Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 39-44

  Zheng, Can Hui ^a   Yang, Hui ^a   Zhang, Meng ^a   Lu, Shi Hai ^a   Shi, Duo ^a   Wang, Juan ^b   Chen, Xiu Hua ^b   Ren, Xiao Hui ^a   Liu, Jia ^a   Lv, Jia Guo ^a   Zhu, Ju ^a   Zhou, You Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

Anti apoptotic Bcl 2 family proteins; Anti tumor agent; Broad spectrum; Inhibitor

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTINEOPLASTIC AGENT; BCL 2 FAMILY PROTEIN INHIBITOR; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; BURKITT LYMPHOMA; CANCER INHIBITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, CHEMICAL; MUTAGENESIS; NITROPHENOLS; PIPERAZINES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFONAMIDES;

EID: 84655163925     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.101     Document Type: Article

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