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Volumn 34, Issue 8, 2011, Pages 630-644

Understanding polycystic ovarian syndrome pathogenesis: An updated of its genetic aspects

Author keywords

Adipose tissue genes; Gonadotropin genes; Insulin gene; PCOS; Steroidogenesis anzyme genes

Indexed keywords

ADIPONECTIN; ANDROGEN RECEPTOR; AROMATASE; CALPAIN 10; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; CYTOKINE; CYTOKINE RECEPTOR; FOLLISTATIN; GONADOTROPIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LEPTIN; LEPTIN RECEPTOR; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SEX HORMONE BINDING GLOBULIN; STEROID 21 MONOOXYGENASE; STEROID HORMONE;

EID: 84855465297     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7746     Document Type: Review
Times cited : (13)

References (185)
  • 3
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • DOI 10.1210/er.18.6.774
    • Dunaif A. Insulin resistance and polycystic ovary syndrome: mechanism and implication for pathogenesis. Endocr Rev 1997, 18: 774-800. (Pubitemid 28009567)
    • (1997) Endocrine Reviews , vol.18 , Issue.6 , pp. 774-800
    • Dunaif, A.1
  • 4
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S. Polycystic ovary syndrome. N Engl J Med 1995, 333: 853-61.
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 5
    • 27744585694 scopus 로고    scopus 로고
    • Genetics of polycystic ovary syndrome: Searching for the way out of the labyrinth
    • DOI 10.1093/humupd/dmi025
    • Diamanti-Kandarakis E, Piperi C. Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth. Hum Reprod Update 2005, 11: 631-43. (Pubitemid 41631312)
    • (2005) Human Reproduction Update , vol.11 , Issue.6 , pp. 631-643
    • Diamanti-Kandarakis, E.1    Piperi, C.2
  • 6
    • 0034061052 scopus 로고    scopus 로고
    • Microsatellite polymorphism (tttta)(n) at -528 base pairs of gene CYP11alpha influences hyperandrogenemia in patients with polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(99)00628-7, PII S0015028299006287
    • Diamanti-Kandarakis E, Bartzis MI, Bergiele AT, et al. Microsatellite polymorphism (tttta)(n) at -528 base pairs of gene CYP11α influences hyperandrogenemia in patient with polycystic ovary syndrome. Fertil Steril 2000, 73: 735-41. (Pubitemid 30154112)
    • (2000) Fertility and Sterility , vol.73 , Issue.4 , pp. 735-741
    • Diamanti-Kandarakis, E.1    Bartzis, M.I.2    Bergiele, A.T.3    Tsianateli, T.C.4    Kouli, C.R.5
  • 7
    • 0036147995 scopus 로고    scopus 로고
    • 17-20 lyase promoters
    • DOI 10.1016/S0015-0282(01)02999-5, PII S0015028201029995
    • Daneshmand S, Weitsman SR, Navab A, Jakimiuk AJ, Magoffin DA. Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promoters. Fertil Steril 2002, 77: 274-80. (Pubitemid 34086909)
    • (2002) Fertility and Sterility , vol.77 , Issue.2 , pp. 274-280
    • Daneshmand, S.1    Weitsman, S.R.2    Navab, A.3    Jakimiuk, A.J.4    Magoffin, D.A.5
  • 8
    • 33745501749 scopus 로고    scopus 로고
    • A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2005.12.037, PII S0015028206005589
    • Wang Y, Wu X, Cao Y, Yi L, Chen J. A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome. Fertil Steril 2006, 86: 223-6. (Pubitemid 43962960)
    • (2006) Fertility and Sterility , vol.86 , Issue.1 , pp. 223-226
    • Wang, Y.1    Wu, X.2    Cao, Y.3    Yi, L.4    Chen, J.5
  • 10
    • 0035059718 scopus 로고    scopus 로고
    • n polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism
    • DOI 10.1016/S0015-0282(01)01677-6, PII S0015028201016776
    • San Millán JL, Sancho J, Calvo RM, Escobar-Morreale HF. Role of the pentanucleotide (tttta)(n) polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism. Fertil Steril 2001, 75: 797-802. (Pubitemid 32273517)
    • (2001) Fertility and Sterility , vol.75 , Issue.4 , pp. 797-802
    • San, M.J.L.1    Sancho, J.2    Calvo, R.M.3    Escobar-Morreale, H.F.4
  • 11
    • 0035040378 scopus 로고    scopus 로고
    • Role of the follistatin gene in women with polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(01)01697-1, PII S0015028201016971
    • Calvo RM, Villuendas G, Sancho J, San Millán JL, Escobar-Morreale HF. Role of the follistatin gene in women with polycystic ovary syndrome Fertil Steril 2001, 75: 1020-3. (Pubitemid 32401685)
    • (2001) Fertility and Sterility , vol.75 , Issue.5 , pp. 1020-1023
    • Calvo, R.M.1    Villuendas, G.2    Sancho, J.3    San, M.J.L.4    Escobar-Morreale, H.F.5
  • 13
    • 0023550055 scopus 로고
    • Cloning and sequence of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase): Similarity with the gene for P450c21
    • Picado-Leonard J, Miller WL. Cloning and sequence of the human gene for P450c17 (steroid 17α-hydroxylase/17-20 lyase): similarity with the gene for P450c21. DNA 1987, 6: 439-48. (Pubitemid 18085844)
    • (1987) DNA , vol.6 , Issue.5 , pp. 439-448
    • Picado-Leonard, J.1    Miller, W.L.2
  • 14
    • 5444229651 scopus 로고    scopus 로고
    • CYP17 gene polymorphisms: Prevalence and associations with hormone levels and related factors. A HuGE review
    • DOI 10.1093/aje/kwh287
    • Sharp L, Cardy AH, Cotton SC, Little J. CYP17 gene polymorphism: prevalence and associations with hormone levels and related factors. A HuGE: review. Am J Epidemiol 2004, 160: 729-40. (Pubitemid 39362210)
    • (2004) American Journal of Epidemiology , vol.160 , Issue.8 , pp. 729-740
    • Sharp, L.1    Cardy, A.H.2    Cotton, S.C.3    Little, J.4
  • 15
    • 0028588696 scopus 로고
    • Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism
    • Rosenfield RL, Barnes RB, Ehrmann DA. Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1994, 79: 1686-92.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1686-1692
    • Rosenfield, R.L.1    Barnes, R.B.2    Ehrmann, D.A.3
  • 16
    • 0025195368 scopus 로고
    • Dysregulation of cytochrome P450c17alpha as the cause of polycystic ovarian syndrome
    • Rosenfield RL, Barnes RB, Cara JF, Lucky AW. Dysregulation of cytochrome P450c 17α as the cause of polycystic ovarian syndrome. Fertil Steril 1990, 53: 785-91. (Pubitemid 20180464)
    • (1990) Fertility and Sterility , vol.53 , Issue.5 , pp. 785-791
    • Rosenfield, R.L.1    Barnes, R.B.2    Cara, J.F.3    Lucky, A.W.4
  • 17
    • 1542327554 scopus 로고    scopus 로고
    • Increased cytochrome P450 17α-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1
    • Wickenheisser JK, Nelson-DeGrave VL, Quinn PG, McAllister JM. Increased cytochrome P450 17α-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1. Mol Endocrinol 2004, 18: 558-605.
    • (2004) Mol Endocrinol , vol.18 , pp. 558-605
    • Wickenheisser, J.K.1    Nelson-DeGrave, V.L.2    Quinn, P.G.3    McAllister, J.M.4
  • 18
    • 15944407338 scopus 로고    scopus 로고
    • Dysregulation of cytochrome P450 17alpha-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome
    • DOI 10.1210/jc.2004-1860
    • Wickenheisser JK, Nelson-DeGrave VL, McAllister JM. Dysregulation of cytochrome P450 17α-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005, 90: 1720-7. (Pubitemid 40464044)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.3 , pp. 1720-1727
    • Wickenheisser, J.K.1    Nelson-DeGrave, V.L.2    McAllister, J.M.3
  • 21
    • 16044372273 scopus 로고    scopus 로고
    • 5' Polymorphism of the CYP17 gene is not associated with serum testosterone levels in women with polycystic ovaries [1]
    • DOI 10.1210/jc.81.11.4174
    • Gharani N, Waterworth DM, Williamson R, Franks S. 5′ polymorphism of the CYP17 gene is not associated with serum testosterone levels in women with polycystic ovary. J Clin Endocrinol Metab 1996, 81: 4174. (Pubitemid 26380437)
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , Issue.11 , pp. 4174
    • Gharani, N.1    Waterworth, D.M.2    Williamson, R.3    Franks, S.4
  • 22
    • 0030988978 scopus 로고    scopus 로고
    • Frequency of a polymorphism in the regulatory region of the 17alpha-hydroxylase-17,20-lyase (CYP17) gene in hyperandrogenic states
    • Techatraisak K, Conway GS, Rumsby G. Frequency of a polymorphism in the regulatory region of the 17α.hydroxylase-17,20-lyase (CYP17) gene in hyperandrogenic states. Clin Endocrinol 1997, 46: 131-4. (Pubitemid 27122156)
    • (1997) Clinical Endocrinology , vol.46 , Issue.2 , pp. 131-134
    • Techatraisak, K.1    Conway, G.S.2    Rumsby, G.3
  • 25
    • 55649118861 scopus 로고    scopus 로고
    • C (-34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: A preliminary study
    • Echiburú B, Pérez-Bravo F, Maliqueo M, Sánchez F, Crisosto N, Sir-Petermann T. Polymorphism T→ C (-34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: a preliminary study. Metabolism 2008, 57: 1765-71.
    • (2008) Metabolism , vol.57 , pp. 1765-1771
    • Echiburú, B.1    Pérez-Bravo, F.2    Maliqueo, M.3    Sánchez, F.4    Crisosto, N.5    Sir-Petermann, T.6    Polymorphism, T.7
  • 26
    • 0028786656 scopus 로고
    • Serine phosphorylation of human P450c17 increases 17, 20-lyase activity: Implications for adrenarche and the polycystic ovary syndrome
    • Zhang LH, Rodriguez H, Ohno S, Miller WL. Serine phosphorylation of human P450c17 increases 17, 20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Proc Natl Acad Sci U S A 1995, 92: 10619-23.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10619-10623
    • Zhang, L.H.1    Rodriguez, H.2    Ohno, S.3    Miller, W.L.4
  • 27
    • 0032566950 scopus 로고    scopus 로고
    • Role of cytochrome P450c17 in polycystic ovary syndrome
    • DOI 10.1016/S0303-7207(98)00177-4, PII S0303720798001774
    • Qin KN, Rosenfield RL. Role of cytochrome P450c17 in polycystic ovary syndrome. Mol Cell Endocrinol 1998, 145: 111-21. (Pubitemid 29003185)
    • (1998) Molecular and Cellular Endocrinology , vol.145 , Issue.1-2 , pp. 111-121
    • Qin, K.-N.1    Rosenfield, R.L.2
  • 28
    • 0023834876 scopus 로고
    • Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
    • Takayama S, White MF, Kahn CR. Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem 1988, 263: 3440-7. (Pubitemid 18072805)
    • (1988) Journal of Biological Chemistry , vol.263 , Issue.7 , pp. 3440-3447
    • Takayama, S.1    White, M.F.2    Kahn, C.R.3
  • 29
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • Dunaif A, Xia J, Book C-B, Schenker E, Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 1995, 96: 801-10.
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.-B.3    Schenker, E.4    Tang, Z.5
  • 30
    • 17144426051 scopus 로고    scopus 로고
    • 5 and by serine phosphorylation of P450c17
    • DOI 10.1074/jbc.M414673200
    • Pandey AV, Miller WL. Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P45017. J Biol Chem 2005, 280: 13265-71. (Pubitemid 40517210)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 13265-13271
    • Pandey, A.V.1    Miller, W.L.2
  • 31
    • 42449129236 scopus 로고    scopus 로고
    • Pathways leading to phosphorylation of P450c17 and to the posttranslational regulation of androgen biosynthesis
    • DOI 10.1210/en.2007-1527
    • Tee MK, Dong Q, Miller WL. Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis. Endocrinology 2008, 149: 2667-77. (Pubitemid 351574538)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2667-2677
    • Meng, K.T.1    Dong, Q.2    Miller, W.L.3
  • 32
    • 0033214141 scopus 로고    scopus 로고
    • The presence of the 21-hydroxylase deficiency carrier status in hirsute women: Phenotype-genotype correlations
    • DOI 10.1016/S0015-0282(99)00317-9, PII S0015028299003179
    • Escobar-Morreale HF, San Millán JL, Smith RR, Sancho J, Witchel SF. The presence of the 21-hydroxylase deficiency carrier status in hirsute women: phenotype-genotype correlations. Fertil Steril 1999, 72: 629-38. (Pubitemid 29475120)
    • (1999) Fertility and Sterility , vol.72 , Issue.4 , pp. 629-638
    • Escobar-Morreale, H.F.1    San, M.J.L.2    Smith, R.R.3    Sancho, J.4    Witchel, S.F.5
  • 33
    • 0033673366 scopus 로고    scopus 로고
    • The role of heterozygosity for CYP21 in the polycystic ovary syndrome
    • Witchel SF, Aston CE. The role of heterozygosity for CYP21 in the polycystic ovary syndrome. J Pediatr Endocrinol Metab 2000, 13: 1315-7.
    • (2000) J Pediatr Endocrinol Metab , vol.13 , pp. 1315-1317
    • Witchel, S.F.1    Aston, C.E.2
  • 34
    • 33646841046 scopus 로고    scopus 로고
    • Hyperandrogenism in carriers of CYP21 mutations: The role of genotype
    • DOI 10.1111/j.1365-2265.2006.02521.x
    • Admoni O, Israel S, Lavi I, Gur M, Tenenbaum-Rakover Y. Hyperandrogenism in carriers of CYP21 mutations: the role of CYP21. Clin Endocrinol (Oxf) 2006, 64: 645-51. (Pubitemid 43775002)
    • (2006) Clinical Endocrinology , vol.64 , Issue.6 , pp. 645-651
    • Admoni, O.1    Israel, S.2    Lavi, I.3    Gur, M.4    Tenenbaum-Rakover, Y.5
  • 35
    • 13544272786 scopus 로고    scopus 로고
    • Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess
    • DOI 10.1016/j.fertnstert.2004.10.027
    • Witchel SF, Kahsar-Miller M, Aston CE, White C, Azziz R. Prevalence of CYP21 mutations and IRS1 variant among women with polycystic syndrome and androgen excess. Fertil Steril 2005, 83: 371-5. (Pubitemid 40221791)
    • (2005) Fertility and Sterility , vol.83 , Issue.2 , pp. 371-375
    • Witchel, S.F.1    Kahsar-Miller, M.2    Aston, C.E.3    White, C.4    Azziz, R.5
  • 38
    • 0018672003 scopus 로고
    • Functional studies of aromatase activity in human granulosa cells from normal and polycystic ovaries
    • Erickson GF, Hsueh AJW, Quigley ME, Rebar RW, Yen SS. Functional studies of aromatase activity in human granulose cells from normal and polycystic ovaries. J Clin Endocrinol Metab 1979, 49: 514-9. (Pubitemid 10231734)
    • (1979) Journal of Clinical Endocrinology and Metabolism , vol.49 , Issue.4 , pp. 514-519
    • Erickson, G.F.1    Hsueh, A.J.W.2    Quigley, M.E.3
  • 40
    • 0031154045 scopus 로고    scopus 로고
    • arom Gene: Impact of Estrogens on Hypergonadotropic Hypogonadism, Multicystic Ovaries, and Bone Densitometry in Childhood
    • Mullis PE, Yoshimura N, Kuhlmann B, Lippuner K, Jaeger P, Harada H. Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens or hypergonadotropic hypogonadism, multicystic ovaries and bone densitometry in childhood. J Clin Endocrinol Metab 1997, 82: 1739-45. (Pubitemid 127495177)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.6 , pp. 1739-1745
    • Mullis, P.E.1    Yoshimura, N.2    Kuhlmann, B.3    Lippuner, K.4    Jaeger, P.5    Harada, H.6
  • 46
    • 0026551039 scopus 로고
    • Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups
    • Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 1992, 12: 241-53.
    • (1992) Genomics , vol.12 , pp. 241-253
    • Edwards, A.1    Hammond, H.A.2    Jin, L.3    Caskey, C.T.4    Chakraborty, R.5
  • 47
    • 0028033594 scopus 로고
    • The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function
    • Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994, 22: 3181-6. (Pubitemid 24260654)
    • (1994) Nucleic Acids Research , vol.22 , Issue.15 , pp. 3181-3186
    • Chamberlain, N.L.1    Driver, E.D.2    Miesfeld, R.L.3
  • 48
    • 0028238319 scopus 로고
    • Size polymorphisms of the androgen receptor among female Hispanics and correlation with androgenic characteristics
    • Legro RS, Shahbahrami M, Lobo RA, Kovaes BW. Size polymorphisms of the androgen-receptor among female Hispanics and correlation with androgenic characteristics. Obstet Gynecol 1994, 83: 701-6. (Pubitemid 24153462)
    • (1994) Obstetrics and Gynecology , vol.83 , Issue.5 I , pp. 701-706
    • Legro, R.S.1    Shahbahrami, B.2    Lobo, R.A.3    Kovacs, B.W.4
  • 49
    • 0031829734 scopus 로고    scopus 로고
    • Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne
    • Sawaya ME, Shalita AR. Androgen receptor polymorphism (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J Cutan Med Surg 1998, 3: 9-15. (Pubitemid 28352163)
    • (1998) Journal of Cutaneous Medicine and Surgery , vol.3 , Issue.1 , pp. 9-15
    • Sawaya, M.E.1    Shalita, A.R.2
  • 51
    • 0033724587 scopus 로고    scopus 로고
    • Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries
    • Mifsud A, Ramirez S, Yong EL. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J Clin Endocrinol Metab 2000, 85: 3484-8.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3484-3488
    • Mifsud, A.1    Ramirez, S.2    Yong, E.L.3
  • 52
    • 43249092469 scopus 로고    scopus 로고
    • Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome
    • Kim JJ, Choung SH, Choi YM, Yoon SH, Kim SH, Moon SY. Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome. Fertil Steril 2008, 90: 2318-23.
    • (2008) Fertil Steril , vol.90 , pp. 2318-2323
    • Kim, J.J.1    Choung, S.H.2    Choi, Y.M.3    Yoon, S.H.4    Kim, S.H.5    Moon, S.Y.6
  • 53
    • 20444452949 scopus 로고    scopus 로고
    • Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2004.11.080, PII S0015028205003985
    • Jääskeläinen J, Korhonen S, Voutilainen R, Hippeläinen M, Heinonen S. Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome. Fertil Steril 2005, 83: 1724-8. (Pubitemid 40824805)
    • (2005) Fertility and Sterility , vol.83 , Issue.6 , pp. 1724-1728
    • Jaaskelainen, J.1    Korhonen, S.2    Voutilainen, R.3    Hippelainen, M.4    Heinonen, S.5
  • 54
    • 33846463033 scopus 로고    scopus 로고
    • The genetics of the polycystic ovary syndrome
    • DOI 10.1038/ncpendmet0400, PII NCPENDMET0400
    • Urbanek M. The genetics of the polycystic ovary syndrome. Nat Clin Pract Endocrinol Metab 2007, 3: 103-11. (Pubitemid 46146963)
    • (2007) Nature Clinical Practice Endocrinology and Metabolism , vol.3 , Issue.2 , pp. 103-111
    • Urbanek, M.1
  • 55
    • 0036146428 scopus 로고    scopus 로고
    • The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome
    • DOI 10.1210/jc.87.1.161
    • Hickey T, Chandy A, Norman RJ. The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome. J Clin Endocrinol Metab 2002, 87: 161-5. (Pubitemid 34084686)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.1 , pp. 161-165
    • Hickey, T.1    Chandy, A.2    Norman, R.J.3
  • 56
    • 49649097971 scopus 로고    scopus 로고
    • Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome
    • Liu Q, Hong J, Cui B et al. Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome. Endocrine 2008, 33: 165-70.
    • (2008) Endocrine , vol.33 , pp. 165-170
    • Liu, Q.1    Hong, J.2    Cui, B.3
  • 57
    • 0025251140 scopus 로고
    • Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12>p13)
    • Bérubé D, Séralini GE, Gagné R, Hammond GL. Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12>p13). Cytogenet Cell Genet 1990, 54: 65-7.
    • (1990) Cytogenet Cell Genet , vol.54 , pp. 65-67
    • Bérubé, D.1    Séralini, G.E.2    Gagné, R.3    Hammond, G.L.4
  • 58
    • 0029926756 scopus 로고    scopus 로고
    • Clinical utility of sex hormone-binding globulin measurement
    • Pugeat M, Crave JC, Tournaire J, Forest MG. Clinical utility of sex hormone-binding globulin measurement. Horm Res 1996, 45: 148-55. (Pubitemid 26079699)
    • (1996) Hormone Research , vol.45 , Issue.3-5 , pp. 148-155
    • Pugeat, M.1    Crave, J.C.2    Tourniaire, J.3    Forest, M.G.4
  • 59
    • 0035965331 scopus 로고    scopus 로고
    • Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element an AIu sequence
    • Hogeveen KN, Talikka M, Hammond GL. Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element an AIu sequence. J Biol Chem 2001, 276: 36383-90.
    • (2001) J Biol Chem , vol.276 , pp. 36383-36390
    • Hogeveen, K.N.1    Talikka, M.2    Hammond, G.L.3
  • 60
    • 0346101832 scopus 로고    scopus 로고
    • Association of the (TAAAA)n Repeat Polymorphism in the Sex Hormone-Binding Globulin (SHBG) Gene with Polycystic Ovary Syndrome and Relation to SHBG Serum Levels
    • DOI 10.1210/jc.2003-030197
    • Xita N, Tsatsoulis A, Chatzikyriakidou A, Georgiou I. Association of the (TAAAA) in repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. J Clin Endocrinol Metab 2003, 88: 5976-80. (Pubitemid 38033081)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.12 , pp. 5976-5980
    • Xita, N.1    Tsatsoulis, A.2    Chatzikyriakidou, A.3    Georgiou, I.4
  • 62
    • 40749109396 scopus 로고    scopus 로고
    • The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome
    • Xita N, Georgiou I, Lazaros L, Psofaki V, Kolios G, Tsatsoulis A. The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome. Hum Reprod 2008, 23: 693-6.
    • (2008) Hum Reprod , vol.23 , pp. 693-696
    • Xita, N.1    Georgiou, I.2    Lazaros, L.3    Psofaki, V.4    Kolios, G.5    Tsatsoulis, A.6
  • 63
    • 44949233161 scopus 로고    scopus 로고
    • The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype
    • DOI 10.1530/EJE-07-0905
    • Xita N, Georgiou I, Lazaros L, Psofaki V, Kolios G, Tsatsoulis A. The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome. Eur J Endocrinol 2008, 158: 861-5. (Pubitemid 351837375)
    • (2008) European Journal of Endocrinology , vol.158 , Issue.6 , pp. 861-865
    • Xita, N.1    Georgiou, I.2    Lazaros, L.3    Psofaki, V.4    Kolios, G.5    Tsatsoulis, A.6
  • 64
    • 33749568755 scopus 로고    scopus 로고
    • Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS
    • Chen MJ, Yang WES, Ho HN et al. Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS. Hum Reprod 2006, 21: 2266-71.
    • (2006) Hum Reprod , vol.21 , pp. 2266-2271
    • Chen, M.J.1    Yang, W.E.S.2    Ho, H.N.3
  • 65
    • 0027504772 scopus 로고
    • Hypersecretion of luteinizing hormone and the polycystic ovary syndrome
    • Balen AH. Hypersecretion of luteinizing hormone and the polycystic ovary syndrome. Hum Reprod 1993, 8 (Suppl 2): 123-8. (Pubitemid 23337190)
    • (1993) Human Reproduction , vol.8 , Issue.SUPPL. 2 , pp. 123-128
    • Balen, A.H.1
  • 66
    • 0028234997 scopus 로고
    • Antigenic alteration of an anomalous human luteinizing hormone caused by two chorionic gonadotropin-type amino-acid substitutions
    • DOI 10.1006/bbrc.1994.1488
    • Okuda K, Yamada T, Imoto H, Komatsubara H, Sugimoto O. Antigenic alteration of an anomalous human luteinizing hormone caused by two chorionic gonadotropin-type amino-acid substitutions. Biochem Biophys Res Comm 1994, 200: 584-90. (Pubitemid 24183647)
    • (1994) Biochemical and Biophysical Research Communications , vol.200 , Issue.1 , pp. 584-590
    • Okuda, K.1    Yamada, T.2    Imoto, H.3    Komatsubara, H.4    Sugimoto, O.5
  • 68
    • 0029092526 scopus 로고
    • Prevalence of an immunological LH β-subunit variant in a UK population of healthy women and women with polycystic ovary syndrome
    • Rajkhowa M, Talbot JA, Jones PW, et al. Prevalence of an immunological LH β-subunit variant in a UK population of healthy women and women with polycystic ovary syndrome. Clin Endocrinol 1995, 43: 297-303.
    • (1995) Clin Endocrinol , vol.43 , pp. 297-303
    • Rajkhowa, M.1    Talbot, J.A.2    Jones, P.W.3
  • 71
    • 0032586938 scopus 로고    scopus 로고
    • 15 > Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(98)00491-9, PII S0015028298004919
    • Elter K, Erel CT, Cine N et al. Role of the mutation Trp8->Arg and Ile15->Thr of the human luteinizing hormone β-subunit in women with polycystic ovary syndrome. Fertil Steril 1999, 71: 425-30. (Pubitemid 29094116)
    • (1999) Fertility and Sterility , vol.71 , Issue.3 , pp. 425-430
    • Elter, K.1    Erel, C.T.2    Cine, N.3    Ozbek, U.4    Hacihanefioglu, B.5    Ertungealp, E.6
  • 72
    • 0032775220 scopus 로고    scopus 로고
    • Association of molecular variants of luteinizing hormone with menstrual disorders
    • DOI 10.1046/j.1365-2265.1999.00791.x
    • Ramanujam LN, Liao WX, Roy AC, Loganath A, Goh HH, Ng SC. Association of molecular variants of luteinizing hormone with menstrual disorders. Clin Endocrinol (Oxf) 1999, 51: 243-6. (Pubitemid 29378911)
    • (1999) Clinical Endocrinology , vol.51 , Issue.2 , pp. 243-246
    • Ramanujam, L.N.1    Liao, W.X.2    Roy, A.C.3    Loganath, A.4    Goh, H.H.5    Ng, S.C.6
  • 75
    • 0034937378 scopus 로고    scopus 로고
    • Candidate genes in polycystic ovary syndrome
    • DOI 10.1093/humupd/7.4.405
    • Franks S, Gharani N, McCarthy M. Candidate genes in polycystic ovary syndrome. Hum Reprod Update 2001, 7: 405-10. (Pubitemid 32655326)
    • (2001) Human Reproduction Update , vol.7 , Issue.4 , pp. 405-410
    • Franks, S.1    Gharani, N.2    McCarthy, M.3
  • 78
    • 0029833087 scopus 로고    scopus 로고
    • Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: Common and distinct features
    • Morales AJ, Laughlin GA, Bützow T, Maheshwari H, Baumann G, Yen SS. Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features. J Clin Endocrinol Metab 1996, 81: 3854-64.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3854-3864
    • Morales, A.J.1    Laughlin, G.A.2    Bützow, T.3    Maheshwari, H.4    Baumann, G.5    Yen, S.S.6
  • 80
    • 0033304934 scopus 로고    scopus 로고
    • The insulin-related ovarian regulatory system in health and disease
    • Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. The insulin-related ovarian regulatory system in health and disease. Endocr Rev 1999, 20: 535-82. (Pubitemid 30647079)
    • (1999) Endocrine Reviews , vol.20 , Issue.4 , pp. 535-582
    • Poretsky, L.1    Cataldo, N.A.2    Rosenwaks, Z.3    Giudice, L.C.4
  • 81
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • DOI 10.1016/0026-0495(94)90209-7
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin terapy in polycystic ovarian syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994, 43: 647-54. (Pubitemid 24145474)
    • (1994) Metabolism: Clinical and Experimental , vol.43 , Issue.5 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 82
    • 0029795871 scopus 로고    scopus 로고
    • The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome
    • DOI 10.1210/jc.81.9.3299
    • Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R. The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996, 81: 3299-306. (Pubitemid 26296206)
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , Issue.9 , pp. 3299-3306
    • Dunaif, A.1    Scott, D.2    Finegood, D.3    Quintana, B.4    Whitcomb, R.5
  • 84
    • 0025691614 scopus 로고
    • Report of the committee on the genetic constitution of chromosome 11
    • Junien C, van Heyningen V. Report of the committee on the genetic constitution of chromosome 11. Cytogenet Cell Genet 1990, 55: 153-69.
    • (1990) Cytogenet Cell Genet , vol.55 , pp. 153-169
    • Junien, C.1    Van Heyningen, V.2
  • 85
    • 0028881617 scopus 로고
    • The minisatellite in the diabetes susceptibility locus IDDM regulates insulin transcription
    • Kennedy GC, German MS, Rutter WJ. The minisatellite in the diabetes susceptibility locus IDDM regulates insulin transcription. Nat Genet 1995, 9: 293-8.
    • (1995) Nat Genet , vol.9 , pp. 293-298
    • Kennedy, G.C.1    German, M.S.2    Rutter, W.J.3
  • 86
    • 0032486384 scopus 로고    scopus 로고
    • The INS 5' variable number of tandem repeats is associated with IGF2 expression in humans
    • DOI 10.1074/jbc.273.23.14158
    • Paquette J, Giannoukakis N, Polychronakos C, Vafiadis P, Deal C. The INS 5′ variable number tandem repeats is associated with IGF2 expression in humans. J Biol Chem 1998, 273: 14158-64. (Pubitemid 28319124)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.23 , pp. 14158-14164
    • Paquette, J.1    Giannoukakis, N.2    Polychronakos, C.3    Vafiadis, P.4    Deal, C.5
  • 87
    • 0030969526 scopus 로고    scopus 로고
    • Association of insulin gene VNTR polymorphism with polycystic ovary syndrome (multiple letters) [10]
    • Waterworth DM, Bennett ST, Gharani N, et al. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 1997, 349: 1771-2. (Pubitemid 27252687)
    • (1997) Lancet , vol.349 , Issue.9067 , pp. 1771-1772
    • McKeigue, P.1    Wild, S.2    Bennett, S.T.3    Todd, J.A.4    Waterworth, D.M.5    Franks, S.6    McCarthy, M.I.7
  • 89
    • 0034797755 scopus 로고    scopus 로고
    • Clinical features in women with polycystic ovaries: Relationships to insulin sensitivity, insulin gene VNTR and birth weight
    • DOI 10.1046/j.1365-2265.2001.01375.x
    • Michelmore K, Ong K, Mason S, et al. Clinical features in women with polycystic ovaries: relationship to insulin sensitivity, insulin gene VNTR and birth weight. Clin Endocrinol (Oxf) 2001, 55: 439-46. (Pubitemid 32955480)
    • (2001) Clinical Endocrinology , vol.55 , Issue.4 , pp. 439-446
    • Michelmore, K.1    Ken, O.S.M.2    Bennett, S.3    Perry, L.4    Vessey, M.5    Balen, A.6    Dunger, D.7
  • 90
    • 0036009790 scopus 로고    scopus 로고
    • Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women
    • DOI 10.1016/S0015-0282(01)03238-1, PII S0015028201032381
    • Calvo RM, Tellería D, Sancho J, San Millán JL, Escobar-Morreale HF. Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women. Fertil Steril 2002, 77: 666-8. (Pubitemid 34275340)
    • (2002) Fertility and Sterility , vol.77 , Issue.4 , pp. 666-668
    • Calvo, R.M.1    Telleria, D.2    Sancho, J.3    San, M.J.L.4    Escobar-Morreale, H.F.5
  • 92
    • 0037442235 scopus 로고    scopus 로고
    • Genetic associations in large versus small studies: An empirical assessment
    • DOI 10.1016/S0140-6736(03)12516-0
    • Ioannidis JP, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG. Genetic associations in large versus small studies: an empirical assessment. Lancet 2003, 361: 567-71. (Pubitemid 36207475)
    • (2003) Lancet , vol.361 , Issue.9357 , pp. 567-571
    • Ioannidis, J.P.A.1    Trikalinos, T.A.2    Ntzani, E.E.3    Contopoulos-Ioannidis, D.G.4
  • 95
    • 0023392635 scopus 로고
    • The insulin receptor: Molecular biology and transmembran signaling
    • Goldfine ID. The insulin receptor: molecular biology and transmembran signaling. Endocr Rev 1987, 8: 235-55.
    • (1987) Endocr Rev , vol.8 , pp. 235-255
    • Goldfine, I.D.1
  • 96
    • 0024272188 scopus 로고
    • Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance)
    • Moller DE, Flier JS. Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). N Engl J Med 1988, 319: 1526-9. (Pubitemid 19003412)
    • (1988) New England Journal of Medicine , vol.319 , Issue.23 , pp. 1526-1529
    • Moller, D.E.1    Flier, J.S.2
  • 97
    • 0028132564 scopus 로고
    • The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome
    • Conway GS, Avey C, Rumsby G. The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinemia and polycystic ovary syndrome. Hum Reprod 1994, 9: 1681-3. (Pubitemid 24291083)
    • (1994) Human Reproduction , vol.9 , Issue.9 , pp. 1681-1683
    • Conway, G.S.1    Avey, C.2    Rumsby, G.3
  • 102
    • 0037227264 scopus 로고    scopus 로고
    • Association between the D19S884 marker at the insulin receptor gene locus and polycystic ovary syndrome [2]
    • DOI 10.1016/S0015-0282(02)04570-3, PII S0015028202045703
    • Villuendas G, Escobar-Morreale HF, Tosi F, Sancho J, Moghetti P, San Millán JL. Association between the D19S884 marker at the insulin receptor gene locus and polycystic ovary syndrome. Fertil Steril 2003, 79: 219-20. (Pubitemid 36071268)
    • (2003) Fertility and Sterility , vol.79 , Issue.1 , pp. 219-220
    • Villuendas, G.1    Escobar-Morreale, H.F.2    Tosi, F.3    Sancho, J.4    Moghetti, P.5    San, M.J.L.6
  • 103
    • 0036902524 scopus 로고    scopus 로고
    • A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(02)04241-3, PII S0015028202042413
    • Siegel S, Futterweit W, Davies TF, et al. A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome. Fertil Steril 2002, 78: 1240-3. (Pubitemid 35469148)
    • (2002) Fertility and Sterility , vol.78 , Issue.6 , pp. 1240-1243
    • Siegel, S.1    Futterweit, W.2    Davies, T.F.3    Concepcion, E.S.4    Greenberg, D.A.5    Villanueva, R.6    Tomer, Y.7
  • 104
    • 33645838384 scopus 로고    scopus 로고
    • A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS
    • Jin L, Zhu XM, Luo Q, Qian Y, Jin F, Huang HF. A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS. Mol Hum Reprod 2006, 12: 151-5.
    • (2006) Mol Hum Reprod , vol.12 , pp. 151-155
    • Jin, L.1    Zhu, X.M.2    Luo, Q.3    Qian, Y.4    Jin, F.5    Huang, H.F.6
  • 105
    • 43449103085 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism of INSR gene for polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2007.05.026, PII S0015028207011521
    • Lee EJ, Oh B, Lee JY, Kimm K, Lee SH, Baek KH. A novel single nucleotide polymorphism of INSR gene for polycystic ovary syndrome. Fertil Steril 2008, 89: 1213-20. (Pubitemid 351671737)
    • (2008) Fertility and Sterility , vol.89 , Issue.5 , pp. 1213-1220
    • Lee, E.-J.1    Oh, B.2    Lee, J.-Y.3    Kimm, K.4    Lee, S.-H.5    Baek, K.-H.6
  • 106
    • 0036731440 scopus 로고    scopus 로고
    • Polycystic ovary syndrome, insulin resistance, and molecular defects of insulin signaling
    • Azziz R. Polycystic ovary syndrome, insulin resistance, and molecular defects of insulin signaling. J Clin Endocrinol Metab 2002, 87: 4085-7.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4085-4087
    • Azziz, R.1
  • 107
    • 0028582185 scopus 로고
    • Crystal structure of the tyrosine kinase domain of the human insulin receptor
    • Hubbard SR, Wei L, Ellis L, Hendrickson WA. Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 1994, 372: 746-54.
    • (1994) Nature , vol.372 , pp. 746-754
    • Hubbard, S.R.1    Wei, L.2    Ellis, L.3    Hendrickson, W.A.4
  • 108
    • 0031616132 scopus 로고    scopus 로고
    • The IRS-Signaling system: A Network of Docking Proteins That Mediate Insulin and Cytokine Action
    • White MF. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog Horm Res 1998, 53: 119-38. (Pubitemid 128472739)
    • (1998) Recent Progress in Hormone Research , vol.53 , pp. 119-138
    • White, M.F.1
  • 109
    • 0035125526 scopus 로고    scopus 로고
    • IRS proteins and beta-cell function
    • Burks DJ, White MF. IRS proteins and beta-cell function. Diabetes 2001, 50 (Suppl 1): S140-5.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Burks, D.J.1    White, M.F.2
  • 110
    • 0042572474 scopus 로고    scopus 로고
    • Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: A meta-analysis of 27 studies
    • DOI 10.1007/s00125-003-1126-4
    • Jellema A, Zeegers MPA, Feskens EJM, Dagnelie PC, Mensink RP. Gly972Arg variant in the insulin receptor substrate-1 gene and association with type 2 diabetes: a meta-analysis of 27 studies. Diabetologie 2003, 46: 990-5. (Pubitemid 36961324)
    • (2003) Diabetologia , vol.46 , Issue.7 , pp. 990-995
    • Jellema, A.1    Zeegers, M.P.A.2    Feskens, E.J.M.3    Dagnelie, P.C.4    Mensink, R.P.5
  • 111
  • 113
    • 23744480735 scopus 로고    scopus 로고
    • Association of Gly972Arg variant of insulin receptor substrate-1 with metabolic features in women with polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2005.01.133, PII S0015028205008538
    • Dilek S, Ertunc D, Tok EC, Erdal EM, Aktas A. Association of the Gly972Arg variant of insulin receptor substrate-1 with metabolic features in women with polycystic ovary syndrome. Fertil Steril 2005, 84: 407-12. (Pubitemid 41125262)
    • (2005) Fertility and Sterility , vol.84 , Issue.2 , pp. 407-412
    • Dilek, S.1    Ertunc, D.2    Tok, E.C.3    Erdal, E.M.4    Aktas, A.5
  • 114
    • 27944431725 scopus 로고    scopus 로고
    • Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls
    • DOI 10.1093/humrep/dei205
    • Villuendas G, Botella-Carretero JI, Roldán B, Sancho J, Escobar-Morreale HF, San Millán JL. Polymorphism in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls. Hum Reprod 2005, 20: 3184-91. (Pubitemid 41662676)
    • (2005) Human Reproduction , vol.20 , Issue.11 , pp. 3184-3191
    • Villuendas, G.1    Botella-Carretero, J.I.2    Roldan, B.3    Sancho, J.4    Escobar-Morreale, H.F.5    San, M.J.L.6
  • 115
    • 20344408508 scopus 로고    scopus 로고
    • The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome
    • DOI 10.1093/humrep/deh747
    • Ertunc D, Tok EC, Aktas A, Erdal EM, Dilek S. The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome. Hum Reprod 2005, 20: 1207-12. (Pubitemid 40790243)
    • (2005) Human Reproduction , vol.20 , Issue.5 , pp. 1207-1212
    • Ertunc, D.1    Tok, E.C.2    Aktas, A.3    Erdal, E.M.4    Dilek, S.5
  • 116
    • 0032697674 scopus 로고    scopus 로고
    • The antihyperglycaemic effect of metf ormin therapeutic and cellular mechanisms
    • Wiemsperger NF, Bailey CJ. The antihyperglycaemic effect of metformin therapeutic and cellular mechanism. Drugs 1995, 58 (Suppl 1): 31-9. (Pubitemid 129758579)
    • (1999) Drugs , vol.58 , Issue.SUPPL. 1 , pp. 31-39
    • Wiernsperger, N.F.1    Bailey, C.J.2
  • 117
    • 0036739962 scopus 로고    scopus 로고
    • Relationship of insulin receptor substrate-1 e -2 genotypes to phenotypic features of polycystic ovary syndrome
    • Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI. Relationship of insulin receptor substrate-1 e -2 genotypes to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab 2002, 87: 4297-300.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4297-4300
    • Ehrmann, D.A.1    Tang, X.2    Yoshiuchi, I.3    Cox, N.J.4    Bell, G.I.5
  • 118
    • 39849093269 scopus 로고    scopus 로고
    • No association between common Gly972Arg variant of the insulin receptor substrate-1 and polycystic ovary syndrome in Southern Chilean women
    • Valdés P, Cerda A, Barrenechea C, Kehr M, Soto C, Salazar LA. No association between common Gly972Arg variant of the insulin receptor substrate-1 and polycystic ovary syndrome in Southern Chilean women. Clin Chim Act 2008, 390: 63-6.
    • (2008) Clin Chim Act , vol.390 , pp. 63-66
    • Valdés, P.1    Cerda, A.2    Barrenechea, C.3    Kehr, M.4    Soto, C.5    Salazar, L.A.6
  • 119
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 2000, 26: 163-75.
    • (2000) Nat Genet , vol.26 , pp. 163-175
    • Horikawa, Y.1    Oda, N.2    Cox, N.J.3
  • 122
    • 34147139917 scopus 로고    scopus 로고
    • CAPN10 UCSNP-43, UCSNP-19 and UCSNP-63 polymorphisms and metabolic syndrome in polycystic ovary syndrome
    • DOI 10.1080/09513590701233661, PII 776487843
    • Wiltgen D, Furtado L, Kohek MB, Spritzer PM. CAPN10 UCSNP-43, UCSNP-19 and UCSNP-63 polymorphisms and metabolic syndrome in polycystic ovary syndrome. Gynecol Endocrinol 2007, 23: 173-8. (Pubitemid 46570217)
    • (2007) Gynecological Endocrinology , vol.23 , Issue.3 , pp. 173-178
    • Wiltgen, D.1    Furtado, L.2    Kohek, M.B.F.3    Spritzer, P.M.4
  • 124
    • 0036183135 scopus 로고    scopus 로고
    • Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism
    • DOI 10.1016/S0015-0282(01)03206-X, PII S001502820103206X
    • Escobar-Morreale HF, Peral B, Villuendas G, Calvo RM, Sancho J, San Millán JL. Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism. Fertil Steril 2002, 77: 581-7. (Pubitemid 34177215)
    • (2002) Fertility and Sterility , vol.77 , Issue.3 , pp. 581-587
    • Escobar-Morreale, H.F.1    Peral, B.2    Villuendas, G.3    Calvo, R.M.4    Sancho, J.5    San, M.J.L.6
  • 126
    • 0034761116 scopus 로고    scopus 로고
    • The role of leptin in human physiology and pathophysiology
    • Janeckova R. The role of leptin in human physiology and pathophysiology. Physiol Res 2001, 50: 439-59.
    • (2001) Physiol Res , vol.50 , pp. 439-459
    • Janeckova, R.1
  • 128
    • 0033799366 scopus 로고    scopus 로고
    • No evidence for mutation of the leptin or leptin receptor genes in women with polycystic ovary syndrome
    • Oksanen L, Tiitinen A, Kaprio J, Koistinen HA, Karonen S, Kontula K. No evidence for mutation of the leptin or leptin receptor genes in women with polycystic ovary syndrome. Mol Hum Reprod 2000, 6: 873-6.
    • (2000) Mol Hum Reprod , vol.6 , pp. 873-876
    • Oksanen, L.1    Tiitinen, A.2    Kaprio, J.3    Koistinen, H.A.4    Karonen, S.5    Kontula, K.6
  • 131
    • 0036091918 scopus 로고    scopus 로고
    • Association of the T-G polymorphism in adiponectin (Exon 2) with obesity and insulin sensitivity: Interaction with family history of type 2 diabetes
    • Stumvoll M, Tschritter O, Fritsche A, et al. Association of the T-G polymorphism in adiponectin (Exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002, 51: 37-41. (Pubitemid 34517977)
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 37-41
    • Stumvoll, M.1    Tschritter, O.2    Fritsche, A.3    Staiger, H.4    Renn, W.5    Weisser, M.6    Machicao, F.7    Haring, H.8
  • 133
    • 2942653176 scopus 로고    scopus 로고
    • Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity
    • DOI 10.1210/jc.2003-031252
    • San Millán JL, Cortòn M, Villuendas G, Sancho J, Peral B, Escobar-Morreale HF. Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. J Clin Endocrinol Metab 2004, 89: 2640-6. (Pubitemid 38766343)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.6 , pp. 2640-2646
    • San, M.J.L.1    Corton, M.2    Villuendas, G.3    Sancho, J.4    Peral, B.5    Escobar-Morreale, H.F.6
  • 141
    • 0037336327 scopus 로고    scopus 로고
    • Effect of rosiglitazone on spontaneous and clomiphene citrate-induced ovulation in women with polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(02)04843-4
    • Ghazeeri G, Kutteh WH, Bryer-Ash M, Haas D, Ke RW. Effect of rosiglitazone on spontaneous clomiphene citrate-induced ovulation in women with polycystic ovary syndrome. Fertil Steril 2003, 79: 562-6. (Pubitemid 36293452)
    • (2003) Fertility and Sterility , vol.79 , Issue.3 , pp. 562-566
    • Ghazeeri, G.1    Kutteh, W.H.2    Bryer-Ash, M.3    Haas, D.4    Ke, R.W.5
  • 145
    • 28844489933 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in first-degree relatives of subjects with polycystic ovary syndrome
    • DOI 10.1080/09513590500231593
    • Yilmaz M, Ergün MA, Karakoç A, et al. Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in first-degree relatives of subjects with polycystic ovary syndrome. Gynecol Endocrinol 2005, 21: 206-10. (Pubitemid 41769996)
    • (2005) Gynecological Endocrinology , vol.21 , Issue.4 , pp. 206-210
    • Yilmaz, M.1    Ergun, M.A.2    Karakoc, A.3    Yurtcu, E.4    Yetkin, I.5    Ayvaz, G.6    Cakir, N.7    Arslan, M.8
  • 146
    • 33745366449 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in women with polycystic ovary syndrome
    • DOI 10.1080/09513590600733357, PII L421391139745874
    • Yilmaz M, Ergün MA, Karakoç A, Yurtçu E, Cakir N, Arslan M. Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in women with polycystic ovary syndrome. Gynecol Endocrinol 2006, 22: 336-42. (Pubitemid 43941411)
    • (2006) Gynecological Endocrinology , vol.22 , Issue.6 , pp. 336-342
    • Yilmaz, M.1    Ali, E.M.2    Karakoc, A.3    Yurtcu, E.4    Cakir, N.5    Arslan, M.6
  • 148
    • 0037631831 scopus 로고    scopus 로고
    • Insulin resistance and chronic cardiovascular inflammatory syndrome
    • Fernández-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 2003, 24: 278-301. (Pubitemid 36724371)
    • (2003) Endocrine Reviews , vol.24 , Issue.3 , pp. 278-301
    • Fernandez-Real, J.M.1    Ricart, W.2
  • 149
    • 33745268423 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: The influence of environmental and genetic factors
    • Diamanti-Kandarakis E, Piperi C, Spina J, et al. Polycystic ovary syndrome: the influence of environmental and genetic factors. Hormones (Athens) 2006, 5: 17-34.
    • (2006) Hormones (Athens) , vol.5 , pp. 17-34
    • Diamanti-Kandarakis, E.1    Piperi, C.2    Spina, J.3
  • 151
    • 0032922944 scopus 로고    scopus 로고
    • Circulating tumor necrosis factor-alpha concentrations in a native canadian population with high rates of type 2 diabetes mellitus
    • DOI 10.1210/jc.84.1.272
    • Zinman B, Hanley AJ, Harris SB, Kwan J, Fantus IG. Circulating tumor necrosis factor-α concentrations in a native Canadian population with high rates of type 2 diabetes mellitus. J Clin Endocrinol Metab 1999, 84: 272-8. (Pubitemid 29036713)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , Issue.1 , pp. 272-278
    • Zinman, B.1    Hanley, A.J.G.2    Harris, S.B.3    Kwan, J.4    Fantus, I.G.5
  • 154
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 1995, 95: 2409-15.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 155
    • 0031053823 scopus 로고    scopus 로고
    • Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    • Hotamisligil GS, Amer P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 1997, 46: 451-5. (Pubitemid 27090275)
    • (1997) Diabetes , vol.46 , Issue.3 , pp. 451-455
    • Hotamisligil, G.S.1    Arner, P.2    Atkinson, R.L.3    Spiegelman, B.M.4
  • 156
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance. Science 1996, 271: 665-8. (Pubitemid 26052915)
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 157
    • 0033984744 scopus 로고    scopus 로고
    • Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?
    • DOI 10.1016/S0021-9150(99)00463-3, PII S0021915099004633
    • Yudkin JS, Kumari M, Humphries SE, Mohamed-Alì V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000, 148: 209-14. (Pubitemid 30064452)
    • (2000) Atherosclerosis , vol.148 , Issue.2 , pp. 209-214
    • Yudkin, J.S.1    Kumari, M.2    Humphries, S.E.3    Mohamed-Ali, V.4
  • 164
    • 1442321080 scopus 로고    scopus 로고
    • Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism
    • Escobar-Morreale HF, Calvo RM, Villuendas G, Sancho J, San Millán JL. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Obes Res 2003, 11: 987-96. (Pubitemid 41137511)
    • (2003) Obesity Research , vol.11 , Issue.8 , pp. 987-996
    • Escobar-Morreale, H.F.1    Calvo, R.M.2    Villuendas, G.3    Sancho, J.4    San, M.J.L.5
  • 165
    • 0032926255 scopus 로고    scopus 로고
    • No association between the -308 polymorphism in the tumour necrosis favor alpha (TNFalpha) promoter region and polycystic ovaries
    • DOI 10.1093/molehr/5.1.5
    • Milner CR, Craig JE, Hussey ND, Norman RJ. No association between the -308 polymorphism in the tumor necrosis factors α (TNF-α) promoter region and polycystic ovaries. Mol Hum Reprod 1995, 5: 5-9. (Pubitemid 29045632)
    • (1999) Molecular Human Reproduction , vol.5 , Issue.1 , pp. 5-9
    • Milner, C.R.1    Craig, J.E.2    Hussey, N.D.3    Norman, R.J.4
  • 166
    • 0034286057 scopus 로고    scopus 로고
    • Study on the relationship between a polymorphism of tumor necrosis factor-α gene and the pathogenesis of polycystic ovary syndrome
    • Mao W, Yu L, Chen Y. Study on the relationship between a polymorphism of tumor necrosis factor-α gene and the pathogenesis of polycystic ovary syndrome. Zhonghua Fu Chan Ke Za Zhi 2000, 35: 536-9.
    • (2000) Zhonghua Fu Chan Ke Za Zhi , vol.35 , pp. 536-539
    • Mao, W.1    Yu, L.2    Chen, Y.3
  • 168
    • 85047684104 scopus 로고    scopus 로고
    • The methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism
    • DOI 10.1210/jc.87.8.3977
    • Peral B, San Millán JL, Castello R, Moghetti P, Escobar-Morreale HF. Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. J Clin Endocrinol Metab 2002, 87: 3977-83. (Pubitemid 34879557)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.8 , pp. 3977-3983
    • Peral, B.1    San, M.J.L.2    Castello, R.3    Moghetti, P.4    Escobar-Morreale, H.F.5
  • 169
    • 0036511860 scopus 로고    scopus 로고
    • The -597 G>A and -174 G>C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism
    • DOI 10.1210/jc.87.3.1134
    • Villuendas G, San Millán JL, Sancho J, Escobar-Morreale HF. The -597G->A and 174G->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism. J Clin Endocrinol Metab 2002, 87: 1134-41. (Pubitemid 36121078)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.3 , pp. 1134-1141
    • Villuendas, G.1    San, M.J.L.2    Sancho, J.3    Escobar-Morreale, H.F.4
  • 170
    • 17044370727 scopus 로고    scopus 로고
    • The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    • Escobar-Morreale HF, Luque-Ramírez M, San Millán JL. The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. Endocr Rev 2005, 26: 251-82.
    • (2005) Endocr Rev , vol.26 , pp. 251-282
    • Escobar-Morreale, H.F.1    Luque-Ramírez, M.2    San Millán, J.L.3
  • 171
    • 54549096932 scopus 로고    scopus 로고
    • Increased low grade inflammatory serum markers in patients with polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variants
    • Knebel B, Janssen OE, Hahn S, et al. Increased low grade inflammatory serum markers in patients with polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variants. Exp Clin Endocrinol Diabetes 2008, 116: 481-6.
    • (2008) Exp Clin Endocrinol Diabetes , vol.116 , pp. 481-486
    • Knebel, B.1    Janssen, O.E.2    Hahn, S.3
  • 172
    • 54949126723 scopus 로고    scopus 로고
    • The relationship of the interleukin-6 -174 G>C gene polymorphism with oxidative stress markers in Turkish polycystic ovary syndrome patients
    • Erdogan M, Karadeniz M, Berdeli A, Alper G, Caglayan O, Yilmaz C. The relationship of the interleukin-6 -174 G>C gene polymorphism with oxidative stress markers in Turkish polycystic ovary syndrome patients. J Endocrinol Invest 2008, 31: 624-9.
    • (2008) J Endocrinol Invest , vol.31 , pp. 624-629
    • Erdogan, M.1    Karadeniz, M.2    Berdeli, A.3    Alper, G.4    Caglayan, O.5    Yilmaz, C.6
  • 173
    • 0038307320 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and cardiovascular disease: A premature association?
    • Legro RS. Polycystic ovary syndrome and cardiovascular disease: a premature association? Endocr Rev 2003, 24: 302-12. (Pubitemid 36724372)
    • (2003) Endocrine Reviews , vol.24 , Issue.3 , pp. 302-312
    • Legro, R.S.1
  • 174
    • 0028901713 scopus 로고
    • Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 is associated with myocardial infarction
    • Eriksson P, Kallin B, van 't Hooft FM, Båvenholm P, Hamsten A. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 is associated with myocardial infarction. Proc Natl Acad Sci U S A 1995, 92: 1851-5.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1851-1855
    • Eriksson, P.1    Kallin, B.2    Van 't Hooft, F.M.3    Båvenholm, P.4    Hamsten, A.5
  • 175
    • 3242720491 scopus 로고    scopus 로고
    • The prevalence of 4G5G polymorphism of plasminogen activator ihibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels
    • DOI 10.1530/eje.0.1500793
    • Diamanti-Kandarakis E, Palioniko G, Alexandraki K, Bergiele A, Koutsouba T, Bartzis M. The prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels. Eur J Endocrinol 2004, 150: 793-8. (Pubitemid 38961652)
    • (2004) European Journal of Endocrinology , vol.150 , Issue.6 , pp. 793-798
    • Diamanti-Kandarakis, E.1    Palioniko, G.2    Alexandraki, K.3    Bergiele, A.4    Koutsouba, T.5    Bartzis, M.6
  • 176
    • 32544437834 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome
    • DOI 10.1016/j.metabol.2005.09.008, PII S0026049505003653
    • Glueck CJ, Sieve L, Zhu B, Wang P. Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome. Metabolism 2006, 55: 345-52. (Pubitemid 43234388)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.3 , pp. 345-352
    • Glueck, C.J.1    Sieve, L.2    Zhu, B.3    Wang, P.4
  • 178
    • 42749101427 scopus 로고    scopus 로고
    • The genetic basis of the polycystic ovary syndrome: A literature review including discussion of PPARγ
    • Unluturk U, Harmanci A, Kocaefe C, Yildiz BO. The genetic basis of the polycystic ovary syndrome: A literature review including discussion of PPARγ. PPAR Res 2007, 2007: 49109.
    • (2007) PPAR Res , vol.2007 , pp. 49109
    • Unluturk, U.1    Harmanci, A.2    Kocaefe, C.3    Yildiz, B.O.4
  • 179
    • 0031969055 scopus 로고    scopus 로고
    • The development of the polycystic ovary syndrome: Family history as a risk factor
    • DOI 10.1016/S1043-2760(98)00021-6, PII S1043276098000216
    • Kahsar-Miller M, Azziz R. The developmentof the polycystic ovary syndrome: family history as a risk factor. Trends Endo Metab 1998, 9: 55-8. (Pubitemid 28207613)
    • (1998) Trends in Endocrinology and Metabolism , vol.9 , Issue.2 , pp. 55-58
    • Kahsar-Miller, M.1    Azziz, R.2
  • 180
    • 33845887170 scopus 로고    scopus 로고
    • Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome
    • DOI 10.1385/ENDO:30:1:35, PII ENDO30135
    • Norman RJ, Homan G, Moran L, Noakes M. Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome. Endocrine 2006, 30: 35-43. (Pubitemid 46020328)
    • (2006) Endocrine , vol.30 , Issue.1 , pp. 35-43
    • Norman, R.J.1    Homan, G.2    Moran, L.3    Noakes, M.4
  • 181
    • 0029821801 scopus 로고    scopus 로고
    • Effects of weight loss on the hormonal profile in obese, infertile women
    • Hollmann M, Runnebaum B, Gerhard I. Effects of weight loss on the hormonal profile in obese, infertile women. Hum Reprod 1996, 11: 1884-91. (Pubitemid 26381432)
    • (1996) Human Reproduction , vol.11 , Issue.9 , pp. 1884-1891
    • Hollmann, M.1    Runnebaum, B.2    Gerhard, I.3
  • 182
    • 0028843928 scopus 로고
    • Weight loss results in significant improvement in pregnancy and ovulation rates in oanovulatory obese women
    • Clark AM, Ledger W, Galletly C et al. Weight loss results in significant improvement in pregnancy and ovulation rates in oanovulatory obese women. Hum Reprod 1995, 10: 2702-12.
    • (1995) Hum Reprod , vol.10 , pp. 2702-2712
    • Clark, A.M.1    Ledger, W.2    Galletly, C.3
  • 183
    • 0035061993 scopus 로고    scopus 로고
    • Risks of smoking to reproductive health: Assessment of women's knowledge
    • DOI 10.1067/mob.2001.112103
    • Roth LK, Taylor HS. Risk of smoking to reproductive health: assessment of women's knowledge. Am J Obstet Gynecol 2001, 184: 934-9. (Pubitemid 32368112)
    • (2001) American Journal of Obstetrics and Gynecology , vol.184 , Issue.5 , pp. 934-939
    • Roth, L.K.1    Taylor, H.S.2
  • 184
    • 0033835433 scopus 로고    scopus 로고
    • Cigarette smoking, menstrual symptoms and miscarriage among young women
    • Mishra GD, Dobson AJ, Schofield MJ. Cigarette smoking, menstrual symptoms and miscarriage among young women. Aust N Z J Public Health 2000, 24: 413-20.
    • (2000) Aust N Z J Public Health , vol.24 , pp. 413-420
    • Mishra, G.D.1    Dobson, A.J.2    Schofield, M.J.3
  • 185
    • 0026034007 scopus 로고
    • The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment
    • Pattinson HA, Taylor PJ, Pattinson MH. The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment. Fertil Steril 1991, 55: 780-3.
    • (1991) Fertil Steril , vol.55 , pp. 780-783
    • Pattinson, H.A.1    Taylor, P.J.2    Pattinson, M.H.3


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