Pubitemid 29222563)
97. Potts, J.D. & Runyan, R.B. (1989). Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta. Dev Biol 134(2), 392-401. (Pubitemid 19201058)
98. Prockop, D.J. & Kivirikko, K.I. (1995). Collagens: Molecular biology, diseases, and potentials for therapy. Annu Rev Biochem 64, 403-434.
99. Rehsia, N.S. & Dhalla, N.S. (2010). Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure. Heart Fail Rev 15(1), 85-101.
100. Ren, G., Michael, L.H., Entman, M.L. & Frangogiannis, N.G. (2002).Morphological characteristics of the microvasculature in healingmyocardial infarcts. J Histochem Cytochem 50(1), 71-79. (Pubitemid 34074624)
101. Rodriguez-Pascual, F., Busnadiego, O., Lagares, D. & Lamas, S. (2011). Role of endothelin in the cardiovascular system. Pharmacol Res 63(6), 463-472.
102. Roger, V.L., Go, A.S., Lloyd-Jones, D.M., Adams, R.J., Berry, J.D., Brown, T.M., Carnethon, M.R., Dai, S., de Simone, G., Ford, E.S., Fox, C.S., Fullerton, H.J., Gillespie, C., Greenlund, K.J., Hailpern, S.M., Heit, J.A., Ho, P.M., Howard, V.J., Kissela, B.M., Kittner, S.J., Lackland, D.T., Lichtman, J.H., Lisabeth, L.D., Makuc, D.M., Marcus, G.M., Marelli, A., Matchar, D.B., McDermott, M.M., Meigs, J.B., Moy, C.S., Mozaffarian, D., Mussolino, M.E., Nichol, G., Paynter, N.P., Rosamond, W.D., Sorlie, P.D., Stafford, R.S., Turan, T.N., Turner, M.B., Wong, N.D. & Wylie-Rosett, J. (2011). Heart disease and stroke statistics-2011 update: A report from the American Heart Association. Circulation 123(4), e18-e209.
103. Rohr, S. (2009). Myofibroblasts in diseased hearts: New players in cardiac arrhythmias? Heart Rhythm 6(6), 848-856.
104. Rosenkranz, S. (2004). TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res 63(3), 423-432. (Pubitemid 38970186)
105. Samuel, C.S., Cendrawan, S., Gao, X.M., Ming, Z., Zhao, C., Kiriazis, H., Xu, Q., Tregear, G.W., Bathgate, R.A. & Du, X.J. (2011). Relaxin remodels fibrotic healing following myocardial infarction. Lab Invest 91(5), 675-690.
106. Schieffer, B., Wirger, A., Meybrunn, M., Seitz, S., Holtz, J., Riede, U.N. & Drexler, H. (1994). Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation 89(5), 2273-2282. (Pubitemid 24142808)
107. Serini, G., Bochaton-Piallat, M.L., Ropraz, P., Geinoz, A., Borsi, L., Zardi, L. & Gabbiani, G. (1998). The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142(3), 873-881. (Pubitemid 28381502)
108. Shiroshita-Takeshita, A., Brundel, B.J., Burstein, B., Leung, T.K., Mitamura, H., Ogawa, S. & Nattel, S. (2007). Effects of simvastatin on the development of the a trial fibrillation substrate in dogs with congestive heart failure. Cardiovasc Res 74(1), 75-84. (Pubitemid 46366949)
109. Shi-wen, X., Kennedy, L., Renzoni, E.A., Bou-Gharios, G., du Bois, R.M., Black, C.M., Denton, C.P., Abraham, D.J. & Leask, A. (2007). Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum 56(12), 4189-4194. (Pubitemid 350262347)
110. Siwik, D.A., Chang, D.L. & Colucci, W.S. (2000). Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circ Res 86(12), 1259-1265. (Pubitemid 30436667)
111. SOLVD Investigators. (1991). Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. N Engl J Med 325(5), 293-302.
112. Soonpaa, M.H., Daud, A.I., Koh, G.Y., Klug, M.G., Kim, K.K., Wang, H. & Field, L.J. (1995). Potential approaches for myocardial regeneration. Ann NY Acad Sci 752, 446-454.
113. Sorrell, J.M. & Caplan, A.I. (2004). Fibroblast heterogeneity: More than skin deep. J Cell Sci 117(Pt 5), 667-675. (Pubitemid 38263212)
114. Souders, C.A., Bowers, S.L. & Baudino, T.A. (2009). Cardiac fibroblast: The renaissance cell. Circ Res 105(12), 1164-1176.
115. Strieter, R.M., Keeley, E.C., Burdick, M.D. & Mehrad, B. (2009). The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis. Trans Am Clin Climatol Assoc 120, 49-59.
116. Sumimoto, H., Miyano, K. & Takeya, R. (2005). Molecular composition and regulation of the Nox family NAD(P)H oxidases. Biochem Biophys Res Commun 338(1), 677-686. (Pubitemid 41540615)
117. Sun, Y. & Weber, K.T. (1996). Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart. J Mol Cell Cardiol 28(5), 851-858. (Pubitemid 26169296)
118. Sun, Y., Zhang, J.Q., Zhang, J. & Ramires, F.J. (1998). Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart. J Mol Cell Cardiol 30(8), 1559-1569. (Pubitemid 28418646)
119. Tan, S.M., Zhang, Y., Connelly, K.A., Gilbert, R.E. & Kelly, D.J. (2010). Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol 298(5), H1415-H1425.
120. Taylor, K., Patten, R.D., Smith, J.J., Aronovitz, M.J., Wight, J., Salomon, R.N. & Konstam, M.A. (1998). Divergent effects of angiotensin-converting enzyme inhibition and angiotensin IIreceptor antagonism on myocardial cellular proliferation and collagen deposition after myocardial infarction in rats. J Cardiovasc Pharmacol 31(5), 654-660. (Pubitemid 28217584)
121. Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., Castoldi, M., Soutschek, J., Koteliansky, V., Rosenwald, A., Basson, M.A., Licht, J.D., Pena, J.T., Rouhanifard, S.H., Muckenthaler, M.U., Tuschl, T., Martin, G.R., Bauersachs, J. & Engelhardt, S. (2008). MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456(7224), 980-984.
122. Tomasek, J.J., Gabbiani, G., Hinz, B., Chaponnier, C. & Brown, R.A. (2002).Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3(5), 349-363. (Pubitemid 34619269)
123. Trueblood, N.A., Xie, Z., Communal, C., Sam, F., Ngoy, S., Liaw, L., Jenkins, A.W., Wang, J., Sawyer, D.B., Bing, O.H., Apstein, C.S., Colucci, W.S. & Singh, K. (2001). Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ Res 88(10), 1080-1087. (Pubitemid 34137122)
124. Turner, N.A., Das, A., Warburton, P., O'Regan, D.J., Ball, S.G. & Porter, K.E. (2009). Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts. Am J Physiol Heart Circ Physiol 297(3), H1117-H1127.
125. Turner, N.A., Porter, K.E., Smith, W.H., White, H.L., Ball, S.G. & Balmforth, A.J. (2003). Chronic beta2-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanism. Cardiovasc Res 57(3), 784-792. (Pubitemid 36254872)
126. Turner, N.A., Warburton, P., O'Regan, D.J., Ball, S.G. & Porter, K.E. (2010). Modulatory effect of interleukin-1alpha on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: Role of p38 MAP kinase. Matrix Biol 29(7), 613-620.
127. van den Borne, S.W., Cleutjens, J.P., Hanemaaijer, R., Creemers, E.E., Smits, J.F., Daemen, M.J. & Blankesteijn, W.M. (2009a). Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction. Cardiovasc Pathol 18(1), 37-43.
128. van den Borne, S.W., Diez, J., Blankesteijn, W.M., Verjans, J., Hofstra, L. & Narula, J. (2010). Myocardial remodeling after infarction: The role of myofibroblasts. Nat Rev Cardiol 7(1), 30-37.
129. van den Borne, S.W., Isobe, S., Verjans, J.W., Petrov, A., Lovhaug, D., Li, P., Zandbergen, H.R., Ni, Y., Frederik, P., Zhou, J., Arbo, B., Rogstad, A., Cuthbertson, A., Chettibi, S., Reutelingsperger, C., Blankesteijn, W.M., Smits, J.F., Daemen, M.J., Zannad, F., Vannan, M.A., Narula, N., Pitt, B., Hofstra, L. & Narula, J. (2008). Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction. J Am Coll Cardiol 52(24), 2017-2028.
130. van den Borne, S.W., van de Schans, V.A., Strzelecka, A.E., Vervoort-Peters, H.T., Lijnen, P.M., Cleutjens, J.P., Smits, J.F., Daemen, M.J., Janssen, B.J. & Blankesteijn, W.M. (2009b). Mouse strain determines the outcome of wound healing after myocardial infarction. Cardiovasc Res 84(2), 273-282.
131. van der Laan, A.M., Piek, J.J. & van Royen, N. (2009). Targeting angiogenesis to restore the microcirculation after reperfused MI. Nat Rev Cardiol 6(8), 515-523.
132. van de Schans, V.A., Smits, J.F. & Blankesteijn, W.M. (2008). The Wnt/frizzled pathway in cardiovascular development and disease: Friend or foe? Eur J Pharmacol 585(2-3), 338-345.
133. van Rooij, E., Sutherland, L.B., Thatcher, J.E., DiMaio, J.M., Naseem, R.H., Marshall, W.S., Hill, J.A. & Olson, E.N. (2008). Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 105(35), 13027-13032.
134. Wang, J., Zohar, R. & McCulloch, C.A. (2006). Multiple roles of alpha-smooth muscle actin in mechanotransduction. Exp Cell Res 312(3), 205-214. (Pubitemid 41814831)
135. Webber, J., Jenkins, R.H., Meran, S., Phillips, A. & Steadman, R. (2009). Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan. Am J Pathol 175(1), 148-160.
136. Wexler, D.J., Chen, J., Smith, G.L., Radford, M.J., Yaari, S., Bradford, W.D. & Krumholz, H.M. (2001). Predictors of costs of caring for elderly patients discharged with heart failure. Am Heart J 142(2), 350-357. (Pubitemid 32706295)
137. WHO. (2011). WHO Fact Sheet N8317-Cardiovascular diseases (CVDs). Available at www.who.int/mediacentre/factsheets/fs317/en/24-05-11.
138. Widyantoro, B., Emoto, N., Nakayama, K., Anggrahini, D.W., Adiarto, S., Iwasa, N., Yagi, K., Miyagawa, K., Rikitake, Y., Suzuki, T., Kisanuki, Y.Y., Yanagisawa, M. & Hirata, K. (2010). Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelialto-mesenchymal transition. Circulation 121(22), 2407-2418.
139. Willems, I.E., Havenith, M.G., De Mey, J.G. & Daemen, M.J. (1994). The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am J Pathol 145(4), 868-875.
140. Yu, C.M., Tipoe, G.L., Wing-Hon Lai, K. & Lau, C.P. (2001). Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction. J Am Coll Cardiol 38(4), 1207-1215. (Pubitemid 32912734)
141. Zak, R. (1974). Development and proliferative capacity of cardiac muscle cells. Circ Res 35(2), Suppl II:17-26.
142. Zeisberg, E.M., Tarnavski, O., Zeisberg, M., Dorfman, A.L., McMullen, J.R., Gustafsson, E., Chandraker, A., Yuan, X., Pu, W.T., Roberts, A.B., Neilson, E.G., Sayegh, M.H., Izumo, S. & Kalluri, R. (2007). Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13(8), 952-961. (Pubitemid 47222040)
143. Zhang, C. (2008). Micro R Nomics: A newly emerging approach for disease biology. Physiol Genomics 33(2), 139-147. (Pubitemid 351629522)
144. Zhang, Y., Kanter, E.M., Laing, J.G., Aprhys, C., Johns, D.C., Kardami, E. & Yamada, K.A. (2008). Connexin43 expression levels influence intercellular coupling and cell proliferation of native murine cardiac fibroblasts. Cell Commun Adhes 15(3), 289-303.
145. Zhou, G., Kandala, J.C., Tyagi, S.C., Katwa, L.C. & Weber, K.T. (1996). Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts. Mol Cell Biochem 154(2), 171-178. (Pubitemid 26038059)
146. Zymek, P., Nah, D.Y., Bujak, M., Ren, G., Koerting, A., Leucker, T., Huebener, P., Taffet, G., Entman, M. & Frangogiannis, N.G. (2007). Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling. Cardiovasc Res 74(2), 313-322. (Pubitemid 46517506)