Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression

Neuropsychopharmacology

Volumn 31, Issue 3, 2006, Pages 620-627

  Van West, Dirk ^a,b   Van Den Eede, Filip ^a,b   Del Favero, Jurgen ^a   Souery, Daniel ^c   Norrback, Karl Fredrik ^d   Van Duijn, Cornelia ^a,e   Sluijs, Sam ^a   Adolfsson, Rolf ^d   Mendlewicz, Julien ^c   Deboutte, Dirk ^b   Van Broeckhoven, Christine ^a   Claes, Stephan ^a,b,f  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c ERASME HOSPITAL   (Belgium)

^d UMEÅ UNIVERSITY   (Sweden)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Genetic; Glucocorticoid receptor; HPA axis; Major depression; Polymorphism; Stress

Indexed keywords

CELL NUCLEUS RECEPTOR; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE;

ADULT; AGED; ALLELE; ARTICLE; BELGIUM; CONTROLLED STUDY; DNA FLANKING REGION; FEMALE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; RECEPTOR GENE; RECURRENT DISEASE; SAMPLE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; SWEDEN;

BELGIUM; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCOCORTICOID; RECURRENCE; SWEDEN;

EID: 33244463459     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300898     Document Type: Article

References (31)

1. Adkins RM (2004). Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset. BMC Genet 5: 22-29.
2. American Psychiatric Association (1994). Diagnostic and Statistical Manual for Mental Disorders. American Psychiatric Press: Washington, DC.
3. Andreasen NC, Endicott J, Spitzer RL, Winokur G (1977). The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry 34: 1229-1235.
4. Binder EB, Salyakine D, Lichtner P, Wochnik GM, Ising M, Pütz B et al (2004). Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 36: 1319-1325.
5. Bamberger CM, Schulte HM, Chrousos GP (1996). Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17: 245-261.
6. Boyle MP, Brewer JA, Funatsu M, Wozniak DF, Tsien JZ, Izumi Y et al (2005). Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci USA 102: 473-478.
7. Breslin MB, Geng CD, Vedeckis WV (2001). Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol 15: 1381-1395.
8. Claes S, Villafuerte S, Forsgren T, Sluijs S, Del-Favero J, Adolfsson R et al (2003). The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Biol Psychiatry 54: 867-872.
9. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998). Brain corticosteroid receptor balance in health and disease. Endocr Rev 19: 269-301.
10. DeRijk RH, Schaaf M, de Kloet ER (2002). Glucocorticoid receptor variants: clinical implications. J Steroid Biochem Mol Biol 81: 103-122.
11. Feng J, Zheng J, Bennett WP, Heston LL, Jones IR, Craddock N et al (2000). Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia. Am J Med Genet 12: 412-417.
12. Gold PW, Goodwin FK, Chrousos GP (1988). Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress. N Engl J Med 319: 413-420.
13. Holsboer F, Barden N (1996). Antidepressants and hypothalamic-pituitary- adrenocortical regulation. Endocr Rev 17: 187-205.
14. Holsboer F (2000). The corticosteroid hypothesis of depression. Neuropsychopharmacology 23: 477-501.
15. Huizenga N, Koper J, de Lange P, Pols H, Stolk R, Burger H et al (1998). A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocr Metab 83: 144-151.
16. Juruena MF, Cleare AJ, Bauer ME, Pariante CM (2003). Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders. Acta Neuropsychiatrica 15: 354-367.
17. Moutsatsou P, Tsolakidou A, Trikkas G, Troungos C, Sekeris CE (2000). Glucocorticoid receptor alpha and beta isoforms are not mutated in bipolar affective disorder. Mol Psychiatry 5: 196-202.
18. Nemeroff CB (1996). The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Mol Psychiatry 1: 336-342.
19. Nobukuni Y, Smith CL, Hager GL, Detera Wadleigh SD (1995). Characterization of the human glucocorticoid receptor promoter. Biochemistry 34: 8207-8214.
20. Owens MJ, Nemeroff CB (1993). The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies. Ciba Found Symp 172: 296-308.
21. Pariante CM, Miller AH (2001). Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49: 391-404.
22. Plotsky PM, Owens MJ, Nemeroff CB (1998). Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis. Psychiatr Clin N Am 21: 293-307.
23. Raymond M, Rousset F (1995). GENEPOP (version 1.2). A population genetics software for exact tests and ecumenicism. J Hered 86: 248-249.
24. Reul JM, de Kloet ER (1985). Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117: 2505-2511.
25. Russcher H, van Rossum E, de Jong F, Brinkmann A, Lamberts S, Koper J (2005). Increased expression of the glucocorticoid receptor: a translation isoforms as a result of the ER22/23EK polymorphism. Mol Endocinol 19: 1687-1696.
26. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiler E (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl): 22-33.
27. Spencer RL, Kim PJ, Kalman BA, Cole MA (1998). Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity. Endocrinology 139: 2718-2726.
28. van Rossum E, Koper J, Huizenga N, Uitterlinden A, Janssen J, Brinkmann A et al (2002). A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 51: 3128-3134.
29. van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T et al (2004). A major SNP haplotype of the arginine vasopressin Ib receptor protects against recurrent major depression. Mol Psychiatry 9: 287-292.
30. Villafuerte S, Del-Favero J, Adolfsson R, Souery D, Massat I, Mendlewicz J et al (2002). Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. Am J Med Genet 114: 222-226.
31. Wüst S, Van Rossum EF, Frederenko IS, Koper JW, Kumsta R, Hellhammer DW (2004). Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab 89: 565-573.