Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitro

Hypertension

Volumn 39, Issue 3, 2002, Pages 756-760

  Neumann, Susanne ^a   Huse, Klaus ^a   Semrau, Robert ^a   Diegeler, Anno ^a   Gebhardt, Rolf ^a   Buniatian, Gayane Hrachia ^a   Scholz, Gerhard H ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Aldosterone; Cardiac myofibroblasts; Glucose; Human

Indexed keywords

ALDOSTERONE; GLUCOSE;

ADULT; AGED; ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FETAL CALF SERUM; GLUCOSE HOMEOSTASIS; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERALDOSTERONISM; MALE; MYOFIBROBLAST; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK FACTOR; RODENT;

ACTINS; AGED; ALDOSTERONE; ANTIGENS, CD11; ANTIGENS, CD14; ANTIGENS, CD31; CELL DIVISION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; GLUCOSE; HEART ATRIA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUSCLE, SMOOTH;

EID: 0036193852     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/hy0302.105295     Document Type: Article

References (36)

1. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
2. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with CHF: Insight from the randomized aldactone evaluation study (RALES)
3. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis
4. Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo
5. Determinants of cardiac fibrosis in experimental hypermineralocorticoid states
6. Regulation and role of myocardial collagen matrix remodeling in hypertensive heart disease
7. Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac fibroblasts: Effects of TGF-β, thyroid hormone, angiotensin II and basic FGF
8. Prerequisite for cardiac aldosterone action: Mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase in the human heart
9. Myocardial production of aldosterone and corticosterone in the rat
10. Steroidogenic enzyme gene expression in the human heart
11. Capillary microaneurysms in the human diabetic heart
12. Common myofibroblastic features of newborn rat astrocytes and cirrhotic rat liver stellate cells in early cultures and in vivo
13. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
14. Effects of glucocorticoids and mineralocorticoids on proliferation and maturation of human peripheral blood stem cells
15. Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms
16. Aldosterone mediates angiotensin II-stimulated rat vascular smooth muscle cell proliferation
17. Aldosterone and cardiac fibrosis: In vitro studies
18. High-affinity aldosterone binding sites (type I receptors) in rat heart
19. +-dependent 11β-hydroxysteroid dehydrogenase in the human heart
20. Aldosterone: Intracellular receptors in human heart
21. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor mediated
22. Does aldosterone-induced cardiac fibrosis involve direct effects on cardiac fibroblasts?
23. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor
24. Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy
25. Cardiac steroidogenesis in the normal and failing heart
26. Aldosterone production is activated in failing ventricle in humans
27. The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel
28. Effects of glucose and sorbitol on proliferation of cultured human skin fibroblasts and arterial smooth-muscle cells
29. High glucose increase growth and collagen synthesis in cultured human tubulointerstitial cells
30. Glucose inhibition of human fibroblast proliferation and response to growth factors is prevented by inhibitors of aldose reductase
31. High glucose induced proliferation in mesangial cells is reversed by autocrine TGF-β
32. Role of PKC and TGF-β receptor in glucose-induced proliferation of smooth muscle cells
33. DNA binding of activator protein-1 is increased in human mesangial cells cultured in high glucose concentrations
34. Effects of aldosterone and glucose on the proliferation and collagenase secretion of cultured human cardiac fibroblasts
35. High glucose stimulates aldosterone-induced hypertrophy via type I mineralocorticoid receptors in neonatal rat cardiomyocytes
36. Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells