Pre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)

Environmental Science and Technology

Volumn 44, Issue 18, 2010, Pages 7123-7129

  Fromme, Hermann ^a   Mosch, Christine ^a   Morovitz, Maria ^b   Alba Alejandre, Irene ^b   Boehmer, Sigrun ^a   Kiranoglu, Mandy ^a   Faber, Fabienne ^c   Hannibal, Iris ^c   Genzel Boroviczény, Orsolya ^c   Koletzko, Berthold ^c   Völkel, Wolfgang ^a  

^a Bavarian Health and Food Safety Authority   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BODY BURDEN; BREAST MILK; BREAST MILK SAMPLES; CORD BLOOD; CORD SERUM; GERMANY; LOW LEVEL; MATERNAL SERUM; PERFLUORINATED COMPOUNDS; PERFLUOROOCTANE SULFONATES; PERFLUOROOCTANOIC ACID; POSTNATAL EXPOSURE; TIME POINTS;

BLOOD;

PERFLUORO COMPOUND; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID;

BIOACCUMULATION; HEALTH IMPACT; MILK; ORGANOFLUORINE; POLLUTION EXPOSURE; PREGNANCY; SERUM;

ADULT; ARTICLE; BREAST MILK; CHILD; DELIVERY; FEMALE; GERMANY; HUMAN; HUMAN EXPERIMENT; INFANT; MATERNAL BLOOD; MATERNAL SERUM; NORMAL HUMAN; POSTNATAL DEVELOPMENT; PREGNANCY; PRENATAL EXPOSURE; UMBILICAL CORD BLOOD;

ADULT; ALKANESULFONIC ACIDS; ENVIRONMENTAL MONITORING; FEMALE; FETAL BLOOD; FLUOROCARBONS; HUMANS; INFANT FORMULA; INFANT, NEWBORN; MILK, HUMAN; OCTANOIC ACIDS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; YOUNG ADULT;

EID: 77956508145     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es101184f     Document Type: Article

References (54)

1. Hekster, F. M.; Laane, R. W.; de Voogt, P. Environmental and toxicity effects of perfluoroalkylated substances Rev. Environ. Contam. Toxicol. 2003, 179, 99-121
2. Lehmler, H.-J. Synthesis of environmentally relevant fluorinated surfactants-a review Chemosphere 2005, 58, 1471-1496
3. Organization for Economic Co-operation and Development. Results of Survey on Production and Use of PFOS, PFAS and PFOA, Related Substances and Products/ Mixtures Containing These Substances; ENV/JM/MONO(2005)1; Paris 2005.
4. Danish Agency for Environmental Protection. Survey and Environmental/Health Assessment of Fluorinated Substances in Impregnated Consumer Products and Impregnating Agents; Report No. 99; 2008.
5. Giesy, J. P.; Kannan, K. Global distribution of perfluoroctane sulfonate in wildlife Environ. Sci. Technol. 2001, 35, 1339-1342
6. Yamashita, N.; Taniyasu, S.; Petrick, G.; Wei, S.; Gamo, T.; Lam, P. K.; Kannan, K. Perfluorinated acids as novel chemical tracers of global circulation of ocean water Chemosphere 2008, 70, 1247-1255
7. Kennedy, G. L.; Butenhoff, J. L.; Olsen, G. W.; OâConnor, J. C.; Seacat, A. M.; Perkins, R. G.; Biegel, L. B.; Murphy, S. R.; Farrar, D. G. The toxicology of perfluorooctanoate Crit. Rev. Toxicol. 2004, 34, 351-384
8. U.S. EPA. Draft risk assessment of the potential human health effects associated with exposure to perfluorooctanoic acid and its salts. OPPT review, 2005, http://www.epa.gov/oppt/pfoa/pubs/pfoarisk.pdf; accessed January 4, 2008.
9. Lau, C.; Anitole, K.; Hodes, C.; Lai, D.; Pfahles-Hutchens, A.; Seed, J. Perfluoroalkyl acids: a review of monitoring and toxicological findings Toxicol. Sci. 2007, 99, 366-394
10. Andersen, M. E.; Butenhoff, J. L.; Chang, S. C.; Farrar, D. G.; Kennedy, G. L.; Lau, C.; Olsen, G. W.; Seed, J.; Wallace, K. B. Perfluoroalkyl acids and related chemistries-toxicokinetics and modes of action Toxicol. Sci. 2008, 102, 3-14
11. Fei, C.; McLaughlin, J. K.; Lipworth, L.; Olsen, J. Maternal levels of perfluorinated chemicals and subfecundity Hum. Reprod. 2009, 24, 1200-1205
12. Joensen, U. N.; Bossi, R.; Leffers, H.; Jensen, A. A.; Skakkebaek, N. E.; Jørgensen, N. Do Perfluoroalkyl Compounds Impair Human Semen Quality? Environ. Health Perspect. 2009, 117, 923-927
13. Fei, C.; McLaughlin, J. K.; Lipworth, L.; Olsen, J. Prenatal exposure to Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy Environ. Health Perspect. 2008, 116, 1391-1395
14. Fei, C.; McLaughlin, J. K.; Tarone, R. E.; Olsen, J. Perfluorinated chemicals and fetal growth: A study within the Danish National Birth Cohort Environ. Health Perspect. 2007, 115, 1677-1682
15. Washino, N.; Saijo, Y.; Sasaki, S.; Kato, S.; Ban, S.; Konishi, K.; Ito, R.; Nakata, A.; Iwasaki, Y.; Saito, K.; Nakazawa, H.; Kishi, R. Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth Environ. Health Perspect. 2009, 117, 660-667
16. Nolan, L. A.; Nolan, J. M.; Shofer, F. S.; Rodway, N. V.; Emmett, E. A. The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water Reprod. Toxicol. 2009, 27, 231-238
17. Nolan, L. A.; Nolan, J. M.; Shofer, F. S.; Rodway, N. V.; Emmett, E. A. Congenital anomalies, labor/delivery complications, maternal risk factors and their relationship with perfluorooctanoic acid (PFOA)-contaminated public drinking water Reprod. Toxicol. 2010, 29, 147-155
18. Apelberg, B. J.; Goldman, L. R.; Calafat, A. M.; Herbstmann, J. B.; Kuklenyik, Z.; Heidler, J.; Needham, L. L.; Halden, R. U.; Witter, F. R. Derterminants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland Environ. Sci. Technol. 2007, 41, 3891-3897
19. Nelson, J. W.; Hatch, E. E.; Webster, T. F. Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population Environ. Health Perspect. 2010, 118, 197-202
20. European Union. Directive 2006/122/EC of the European Parliament and of the Council of 12 December 2006 amending for the 30th time Council Directive 76/769/EEC. Official Journal of the European Union L 372/32, 27.12.2006.
21. Fromme, H.; Tittlemier, S. A.; Völkel, W.; Wilhelm, M.; Twardella, D. Perfluorinated compounds-Exposure assessment for the general population in western countries Int. J. Hyg. Environ. Health 2009, 212, 239-270
22. Kannan, K.; Corsolini, S.; Falandysz, J.; Fillmann, K.; Kumar, K. S.; Loganathan, B. G.; Mohd, M. A.; Olivero, J.; Van Wouwe, N.; Yang, J. H.; Aldous, K. M. Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries Environ. Sci. Technol. 2004, 38, 4489-4495
23. Brede, E.; Wilhelma, M.; Göen, T.; M; uller, J.; Rauchfuss, K.; Kraft, M.; Hölzer, J. Two-year follow-up biomonitoring pilot study of residentsâ and controlsâ PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany Int. J. Hyg. Environ. Health 2010, 213, 217-223
24. Calafat, A. M.; Kuklenyik, Z.; Reidy, J. A.; Caudill, S. P.; Tully, J. S.; Needdham, L. L. Serum concentrations of 11 polyfluoroalkyl compounds in the U.S. population: data from the national health and nutrition examination survey (NHANES) Environ. Sci. Technol. 2007, 41, 2237-2242
25. Olsen, G. W.; Church, T. R.; Hansen, K. J.; Burris, J. M.; Butenhoff, J. L.; Mandel, J. H.; Zobel, L. R. Quantitative evaluation of perfluorooctane sulfonate (PFOS) and other fluorochemicals in the serum of children J. Childrenâs Health 2004, 2, 53-76
26. Hölzer, J.; Midasch, O.; Rauchfuss, K.; Kraft, M.; Reupert, R.; Angerer, J.; Kleeschulte, P.; Marschall, N.; Wilhelm, M. Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate (PFOA)-contaminated drinking water Environ. Health Perspect. 2008, 116, 651-657
27. Kato, K.; Calafat, A. M.; Wong, L. Y.; Wanigatunga, A. A.; Caudill, S. P.; Needham, L. L. Polyfluoroalkyl compounds in pooled sera from children participating in the National Health and Nutrition Examination Survey 2001-2002 Environ. Sci. Technol. 2009, 43, 2641-2647
28. Fromme, H.; Völkel, W.; Genzel-Boroviczény, O.; Demmelmair, H.; Gebauer, C.; Koletzko, B.; Raab, U.; Twardella, D. Internal exposure of newborns to perfluorinated substances and estimation of relevant intake pathways Umwelt. Forsch. Prax. 2007, 12, 319 [in German]
29. Haug, L. S.; Thomsen, C.; Becher, G. Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples Environ. Sci. Technol. 2009, 43, 2131-2136
30. Toms, L. M.; Calafat, A. M.; Kato, K.; Thompson, J.; Harden, F.; Hobson, P.; Sjödin, A.; Mueller, J. F. Polyfluoroalkyl chemicals in pooled blood serum from infants, children, and adults in Australia Environ. Sci. Technol. 2009, 43, 4194-4199
31. Hinderliter, P. M.; Mylchreest, E.; Gannon, S. A.; Butenhoff, J. L.; Kennedy, G. L. Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats Toxicology 2005, 211, 139-148
32. Tittlemier, S. A.; Ryan, J. J.; Van Oostdam, J. Presence of anionic perfluorinated organic compounds in serum collected from northern Canadian populations Organohalogen Compd. 2004, 66, 4009-4014
33. Inoue, K.; Okada, F.; Ito, R.; Kato, S.; Sasaki, S.; Nakajima, S.; Uno, A.; Saijo, Y.; Sata, F.; Yoshimura, Y.; Kishi, R.; Nakazawa, H. Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy Environ. Health Perspect. 2004, 112, 1204-1207
34. Midasch, O.; Drexler, H.; Hart, N.; Beckmann, M. W.; Angerer, J. Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study Int. Arch. Occup. Environ. Health 2007, 80, 643-648
35. Apelberg, B. J.; Witter, F. R.; Herbstmann, J. B.; Calafat, A. M.; Halden, R. U.; Needham, L. L.; Goldman, L. R. Cord serum concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in relation to weight and size at birth Environ. Health Perspect. 2007, 115, 1670-1676
36. Monroy, R.; Morrison, K.; Teo, K.; Atkinson, S.; Kubwabo, C.; Steward, B.; Foster, W. G. Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples Environ. Res. 2008, 108, 56-62
37. Kuklenyik, Z.; Reich, J. A.; Tully, J. S.; Needham, L. L.; Calafat, A. M. Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk Environ. Sci. Technol. 2004, 38, 3698-3704
38. So, M. K.; Taniyasu, S.; Yamashita, N.; Giesy, J. P.; Zheng, J.; Fang, Z.; Im, S. H.; Lam, P. K. S. Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan Environ. Sci. Technol. 2006, 40, 2924-2929
39. Nakata, A.; Katsumata, T.; Iwasaki, Y.; Ito, R.; Saito, K.; Izumi, S.; Makino, T.; Kishi, R.; Nakazawa, H. Measurement of perfluorinated compounds in human milk and house dust Organohalogen Compd. 2007, 69, 2844-2846
40. Tao, L.; Ma, J.; Kunisue, T.; Libelo, E. L.; Tanabe, S.; Kannan, K. Perfluorinated compounds in human breast milk from several Asian countries, and in infant formula and dairy milk from the United States Environ. Sci. Technol. 2008, 42, 8597-8602
41. Tao, L.; Kannan, K.; Wong, C. M.; Arcaro, K. F.; Butenhoff, J. L. Perfluorinated compounds in human milk from Massachusetts, U.S.A Environ. Sci. Technol. 2008, 42, 3096-3101
42. von Ehrenstein, O. S.; Fenton, S. E.; Kato, K.; Kuklenyik, Z.; Calafat, A. M.; Hines, E. P. Polyfluoroalkyl chemicals in the serum and milk of breastfeeding women Reprod. Toxicol. 2009, 27, 239-245
43. Kärrman, A.; Ericson, I.; van Bavel, B.; Darnerud, P. O.; Aune, M.; Glynn, A.; Lignell, S.; Lindström, G. Exposure of perfluorinated chemicals through lactation- levels of matched human milk and serum and temporal trend, 1996-2004, in Sweden Environ. Health Perspect. 2007, 115, 226-230
44. Kärrman, A.; Domingo, J. L.; Llebaria, X.; Nadal, M.; Bigas, E.; van Bavel, B.; Lindström, G. Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples Environ. Sci. Pollut. Res. 2010, 17, 750-758
45. Völkel, W.; Genzel-Boroviczény, O.; Demmelmair, H.; Gebauer, C.; Koletzko, B.; Twardella, D.; Raab, U.; Fromme, H. Perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) in human breast milk: results of a pilot study Int. J. Hyg. Environ. Health 2008, 211, 440-446
46. Bernsmann, T.; Fürst, P. Determination of perfluorinated compounds in human milk Organohalogen Compd. 2008, 70, 718-721
47. Mosch, C.; Kiranoglu, M.; Fromme, H.; Völkel, W. Simultaneous quantitation of perfluoroalkyl acids in human serum and breast milk using on-line sample preparation by HPLC column switching coupled to ESI-MS/MS J. Chromatogr. B 2010, doi: 10.1016/j.jchromb.2010.01.015
48. Fromme, H.; Midasch, O.; Twardella, D.; Angerer, J.; Boehmer, S.; Liebl, B. Occurrence of perfluorinated substances in an adult German population in southern Bavaria Int. Arch. Occup. Environ. Health 2007, 80, 313-319
49. Calafat, A. M.; Wong, L. Y.; Kuklenyik, Z.; Reidy, J. A.; Needham, L. L. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000 Environ. Health Perspect. 2007, 115, 1596-1602
50. Olsen, G. W.; Mair, D. C.; Church, T. R.; Ellefson, M. E.; Reagen, W. K.; Boyd, T. M.; Herron, R. M.; Medhdizadehkashi, Z.; Nobiletti, J. B.; Rios, J. A.; Butenhoff, J. L.; Zobel, L. R. Decline in perfluoroctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors Environ. Sci. Technol. 2008, 42, 4989-4995
51. Wilhelm, M.; Hölzer, J.; Dobler, L.; Rauchfuss, K.; Midasch, O.; Kraft, M.; Angerer, J.; Wiesmüller, G. Preliminary observations on perfluorinated compounds in plasma samples (1977-2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water Int. J. Hyg. Environ. Health 2009, 212, 142-145
52. Spliethoff, H. M.; Bloom, M. S.; Vena, J.; Sorce, J.; Aldous, K. M.; Eadon, G. Use of newborn screening program blood spots for exposure assessment: declining levels of perfluorinated compounds in New York State infants Environ. Res. 2008, 108, 340-347
53. Kato, K.; Wanigatunga, A. A.; Needham, L. L.; Calafat, A. M. Analysis of blood spots for polyfluoroalkyl chemicals Anal. Chim. Acta 2009, 659, 51-55
54. Völkel, W.; Mosch, C.; Kiranoglu, M.; Verdugo-Raab, U.; Fromme, H. Perfluorinated compounds (PFC) in human breast milk Toxicol. Lett. 2009, 1895, S151-S152