Effect of Environmental Contaminants on Beta Cell Function

International Journal of Toxicology

Volumn 30, Issue 4, 2011, Pages 410-418

  Makaji, Emilija ^a   Raha, Sandeep ^a   Wade, Michael G ^b   Holloway, Alison C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HEALTH CANADA   (Canada)

Author keywords

benzo a pyrene; beta TC 6 cells; bisphenol A; endoplasmic reticulum stress; insulin; mitochondria; parabens; polyfluorinated compounds

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BENZO[A]PYRENE; ENVIRONMENTAL, INDUSTRIAL AND DOMESTIC CHEMICALS; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 70; INSULIN; METHYL PARABEN; PERFLUOROOCTANOIC ACID; PERFLUOROOCTYLSULFONE; PROPYL PARABEN; SULFONE DERIVATIVE; UNCLASSIFIED DRUG; 4 HYDROXYBENZOIC ACID ESTER; BIOLOGICAL MARKER; FLUOROCARBON; OCTANOIC ACID DERIVATIVE; PHENOL DERIVATIVE;

ANIMAL CELL; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL EXPOSURE; INSULIN RELEASE; LONG TERM EXPOSURE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ARTICLE; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; MITOCHONDRION; POLLUTANT; PREVALENCE; SECRETION;

ANIMALS; BENZO(A)PYRENE; BIOLOGICAL MARKERS; CELL LINE; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL POLLUTANTS; FLUOROCARBONS; INSULIN; INSULIN-SECRETING CELLS; MICE; MITOCHONDRIA; OCTANOIC ACIDS; PARABENS; PHENOLS; PREVALENCE;

EID: 84555217997     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581811405544     Document Type: Review

References (78)

1. Narayan KM, Gregg EW, Fagot-Campagna A, Engelgau MM, Vinicor F. Diabetes–a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Res Clin Pract. 2000; 50 (suppl 2): S77-S84.
2. Harris MI, Flegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care. 1998; 21(4):518-524.
3. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998; 21(9):1414-1431.
4. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001; 414(6865):782-787.
5. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5):1047-1053.
6. Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr. 1996;128(5 Pt 1):608-615.
7. Mainous AG III, Baker R, Koopman RJ, et al. Impact of the population at risk of diabetes on projections of diabetes burden in the United States: an epidemic on the way. Diabetologia. 2007;50(2):934-940.
8. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-cell deficit and increased b-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003; 52(1):102-110.
9. Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia. 2003; 46(1):3-19.
10. Leahy JL. Pathogenesis of type 2 diabetes mellitus. Arch Med Res. 2005; 36(3):197-209.
11. Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol. 2008; 9(3):193-205.
12. Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010; 31(3):364-395.
13. Thomas SE, Dalton LE, Daly ML, Malzer E, Marciniak SJ. Diabetes as a disease of endoplasmic reticulum stress. Diabetes Metab Res Rev. 2010; 26(8):611-621.
14. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006; 116(8):1802-1812.
15. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia. 2002; 45(1):85-96.
16. Yoon KH, Ko SH, Cho JH, et al. Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinl Metab. 2003; 88(5):2300-2308.
17. Longnecker MP, Daniels JL. Environmental contaminants as etiologic factors for diabetes. Environ. Health Perspect. 2001; 109 (suppl 6): 871-876.
18. Henriksen GL, Ketchum NS, Michalek JE, Swaby JA. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology. 1997; 8(3):252-258.
19. Bertazzi PA, Consonni D, Bachetti S, et al. Health effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol. 2001; 153(11):1031-1041.
20. Steenland K, Clavert G, Ketchum N, Michalek J. Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand data. Occup Environ Med. 2001; 58(10):641-648.
21. Vasiliu O, Cameron L, Gardiner J, Deguire P, Karmaus W. Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus. Epidemiology. 2006; 17(4):352-359.
22. Everett CJ, Frithsen IL, Diaz VA, Koopman RJ, Simpson WM Jr, Mainous AG 3rd. Association of a polychlorinated dibenzo-p-dioxin, a polychlorinated biphenyl, and DDT with diabetes in the 1999-2002 National Health and Nutrition Examination Survey. Environ Res. 2007; 103(3):413-418.
23. Lee DH, Lee IK, Jin SH, Jacobs DR Jr. Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetes Care. 2007; 30(3):622-628.
24. Rignell-Hydbom A, Rylander L, Hagmar L. Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus. Hum Exp Toxicol. 2007; 26(5):447-452.
25. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect. 2007; 115(6):876-882.
26. Pereira Filho MA, Pereira LA, Arbex FF, et al. Effect of air pollution on diabetes and cardiovascular diseases in Sao Paulo, Brazil. Braz J Med Biol Res. 2008; 41(6):526-532.
27. Centres of Disease Control. Fourth National Report on Human Exposure to Environmental Chemicals. US Department of Health and Human Services; 2009. http://www.cdc.gov/exposurereport/pdf/Fourth Report.pdf. Accessed December 21, 2010.
28. Canadian Health Measures Survey. Report on Human Biomonitoring of Environmental Chemicals in Canada. 2010. http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/chms-ecms/index-eng.php. Accessed December 20, 2010.
29. Calafat AM, Wong LY, Kuklenyik Z, Reidy JA, Needham LL. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environ Health Perspect. 2007; 115(11):1596-1602.
30. Lang IA, Galloway TS, Scarlett A, et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 2008; 300(11):1303-1310.
31. Lin CY, Chen PC, Lin YC, Lin LY. Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults. Diabetes Care. 2009; 32(4):702-707.
32. Figueiredo PA, Ferreira RM, Appell HJ, Duarte JA. Age-induced morphological, biochemical, and functional alterations in isolated mitochondria from murine skeletal muscle. J Gerontol A Biol Sci Med Sci. 2008; 63(4):350-359.
33. Bruin JE, Petre MA, Raha S, Morrison KM, Gerstein HC, Holloway AC. Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction. PLoS ONE. 2008; 3(10):e3371.
34. Parise G, Phillips SM, Kaczor JJ, Tarnopolsky MA. Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Radic Biol Med. 2005; 39(2):289-295.
35. Fall CHD. Non-industrialised countries and affluence. Br Med Bull. 2001; 60: 33-50.
36. Green A, Hirsch NC, Pramming SK. The changing world demography of type 2 diabetes. Diabetes Metab Res Rev. 2003; 19(1):3-7.
37. Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993; 101(5):378-384.
38. Brook RD, Jerrett M, Brook JR, Bard RL, Finkelstein MM. The relationship between diabetes mellitus and traffic-related air pollution. J Occup Environ Med. 2008; 50(1):32-38.
39. Hutcheon DE, Kantrowitz J, Van Gelder RN, Flynn E. Factors affecting plasma benzo[a]pyrene levels in environmental studies. Environ Res. 1983; 32(1):104-110.
40. Miller KP, Ramos KS. Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons. Drug Metab Rev. 2001; 33(1):1-35.
41. Wells PG, Kim PM, Laposa RR, Nicol CJ, Parman T, Winn LM. Oxidative damage in chemical teratogenesis. Mutat Res. 1997; 396 (1-2): 65-78.
42. Wells PG, McCallum GP, Chen CS, et al. Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits and cancer. Toxicol Sci. 2009; 108(1):4-18.
43. Polzer RJ, Coffing SL, Marcus CB, Park SS, Gelboin HV, Baird WM Inhibition of benzo[a]pyrene metabolism by insulin, FITC-insulin and an FITC-insulin-antibody conjugate in the human hepatoma cell line HepG2. Chem Biol Interact. 1995; 97(3):307-318.
44. Newsholme P, Haber EP, Hirabara SM, et al. Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol. 2007; 583 (Pt 1): 9-24.
45. Laybutt DR, Preston AM, Akerfeldt MC, et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia. 2007; 50(4):752-763.
46. Drews G, Krippeit-Drews P, Dufer M. Oxidative stress and beta-cell dysfunction. Eur J Physiol. 2010; 460(4):703-718.
47. Fromme H, Mosch C, Morovich M, et al. Pre- and postnatal exposure to perfluorinated compounds (PFCs). Envrion Sci Technol. 2010; 44(18):7123-7129.
48. Nelson JW, Hatch EE, Webster TF. Exposure to polyfluoroalkyl chemicals and cholesterol, body weight and insulin resistance in the general U.S. population. Env Health Perspect. 2010; 118(2):197-202.
49. Luebker DJ, York RG, Hansen KJ, Moore JA, Butenhoff JL. Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharmacokinetic parameters. Toxicology. 2005; 215 (1-2): 149-169.
50. Abbott BD, Wolf CJ, Schmid JE, et al. Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha. Toxicol Sci. 2007; 98(2):571-581.
51. Takacs ML, Abbott BD. Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluoroctanoic acid and perfluorooctane sulfonate. Toxicol Sci. 2007; 95(1):108-117.
52. Rosen MB, Schmid JR, Corton JC, et al. Gene expression profiling in wild-type and PPARα-null mice exposed to perfluorooctane sulfonate reveals PPARα-independent effects. PPAR Res. 2010; pii:794739 Epub 2010 Sep 27.
53. Chuang JC, Cha JY, Garney JC, Mirmira RG, Repa JJ. Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol. 2008; 22(10):2353-2363.
54. Francis GA, Fayard E, Picard F, Auwerx J. Nuclear receptors and the control of metabolism. Annu Rev Physiol. 2003; 65: 261-311.
55. Calafat AM, Ye X, Wong LY, Bishop AM, Needham LL. Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006. Env Health Perspect. 2010; 118(5):679-685.
56. Boberg J, Taxvig C, Christiansen S, Hass U. Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol. 2010; 30(2):301-312.
57. Foryst-Ludwig A, Kintscher U. Metabolic impact of estrogen signaling through ERalpha and ERbeta. J Steroid Biochem Mol Biol. 2010; 122 (1-3): 74-81.
58. Boberg J, Metzdorff S, Wortziger R, et al. Impact of diisobutyl phthalate and other PPAR agonists on steroidogeneis and plasma insulin and leptin levels in fetal rats. Toxicology. 2008; 250 (2-3): 75-81.
59. Vandenberg LN, Chahoud I, Heindel JJ, Padmanabhan V, Paumgartten FJ, Schoenfelder G. Urinary, circulating and tissue monitoring studies indicate widespread exposure to bisphenol A. Env Health Perspect. 2010; 118(8):1055-1070.
60. Alonso-Magdalena P, Ropero AB, Soriano S, Quesada I, Nadal A. Bisphenol A: a new diabetogenic factor? Hormones. 2010; 9(2):118-126.
61. Adachi T, Yasuda K, Cori C, et al. Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors. Food Chem Toxicol. 2005; 46(5):713-719.
62. Jitrapakdee S, Wutthisathapornachai A, Wallace JC, MacDonald MJ. Regulation of insulin secretion: role of mitochondrial signaling. Diabetologia. 2010; 53(6):1019-1032.
63. Asahi J, Kamo H, Baba R, et al. Bisphenol A induced endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes. Life Sci. 2010; 87 (13-14): 431-438.
64. Ooe H, Taira T, Iguchi-Ariga SM, Ariga H. Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. Toxicol Sci. 2005; 88(1):114-126.
65. Nakagawa Y, Tayama S. Metabolism and cytotoxicity of bisphenol A and other bisphenols in isolated rat hepatocytes. Arch Toxicol. 2000; 74(2):99-105.
66. Kumar S, Lata K, Mukhopadhyay S, Mukherjee TK. Role of estrogen receptors in pro-oxidative and anti-oxidative actions of estrogens: a perspective. Biochim Biophys Acta. 2010; 1800(10):1127-1135.
67. Balhuizen A, Kumar R, Amisten S, Lundquist I, Salehi A. Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice. Mol Cell Endocrinol. 2010; 320 (1-2): 16-24.
68. Alonso-Magdalena P, Ropero AB, Carrera MP, et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS One. 3(4):e2069.
69. Dong S, Terasaka S, Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut. 2011; 159(1):212-218.
70. Ortmann J, Veit M, Zingg S, et al. Estrogen receptor-alpha but not -beta or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK. J Clin Endocrinol Metab. 2011; 96(1):220-228.
71. Liu S, Le May C, Wong WP, et al. Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009; 58(10):2292-2302.
72. Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004; 11(4):372-380.
73. Hooper PL. Insulin signaling, GSK3, heat shock proteins and the natural history of type 2 diabetes mellitus: a hypothesis. Metab Syndr Relat Disord. 2007; 5(3):220-230.
74. Kavanagh K, Zhang L, Wagner J. Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. Cell Stress Chaperones. 2009; 14(3):291-299.
75. Cribb AE, Peyrou M, Muruganandan S, Schneider L. The endoplasmic reticulum in xenobiotic toxicity. Drug Metab Rev. 2005; 37(3):405-442.
76. Matsuda T, Kido Y, Ashara S, et al. Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice. J Clin Invest. 2010; 120(1):115-126.
77. Pan Z, Erkan M, Streit S, Friess H, Kleeff J. Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells. Int J Oncol. 2009; 35(4):823-828.
78. Wang M, Wang P, Peng JL, et al. The altered expression of glucose-regulated proteins 78 in different phase of streptozotocin-affected pancreatic beta cells. Cell Stress Chaperones. 2009; 14(1):43-48.