메뉴 건너뛰기




Volumn 149, Issue 5, 2008, Pages 2667-2677

Pathways leading to phosphorylation of P450c17 and to the posttranslational regulation of androgen biosynthesis

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ANDROGEN; CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450C17; LYASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE KINASE; RHO KINASE; SMALL INTERFERING RNA;

EID: 42449129236     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1527     Document Type: Article
Times cited : (49)

References (66)
  • 2
    • 0035127474 scopus 로고    scopus 로고
    • Current concepts in the polycystic ovary syndrome
    • Dunaif A, Thomas A 2001 Current concepts in the polycystic ovary syndrome. Annu Rev Med 52:401-419
    • (2001) Annu Rev Med , vol.52 , pp. 401-419
    • Dunaif, A.1    Thomas, A.2
  • 4
    • 0025320027 scopus 로고
    • Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: The relative importance of the ovary and the adrenal in the pathogenesis of hirsutism
    • Rittmaster RS, Thompson DL 1990 Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. J Clin Endocrinol Metab 70:1096-1102
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1096-1102
    • Rittmaster, R.S.1    Thompson, D.L.2
  • 5
    • 0021255755 scopus 로고
    • The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women
    • Hoffman DI, Klove K, Lobo RA 1984 The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. Fertil Steril 42:76-81
    • (1984) Fertil Steril , vol.42 , pp. 76-81
    • Hoffman, D.I.1    Klove, K.2    Lobo, R.A.3
  • 6
    • 0024602863 scopus 로고
    • Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome
    • Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA 1989 Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med 320:559-565
    • (1989) N Engl J Med , vol.320 , pp. 559-565
    • Barnes, R.B.1    Rosenfield, R.L.2    Burstein, S.3    Ehrmann, D.A.4
  • 8
    • 0024064517 scopus 로고
    • Molecular biology of steroid hormone synthesis
    • Miller WL 1988 Molecular biology of steroid hormone synthesis. Endocr Rev 9:295-318
    • (1988) Endocr Rev , vol.9 , pp. 295-318
    • Miller, W.L.1
  • 9
    • 0022578632 scopus 로고
    • Hormonal regulation of P450scc (20,22-desmolase) and P450c17 (17α-hydroxylase/17,20-lyase) in cultured human granulosa cells
    • Voutilainen R, Tapanainen J, Chung B, Matteson KJ, Miller WL 1986 Hormonal regulation of P450scc (20,22-desmolase) and P450c17 (17α-hydroxylase/17,20-lyase) in cultured human granulosa cells. J Clin Endocrinol Metab 63:202-207
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 202-207
    • Voutilainen, R.1    Tapanainen, J.2    Chung, B.3    Matteson, K.J.4    Miller, W.L.5
  • 10
    • 0035047848 scopus 로고    scopus 로고
    • StAR protein and the regulation of steroid hormone biosynthesis
    • Stocco DM 2001 StAR protein and the regulation of steroid hormone biosynthesis. Ann Rev Physiol 63:193-213
    • (2001) Ann Rev Physiol , vol.63 , pp. 193-213
    • Stocco, D.M.1
  • 11
    • 33847235315 scopus 로고    scopus 로고
    • StAR search: What we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import
    • Miller WL 2007 StAR search: what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import. Mol Endocrinol 21:589-601
    • (2007) Mol Endocrinol , vol.21 , pp. 589-601
    • Miller, W.L.1
  • 12
    • 0031032651 scopus 로고    scopus 로고
    • The regulation of 17,20 lyase activity
    • Miller WL, Auchus RJ, Geller DH 1997 The regulation of 17,20 lyase activity. Steroids 62:133-142
    • (1997) Steroids , vol.62 , pp. 133-142
    • Miller, W.L.1    Auchus, R.J.2    Geller, D.H.3
  • 14
    • 0012293592 scopus 로고
    • Cytochrome P450c17 (steroid 17α-hydroxylase/17,20 lyase): Cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues
    • Chung B, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shivley JE, Miller WL 1987 Cytochrome P450c17 (steroid 17α-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. Proc Natl Acad Sci USA 84:407-411
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 407-411
    • Chung, B.1    Picado-Leonard, J.2    Haniu, M.3    Bienkowski, M.4    Hall, P.F.5    Shivley, J.E.6    Miller, W.L.7
  • 15
    • 0022847113 scopus 로고
    • Expression of bovine 17α-hydroxylase cytochrome P450 cDNA in non-steroidogenic (COS-1) cells
    • Zuber MX, Simpson ER, Waterman MR 1986 Expression of bovine 17α-hydroxylase cytochrome P450 cDNA in non-steroidogenic (COS-1) cells. Science 234:1258-1261
    • (1986) Science , vol.234 , pp. 1258-1261
    • Zuber, M.X.1    Simpson, E.R.2    Waterman, M.R.3
  • 19
    • 0036893558 scopus 로고    scopus 로고
    • Molecular evolution of adrenarche: Structural and functional analysis of P450c17 from four primate species
    • Arlt W, Martens JWM, Song M, Wang JT, Auchus RJ, Miller WL 2002 Molecular evolution of adrenarche: structural and functional analysis of P450c17 from four primate species. Endocrinology 143:4665-4672
    • (2002) Endocrinology , vol.143 , pp. 4665-4672
    • Arlt, W.1    Martens, J.W.M.2    Song, M.3    Wang, J.T.4    Auchus, R.J.5    Miller, W.L.6
  • 20
    • 0029798470 scopus 로고    scopus 로고
    • The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3β-hydroxysteroid dehydrogenase
    • Endoh A, Kristiansen SB, Casson PR, Buster JE, Hornsby PJ 1996 The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 81:3558-3565
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3558-3565
    • Endoh, A.1    Kristiansen, S.B.2    Casson, P.R.3    Buster, J.E.4    Hornsby, P.J.5
  • 22
    • 18844367746 scopus 로고    scopus 로고
    • Regulation of steroidogenesis by electron transfer
    • Miller WL 2005 Regulation of steroidogenesis by electron transfer. Endocrinology 146:2544-2550
    • (2005) Endocrinology , vol.146 , pp. 2544-2550
    • Miller, W.L.1
  • 23
    • 0022997597 scopus 로고
    • Role of electron transport in the regulation of the lyase activity of C-21 side-chain cleavage P450 from porcine adrenal and testicular microsomes
    • Yanagibashi K, Hall PF 1986 Role of electron transport in the regulation of the lyase activity of C-21 side-chain cleavage P450 from porcine adrenal and testicular microsomes. J Biol Chem 261:8429-8433
    • (1986) J Biol Chem , vol.261 , pp. 8429-8433
    • Yanagibashi, K.1    Hall, P.F.2
  • 25
    • 0032488666 scopus 로고    scopus 로고
    • 5 augments the 17,20 lyase activity of human P450c17 without direct electron transfer
    • 5 augments the 17,20 lyase activity of human P450c17 without direct electron transfer. J Biol Chem 273:3158-3165
    • (1998) J Biol Chem , vol.273 , pp. 3158-3165
    • Auchus, R.J.1    Lee, T.C.2    Miller, W.L.3
  • 27
    • 0028786656 scopus 로고
    • Serine phosphorylation of human P450c17 increases 17,20 lyase activity: Implications for adrenarche and for the polycystic ovary syndrome
    • Zhang L, Rodriguez H, Ohno S, Miller WL 1995 Serine phosphorylation of human P450c17 increases 17,20 lyase activity: implications for adrenarche and for the polycystic ovary syndrome. Proc Natl Acad Sci USA 92:10619-10623
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10619-10623
    • Zhang, L.1    Rodriguez, H.2    Ohno, S.3    Miller, W.L.4
  • 28
    • 0034456536 scopus 로고    scopus 로고
    • Effect of leptin on CYP17 enzymatic activities in human adrenal cells: New insight in the onset of adrenarche
    • Biason-Lauber A, Zachmann M, Schoenle EJ 2000 Effect of leptin on CYP17 enzymatic activities in human adrenal cells: new insight in the onset of adrenarche. Endocrinology 141:1446-1454
    • (2000) Endocrinology , vol.141 , pp. 1446-1454
    • Biason-Lauber, A.1    Zachmann, M.2    Schoenle, E.J.3
  • 29
    • 0037474198 scopus 로고    scopus 로고
    • Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17
    • Pandey AV, Mellon SH, Miller WL 2003 Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. J Biol Chem 278:2837-2844
    • (2003) J Biol Chem , vol.278 , pp. 2837-2844
    • Pandey, A.V.1    Mellon, S.H.2    Miller, W.L.3
  • 30
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham B, Kahn CR 1995 Insulin action and the insulin signaling network. Endocr Rev 16:117-142
    • (1995) Endocr Rev , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 31
    • 10344236432 scopus 로고    scopus 로고
    • Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes
    • Watson RT, Kanzaki M, Pessin JE 2004 Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev 25:177-204
    • (2004) Endocr Rev , vol.25 , pp. 177-204
    • Watson, R.T.1    Kanzaki, M.2    Pessin, J.E.3
  • 32
    • 0030780254 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
    • White MF, Yenush L 1998 The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr Topics Microbiol Immunol 228:179-208
    • (1998) Curr Topics Microbiol Immunol , vol.228 , pp. 179-208
    • White, M.F.1    Yenush, L.2
  • 33
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR 1999 Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 34
    • 0141434860 scopus 로고
    • Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity
    • Bollag GE, Roth RA, Beaudoin J, Mochley-Rosen D, Koshland Jr DE 1986 Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity. Proc Natl Acad Sci USA 83:5822-5824
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 5822-5824
    • Bollag, G.E.1    Roth, R.A.2    Beaudoin, J.3    Mochley-Rosen, D.4    Koshland Jr, D.E.5
  • 35
    • 0022981630 scopus 로고
    • Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor
    • Stadtmauer L, Rosen OM 1986 Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor. J Biol Chem 261:3402-3407
    • (1986) J Biol Chem , vol.261 , pp. 3402-3407
    • Stadtmauer, L.1    Rosen, O.M.2
  • 36
    • 0023834876 scopus 로고
    • Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
    • Takayama S, White MF, Kahn CR 1988 Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem 263:3440-3447
    • (1988) J Biol Chem , vol.263 , pp. 3440-3447
    • Takayama, S.1    White, M.F.2    Kahn, C.R.3
  • 37
    • 0027418067 scopus 로고
    • Overexpression of protein kinase C isozymes α, βI, γ and ε in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling
    • Chin JE, Dickens M, Tavare JM, Roth RA 1993 Overexpression of protein kinase C isozymes α, βI, γ and ε in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J Biol Chem 268:6338-6347
    • (1993) J Biol Chem , vol.268 , pp. 6338-6347
    • Chin, J.E.1    Dickens, M.2    Tavare, J.M.3    Roth, R.A.4
  • 38
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle
    • Dunaif A, Xia J, Book CB, Schenker E, Tang Z 1995 Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. J Clin Invest 96:801-810
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3    Schenker, E.4    Tang, Z.5
  • 41
    • 0031965926 scopus 로고    scopus 로고
    • The regulation of human P450c17 activity: Relationship to premature adrenarche and the polycystic ovary syndrome
    • Auchus RJ, Geller DH, Lee TC, Miller WL 1998 The regulation of human P450c17 activity: relationship to premature adrenarche and the polycystic ovary syndrome. Trends Endocrinol Metab 9:47-50
    • (1998) Trends Endocrinol Metab , vol.9 , pp. 47-50
    • Auchus, R.J.1    Geller, D.H.2    Lee, T.C.3    Miller, W.L.4
  • 42
    • 0346458803 scopus 로고    scopus 로고
    • Insulin augmentation of 17α-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells
    • Munir I, Yen H-W, Geller DH, Torbati D, Bierden RM, Weitsman SR, Agarwal AK, Magoffin DA 2004 Insulin augmentation of 17α-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells. Endocrinology 145:175-183
    • (2004) Endocrinology , vol.145 , pp. 175-183
    • Munir, I.1    Yen, H.-W.2    Geller, D.H.3    Torbati, D.4    Bierden, R.M.5    Weitsman, S.R.6    Agarwal, A.K.7    Magoffin, D.A.8
  • 43
    • 33644779914 scopus 로고    scopus 로고
    • Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome
    • Corbould A, Zhao H, Mirzoeva S, Aird F, Dunaif A 2006 Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome. Diabetes 55:751-759
    • (2006) Diabetes , vol.55 , pp. 751-759
    • Corbould, A.1    Zhao, H.2    Mirzoeva, S.3    Aird, F.4    Dunaif, A.5
  • 45
    • 0027450247 scopus 로고
    • Regulation of steroidogenesis in NCIH295 cells: A cellular model of the human fetal adrenal
    • Staels B, Hum DW, Miller WL 1993 Regulation of steroidogenesis in NCIH295 cells: a cellular model of the human fetal adrenal. Mol Endocrinol 7:423-433
    • (1993) Mol Endocrinol , vol.7 , pp. 423-433
    • Staels, B.1    Hum, D.W.2    Miller, W.L.3
  • 46
    • 0031035905 scopus 로고    scopus 로고
    • Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells
    • Rodriguez H, Hum DW, Staels B, Miller WL 1997 Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells. J Clin Endocrinol Metab 82:365-371
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 365-371
    • Rodriguez, H.1    Hum, D.W.2    Staels, B.3    Miller, W.L.4
  • 48
    • 0033514376 scopus 로고    scopus 로고
    • Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species
    • Brock BJ, Waterman MR 1999 Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species. Biochemistry 38:1598-1606
    • (1999) Biochemistry , vol.38 , pp. 1598-1606
    • Brock, B.J.1    Waterman, M.R.2
  • 51
    • 17144426051 scopus 로고    scopus 로고
    • 5 and by serine phosphorylation of P450c17
    • 5 and by serine phosphorylation of P450c17. J Biol Chem 280:13265-13271
    • (2005) J Biol Chem , vol.280 , pp. 13265-13271
    • Pandey, A.V.1    Miller, W.L.2
  • 53
    • 42449123218 scopus 로고    scopus 로고
    • Design and performance of the Gene Chip Human Genome U133 Plus 2.0 and Human Genome U133A 2.0 arrays. Affymetrix Technical Note
    • Anonymous
    • Anonymous, Design and performance of the Gene Chip Human Genome U133 Plus 2.0 and Human Genome U133A 2.0 arrays. Affymetrix Technical Note: www.affymetrix.com
  • 54
    • 0141557549 scopus 로고    scopus 로고
    • A regulatory role for p38δ MAPK in keratinocyte differentiation. Evidence for p38 -ERK1/2 complex formation
    • Efimova T, Broome AM, Eckert RL 2003 A regulatory role for p38δ MAPK in keratinocyte differentiation. Evidence for p38 -ERK1/2 complex formation. J Biol Chem 278:34277-34285
    • (2003) J Biol Chem , vol.278 , pp. 34277-34285
    • Efimova, T.1    Broome, A.M.2    Eckert, R.L.3
  • 55
    • 1842523229 scopus 로고    scopus 로고
    • Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene
    • Beale EG, Hammer RE, Antoine B, Forest C 2004 Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene. Trends Endocrinol Metab 15:129-135
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 129-135
    • Beale, E.G.1    Hammer, R.E.2    Antoine, B.3    Forest, C.4
  • 57
    • 0036077667 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor
    • Ikenoya M, Hidaka H, Hosoya T, Suzuki M, Yamamoto N, Sasaki Y 2002 Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem 81:9-16
    • (2002) J Neurochem , vol.81 , pp. 9-16
    • Ikenoya, M.1    Hidaka, H.2    Hosoya, T.3    Suzuki, M.4    Yamamoto, N.5    Sasaki, Y.6
  • 58
    • 0035213641 scopus 로고    scopus 로고
    • AGC protein kinase phosphorylation and protein kinase C
    • Parker PJ, Parkinson SJ 2001 AGC protein kinase phosphorylation and protein kinase C. Biochem Soc Trans 29:860-863
    • (2001) Biochem Soc Trans , vol.29 , pp. 860-863
    • Parker, P.J.1    Parkinson, S.J.2
  • 59
    • 1342304087 scopus 로고    scopus 로고
    • Structural insights into the interaction of ROCK1 with the switch regions of RhoA
    • Dvorsky R, Blumenstein L, Vetter IR, Ahmadian MR 2004 Structural insights into the interaction of ROCK1 with the switch regions of RhoA. J Biol Chem 279:7098-7104
    • (2004) J Biol Chem , vol.279 , pp. 7098-7104
    • Dvorsky, R.1    Blumenstein, L.2    Vetter, I.R.3    Ahmadian, M.R.4
  • 61
    • 0035933849 scopus 로고    scopus 로고
    • Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase α
    • Sumi T, Matsumoto K, Shibuya A, Nakamura T 2001 Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase α. J Biol Chem 276:23092-23096
    • (2001) J Biol Chem , vol.276 , pp. 23092-23096
    • Sumi, T.1    Matsumoto, K.2    Shibuya, A.3    Nakamura, T.4
  • 62
    • 0033346398 scopus 로고    scopus 로고
    • Molecular modeling of human P450c17 (17α-hydroxylase/17,20-lyase): Insights into reaction mechanisms and effects of mutations
    • Auchus RJ, Miller WL 1999 Molecular modeling of human P450c17 (17α-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations. Mol Endocrinol 13:1169-1182
    • (1999) Mol Endocrinol , vol.13 , pp. 1169-1182
    • Auchus, R.J.1    Miller, W.L.2
  • 63
    • 33645843055 scopus 로고    scopus 로고
    • Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20 lyase activity
    • Souter I, Munir I, Mallick P, Weitsman SR, Geller DH, Magoffin DA 2006 Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20 lyase activity. Ferti Steril 85(Suppl 1):1290-1299
    • (2006) Ferti Steril , vol.85 , Issue.SUPPL. 1 , pp. 1290-1299
    • Souter, I.1    Munir, I.2    Mallick, P.3    Weitsman, S.R.4    Geller, D.H.5    Magoffin, D.A.6
  • 64
  • 65
    • 0036460051 scopus 로고    scopus 로고
    • Rho/Rho-kinase mediated signaling in physiology and pathophysiology
    • Wettschureck N, Offermanns S 2002 Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med 80:629-638
    • (2002) J Mol Med , vol.80 , pp. 629-638
    • Wettschureck, N.1    Offermanns, S.2
  • 66
    • 0037155132 scopus 로고    scopus 로고
    • Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells
    • Begum N, Sandu OA, Ito M, Lohmann SM, Smolenski A 2002 Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J Biol Chem 277:6214-6222
    • (2002) J Biol Chem , vol.277 , pp. 6214-6222
    • Begum, N.1    Sandu, O.A.2    Ito, M.3    Lohmann, S.M.4    Smolenski, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.