Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne

Journal of Cutaneous Medicine and Surgery

Volumn 3, Issue 1, 1998, Pages 9-15

  Sawaya, Marty E ^a,b,d   Shalita, Alan R ^c  

^a ARATEC: Alopecia Res Assoc T   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c and Maimonides Medical Center Jaffe Stroke Center   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; DNA;

ACNE; ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; HAIR FOLLICLE; HIRSUTISM; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MALE TYPE ALOPECIA; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEBACEOUS GLAND; TRINUCLEOTIDE REPEAT;

EID: 0031829734     PISSN: 12034754     EISSN: None     Source Type: Journal    
DOI: 10.1177/120347549800300103     Document Type: Article

References (24)

1. Sawaya ME, Price VH. Different Levels of 5α-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 1997; 109:296-300.
2. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade. Cell 1995; 83:835-839.
3. Hardy DO, Scher HI, Bogenreider T, et al. Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrin Metab 1996; 81:4400-4405.
4. Sawaya ME. Androgen action at the cellular level. In: Redmond GP, ed. Androgenic disorders. New York: Raven Press, 1995: 35-17.
5. Tilley WD, Marcelli M, McPhaul MJ. Recent studies on the androgen receptor: new insights into old questions. Mol Cell Endocrinol 1990; 68:C7-C10.
6. Kremer EJ, Pritchard M, Lynch M, et al. Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(GGG)n. Science 1991; 252:1711-1714.
7. Verkerk AJMH, Pieretti M, Sutcliffe JS. Identification of a gene (FMR-1) containing a CGG repeat coincident with a break-point cluster region exhibiting length variation in fragile X syndrome. Cell 1991; 65:905-914.
8. Fu YH, Pizzuti A, Fenwick RG Jr, et al. An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science 1992; 255:1256-1258.
9. La Spada AR, Wilson EM, Lubahn DB, et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991; 352:77-91.
10. Orr HT, Chung MY, Banfi S, et al. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1. Nat Genet 1993; 4:221-226.
11. Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72:971-983.
12. Koide R, Ikeucki I, Onodera O, et al. Expansion of an unstable trinucleotide CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DR-PLA). Nat Genet 1994; 6:9-13.
13. Nagatuchi S, Yanagisawa H, Sato K, et al. Dentatorubral and pallidoluysian atrophy: expansion of an unstable CAG trinucleotide on chromosome 12p. Nat Genet 1994; 6:14-18.
14. La Spada AR, Paulson HL, Fischbeck KH. Trinucleotide repeat expansion in neurological disease. Ann Neurol 1994; 36:814-822.
15. Chamberlain NL, Driver ED, Miesfield RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994; 22:3181-3186.
16. Coetzee GA, Ross RK. Prostate cancer and the androgen receptor. J Natl Cancer Inst 1994; 86:872-873.
17. Legro RS, Shahbahrami B, Lobo RA, Kovacs BW. Size polymorphisms of the androgen receptor among female hispanics and correlation with androgenic characteristics. Obstet Gynecol 1994; 83:701-706.
18. Nanus DM, Mentle IR, Matzer RJ, et al. Infrequent ras oncogene point mutations in renal cell carcinoma. J Urol 1990; 143:175-178.
19. Edwards A, Hammond HA, Jin L, et al. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 1992; 12:241-253.
20. McPhaul MJ, Marcelli M, Tilley WD, et al. Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen receptor and responsive to high-dose androgen therapy. J Clin Invest 1991; 87:1413-1421.
21. Caskey CT, Pizzuti A, Jing-Hui L, et al. Triplet repeat mutations in human disease. Science 1992; 256:784-788.
22. Mowszowicz I, Melanitou E, Doukani A, et al. Androgen binding capacity and 5α-reductase activity in pubic skin fibroblasts from hirsute patients. J Clin Endocrinol Metab 1983; 56: 1209-1213.
23. Labri F, Belanger A, Cusan L, Candas B. Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. J Clin Endocrinol Metab 1997; 82:2403-2409.
24. Deslypere JP, Young M, Wilson JD, McPhaul MJ. Testosterone and 5α-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene. Mol Cell Endocrinol 1992; 88:15-22.