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Volumn 125, Issue 1, 2012, Pages 219-232

Standardized extracts of Bacopa monniera protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways

Author keywords

Bacopa monniera; Complex I; Oxidative stress; Parkinson's disease; Redox regulation

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BACOPA MONNIERI EXTRACT; GLUTATHIONE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PARAQUAT; PROTEASOME; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; TRANSCRIPTION FACTOR NRF2;

EID: 84555195332     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr255     Document Type: Article
Times cited : (38)

References (80)
  • 1
    • 60349100004 scopus 로고    scopus 로고
    • Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson's disease
    • Alladi, P. A., Mahadevan, A., Yasha, T. C., Raju, T. R., Shankar, S. K., and Muthane, U. (2009). Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson's disease. Neuroscience 159, 236-245.
    • (2009) Neuroscience , vol.159 , pp. 236-245
    • Alladi, P.A.1    Mahadevan, A.2    Yasha, T.C.3    Raju, T.R.4    Shankar, S.K.5    Muthane, U.6
  • 2
    • 25144497185 scopus 로고    scopus 로고
    • Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats
    • Anbarasi, K., Vani, G., and Devi, C. S. (2005). Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats. J. Environ. Pathol. Toxicol. Oncol. 24, 225-234.
    • (2005) J. Environ. Pathol. Toxicol. Oncol. , vol.24 , pp. 225-234
    • Anbarasi, K.1    Vani, G.2    Devi, C.S.3
  • 3
    • 0030008052 scopus 로고    scopus 로고
    • Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
    • Bindokas, V. P., Jordan, J., Lee, C. C., and Miller, R. J. (1996). Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine. J. Neurosci. 16, 1324-1336.
    • (1996) J. Neurosci. , vol.16 , pp. 1324-1336
    • Bindokas, V.P.1    Jordan, J.2    Lee, C.C.3    Miller, R.J.4
  • 4
    • 0035231595 scopus 로고    scopus 로고
    • Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues
    • Birch-Machin, M. A., and Turnbull, D. M. (2001). Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues. Methods Cell Biol. 65, 97-117.
    • (2001) Methods Cell Biol , vol.65 , pp. 97-117
    • Birch-Machin, M.A.1    Turnbull, D.M.2
  • 5
    • 33947217828 scopus 로고    scopus 로고
    • Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes
    • Bishop, G. M., Dringen, R., and Robinson, S. R. (2007). Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes. Free Radic. Biol. Med. 42, 1222-1230.
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 1222-1230
    • Bishop, G.M.1    Dringen, R.2    Robinson, S.R.3
  • 6
    • 17644375851 scopus 로고    scopus 로고
    • Toxicity of redox cycling pesticides in primary mesencephalic cultures
    • Bonneh-Barkay, D., Langston, W. J., and Di Monte, D. A. (2005). Toxicity of redox cycling pesticides in primary mesencephalic cultures. Antioxid. Redox Signal. 7, 649-653.
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 649-653
    • Bonneh-Barkay, D.1    Langston, W.J.2    Di Monte, D.A.3
  • 8
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L. C. (2002). The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 9
    • 34347242465 scopus 로고    scopus 로고
    • Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain
    • Castello, P. R., Drechsel, D. A., and Patel, M. (2007). Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J. Biol. Chem. 282, 14186-14193.
    • (2007) J. Biol. Chem. , vol.282 , pp. 14186-14193
    • Castello, P.R.1    Drechsel, D.A.2    Patel, M.3
  • 11
    • 22044448363 scopus 로고    scopus 로고
    • Melatonin protects against MPTP/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro
    • Chen, L. J., Gao, Y. Q., Li, X. J., Shen, D. H., and Sun, F. Y. (2005). Melatonin protects against MPTP/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro. J. Pineal Res. 39, 34-42.
    • (2005) J. Pineal Res. , vol.39 , pp. 34-42
    • Chen, L.J.1    Gao, Y.Q.2    Li, X.J.3    Shen, D.H.4    Sun, F.Y.5
  • 12
    • 0031870668 scopus 로고    scopus 로고
    • Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice
    • Cheng, W. H., Ho, Y. S., Valentine, B. A., Ross, D. A., Combs, G. F. J., and Lei, X. G. (1998). Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice. J. Nutr. 128, 1070-1076.
    • (1998) J. Nutr. , vol.128 , pp. 1070-1076
    • Cheng, W.H.1    Ho, Y.S.2    Valentine, B.A.3    Ross, D.A.4    Combs, G.F.J.5    Lei, X.G.6
  • 13
    • 33749047253 scopus 로고    scopus 로고
    • Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: Implications for Parkinson's disease
    • Chinta, S. J., and Andersen, J. K. (2006). Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: Implications for Parkinson's disease. Free Radic. Biol. Med. 41, 1442-1448.
    • (2006) Free Radic. Biol. Med. , vol.41 , pp. 1442-1448
    • Chinta, S.J.1    Andersen, J.K.2
  • 14
    • 23844529468 scopus 로고    scopus 로고
    • Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity
    • Cleren, C., Calingasan, N. Y., Chen, J., and Beal, M. F. (2005). Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. J. Neurochem. 94, 995-1004.
    • (2005) J. Neurochem. , vol.94 , pp. 995-1004
    • Cleren, C.1    Calingasan, N.Y.2    Chen, J.3    Beal, M.F.4
  • 15
    • 40049088820 scopus 로고    scopus 로고
    • The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity
    • Copple, I. M., Goldring, C. E., Kitteringham, N. R., and Park, B. K. (2008). The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity. Toxicology 246, 24-33.
    • (2008) Toxicology , vol.246 , pp. 24-33
    • Copple, I.M.1    Goldring, C.E.2    Kitteringham, N.R.3    Park, B.K.4
  • 16
    • 65549095883 scopus 로고    scopus 로고
    • The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
    • Cuadrado, A., Moreno-Murciano, P., and Pedraza-Chaverri, J. (2009). The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Expert Opin. Ther. Targets 13, 319-329.
    • (2009) Expert Opin. Ther. Targets , vol.13 , pp. 319-329
    • Cuadrado, A.1    Moreno-Murciano, P.2    Pedraza-Chaverri, J.3
  • 19
    • 74949117647 scopus 로고    scopus 로고
    • Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism
    • Drechsel, D. A., and Patel, M. (2009). Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism. Toxicol. Sci. 112, 427-434.
    • (2009) Toxicol. Sci. , vol.112 , pp. 427-434
    • Drechsel, D.A.1    Patel, M.2
  • 20
    • 34247269064 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons
    • Drechsel, D. A., Liang, L. P., and Patel, M. (2007). 1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons. Toxicol. Appl. Pharmacol. 220, 341-348.
    • (2007) Toxicol. Appl. Pharmacol. , vol.220 , pp. 341-348
    • Drechsel, D.A.1    Liang, L.P.2    Patel, M.3
  • 21
    • 70350031561 scopus 로고    scopus 로고
    • Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator
    • Endo, R., Saito, T., Asada, A., Kawahara, H., Ohshima, T., and Hisanaga, S. (2009). Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator. J. Biol. Chem. 284, 26029-26039.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26029-26039
    • Endo, R.1    Saito, T.2    Asada, A.3    Kawahara, H.4    Ohshima, T.5    Hisanaga, S.6
  • 22
    • 0021288821 scopus 로고
    • Assays of glutathione peroxidase
    • Flohé, L., and Günzler, W. A. (1984). Assays of glutathione peroxidase. Methods Enzymol. 105, 114-121.
    • (1984) Methods Enzymol , vol.105 , pp. 114-121
    • Flohé, L.1    Günzler, W.A.2
  • 23
    • 65549127731 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways
    • Gao, Q. G., Chen, W. F., Xie, J. X., and Wong, M. S. (2009). Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. J. Neurochem. 109, 1338-1347.
    • (2009) J. Neurochem. , vol.109 , pp. 1338-1347
    • Gao, Q.G.1    Chen, W.F.2    Xie, J.X.3    Wong, M.S.4
  • 24
    • 79957490305 scopus 로고    scopus 로고
    • Synergy between glutathione peroxidase-1 and astrocytic growth factors suppresses free radical generation and protects dopaminergic neurons against 6-hydroxydopamine
    • Gardaneh, M., Gholami, M., and Maghsoudi, N. (2011). Synergy between glutathione peroxidase-1 and astrocytic growth factors suppresses free radical generation and protects dopaminergic neurons against 6-hydroxydopamine. Rejuvenation Res. 14, 195-204.
    • (2011) Rejuvenation Res , vol.14 , pp. 195-204
    • Gardaneh, M.1    Gholami, M.2    Maghsoudi, N.3
  • 25
    • 79954575965 scopus 로고    scopus 로고
    • Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons
    • Garrido, M., Tereshchenko, Y., Zhevtsova, Z., Taschenberger, G., Bähr, M., and Kügler, S. (2011). Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons. Acta Neuropathol. 121, 475-485.
    • (2011) Acta Neuropathol , vol.121 , pp. 475-485
    • Garrido, M.1    Tereshchenko, Y.2    Zhevtsova, Z.3    Taschenberger, G.4    Bähr, M.5    Kügler, S.6
  • 26
    • 0018095085 scopus 로고
    • Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
    • Graham, D. G. (1978). Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol. Pharmacol. 14, 633-643.
    • (1978) Mol. Pharmacol. , vol.14 , pp. 633-643
    • Graham, D.G.1
  • 27
    • 0033231162 scopus 로고    scopus 로고
    • Biologic and pharmacologic regulation of mammalian glutathione synthesis
    • Griffith, W. O. (1999). Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic. Biol. Med. 27, 922-935.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 922-935
    • Griffith, W.O.1
  • 28
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig, H. W., Pabst, J. M., and Jakoby, B. W. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7139
    • Habig, H.W.1    Pabst, J.M.2    Jakoby, B.W.3
  • 30
    • 76949108822 scopus 로고    scopus 로고
    • The role of dopamine oxidation in mitochondrial dysfunction: Implications for Parkinson's disease
    • Hastings, T. G. (2009). The role of dopamine oxidation in mitochondrial dysfunction: Implications for Parkinson's disease. J. Bioenerg. Biomembr. 41, 469-472.
    • (2009) J. Bioenerg. Biomembr. , vol.41 , pp. 469-472
    • Hastings, T.G.1
  • 31
    • 44549088952 scopus 로고    scopus 로고
    • Parkinson's disease and pesticides: A toxicological perspective
    • Hatcher, J. M., Pennell, K. D., and Miller, G. W. (2008). Parkinson's disease and pesticides: A toxicological perspective. Trends Pharmacol. Sci. 29, 322-329.
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 322-329
    • Hatcher, J.M.1    Pennell, K.D.2    Miller, G.W.3
  • 32
    • 62149137729 scopus 로고    scopus 로고
    • Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment
    • Hota, S. K., Barhwal, K., Baitharu, I., Prasad, D., Singh, S. B., and Ilavazhagan, G. (2009). Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment. Neurobiol. Dis. 34, 23-39.
    • (2009) Neurobiol. Dis. , vol.34 , pp. 23-39
    • Hota, S.K.1    Barhwal, K.2    Baitharu, I.3    Prasad, D.4    Singh, S.B.5    Ilavazhagan, G.6
  • 33
    • 0043204252 scopus 로고    scopus 로고
    • Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
    • Howes, M. J., and Houghton, P. J. (2003). Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol. Biochem. Behav. 75, 513-527.
    • (2003) Pharmacol. Biochem. Behav. , vol.75 , pp. 513-527
    • Howes, M.J.1    Houghton, P.J.2
  • 34
    • 77955516215 scopus 로고    scopus 로고
    • Fibroblast growth factor 9 upregulates heme oxygenase-1 and gamma glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity
    • Huang, J. Y., and Chuang, J. I. (2010). Fibroblast growth factor 9 upregulates heme oxygenase-1 and gamma glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity. Free Radic. Biol. Med. 49, 1099-1108.
    • (2010) Free Radic. Biol. Med. , vol.49 , pp. 1099-1108
    • Huang, J.Y.1    Chuang, J.I.2
  • 35
    • 70449535513 scopus 로고    scopus 로고
    • Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells
    • Hwang, P. Y., and Jeong, G. H. (2010). Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells. Toxicol. Appl. Pharmacol. 242, 18-28.
    • (2010) Toxicol. Appl. Pharmacol. , vol.242 , pp. 18-28
    • Hwang, P.Y.1    Jeong, G.H.2
  • 36
    • 0036368596 scopus 로고    scopus 로고
    • Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities
    • Ikeyama, S., Kokkonen, G., Shack, S., Wang, X. T., and Holbrook, N. J. (2002). Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J. 16, 114-116.
    • (2002) FASEB J , vol.16 , pp. 114-116
    • Ikeyama, S.1    Kokkonen, G.2    Shack, S.3    Wang, X.T.4    Holbrook, N.J.5
  • 37
    • 0027185713 scopus 로고
    • Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease
    • Jenner, P. (1993). Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta Neurol. Scand. 146, 6-13.
    • (1993) Acta Neurol. Scand. , vol.146 , pp. 6-13
    • Jenner, P.1
  • 38
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • Jenner, P. (1998). Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov. Disord. 13, 24-34.
    • (1998) Mov. Disord. , vol.13 , pp. 24-34
    • Jenner, P.1
  • 39
    • 11144232015 scopus 로고    scopus 로고
    • Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter
    • Jiang, H., Jiang, Q., and Feng, J. (2004). Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. J. Biol. Chem. 279, 54380-54386.
    • (2004) J. Biol. Chem. , vol.279 , pp. 54380-54386
    • Jiang, H.1    Jiang, Q.2    Feng, J.3
  • 40
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler, W. T., Wakabayashi, N., and Biswal, S. N. (2007). Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47, 89-116.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89-116
    • Kensler, W.T.1    Wakabayashi, N.2    Biswal, S.N.3
  • 41
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease
    • Lang, A. E., and Lozano, A. M. (1998). Parkinson's disease. N. Engl. J. Med. 339, 1044-1053.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 42
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston, J. W., Ballard, P., Tetrud, J. W., and Irwin, I. (1983). Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 43
    • 0141621061 scopus 로고    scopus 로고
    • NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
    • Lee, J. M., Shih, A. Y., Murphy, T. H., and Johnson, J. A. (2003). NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J. Biol. Chem. 278, 37948-37956.
    • (2003) J. Biol. Chem. , vol.278 , pp. 37948-37956
    • Lee, J.M.1    Shih, A.Y.2    Murphy, T.H.3    Johnson, J.A.4
  • 44
    • 0034624017 scopus 로고    scopus 로고
    • The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation A novel mechanism of toxicity
    • Lotharius, J., and O'Malley, K. L. (2000). The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J. Biol. Chem. 275, 38581-38588.
    • (2000) J. Biol. Chem. , vol.275 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.L.2
  • 45
    • 0037380982 scopus 로고    scopus 로고
    • Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration
    • McCormack, A. L., and Di Monte, D. A. (2003). Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration. J. Neurochem. 85, 82-86.
    • (2003) J. Neurochem. , vol.85 , pp. 82-86
    • McCormack, A.L.1    Di Monte, D.A.2
  • 47
    • 79955117911 scopus 로고    scopus 로고
    • Biochemical and toxicological evidence of neurological effects of pesticides: The example of Parkinson's disease
    • Moretto, A., and Colosio, C. (2011). Biochemical and toxicological evidence of neurological effects of pesticides: The example of Parkinson's disease. Neurotoxicology 32, 383-391.
    • (2011) Neurotoxicology , vol.32 , pp. 383-391
    • Moretto, A.1    Colosio, C.2
  • 49
    • 0031914408 scopus 로고    scopus 로고
    • Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India
    • Muthane, U., Yasha, T. C., and Shankar, S. K. (1998). Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Ann. Neurol. 43, 283-287.
    • (1998) Ann. Neurol. , vol.43 , pp. 283-287
    • Muthane, U.1    Yasha, T.C.2    Shankar, S.K.3
  • 50
    • 0034942970 scopus 로고    scopus 로고
    • The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects
    • Nathan, P. J., Clarke, J., Lloyd, J., Hutchison, C. W., Downey, L., and Stough, C. (2001). The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects. Hum. Psychopharmacol. 16, 345-351.
    • (2001) Hum. Psychopharmacol. , vol.16 , pp. 345-351
    • Nathan, P.J.1    Clarke, J.2    Lloyd, J.3    Hutchison, C.W.4    Downey, L.5    Stough, C.6
  • 52
    • 18844394828 scopus 로고    scopus 로고
    • Pathogenesis of nigral cell death in Parkinson's disease
    • Przedborski, S. (2005). Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism Relat. Disord. 11, S3-S7.
    • (2005) Parkinsonism Relat. Disord. , vol.11
    • Przedborski, S.1
  • 53
    • 10244222286 scopus 로고    scopus 로고
    • MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    • Przedborski, S., Tieu, K., Perier, C., and Vila, M. (2004). MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J. Bioenerg. Biomembr. 36, 375-379.
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 375-379
    • Przedborski, S.1    Tieu, K.2    Perier, C.3    Vila, M.4
  • 54
    • 0023001744 scopus 로고
    • Energy-dependent uptake of Nmethyl-4-phenylpyridinium the neurotoxic metabolite of 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine, by mitochondria
    • Ramsay, R. R., and Singer, T. P. (1986). Energy-dependent uptake of Nmethyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1, 2, 3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 261, 7585-7587.
    • (1986) J. Biol. Chem. , vol.261 , pp. 7585-7587
    • Ramsay, R.R.1    Singer, T.P.2
  • 56
    • 29144471237 scopus 로고    scopus 로고
    • Lentivirus-mediated expression of glutathione peroxidase: Neuroprotection in murine models of Parkinson's disease
    • Ridet, J. L., Bensadoun, J. C., Déglon, N., Aebischer, P., and Zurn, A. D. (2006). Lentivirus-mediated expression of glutathione peroxidase: Neuroprotection in murine models of Parkinson's disease. Neurobiol. Dis. 21, 29-34.
    • (2006) Neurobiol. Dis. , vol.21 , pp. 29-34
    • Ridet, J.L.1    Bensadoun, J.C.2    Déglon, N.3    Aebischer, P.4    Zurn, A.D.5
  • 58
    • 16344365853 scopus 로고    scopus 로고
    • Bacopa monniera, a reputed nootropic plant: An overview
    • Russo, A., and Borrelli, F. (2005). Bacopa monniera, a reputed nootropic plant: An overview. Phytomedicine 12, 305-317.
    • (2005) Phytomedicine , vol.12 , pp. 305-317
    • Russo, A.1    Borrelli, F.2
  • 59
    • 0034746573 scopus 로고    scopus 로고
    • Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals
    • Salinas, M., Martín, D., Alvarez, A., and Cuadrado, A. (2001). Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Mol. Cell. Neurosci. 17, 67-77.
    • (2001) Mol. Cell. Neurosci. , vol.17 , pp. 67-77
    • Salinas, M.1    Martín, D.2    Alvarez, A.3    Cuadrado, A.4
  • 62
    • 21844446870 scopus 로고    scopus 로고
    • Glutathione redox state regulates mitochondrial reactive oxygen production
    • Shen, D., Dalton, T. P., Nebert, D. W., and Shertzer, H. G. (2005). Glutathione redox state regulates mitochondrial reactive oxygen production. J. Biol. Chem. 280, 25305-25312.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25305-25312
    • Shen, D.1    Dalton, T.P.2    Nebert, D.W.3    Shertzer, H.G.4
  • 65
  • 66
    • 0020055896 scopus 로고
    • Effect of Bacopa monniera Linn (Brahmi) extract on avoidance responses in rat
    • Singh, H. K., and Dhawan, B. N. (1982). Effect of Bacopa monniera Linn. (Brahmi) extract on avoidance responses in rat. J. Ethnopharmacol. 5, 205-214.
    • (1982) J. Ethnopharmacol. , vol.5 , pp. 205-214
    • Singh, H.K.1    Dhawan, B.N.2
  • 67
    • 77954982065 scopus 로고    scopus 로고
    • Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the bacopa monniera extract: Potential implication in Alzheimer's disease
    • Singh, M., Murthy, V., and Ramassamy, C. (2010). Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the bacopa monniera extract: Potential implication in Alzheimer's disease. J. Alzheimers Dis. 21, 229-247.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 229-247
    • Singh, M.1    Murthy, V.2    Ramassamy, C.3
  • 68
  • 70
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes agerelated loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh, J. H., Shenvi, S. V., Dixon, B. M., Liu, H., Jaiswal, A. K., Liu, R. M., and Hagen, T. M. (2004). Decline in transcriptional activity of Nrf2 causes agerelated loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl. Acad. Sci. U.S.A. 101, 3381-3386.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3    Liu, H.4    Jaiswal, A.K.5    Liu, R.M.6    Hagen, T.M.7
  • 71
    • 34247631275 scopus 로고    scopus 로고
    • Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
    • Sulzer, D. (2007). Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends Neurosci. 30, 244-250.
    • (2007) Trends Neurosci , vol.30 , pp. 244-250
    • Sulzer, D.1
  • 72
    • 0036345657 scopus 로고    scopus 로고
    • Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats
    • Sumathy, T., Govindasamy, S., Balakrishna, K., and Veluchamy, G. (2002). Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats. Fitoterapia 73, 381-385.
    • (2002) Fitoterapia , vol.73 , pp. 381-385
    • Sumathy, T.1    Govindasamy, S.2    Balakrishna, K.3    Veluchamy, G.4
  • 74
    • 70350347175 scopus 로고    scopus 로고
    • Akt signal transduction dysfunction in Parkinson's disease
    • Timmons, S., Coakley, M. F., Moloney, A. M., and O'Neill, C. (2009). Akt signal transduction dysfunction in Parkinson's disease. Neurosci. Lett. 467, 30-35.
    • (2009) Neurosci. Lett. , vol.467 , pp. 30-35
    • Timmons, S.1    Coakley, M.F.2    Moloney, A.M.3    O'Neill, C.4
  • 75
    • 41649104650 scopus 로고    scopus 로고
    • Activation of heat shock and antioxidant responses by the natural product celastrol: Transcriptional signatures of a thiol-targeted molecule
    • Trott, A., West, J. D., Klaić, L., Westerheide, S. D., Silverman, R. B., Morimoto, R. I., and Morano, K. A. (2008). Activation of heat shock and antioxidant responses by the natural product celastrol: Transcriptional signatures of a thiol-targeted molecule. Mol. Biol. Cell 19, 1104-1112.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 1104-1112
    • Trott, A.1    West, J.D.2    Klaić, L.3    Westerheide, S.D.4    Silverman, R.B.5    Morimoto, R.I.6    Morano, K.A.7
  • 78
    • 67650153168 scopus 로고    scopus 로고
    • Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones
    • Zhou, Z. D., and Lim, T. M. (2009). Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones. Free Radic. Res. 43, 417-430.
    • (2009) Free Radic. Res. , vol.43 , pp. 417-430
    • Zhou, Z.D.1    Lim, T.M.2
  • 79
    • 33744525840 scopus 로고    scopus 로고
    • Age-related changes in glutathione and glutathione-related enzymes in rat brain
    • Zhu, Y., Carvey, M. P., and Ling, Z. (2006). Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 1090, 35-44.
    • (2006) Brain Res , vol.1090 , pp. 35-44
    • Zhu, Y.1    Carvey, M.P.2    Ling, Z.3


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