Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes

Free Radical Biology and Medicine

Volumn 42, Issue 8, 2007, Pages 1222-1230

  Bishop, Glenda M ^a   Dringen, Ralf ^a,b   Robinson, Stephen R ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF BREMEN   (Germany)

Author keywords

Astrocyte; Carmustine; Epileptiform; Glutathione reductase; Hydrogen peroxide; Ischemia; Reactive oxygen species; Stroke; Traumatic brain injury; Zinc

Indexed keywords

CARMUSTINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; OXIDOREDUCTASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ZINC; ZINC ACETATE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; NERVE CELL CULTURE; NEWBORN; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; KINETICS; RATS; REACTIVE OXYGEN SPECIES; ZINC;

RATTUS;

EID: 33947217828     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.01.022     Document Type: Article

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