Evidence for association of polycystic ovary syndrome in Caucasian women with a marker at the insulin receptor gene locus

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 1, 2001, Pages 446-449

  Tucci, Stefania ^a   Futterweit, Walter ^a   Concepcion, Erlinda S ^a   Greenberg, David A ^a   Villanueva, Ronald ^a   Davies, Terry F ^a   Tomer, Yaron ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CYTOCHROME P450; CYTOCHROME P450 17A; FOLLISTATIN; INSULIN RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANDROGEN RELEASE; ANOVULATION; ARTICLE; CAUCASIAN; CHROMOSOME 19P; CLINICAL FEATURE; CONTROLLED STUDY; ENVIRONMENT; FEMALE; GENE FUNCTION; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HUMAN; HYPERANDROGENISM; MAJOR CLINICAL STUDY; MARKER GENE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL;

EID: 0035142308     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.1.7274     Document Type: Article

References (22)

1. Polycystic ovarian disease: Etiology, diagnosis, and treatment
2. Polycystic oavary syndrome: Clinical perspectives and management
3. The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia
4. Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome
5. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome
6. Familial polycystic ovaries: A genetic disease?
7. Polycystic ovaries are inherited as an autosomal dominant trait: Analysis of 29 polycystic ovary syndrome and 10 control families
8. The genetics of polycystic ovary syndrome
9. Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is with follistatin
10. Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome
11. Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome
12. Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: Evidence for genetic heterogeneity and gene interactions
13. Searching for the polycystic ovary syndrome genes
14. On estimating the relation between blood group and disease
15. A general model for disease-marker association
16. The insulin-related ovarian regulatory system in health and disease
17. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation
18. Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance)
19. A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman
20. Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms
21. The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome
22. Molecular scanning of the insulin receptor gene in syndromes of insulin resistance