Glucocorticoid receptor polymorphisms and post-traumatic stress disorder

Psychoneuroendocrinology

Volumn 30, Issue 3, 2005, Pages 297-306

  Bachmann, Anthony W ^a   Sedgley, Teresa L ^a   Jackson, Richard V ^c   Gibson, John N ^b   Young, Ross McD ^d   Torpy, David J ^e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GREENSLOPES PRIVATE HOSPITAL   (Australia)

^c Logan Hospital   (Australia)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Cortisol; Dermal vessel vasoconstrictor assay; Glucocorticoid receptor polymorphisms; Glucocorticoid sensitivity; Low dose dexamethasone suppression test; Post traumatic stress disorder

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE;

ADULT; AGED; ARTICLE; CAUCASIAN; CONTROLLED STUDY; CORRELATION ANALYSIS; DEXAMETHASONE SUPPRESSION TEST; EXON; GENE REPRESSION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HETEROZYGOSITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MAJOR CLINICAL STUDY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SKIN BLOOD VESSEL; SOLDIER; VASOCONSTRICTION;

ADULT; AGED; COMBAT DISORDERS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DEXAMETHASONE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE DETECTION; HUMANS; HYDROCORTISONE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, GLUCOCORTICOID; SKIN; STIMULATION, CHEMICAL; STRESS DISORDERS, POST-TRAUMATIC; UNITED STATES; VASOCONSTRICTION; VETERANS; VIETNAM CONFLICT;

EID: 7044260794     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2004.08.006     Document Type: Article

References (39)

1. J.A. Boscarino Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: findings and clinical implications J. Consult. Clin. Psychol. 64 1996 191 201
2. P.H. Brown, S. Teelucksingh, S.P. Matusiewicz, A.P. Greening, G.K. Crompton, and C.R.W. Edwards Cutaneous vasoconstrictor response to glucocorticoids in asthma Lancet 337 1991 576 580
3. B. Buemann, M.C. Vohl, M. Chagnon, Y.C. Chagnon, J. Gagnon, L. Perusse, F. Dionne, J.P. Depres, A. Tremblay, A. Nadeau, and C. Bouchard Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus Obes. Res. 5 1997 186 192
4. E.R. de Kloet Brain corticosteroid receptor balance and homeostatic control Front. Neuroendocrinol. 12 1991 95 164
5. P. de Lange, J.W. Koper, N.A.T.M. Huizenga, A.O. Brinkmann, F.H. de Jong, M. Karl, G.P. Chrousos, and S.W.J. Lamberts Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants Mol. Endocrinol. 11 1997 1156 1164
6. M.G. Dobson, C.P.F. Redfern, N. Unwin, and J.U. Weaver The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus J. Clin. Endocrinol. Metab. 86 2001 2270 2274
7. M. Ebrecht, A. Buske-Kirschbaum, D. Hellhammer, S. Kern, N. Rohleder, B. Walker, and C. Kirschbaum Tissue specificity of glucocorticoid sensitivity in healthy adults J. Clin. Endocrinol. Metab. 85 2000 3733 3739
8. S.M. Echwald, T.I.A. Sorensen, T. Andersen, and O. Pedersen The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men Int. J. Obes. 25 2001 1563 1565
9. J. Feng, J. Zheng, W.P. Bennett, L.L. Heston, I.R. Jones, N. Craddock, and S.S. Sommer Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia Am. J. Med. Genet. 96 2000 412 417
10. D. Gaitan, C.R. DeBold, M.K. Turney, P. Zhou, D.N. Orth, and W.J. Kovacs Glucocorticoid receptor structure and function in an adrenocorticotropin- secreting small cell lung cancer Mol. Endocrinol. 9 1995 1193 1201
11. A.K. Goenjian, R. Yehuda, R.S. Pynoos, A.M. Steinberg, M. Tashjian, R.K. Yang, L.M. Najarian, and L.A. Fairbanks Basal cortisol, dexamethasone suppression of cortisol and MHPG in adolescents after the 1988 earthquake in Armenia Am. J. Psychiatry 153 1996 929 934
12. U. Halbreich, J. Olympia, S. Carson, J. Glogowski, C.M. Yeh, S. Axelrod, and M.M. Desu Hypothalamo-pituitary-adrenal activity in endogenously depressed post-traumatic stress disorder patients Psychoneuroendocrinology 14 1989 365 370
13. C. Heim, U. Ehlert, J.P. Hanker, and D.H. Hellhammer Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary- adrenal axis in women with chronic pelvic pain Psychosom. Med. 60 1998 309 318
14. C. Heim, U. Ehlert, and D.H. Hellhammer The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders Psychoneuroendocrinology 25 2000 1 35
15. N.A.T.M. Huizenga, J.W. Koper, P. de Lange, H.A.P. Pols, R.P. Stolk, H. Burger, D.E. Grobbee, A.O. Brinkmann, F.H. de Jong, and S.W.J. Lamberts A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo J. Clin. Endocrinol. Metab. 83 1998 144 151
16. N.A.T.M. Huizenga, J.W. Koper, P. de Lange, H.A.P. Pols, R.P. Stolk, D.E. Grobbee, F.H. de Jong, and S.W.J. Lamberts Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals J. Clin. Endocrinol. Metab. 83 1998 47 54
17. E.D. Kanter, C.W. Wilkinson, A.D. Radant, E.C. Petrie, D.J. Dobie, M.E. McFall, E.R. Peskind, and M.A. Raskind Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder Biol. Psychiatry 50 2001 238 245
18. J.W. Koper, R.P. Stolk, P. de Lange, N.A.T.M. Huizenga, G.J. Molijn, H.A.P. Pols, D.E. Grobbee, M. Karl, F.H. de Jong, A.O. Brinkmann, and S.W.J. Lamberts Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance Hum. Genet. 99 1997 663 668
19. I. Liberzon, J.L. Abelson, S.B. Flagel, J. Raz, and E.A. Young Neuroendocrine and psychophysiologic responses in PTSD: a symptom provocation study Neuropsychopharmacology 21 1999 40 50
20. R.C.Y. Lin, W.Y.S. Wang, and B.J. Morris High penetrance, overweight, and glucocorticoid receptor variant: case-control study Br. Med. J. 319 1999 1337 1338
21. A.H. Miller, R.L. Spencer, M. Pulera, S. Kang, B.S. McEwen, and M. Stein Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: implications for the dexamethasone suppression test Biol. Psychiatry 32 1992 850 869
22. M. Panarelli, C.D. Holloway, R. Fraser, J.M.C. Connell, M.C. Ingram, N.H. Anderson, and C.J. Kenyon Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects J. Clin. Endocrinol. Metab. 83 1998 1846 1852
23. R.K. Pitman, S.P. Orr, D.F. Forgue, B. Altman, J.B. de Jong, and L.R. Herz Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders J. Abnorm. Psychol. 99 1990 49 54
24. R. Rosmond, C. Bouchard, and P. Bjorntorp Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: cohort study Br. Med. J. 322 2001 652 653
25. F. Sanger, S. Nicklen, and A.R. Coulson DNA sequencing with chain-terminating inhibitors Proc. Natl. Acad. Sci. 74 1977 5463 5467
26. M.A. Smith, J. Davidson, J.C. Ritchie, H. Kudler, S. Lipper, P. Chappell, and C.B. Nemeroff The corticotropin-releasing hormone test in patients with PTSD Biol. Psychiatry 26 1989 349 355
27. M.B. Stein, R. Yehuda, C. Koverola, and C. Hanna Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse Biol. Psychiatry 42 1997 680 686
28. D.J. Torpy, J.E. Grice, G.I. Hockings, M.M. Walters, G.V. Crosbie, and R.V. Jackson Diurnal effects of fluoxetine and naloxone on the human hypothalamic-pituitary-adrenal (HPA) axis Clin. Exp. Pharmacol. Physiol. 24 1997 421 423
29. W.R. True, J. Rice, S.A. Eisen, A.C. Heath, J. Goldberg, M.J. Lyons, and J. Nowak A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms Arch. Gen. Psychiatry 50 1993 257 264
30. E.F.C. van Rossum, J.W. Koper, N.A.T.M. Huizenga, A.G. Uitterlinden, J.A.M.J.L. Janssen, A.O. Brinkmann, F.H. de Jong, C.M. van Duyn, H.A.P. Pols, and S.W.J. Lamberts Identification of a restriction site polymorphism in the glucocorticoid receptor gene: association with increased sensitivity to glucocorticoids in vivo, corticosteroid-binding globulin and systolic blood pressure Proc. 84th Annu. Sci. Meeting Endocr. Soc., San Francisco, CA 2002 Oral 49 1
31. B.R. Walker, R. Best, C.H.L. Shackleton, P.L. Padfield, and C.R.W. Edwards Increased vasoconstrictor sensitivity to glucocorticoids in essential hypertension Hypertension 27 1996 190 196
32. J.U. Weaver, G.A. Hitman, and P.G. Kopelman An association between a BclI restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women J. Mol. Endocrinol. 9 1992 295 300
33. S. Wust, E.F.C. van Rossum, I.S. Federenko, J.W. Koper, R. Kumsta, and D.H. Helllhammer Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress J. Clin. Endocrinol. Metab. 89 2004 565 573
34. R. Yehuda Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder Ann. N. Y. Acad. Sci. 821 1997 57 75
35. R. Yehuda Current status of cortisol findings in post-traumatic stress disorder Psychiatr. Clin. N. Am. 25 2002 341 368
36. R. Yehuda, S.M. Southwick, G. Nussbaum, V. Wahby, E.L. Giller, and J.W. Mason Low urinary cortisol excretion in combat-related posttraumatic stress disorder J. Nerv. Ment. Dis. 178 1990 366 369
37. R. Yehuda, D. Boisoneau, M.T. Lowry, and E.L. Giller Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder Arch. Gen. Psychiatry 52 1995 583 593
38. R. Yehuda, R. Levengood, J. Schmeidler, S. Wilso, L.S. Guo, and G. Gerber Increased pituitary activation following metyrapone administration in PTSD Psychoneuroendocrinology 21 1996 1 16
39. R. Yehuda, S.L. Halligan, and L.M. Bierer Cortisol levels in adult offspring of Holocaust survivors: relation to PTSD symptom severity in the parent and child Psychoneuroendocrinology 27 2002 171 180