메뉴 건너뛰기




Volumn 51, Issue 3, 2010, Pages 806-816

Bile Salt Sequestration Induces Hepatic de Novo Lipogenesis Through Farnesoid X Receptor- and Liver X Receptorα-Controlled Metabolic Pathways in Mice

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; COLESEVELAM; FARNESOID X RECEPTOR; FATTY ACID; LIVER X RECEPTOR ALPHA; TRIACYLGLYCEROL;

EID: 77950602541     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23408     Document Type: Article
Times cited : (82)

References (46)
  • 1
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009;50:1955-1966.
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 2
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile Acid receptors in metabolic regulation
    • Lefebvre P, Cariou B,Lien F, Kuipers F, Staels B. Role of bile acids and bile Acid receptors in metabolic regulation. Physiol Rev 2009;89:147-191.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou Blien, F.2    Kuipers, F.3    Staels, B.4
  • 3
    • 34347401852 scopus 로고    scopus 로고
    • Bile acid sequestrants and the treatment of type 2 diabetes mellitus
    • Staels B, Kuipers F. Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs 2007;67:1383-1392.
    • (2007) Drugs , vol.67 , pp. 1383-1392
    • Staels, B.1    Kuipers, F.2
  • 4
    • 33645098531 scopus 로고    scopus 로고
    • Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: A scientific review
    • Insull W Jr. Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: a scientific review. South Med J 2006;99:257-273.
    • (2006) South Med J , vol.99 , pp. 257-273
    • Insull Jr., W.1
  • 5
    • 23044439087 scopus 로고    scopus 로고
    • Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia
    • Donovan JM, Von BK, Setchell KD, Isaacsohn J, Pappu AS, Illingworth DR, et al. Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. Dig Dis Sci 2005;50:1232-1238.
    • (2005) Dig Dis Sci , vol.50 , pp. 1232-1238
    • Donovan, J.M.1    Von Bk Setchell, K.D.2    Isaacsohn, J.3    Pappu, A.S.4    Illingworth, D.R.5
  • 6
    • 54049103635 scopus 로고    scopus 로고
    • Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: Glucose and lipid effects
    • Bays HE, Goldberg RB, Truitt KE, Jones MR. Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects. Arch Intern Med 2008;168:1975-1983.
    • (2008) Arch Intern Med , vol.168 , pp. 1975-1983
    • Bays, H.E.1    Goldberg, R.B.2    Truitt, K.E.3    Jones, M.R.4
  • 7
    • 49649095014 scopus 로고    scopus 로고
    • Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy
    • Fonseca VA, Rosenstock J, Wang AC, Truitt KE, Jones MR. Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy. Diabetes Care 2008;31:1479-1484.
    • (2008) Diabetes Care , vol.31 , pp. 1479-1484
    • Fonseca, V.A.1    Rosenstock, J.2    Wang, A.C.3    Truitt, K.E.4    Jones, M.R.5
  • 8
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of WelChol study (GLOWS): A randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes
    • Zieve FJ, Kalin MF, Schwartz SL, Jones MR, Bailey WL. Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes. Clin Ther 2007;29:74-83.
    • (2007) Clin Ther , vol.29 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3    Jones, M.R.4    Bailey, W.L.5
  • 9
    • 0020074674 scopus 로고
    • Effects of interruption of the enterohepatic circulation of bile acids on the transport of very low density-lipoprotein triglycerides
    • Beil U, Crouse JR, Einarsson K, Grundy SM. Effects of interruption of the enterohepatic circulation of bile acids on the transport of very low density-lipoprotein triglycerides. Metabolism 1982;31:438-444.
    • (1982) Metabolism , vol.31 , pp. 438-444
    • Beil, U.1    Crouse, J.R.2    Einarsson, K.3    Grundy, S.M.4
  • 10
    • 0023624926 scopus 로고
    • Hypertriglyceridemia: A contraindication to the use of bile acid binding resins
    • Crouse JR III. Hypertriglyceridemia: a contraindication to the use of bile acid binding resins. Am J Med 1987;83:243-248.
    • (1987) Am J Med , vol.83 , pp. 243-248
    • Crouse III, J.R.1
  • 11
    • 0018132578 scopus 로고
    • Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia
    • Angelin B, Einarsson K, Hellstrom K, Leijd B. Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia. J Lipid Res 1978;19:1017-1024. (Pubitemid 9059813)
    • (1978) Journal of Lipid Research , vol.19 , Issue.8 , pp. 1017-1024
    • Angelin, B.1    Einarsson, K.2    Hellstrom, K.3    Leijd, B.4
  • 12
    • 0019851145 scopus 로고
    • Chenodeoxycholic acid and ursodeoxycholic acid effects in endogenous hypertriglyceridemias. A controlled double-blind trial
    • Carulli N, Ponz de LM, Podda M, Zuin M, Strata A, Frigerio G, et al. Chenodeoxycholic acid and ursodeoxycholic acid effects in endogenous hypertriglyceridemias. A controlled double-blind trial. J Clin Pharmacol 1981;21:436-442.
    • (1981) J Clin Pharmacol , vol.21 , pp. 436-442
    • Carulli, N.1    Ponz De, L.M.2    Podda, M.3    Zuin, M.4    Strata, A.5    Frigerio, G.6
  • 13
    • 34248392648 scopus 로고    scopus 로고
    • Bile acids, farnesoid X receptor, atherosclerosis and metabolic control
    • Kuipers F, Stroeve JH, Caron S, Staels B. Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. Curr Opin Lipidol 2007;18:289-297.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 289-297
    • Kuipers, F.1    Stroeve, J.H.2    Caron, S.3    Staels, B.4
  • 15
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci USA 2006;103:1006-1011.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzalez, F.J.6
  • 16
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 18
    • 0033552130 scopus 로고    scopus 로고
    • Colesevelam hydrochloride (cholestagel): A new, potent bile acid seques-trant associated with a low incidence of gastrointestinal side effects
    • Davidson MH, Dillon MA, Gordon B, Jones P, Samuels J, Weiss S, et al. Colesevelam hydrochloride (cholestagel): a new, potent bile acid seques-trant associated with a low incidence of gastrointestinal side effects. Arch Intern Med 1999;159:1893-1900.
    • (1999) Arch Intern Med , vol.159 , pp. 1893-1900
    • Davidson, M.H.1    Dillon, M.A.2    Gordon, B.3    Jones, P.4    Samuels, J.5    Weiss, S.6
  • 19
    • 0142211282 scopus 로고    scopus 로고
    • Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    • Kok T, Hulzebos CV, Wolters H, Havinga R, Agellon LB, Stellaard F, et al. Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem 2003;278:41930-41937.
    • (2003) J Biol Chem , vol.278 , pp. 41930-41937
    • Kok, T.1    Hulzebos, C.V.2    Wolters, H.3    Havinga, R.4    Agellon, L.B.5    Stellaard, F.6
  • 21
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 22
    • 0014857680 scopus 로고
    • A fluorimetric and enzymatic method for the estimation of serum total bile acids
    • Murphy GM, Billing BH, Baron DN. A fluorimetric and enzymatic method for the estimation of serum total bile acids. J Clin Pathol 1970;23: 594-598.
    • (1970) J Clin Pathol , vol.23 , pp. 594-598
    • Murphy, G.M.1    Billing, B.H.2    Baron, D.N.3
  • 23
    • 0035204295 scopus 로고    scopus 로고
    • Measurement of parameters of cholic acid kinetics in plasma using a microscale stable isotope dilution technique: Application to rodents and humans
    • Hulzebos CV, Renfurm L, Bandsma RH, Verkade HJ, Boer T, Boverhof R, et al. Measurement of parameters of cholic acid kinetics in plasma using a microscale stable isotope dilution technique: application to rodents and humans. J Lipid Res 2001;42:1923-1929.
    • (2001) J Lipid Res , vol.42 , pp. 1923-1929
    • Hulzebos, C.V.1    Renfurm, L.2    Bandsma, R.H.3    Verkade, H.J.4    Boer, T.5    Boverhof, R.6
  • 24
    • 46349093356 scopus 로고    scopus 로고
    • Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression
    • Tancevski I, Wehinger A, Demetz E, Eller P, Duwensee K, Huber J, et al. Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression. Endocrinology 2008;149:3708-3712.
    • (2008) Endocrinology , vol.149 , pp. 3708-3712
    • Tancevski, I.1    Wehinger, A.2    Demetz, E.3    Eller, P.4    Duwensee, K.5    Huber, J.6
  • 25
    • 0033569441 scopus 로고    scopus 로고
    • Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice
    • Jung HR, Turner SM, Neese RA, Young SG, Hellerstein MK. Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice. Biochem J 1999;343:473-478.
    • (1999) Biochem J , vol.343 , pp. 473-478
    • Jung, H.R.1    Turner, S.M.2    Neese, R.A.3    Young, S.G.4    Hellerstein, M.K.5
  • 26
    • 0027530502 scopus 로고
    • Measurement of endogenous synthesis of plasma cholesterol in rats and humans using MIDA
    • Neese RA, Faix D, Kletke C, Wu K, Wang AC, Shackleton CH, et al. Measurement of endogenous synthesis of plasma cholesterol in rats and humans using MIDA. Am J Physiol 1993;264:E136-E147.
    • (1993) Am J Physiol , vol.264
    • Neese, R.A.1    Faix, D.2    Kletke, C.3    Wu, K.4    Wang, A.C.5    Shackleton, C.H.6
  • 27
    • 0037406445 scopus 로고    scopus 로고
    • Hepatic VLDL production inob/ob mice isnot stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin
    • Wiegman CH, Bandsma RH, Ouwens M, van der Sluijs FH, Havinga R, Boer T, et al. Hepatic VLDL production inob/ob mice isnot stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. Diabetes 2003;52:1081-1089.
    • (2003) Diabetes , vol.52 , pp. 1081-1089
    • Wiegman, C.H.1    Bandsma, R.H.2    Ouwens, M.3    Van Der Sluijs, F.H.4    Havinga, R.5    Boer, T.6
  • 29
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plosch T, Kok T, Bloks VW, Smit MJ, Havinga R, Chimini G, et al. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem 2002;277: 33870-33877.
    • (2002) J Biol Chem , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6
  • 30
    • 46749094102 scopus 로고    scopus 로고
    • Hepatic insulin resistance directly promotes formation of cholesterol gallstones
    • Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, et al. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 2008;14:778-782.
    • (2008) Nat Med , vol.14 , pp. 778-782
    • Biddinger, S.B.1    Haas, J.T.2    Yu, B.B.3    Bezy, O.4    Jing, E.5    Zhang, W.6
  • 31
    • 0036086885 scopus 로고    scopus 로고
    • Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats
    • van Waarde WM, Verkade HJ, Wolters H, Havinga R, Baller J, Bloks V, et al. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. Gastroenterology 2002;122:1842-1852.
    • (2002) Gastroenterology , vol.122 , pp. 1842-1852
    • Van Waarde, W.M.1    Verkade, H.J.2    Wolters, H.3    Havinga, R.4    Baller, J.5    Bloks, V.6
  • 32
    • 53149108993 scopus 로고    scopus 로고
    • Transforming growth factor beta1, tumor necrosis factor a, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression
    • LiT,Ma H,Chiang JY. Transforming growth factor beta1, tumor necrosis factor a, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression. J Lipid Res 2008;49:1981-1989.
    • (2008) J Lipid Res , vol.49 , pp. 1981-1989
    • Litma Hchiang, J.Y.1
  • 33
    • 0025150480 scopus 로고
    • Pathophysiology and pathogenesis of cholesterol gallstone formation
    • Hay DW, Carey MC. Pathophysiology and pathogenesis of cholesterol gallstone formation. Semin Liver Dis 1990;10:159-170.
    • (1990) Semin Liver Dis , vol.10 , pp. 159-170
    • Hay, D.W.1    Carey, M.C.2
  • 34
    • 0033952113 scopus 로고    scopus 로고
    • Association of diabetes, serum insulin, and C-peptide with gallbladder disease
    • Ruhl CE, Everhart JE. Association of diabetes, serum insulin, and C-peptide with gallbladder disease. HEPATOLOGY 2000;31:299-303.
    • (2000) HEPATOLOGY , vol.31 , pp. 299-303
    • Ruhl, C.E.1    Everhart, J.E.2
  • 35
    • 0347895068 scopus 로고    scopus 로고
    • Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits
    • Xu G, Pan LX, Li H, Forman BM, Erickson SK, Shefer S, et al. Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits. J Biol Chem 2002;277:50491-50496.
    • (2002) J Biol Chem , vol.277 , pp. 50491-50496
    • Xu, G.1    Pan, L.X.2    Li, H.3    Forman, B.M.4    Erickson, S.K.5    Shefer, S.6
  • 36
    • 33847057732 scopus 로고    scopus 로고
    • Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin
    • Kobayashi M, Ikegami H, Fujisawa T, Nojima K, Kawabata Y, Noso S, et al. Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes 2007;56:239-247.
    • (2007) Diabetes , vol.56 , pp. 239-247
    • Kobayashi, M.1    Ikegami, H.2    Fujisawa, T.3    Nojima, K.4    Kawabata, Y.5    Noso, S.6
  • 37
    • 27744577847 scopus 로고    scopus 로고
    • Effects of colestimide and/or Bofu-tsusho-san on plasma and liver lipids in mice fed a high-fat diet
    • Sakamoto S, Takeshita S, Sassa S, Suzuki S, Ishikawa Y, Kudo H. Effects of colestimide and/or Bofu-tsusho-san on plasma and liver lipids in mice fed a high-fat diet. In Vivo 2005;19:1029-1033.
    • (2005) In Vivo , vol.19 , pp. 1029-1033
    • Sakamoto, S.1    Takeshita, S.2    Sassa, S.3    Suzuki, S.4    Ishikawa, Y.5    Kudo, H.6
  • 39
    • 22544452537 scopus 로고    scopus 로고
    • The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition
    • Duran-Sandoval D, Cariou B, Percevault F, Hennuyer N, Grefhorst A, van Dijk TH, et al. The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem 2005;280:29971-29979.
    • (2005) J Biol Chem , vol.280 , pp. 29971-29979
    • Duran-Sandoval, D.1    Cariou, B.2    Percevault, F.3    Hennuyer, N.4    Grefhorst, A.5    Van Dijk, T.H.6
  • 40
    • 0942279602 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
    • Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev 2004;18:157-169.
    • (2004) Genes Dev , vol.18 , pp. 157-169
    • Zhang, Y.1    Castellani, L.W.2    Sinal, C.J.3    Gonzalez, F.J.4    Edwards, P.A.5
  • 41
    • 33845573067 scopus 로고    scopus 로고
    • Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase
    • Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase. J Lipid Res 2006;47:2754-2761.
    • (2006) J Lipid Res , vol.47 , pp. 2754-2761
    • Matsukuma, K.E.1    Bennett, M.K.2    Huang, J.3    Wang, L.4    Gil, G.5    Osborne, T.F.6
  • 42
    • 25444512015 scopus 로고    scopus 로고
    • Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice
    • Grefhorst A, van Dijk TH, Hammer A, van der Sluijs FH, Havinga R, Havekes LM, et al. Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice. Am J Physiol Endocrinol Metab 2005;289:E829-E838.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Grefhorst, A.1    Van Dijk, T.H.2    Hammer, A.3    Van Der Sluijs, F.H.4    Havinga, R.5    Havekes, L.M.6
  • 43
    • 0029800090 scopus 로고    scopus 로고
    • Zonation of parenchymal and nonparen-chymal metabolism in liver
    • Jungermann K, Kietzmann T. Zonation of parenchymal and nonparen-chymal metabolism in liver. Annu Rev Nutr 1996;16:179-203.
    • (1996) Annu Rev Nutr , vol.16 , pp. 179-203
    • Jungermann, K.1    Kietzmann, T.2
  • 44
    • 33846970566 scopus 로고    scopus 로고
    • Differential hepatocellular zonation pattern of cholesterol 7alpha-hydrox-ylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse
    • Wang J, Olin M, Rozell B, Bjorkhem I, Einarsson C, Eggertsen G, et al. Differential hepatocellular zonation pattern of cholesterol 7alpha-hydrox-ylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse. Histochem Cell Biol 2007;127:253-261.
    • (2007) Histochem Cell Biol , vol.127 , pp. 253-261
    • Wang, J.1    Olin, M.2    Rozell, B.3    Bjorkhem, I.4    Einarsson, C.5    Eggertsen, G.6
  • 45
    • 0028901070 scopus 로고
    • Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus
    • Twisk J, Hoekman MF, Mager WH, Moorman AF, de Boer PA, Scheja L, et al. Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. J Clin Invest 1995;95: 1235-1243.
    • (1995) J Clin Invest , vol.95 , pp. 1235-1243
    • Twisk, J.1    Hoekman, M.F.2    Mager, W.H.3    Moorman, A.F.4    De Boer, P.A.5    Scheja, L.6
  • 46
    • 0027082241 scopus 로고
    • Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs
    • Groothuis GM, Meijer DK. Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs. Enzyme 1992;46:94-138.
    • (1992) Enzyme , vol.46 , pp. 94-138
    • Groothuis, G.M.1    Meijer, D.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.