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Volumn 116, Issue 8, 2008, Pages 481-486

Increased low grade inflammatory serum markers in patients with polycystic ovary syndrome (PCOS) and their relationship to PPARγ gene variants

Author keywords

Inflammation; Insulin resistance; Metabolic syndrome; PCCOS; PPAR

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA;

EID: 54549096932     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1058085     Document Type: Article
Times cited : (45)

References (40)
  • 1
    • 0035787357 scopus 로고    scopus 로고
    • Insulin resistance in polycystic ovary syndrome: Progress and paradoxes
    • Venkatesan AM, Dunaif A, Corbould A. Insulin resistance in polycystic ovary syndrome: progress and paradoxes. Recent Prog Horm Res 2001;56: 295-308
    • (2001) Recent Prog Horm Res , vol.56 , pp. 295-308
    • Venkatesan, A.M.1    Dunaif, A.2    Corbould, A.3
  • 2
    • 2542490223 scopus 로고    scopus 로고
    • Pathogenesis of the polycystic ovary syndrome: What is the role of obesity?
    • Salesi M, Bravo-Vera R, Sheikh A, Gouller A, Poretzky L. Pathogenesis of the polycystic ovary syndrome: What is the role of obesity? Metabolism 2004; 53: 358-376
    • (2004) Metabolism , vol.53 , pp. 358-376
    • Salesi, M.1    Bravo-Vera, R.2    Sheikh, A.3    Gouller, A.4    Poretzky, L.5
  • 3
    • 0027278472 scopus 로고    scopus 로고
    • O'Meara NM, Blackman JD, Ehrmann DA. Barnes RB, Jaspan JB, Rosenfield RL, Polonsky KS. Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1993; 76: 1241-1247
    • O'Meara NM, Blackman JD, Ehrmann DA. Barnes RB, Jaspan JB, Rosenfield RL, Polonsky KS. Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1993; 76: 1241-1247
  • 4
    • 15444366255 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005; 352: 1223-1236
    • (2005) N Engl J Med , vol.352 , pp. 1223-1236
    • DA, E.1
  • 5
    • 0034964836 scopus 로고    scopus 로고
    • Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome
    • Kirchengast S, Huber J. Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome. Hum Reprod 1999; 16: 1255-1260
    • (1999) Hum Reprod , vol.16 , pp. 1255-1260
    • Kirchengast, S.1    Huber, J.2
  • 6
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Rev 1999; 20: 649-688
    • (1999) Endocrine Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 7
    • 0031589186 scopus 로고    scopus 로고
    • Beamer BA, Negri C, Yen CJ, Gavrilova O, Rumberger JM, Durcan MJ, Yarnall DP, Hawkins AL, Griffin CA, Burns DK, Roth J, Reitman M, Shuldiner AR. Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-gamma (hPPAR gamma) gene. Biochem Biophys Res Commun 1997; 233: 756-759
    • Beamer BA, Negri C, Yen CJ, Gavrilova O, Rumberger JM, Durcan MJ, Yarnall DP, Hawkins AL, Griffin CA, Burns DK, Roth J, Reitman M, Shuldiner AR. Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-gamma (hPPAR gamma) gene. Biochem Biophys Res Commun 1997; 233: 756-759
  • 8
    • 0034214246 scopus 로고    scopus 로고
    • Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev 2000; 14: 1293-1307
    • Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev 2000; 14: 1293-1307
  • 9
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 2000; 106: 467-472
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • JM, O.1
  • 10
    • 0036320603 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism
    • Stumvoll M, Haring H. The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism. Diabetes 2002; 51: 2341-2347
    • (2002) Diabetes , vol.51 , pp. 2341-2347
    • Stumvoll, M.1    Haring, H.2
  • 11
    • 0036170755 scopus 로고    scopus 로고
    • Insulin resistance is attenuated in women with polycystic ovary sindrome with the Pro12Ala polymorphism in the PPARγ gene
    • Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA. Insulin resistance is attenuated in women with polycystic ovary sindrome with the Pro12Ala polymorphism in the PPARγ gene. J Clin Endocrinol & Metab 2002; 87: 772-775
    • (2002) J Clin Endocrinol & Metab , vol.87 , pp. 772-775
    • Hara, M.1    Alcoser, S.Y.2    Qaadir, A.3    Beiswenger, K.K.4    Cox, N.J.5    Ehrmann, D.A.6
  • 13
    • 9144230787 scopus 로고    scopus 로고
    • Di, Palomba S, Labella D, Sanna V, Savastano S, Zullo F, Colao A, Lombardi G. Exon 6 and 2 peroxisome proliferator-activated receptorγ polymorphisms in polycystic ovary sindrome
    • Oil F, Matarese G, Blase S Di, Palomba S, Labella D, Sanna V, Savastano S, Zullo F, Colao A, Lombardi G. Exon 6 and 2 peroxisome proliferator-activated receptorγ polymorphisms in polycystic ovary sindrome. J Clin Endocrinol & Metab 2003; 88: 5887-5892
    • (2003) J Clin Endocrinol & Metab , vol.88 , pp. 5887-5892
    • Oil, F.1    Matarese, G.2    Blase, S.3
  • 15
    • 0031595923 scopus 로고    scopus 로고
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J. Laakso M, Fujimoto W, Auwerx J. A Pro12Ala substitution in PPARγamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20: 284-287
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J. Laakso M, Fujimoto W, Auwerx J. A Pro12Ala substitution in PPARγamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20: 284-287
  • 17
    • 0034974186 scopus 로고    scopus 로고
    • Frequency and significance of Pro12 Ala and Pro115Gln polymorphisms in gene for peroxisome proliferation-activated receptor - gamma regarding metabolic parameters in a Caucasian cohort
    • Schaffler A, Barth N, Schmitz G, Zieht B, Palitzsch KD, Scholmerich J. Frequency and significance of Pro12 Ala and Pro115Gln polymorphisms in gene for peroxisome proliferation-activated receptor - gamma regarding metabolic parameters in a Caucasian cohort. Endocrine 2001; 14: 369-373
    • (2001) Endocrine , vol.14 , pp. 369-373
    • Schaffler, A.1    Barth, N.2    Schmitz, G.3    Zieht, B.4    Palitzsch, K.D.5    Scholmerich, J.6
  • 18
    • 17944362462 scopus 로고    scopus 로고
    • Ek J, Andersen G. Urhammer SA, Hansen L, Carstensen B, Borch-Johnsen K, Drivsholm T, Berglund L, Hansen T, Lithell H, Pedersen O. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians. Diabetologia 2001; 44: 1170-1176
    • Ek J, Andersen G. Urhammer SA, Hansen L, Carstensen B, Borch-Johnsen K, Drivsholm T, Berglund L, Hansen T, Lithell H, Pedersen O. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians. Diabetologia 2001; 44: 1170-1176
  • 20
    • 0033060302 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes
    • Mancini FP, Vaccaro O, Sabatino L, Tufano A, Rivellese AA, Riccardi G, Colantuoni V. Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes. Diabetes 1999; 48: 1466-1468
    • (1999) Diabetes , vol.48 , pp. 1466-1468
    • Mancini, F.P.1    Vaccaro, O.2    Sabatino, L.3    Tufano, A.4    Rivellese, A.A.5    Riccardi, G.6    Colantuoni, V.7
  • 23
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001; 169: 453-459
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 24
    • 0036694663 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and inflammation
    • Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002; 13: 413-421
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 413-421
    • Hanada, T.1    Yoshimura, A.2
  • 25
    • 0032936968 scopus 로고    scopus 로고
    • Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome
    • Gonzalez F, Thusu K, Abdel-Rahman E, Prabhala A, Tomani M, Dandona P. Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome. Metabolism 1999; 48: 437-441
    • (1999) Metabolism , vol.48 , pp. 437-441
    • Gonzalez, F.1    Thusu, K.2    Abdel-Rahman, E.3    Prabhala, A.4    Tomani, M.5    Dandona, P.6
  • 27
    • 0038691619 scopus 로고    scopus 로고
    • Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in premenopausal women
    • Escobar-Morreale HF, Villuendas G, Botella-Carretero JI, Sancho J, San Millan JL. Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in premenopausal women. Diabetologia 2003; 46: 625-633
    • (2003) Diabetologia , vol.46 , pp. 625-633
    • Escobar-Morreale, H.F.1    Villuendas, G.2    Botella-Carretero, J.I.3    Sancho, J.4    San Millan, J.L.5
  • 29
    • 27744459241 scopus 로고    scopus 로고
    • Central fat excess in polycystic ovary syndrome: Relation to low-grade inflammation and insulin resistance
    • Puder JJ, Varga S, Kraenzlin M, Geyter C De, Keller U, Muller B. Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance. J Clin Endocrinol Metab 2005: 90: 6014-6021
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6014-6021
    • Puder, J.J.1    Varga, S.2    Kraenzlin, M.3    Geyter, C.D.4    Keller, U.5    Muller, B.6
  • 30
    • 23944448075 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma polymorphisms affect systemic inflammation and survival in end-stage renal disease patients starting renal replacement therapy
    • Yao Q, Nordfors L, Axelsson J, Heimburger O, Qureshi AR, Barony P, Lindholm B, Lonnqvist F, Schalling M, Stenvinkel P. Peroxisome proliferator-activated receptor gamma polymorphisms affect systemic inflammation and survival in end-stage renal disease patients starting renal replacement therapy. Atherosclerosis 2005; 182: 105-111
    • (2005) Atherosclerosis , vol.182 , pp. 105-111
    • Yao, Q.1    Nordfors, L.2    Axelsson, J.3    Heimburger, O.4    Qureshi, A.R.5    Barony, P.6    Lindholm, B.7    Lonnqvist, F.8    Schalling, M.9    Stenvinkel, P.10
  • 31
    • 20844448393 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome
    • Hahn S, Fingerhut A, Khomtsiv U, Khomtsiv L, Tan S, Quadbeck B, Herrmann BL, Knebel B, Muller-Wieland D, Mann K, Janssen OE. The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome. Clin Endocrinol 2005; 62: 573-579
    • (2005) Clin Endocrinol , vol.62 , pp. 573-579
    • Hahn, S.1    Fingerhut, A.2    Khomtsiv, U.3    Khomtsiv, L.4    Tan, S.5    Quadbeck, B.6    Herrmann, B.L.7    Knebel, B.8    Muller-Wieland, D.9    Mann, K.10    Janssen, O.E.11
  • 32
    • 0032055597 scopus 로고    scopus 로고
    • Di, Martel-Peiletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages
    • Jovanovic DV, Battista JA Di, Martel-Peiletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol 1998; 160: 3513-3521
    • (1998) J Immunol , vol.160 , pp. 3513-3521
    • Jovanovic, D.V.1    Battista, J.A.2
  • 35
    • 4544288392 scopus 로고    scopus 로고
    • Esposito K, Marfella R, Ciotola M, Palo C Di, Giugliano F, Giugliano G. DÁrmiento M, DÁndrea F, Giugliano D. Erectile dysfunction associates with endothelial dysfunction and raised proinflammatory cytokine levels in obese men. JAMA 2004; 292: 1440-1446
    • Esposito K, Marfella R, Ciotola M, Palo C Di, Giugliano F, Giugliano G. DÁrmiento M, DÁndrea F, Giugliano D. Erectile dysfunction associates with endothelial dysfunction and raised proinflammatory cytokine levels in obese men. JAMA 2004; 292: 1440-1446
  • 36
    • 0037422560 scopus 로고    scopus 로고
    • IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells
    • Toraldo G, Roggia C, Qian WP, Pacifici R, Weitzmann MN. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci USA 2003; 100: 125-130
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 125-130
    • Toraldo, G.1    Roggia, C.2    Qian, W.P.3    Pacifici, R.4    Weitzmann, M.N.5
  • 37
    • 33744779045 scopus 로고    scopus 로고
    • Estrogen regulation of immune cell bone interactions
    • Weitzmann MN, Pacifici R. Estrogen regulation of immune cell bone interactions. Ann N Y Acad Sci 2006; 1068: 256-274
    • (2006) Ann N Y Acad Sci , vol.1068 , pp. 256-274
    • Weitzmann, M.N.1    Pacifici, R.2
  • 38
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391: 82-86
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 40
    • 0033626340 scopus 로고    scopus 로고
    • The silent PPAR gamma exon 6 CAC (His) >CAT (His) polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany
    • Koch M, Rett K, Maerker E, Volk A, Haist K, Deninger M, Rettig A, Renn W, Haring HU. The silent PPAR gamma exon 6 CAC (His) >CAT (His) polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany. Exp Clin Endocrinol Diabetes 2000; 108: 341-346
    • (2000) Exp Clin Endocrinol Diabetes , vol.108 , pp. 341-346
    • Koch, M.1    Rett, K.2    Maerker, E.3    Volk, A.4    Haist, K.5    Deninger, M.6    Rettig, A.7    Renn, W.8    Haring, H.U.9


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