Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon

Food and Chemical Toxicology

Volumn 50, Issue 2, 2012, Pages 95-103

  Hebels, Dennie G A J ^a   Sveje, Kirstine M ^a   de Kok, Marloes C ^a   van Herwijnen, Marcel H M ^a   Kuhnle, Gunter G C ^b,e   Engels, Leopold G J B ^c   Vleugels Simon, Carla B E M ^c   Mares, Wout G N ^c,d   Pierik, Marieke ^d   Masclee, Ad A M ^d   Kleinjans, Jos C S ^a   de Kok, Theo M C M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c Sittard Geleen Heerlen   (Netherlands)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF READING   (United Kingdom)

Author keywords

Colorectal cancer; Endogenous nitrosation; Fecal water genotoxicity; N nitroso compounds; Nitrosamines; Whole genome gene expression

Indexed keywords

NITROSO DERIVATIVE; WATER; WNT PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER RISK; CELL CYCLE; CLINICAL ARTICLE; COLITIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA MODIFICATION; DNA REPAIR; ENTERITIS; FECES ANALYSIS; FEMALE; FOOD INTAKE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; HUMAN GENOME; HUMAN TISSUE; MALE; NITROSATION; NUCLEOSOME; NUCLEOTIDE SEQUENCE; RED MEAT; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS;

ADULT; AGED; COLON; DIET; DNA DAMAGE; FECES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATORY BOWEL DISEASES; MALE; MEAT; MIDDLE AGED; NITROSATION; WATER;

EID: 84855252989     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.038     Document Type: Article

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