Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice

Spine

Volumn 36, Issue 22, 2011, Pages

  Kanno, Haruo ^a,b   Ozawa, Hiroshi ^a   Sekiguchi, Akira ^a   Yamaya, Seiji ^a   Itoi, Eiji ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

apoptosis; autophagic cell death; autophagy; LC3; spinal cord injury

Indexed keywords

CELL MARKER; LIGHT CHAIN 3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOPHAGIC CELL DEATH; AUTOPHAGY; BIOCHEMISTRY; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NERVOUS TISSUE; NICK END LABELING; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; TISSUE INJURY; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; APOPTOSIS; AUTOPHAGY; BIOLOGICAL MARKERS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; SPINAL CORD; SPINAL CORD INJURIES; TIME FACTORS;

EID: 80053970026     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182028c3a     Document Type: Article

References (42)

1. Ogier-Denis E , Codogno P . Autophagy: a barrier or an adaptive response to cancer . Biochim Biophys Acta 2003; 1603:113-28. (Pubitemid 36266686)
2. Gozuacik D , Kimchi A . Autophagy as a cell death and tumor suppressor mechanism . Oncogene 2004; 23:2891-906. (Pubitemid 38638851)
3. Shintani T , Klionsky DJ . Autophagy in health and disease: a doubleedged sword . Science 2004; 306:990-5. (Pubitemid 39482894)
4. Rubinsztein DC , DiFiglia M , Heintz N , et al. Autophagy and its possible roles in nervous system diseases, damage and repair . Autophagy 2005; 1:11-22.
5. Tsujimoto Y , Shimizu S . Another way to die: autophagic programmed cell death . Cell Death Differ 2005; 12 ( suppl 2 ): 1528-34. (Pubitemid 41553989)
6. Erlich S , Alexandrovich A , Shohami E , et al. Rapamycin is a neuroprotective treatment for traumatic brain injury . Neurobiol Dis 2007; 26:86-93. (Pubitemid 46436489)
7. Hara T , Nakamura K , Matsui M , et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice . Nature 2006; 441:885-9.
8. Komatsu M , Waguri S , Chiba T , et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice . Nature 2006; 441:880-4.
9. Pan T , Kondo S , Zhu W , et al. Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement . Neurobiol Dis 2008; 32:16-25.
10. Sarkar S , Ravikumar B , Floto RA , et al. Rapamycin and mTORindependent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies . Cell Death Differ 2009; 16:46-56.
11. Kitanaka C , Kuchino Y . Caspase-independent programmed cell death with necrotic morphology . Cell Death Differ 1999; 6:508-15. (Pubitemid 29292106)
12. Scarlatti F , Granata R , Meijer AJ , et al. Does autophagy have a license to kill mammalian cells ? Cell Death Differ 2009; 16:12-20.
13. Clarke PG . Developmental cell death: morphological diversity and multiple mechanisms . Anat Embryol (Berl) 1990; 181:195-213. (Pubitemid 20153523)
14. Larsen KE , Sulzer D . Autophagy in neurons: a review . Histol Histopathol 2002; 17:897-908. (Pubitemid 34784673)
15. Matsui Y , Takagi H , Qu X , et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy . Circ Res 2007; 100:914-22. (Pubitemid 46555697)
16. Rami A , Langhagen A , Steiger S . Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death . Neurobiol Dis 2008; 29:132-41. (Pubitemid 350186114)
17. Suzuki C , Isaka Y , Takabatake Y , et al. Participation of autophagy in renal ischemia/reperfusion injury . Biochem Biophys Res Commun 2008; 368:100-6.
18. Ohsumi Y . Molecular dissection of autophagy: two ubiquitin-like systems . Nat Rev Mol Cell Biol 2001; 2:211-16. (Pubitemid 33675746)
19. Kabeya Y , Mizushima N , Ueno T , et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing . EMBO J 2000; 19:5720-8.
20. Mizushima N . Methods for monitoring autophagy . Int J Biochem Cell Biol 2004; 36:2491-502. (Pubitemid 39119761)
21. Klionsky DJ , Abeliovich H , Agostinis P , et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes . Autophagy 2008; 4:151-75. (Pubitemid 351231180)
22. Adhami F , Liao G , Morozov YM , et al. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy . Am J Pathol 2006; 169:566-83. (Pubitemid 44156315)
23. He Y , Wan S , Hua Y , et al. Autophagy after experimental intracerebral hemorrhage . J Cereb Blood Flow Metab 2008; 28:897-905. (Pubitemid 351589625)
24. Lai Y , Hickey RW , Chen Y , et al. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester . J Cereb Blood Flow Metab 2008; 28:540-50. (Pubitemid 351304265)
25. Liu CL , Chen S , Dietrich D , et al. Changes in autophagy after traumatic brain injury . J Cereb Blood Flow Metab 2008; 28:674-83. (Pubitemid 351432796)
26. Uchiyama Y , Koike M , Shibata M . Autophagic neuron death in neonatal brain ischemia/hypoxia . Autophagy 2008; 4:404-8. (Pubitemid 351705135)
27. Wen YD , Sheng R , Zhang LS , et al. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways . Autophagy 2008; 4:762-9.
28. Kanno H , Ozawa H , Sekiguchi A , et al. Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death . Neurobiol Dis 2009; 33:143-8.
29. Maiuri MC , Zalckvar E , Kimchi A , et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis . Nat Rev Mol Cell Biol 2007; 8:741-52. (Pubitemid 47312826)
30. Dong H , Fazzaro A , Xiang C , et al. Enhanced oligodendrocyte survival after spinal cord injury in Bax-defi cient mice and mice with delayed Wallerian degeneration . J Neurosci 2003; 23:8682-91. (Pubitemid 37176648)
31. Kalderon N , Fuks Z . Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site . Proc Natl Acad Sci U S A 1996; 93:11179-84.
32. Diskin T , Tal-Or P , Erlich S , et al. Closed head injury induces upregulation of Beclin 1 at the cortical site of injury . J Neurotrauma 2005; 22:750-62. (Pubitemid 40995307)
33. Krysko DV , Vanden Berghe T , Parthoens E , et al. Methods for distinguishing apoptotic from necrotic cells and measuring their clearance . Methods Enzymol 2008; 442:307-41.
34. Krysko DV , Vanden Berghe T , D'Herde K , et al. Apoptosis and necrosis: detection, discrimination and phagocytosis . Methods 2008; 44:205-21. (Pubitemid 351296447)
35. Boya P , González-Polo RA , Casares N , et al. Inhibition of macroautophagy triggers apoptosis . Mol Cell Biol 2005; 25:1025-40. (Pubitemid 40165810)
36. Kanno H , Ozawa H , Sekiguchi A , et al. The role of autophagy in spinal cord injury . Autophagy 2009; 5:390-2.
37. Citron BA , Arnold PM , Sebastian C , et al. Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death . Exp Neurol 2000; 166:213-26.
38. Lu J , Ashwell KW , Waite P . Advances in secondary spinal cord injury: role of apoptosis . Spine 2000; 25:1859-66. (Pubitemid 30469668)
39. Yong C , Arnold PM , Zoubine MN , et al. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury . J Neurotrauma 1998; 15:459-72. (Pubitemid 28313405)
40. Lee SJ , Cho KS , Koh JY . Oxidative injury triggers autophagy in astrocytes: the role of endogenous zinc . Glia 2009; 57:1351-61.
41. Calle E , Berciano MT , Fernández R , et al. Activation of the autophagy, c-FOS and ubiquitin expression, and nucleolar alterations in Schwann cells precede demyelination in tellurium-induced neuropathy . Acta Neuropathol 1999; 97:143-55. (Pubitemid 29134543)
42. Carloni S , Buonocore G , Balduini W . Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury . Neurobiol Dis 2008; 32:329-39.