Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice

Vaccine

Volumn 30, Issue 4, 2012, Pages 758-766

  Jiang, Wenzheng ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

B7 H1; CTL; Dendritic cell; HBV; RNAi; Transgenic mice

Indexed keywords

DENDRITIC CELL VACCINE; DOUBLE STRANDED RNA; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; PROGRAMMED DEATH 1 LIGAND 1; RNA; SMALL INTERFERING RNA; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATITIS B VIRUS; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; MAMMAL CELL; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RNA INTERFERENCE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD274; DENDRITIC CELLS; DNA, VIRAL; FEMALE; GENE SILENCING; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; INTERFERON-GAMMA; INTERLEUKIN-10; MICE; MICE, TRANSGENIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TRANSFECTION;

EID: 84855341575     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.11.076     Document Type: Article

References (51)

1. Birrer R.B., Birrer D., Klavins J.V. Hepatocellular carcinoma and hepatitis virus. Ann Clin Lab Sci 2003, 33(1):39-54.
2. Chen M., Sallberg M., Hughes J., Jones J., Guidotti L.G., Chisari F.V., et al. Immune tolerance split between hepatitis B virus precore and core proteins. J Virol 2005, 79(5):3016-3027.
3. Banchereau J., Steinman R. Dendritic cells and the control of immunity. Nature 1998, 392(6673):245-252.
4. Jonuleit H., Schmitt E., Steinbrink K., Enk A. Dendritic cells as a tool to induce anergic and regulatory T-cells. Trends Immunol 2001, 22(7):394-400.
5. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000, 192(9):1213-1322.
6. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001, 193(2):233-238.
7. Bhatt K., Uzelac A., Mathur S., McBride A., Potian J., Salgame P. B7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection. J Immunol 2009, 182(6):3793-3800.
8. Coyle A.J., Gutierrez-Ramos J.C. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat Immunol 2001, 2(3):203-209.
9. Sharpe A.H., Freeman G.J. The B7-CD28 superfamily. Nat Rev Immunol 2002, 2(2):116-226.
10. Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000, 192(7):1027-1034.
11. + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest 2009, 119(3):551-564.
12. + T cells and is overcome by IL-2. Eur J Immunol 2002, 32(3):634-643.
13. Mazanet M.M., Hughes C.C. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol 2002, 169(7):3581-3588.
14. + T cell activation and cytolysis. Eur J Immunol 2003, 33(11):3117-3126.
15. Selenko-Gebauer N., Majdic O., Szekeres A., Höfler G., Guthann E., Korthäuer U., et al. B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J Immunol 2003, 170(7):3637-3644.
16. Brown J.A., Dorfman D.M., Ma F.R., Sullivan E.L., Munoz O., Wood C.R., et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 2003, 170:1257-1266.
17. Iwai Y., Terawaki S., Ikegawa M., Okazaki T., Honjo T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J Exp Med 2003, 198(1):39-50.
18. Wintterle S., Schreiner B., Mitsdoerffer M., Schneider D., Chen L., Meyermann R., et al. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res 2003, 63(21):7462-7467.
19. Bass B.L. Double-stranded RNA as a template for gene silencing. Cell 2000, 101(3):235-238.
20. Hammond S.M., Caudy A.A., Hannon G.J. Posttranscriptional gene silencing by double-stranded RNA. Nat Rev Genet 2001, 2(2):110-119.
21. Fan Y., Jiang W.Z., Wen J.J., Hao W.L., Du J.N., Liu X., et al. B7-DC-silenced dentritic cells induce stronger anti-HBV immunity in transgenic mice. Arch Virol 2009, 154(11):1813-1821.
22. Elbashir S.M., Harborth J., Weber K., Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002, 26(2):199-213.
23. Jiang W.Z., Jin N.Y., Li Z.J., Zhang L.S., Wang H.W., Zhang Y.J., et al. Expression and characterization of Gag protein of HIV-1(CN) in Pichia pastoris. J Virol Methods 2005, 123(1):35-40.
24. Brossart P., Wirths S., Stuhler G., Reichardt V.L., Kanz L., Brugger W. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000, 96(9):3102-3108.
25. Kaplan J.M., Yu Q., Piraino S.T., Pennington S.E., Shankara S., Woodworth L.A., et al. Induction of antitumor immunity with dendritic cells transduced with adenovirus vector-encoding endogenous tumor-associated antigens. J Immunol 1999, 163(2):699-707.
26. Taguchi T., McGhee J.R., Coffman R.L., Beagley K.W., Eldridge J.H., Takatsu K., et al. Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J Immunol Methods 1990, 128(1):65-73.
27. Guidotti L.G., Rochford R., Chung J., Shapiro M., Purcell R., Chisari F.V. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999, 284(5415):825-829.
28. Leirdal M., Sioud M. Gene silencing in mammalian cells by preformed small RNA duplexes. Biochem Biophys Res Commun 2002, 295(3):744-748.
29. Braasch D.A., Jensen S., Liu Y., Kaur K., Arar K., White M.A., et al. RNA interference in mammalian cells by chemically modified RNA. Biochemistry 2003, 42(26):7967-7975.
30. Guermonprez P., Valladeau J., Zitvogel L., Thery C., Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 2002, 20:621-667.
31. Xia H., Mao Q., Paulsonand H.L., Davidson B.L. siRNA mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002, 20(10):1006-1010.
32. McManus M.T., Sharp P.A. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 2002, 3(10):737-747.
33. Gewirtz A.M. Oligonucleotide therapeutics: clothing the emperor. Curr Opin Mol Ther 1999, 1(3):297-306.
34. Drewe E., Powell R.J. Clinically useful monoclonal antibodies in treatment. J Clin Pathol 2002, 55(2):81-85.
35. Martinez J., Patkaniowska A., Urlaub H., Luhrmann R., Tuschl T. Single stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 2002, 110(5):563-574.
36. Hill J.A., Ichim T.E., Kusznieruk K.P., Li M., Huang X., Yan X., et al. Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA. J Immunol 2003, 171(2):691-696.
37. Laderach D., Compagno D., Danos O., Vainchenker W., Galy A. RNA interference shows critical requirement for NF-κB p50 in the production of IL-12 by human dendritic cells. J Immunol 2003, 171(4):1750-1757.
38. Lenschow D.J., Walunas G.S., Bluestone J.A. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996, 14:233-258.
39. Linsley P.S., Clark E.A., Ledbetter J.A. T cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A 1990, 87(13):5031-5035.
40. Thompson C.B., Allison J.P. The emerging role of CTLA-4 as an immune attenuator. Immunity 1997, 7(4):445-450.
41. Nishimura H., Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol 2001, 22(5):265-268.
42. Agata Y., Kawasaki A., Nishimura H., Ishida Y., Tsubata T., Yagita H., et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 1996, 8(5):765-772.
43. -) thymocytes. Int Immunol 1996, 8(5):773-780.
44. Nishimura H., Nose M., Hiai H., Minato N., Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999, 11(2):141-151.
45. Latchman Y.E., Liang S.C., Wu Y., Chernova T., Sobel R.A., Klemm M., et al. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A 2004, 101(29):10691-10696.
46. Pilon-Thomas S., Mackay A., Vohra N., Mulé J.J. Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma. J Immunol 2010, 184(7):3442-3449.
47. Tamura H., Dong H., Zhu G., Sica G.L., Flies D.B., Tamada K., et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001, 97(6):1809-1816.
48. Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006, 439(7077):682-687.
49. + T cell responses in a hepatitis C virus core murine model. J Immunol 2008, 180(7):4875-4884.
50. Guidotti L.G., Ishikawa T., Hobbs M.V., Matzke B., Schreiber R., Chisari F.V. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996, 4(1):25-36.
51. Chisari F.V. Viruses, immunity, and cancer: lessons from hepatitis B. Am J Pathol 2000, 156(4):1117-1132.