Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS

Human Reproduction

Volumn 21, Issue 9, 2006, Pages 2266-2271

  Chen, Mei Jou ^a,b   Yang, Wei Shiung ^a,b   Yang, Jehn Hsiahn ^a   Hsiao, Chuhsing Kate ^c   Yang, Yu Shih ^a   Ho, Hong Nerng ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Cardiovascular disease; High density lipoprotein cholesterol; Metabolic syndrome; PCOS; SHBG

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; SEX HORMONE BINDING GLOBULIN;

ADOLESCENT; ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; INSULIN RESISTANCE; LIVER FUNCTION; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MULTIPLE LINEAR REGRESSION ANALYSIS; OBESITY; OVARY POLYCYSTIC DISEASE; PROTEIN BLOOD LEVEL; TAIWAN;

EID: 33749568755     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del175     Document Type: Article

References (42)

1. Abbas A, Fadel PJ, Wang Z, Arbique D, Jialal I and Vongpatanasin W (2004) Contrasting effects of oral versus transdermal estrogen on serum amyloid A (SAA) and high-density lipoprotein-SAA in postmenopausal women. Arterioscler Thromb Vasc Biol 24,e164-167.
2. Balen AH, Laven JS, Tan SL and Dewailly D (2003) Ultrasound assessment of the polycystic ovary: International consensus definitions. Hum Reprod Update 9,505-514.
3. Bass KM, Newschaffer CJ, Klag MJ and Bush TL (1993) Plasma lipoprotein levels as predictors of cardiovascular death in women. Arch Intern Med 153,2209-2216.
4. Bataille V, Perret B, Evans A, Amouyel P, Arveiler D, Ducimetiere P, Bard JM and Ferrieres J (2005) Sex hormone-binding globulin is a major determinant of the lipid profile: The PRIME study. Atherosclerosis 179,369-373.
5. Burger HG, Dudley EC, Cui J, Dennerstein L and Hopper JL (2000) A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 85,2832-2838.
6. Carmina E and Lobo RA (1999) Polycystic ovary syndrome (PCOS): Arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab 84,1897-1899.
7. Carmina E, Koyama T, Chang L, Stanczyk FZ and Lobo RA (1992) Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol 167,1807-1812.
8. Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF 2nd and Fitzpatrick LA (2003) Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88,2562-2568.
9. Cikim AS, Ozbey N, Sencer E, Molvalilar S and Orhan Y (2004) Associations among sex hormone binding globulin concentrations and characteristics of the metabolic syndrome in obese women. Diabetes Nutr Metab 17,290-295.
10. Corti MC, Guralnik JM, Salive ME, Harris T, Field TS, Wallace RB, Berkman LF, Seeman TE, Glynn RJ, Hennekens CH et al. (1995) HDL cholesterol predicts coronary heart disease mortality in older persons. JAMA 274,539-544.
11. Cousin P, Calemard-Michel L, Lejeune H, Raverot G, Yessaad N, Emptoz-Bonneton A, Morel Y and Pugeat M (2004) Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. J Clin Endocrinol Metab 89,917-924.
12. Desmeules A, Couillard C, Tchernof A, Bergeron J, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Despres JP et al. (2003) Post-heparin lipolytic enzyme activities, sex hormones and sex hormone-binding globulin (SHBG) in men and women: The HERITAGE Family Study. Atherosclerosis 171,343-350.
13. Ducluzeau PH, Cousin P, Malvoisin E, Bornet H, Vidal H, Laville M and Pugeat M (2003) Glucose-to-insulin ratio rather than sex hormone-binding globulin and adiponectin levels is the best predictor of insulin resistance in nonobese women with polycystic ovary syndrome. J Clin Endocrinol Metab 88,3626-3631.
14. von Eckardstein A, Nofer JR and Assmann G (2000) Acceleration of reverse cholesterol transport. Curr Opin Cardiol 15,348-354.
15. Ehrmann DA (2005) Polycystic ovary syndrome. N Engl J Med 352,1223-1236.
16. Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS and Ghazzi MN (2006) Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 91,48-53.
17. Falk RT, Fears TR, Hoover RN, Pike MC, Wu AH, Nomura AM, Kolonel LN, West DW and Ziegler RG (2002) Does place of birth influence endogenous hormone levels in Asian-American women? Br J Cancer 87,54-60.
18. Haffner SM, Dunn JF and Katz MS (1992) Relationship of sex hormone-binding globulin to lipid, lipoprotein, glucose, and insulin concentrations in postmenopausal women. Metabolism 41,278-284.
19. Heald AH, Anderson SG, Ivison F, Riste L, Laing I, Cruickshank JK and Gibson JM (2005) Low sex hormone binding globulin is a potential marker for the metabolic syndrome in different ethnic groups. Exp Clin Endocrinol Diabetes 113,522-528.
20. Hopkinson ZE, Sattar N, Fleming R and Greer IA (1998) Polycystic ovarian syndrome: The metabolic syndrome comes to gynaecology. BMJ 317,329-332.
21. Jayagopal V, Kilpatrick ES, Jennings PE, Hepburn DA and Atkin SL (2003) The biological variation of testosterone and sex hormone-binding globulin (SHBG) in polycystic ovarian syndrome: Implications for SHBG as a surrogate marker of insulin resistance. J Clin Endocrinol Metab 88,1528-1533.
22. Joffe HV, Ridker PM, Manson JE, Cook NR, Buring JE and Rexrode KM (2005) Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Ann Epidemiol 16,105-112.
23. Kahn SM, Hryb DJ, Nakhla AM, Romas NA and Rosner W (2002) Sex hormone-binding globulin is synthesized in target cells. J Endocrinol 175,113-120.
24. Korytkowski MT, Krug EI, Daly MA, Deriso L, Wilson JW and Winters SJ (2005) Does androgen excess contribute to the cardiovascular risk profile in postmenopausal women with type 2 diabetes? Metabolism 54,1626-1631.
25. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC (1985) Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28,412-419.
26. Mudali S, Dobs AS, Ding J, Cauley JA, Szklo M and Golden SH (2005) Endogenous postmenopausal hormones and serum lipids: The atherosclerosis risk in communities study. J Clin Endocrinol Metab 90,1202-1209.
27. Orio F Jr, Palomba S, Spinelli L, Cascella T, Tauchmanova L, Zullo F, Lombardi G and Colao A (2004) The cardiovascular risk of young women with polycystic ovary syndrome: An observational, analytical, prospective case-control study. J Clin Endocrinol Metab 89,3696-3701.
28. Petra PH (1991) The plasma sex steroid binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and function. J Steroid Biochem Mol Biol 40,735-753.
29. Pinheiro SP, Holmes MD, Pollak MN, Barbieri RL and Hankinson SE (2005) Racial differences in premenopausal endogenous hormones. Cancer Epidemiol Biomarkers Prev 14,2147-2153.
30. Pugeat M, Moulin P, Cousin P, Fimbel S, Nicolas MH, Crave JC and Lejeune H (1995) Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk. J Steroid Biochem Mol Biol 53,567-572.
31. Rajkhowa M, Neary RH, Kumpatla P, Game FL, Jones PW, Obhrai MS and Clayton RN (1997) Altered composition of high density lipoproteins in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 82,3389-3394.
32. Rexrode KM, Manson JE, Lee IM, Ridker PM, Sluss PM, Cook NR and Buring JE (2003) Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation 108,1688-1693.
33. Rosner W, Hryb DJ, Khan MS, Nakhla AM and Romas NA (1999) Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate. Steroids 64,100-106.
34. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19,41-47.
35. Sorva R, Kuusi T, Taskinen MR, Perheentupa J and Nikkila EA (1988) Testosterone substitution increases the activity of lipoprotein lipase and hepatic lipase in hypogonadal males. Atherosclerosis 69,191-197.
36. Sowers MR, Jannausch M, Randolph JF, McConnell D, Little R, Lasley B, Pasternak R, Sutton-Tyrrell K and Matthews KA (2005) Androgens are associated with hemostatic and inflammatory factors among women at the mid-life. J Clin Endocrinol Metab 90,6064-6071.
37. Sutton-Tyrrell K, Wildman RP, Matthews KA, Chae C, Lasley BL, Brockwell S, Pasternak RC, Lloyd-Jones D, Sowers MF and Torrens JI (2005) Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 111,1242-1249.
38. Talbott EO, Guzick DS, Sutton-Tyrrell K, McHugh-Pemu KP, Zborowski JV, Remsberg KE and Kuller LH (2000) Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arterioscler Thromb Vasc Biol 20,2414-2421.
39. Tan CE, Ma S, Wai D, Chew SK and Tai ES (2004) Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? Diabetes Care 27,1182-1186.
40. Wijeyaratne CN, Balen AH, Barth JH and Belchetz PE (2002) Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and Caucasians: Is there a difference? Clin Endocrinol (Oxf) 57,343-350.
41. Wild RA (2002) Long-term health consequences of PCOS. Hum Reprod Update 8,231-241.
42. Xita N, Tsatsoulis A, Chatzikyriakidou A and Georgiou I (2003) Association of the (TAAAA) n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. J Clin Endocrinol Metab 88,5976-5980.