메뉴 건너뛰기




Volumn 87, Issue 1, 2012, Pages 69-77

Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics

Author keywords

[No Author keywords available]

Indexed keywords

AFQ1 PROTEIN; ANTINEOPLASTIC AGENT; BRAIN AND ACUTE LEUKEMIA CYTOPLASMIC PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD135 ANTIGEN; CD34 ANTIGEN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ECOTROPIC VIRAL INTEGRATION SITE 1 PROTEIN; FMS RELATED TYROSINE KINASE 3 INTERNAL TANDEM DUPLICATION; FMS RELATED TYROSINE KINASE 3 TYROSINE KINASE DOMAIN; ISOCITRATE DEHYDROGENASE; LACTATE DEHYDROGENASE; LESTAURTINIB; MENINGIOMA 1 PROTEIN; MIDOSTAURIN; MIXED LINEAGE LEUKEMIA PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NUCLEOPHOSMIN; PROTEIN; PROTEIN TYROSINE KINASE; QUIZARTINIB; RAS PROTEIN; RETINOIC ACID; SORAFENIB; SUNITINIB; TEN ELEVEN TRANSLOCATION 2 PROTEIN; TRANSCRIPTION FACTOR ERG; UNCLASSIFIED DRUG; WT1 PROTEIN;

EID: 84155165116     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.22197     Document Type: Review
Times cited : (25)

References (150)
  • 1
    • 33947313964 scopus 로고    scopus 로고
    • American Cancer Society
    • Atlanta: American Cancer Society;
    • American Cancer Society. Cancer Facts & Figures 2011. Atlanta: American Cancer Society; 2011.
    • (2011) Cancer Facts & Figures 2011
  • 2
    • 79960685855 scopus 로고    scopus 로고
    • Management of Acute Leukemias. DeVita, Hellman, and Rosenberg's Cancer Principles & Practice of Oncology, New York: Lippincott Williams & Wilkins
    • Kebriaei P, de Lima M, Estey E. Management of Acute Leukemias. DeVita, Hellman, and Rosenberg's Cancer Principles & Practice of Oncology, Vol. 2. New York: Lippincott Williams & Wilkins; 2008. pp 2232-2265.
    • (2008) , vol.2 , pp. 2232-2265
    • Kebriaei, P.1    de Lima, M.2    Estey, E.3
  • 4
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,1612 patients entered into the MRC AML 10 trial
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1, 1612 patients entered into the MRC AML 10 trial. Blood 1998; 92: 2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 5
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrózek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002; 100: 4325-4336.
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3
  • 6
    • 0035469883 scopus 로고    scopus 로고
    • The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade D, Walker H, Harrison G, et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 2001; 98: 1312-1320.
    • (2001) Blood , vol.98 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3
  • 7
    • 33646404606 scopus 로고    scopus 로고
    • Age and acute myeloid leukemia
    • Appelbaum FR, Gundacker H, Head DR, et al. Age and acute myeloid leukemia. Blood 2006; 107: 3481-3485.
    • (2006) Blood , vol.107 , pp. 3481-3485
    • Appelbaum, F.R.1    Gundacker, H.2    Head, D.R.3
  • 8
    • 0035469856 scopus 로고    scopus 로고
    • Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results of the United Kingdom Medical Research Council AML11 trial
    • Goldstone AH, Burnett AK, Wheatley K, et al. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results of the United Kingdom Medical Research Council AML11 trial. Blood 2001; 98: 1302-1311.
    • (2001) Blood , vol.98 , pp. 1302-1311
    • Goldstone, A.H.1    Burnett, A.K.2    Wheatley, K.3
  • 9
    • 46849120614 scopus 로고    scopus 로고
    • Implications of the Molecular Characterization of Acute Myeloid Leukemia
    • Dohner Hartmut. Implications of the Molecular Characterization of Acute Myeloid Leukemia. Hematology 2004; 412-419.
    • (2004) Hematology , pp. 412-419
    • Dohner, H.1
  • 10
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Dohner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations. Blood 2005; 106: 3740-3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 11
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S, Schoch C, Kern W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 2005; 106: 3733-3739.
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 12
    • 33846635060 scopus 로고    scopus 로고
    • Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: Recent advances
    • Mrozek K, Dohner H, Bloomfield CD. Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: Recent advances. Curr Opin Hematol 2007; 14: 106-114.
    • (2007) Curr Opin Hematol , vol.14 , pp. 106-114
    • Mrozek, K.1    Dohner, H.2    Bloomfield, C.D.3
  • 13
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C, Koch S, Creutzig E, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 2006; 107: 4011-4020.
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3
  • 14
    • 24144494881 scopus 로고    scopus 로고
    • Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
    • Suzuki T, Kiyoi H, Ozeki K, et al. Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. Blood 2005; 106: 2854-2861.
    • (2005) Blood , vol.106 , pp. 2854-2861
    • Suzuki, T.1    Kiyoi, H.2    Ozeki, K.3
  • 15
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Frohling S, Schlenk RF, Stolze I, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations. J Clin Oncol 2004; 22: 624-633.
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3
  • 16
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic Significance of Gene and MicroRNA Expression Signatures Associated With CEBPA Mutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study
    • Marcucci G, Maharry K, Radmacher MD, et al. Prognostic Significance of Gene and MicroRNA Expression Signatures Associated With CEBPA Mutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study. J Clin Oncol 2008; 26: 5078-5087.
    • (2008) J Clin Oncol , vol.26 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3
  • 17
    • 48749123878 scopus 로고    scopus 로고
    • Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics
    • Gaidzik V, Döhner K. Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics. Semin Oncol 2008; 35: 346-355.
    • (2008) Semin Oncol , vol.35 , pp. 346-355
    • Gaidzik, V.1    Döhner, K.2
  • 18
    • 0021264226 scopus 로고
    • Fourth International Workshop on Chromosomes in Leukemia 1982: Clinical significance of chromosomal abnormalities in acute nonlymphoblastic leukemia
    • Bloomfield CD, Goldman A, Hossfeld D, de la Chapelle A. Fourth International Workshop on Chromosomes in Leukemia 1982: Clinical significance of chromosomal abnormalities in acute nonlymphoblastic leukemia. Cancer Genet Cytogenet 1984; 11: 332-350.
    • (1984) Cancer Genet Cytogenet , vol.11 , pp. 332-350
    • Bloomfield, C.D.1    Goldman, A.2    Hossfeld, D.3    de la Chapelle, A.4
  • 19
    • 0024350105 scopus 로고
    • The clinical significance of karyotype in acute myelogenous leukemia
    • Arthur DC, Berger R, Golomb HM, et al. The clinical significance of karyotype in acute myelogenous leukemia. Cancer Genet Cytogenet 1989; 40: 203-216.
    • (1989) Cancer Genet Cytogenet , vol.40 , pp. 203-216
    • Arthur, D.C.1    Berger, R.2    Golomb, H.M.3
  • 20
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study
    • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood 2000; 96: 4075-4083.
    • (2000) Blood , vol.96 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 21
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia. N Engl J Med 2008; 358: 1909-1918.
    • (2008) N Engl J Med , vol.358 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 22
    • 35348896184 scopus 로고    scopus 로고
    • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
    • Wouters BJ, Alberich Jordà M, Keeshan K, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood 2007; 110: 3706-3714.
    • (2007) Blood , vol.110 , pp. 3706-3714
    • Wouters, B.J.1    Alberich Jordà, M.2    Keeshan, K.3
  • 23
    • 33644830601 scopus 로고    scopus 로고
    • Overexpression of the ETS-related gene, ERG, predicts worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
    • Marcucci G, Baldus CD, Ruppert AS, et al. Overexpression of the ETS-related gene, ERG, predicts worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study. J Clin Oncol 2005; 23: 9234-9242.
    • (2005) J Clin Oncol , vol.23 , pp. 9234-9242
    • Marcucci, G.1    Baldus, C.D.2    Ruppert, A.S.3
  • 24
    • 33748450145 scopus 로고    scopus 로고
    • Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization
    • Rucker FG, Bullinger L, Schwaenen C, et al. Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization. J Clin Oncol 2006; 24: 3887-3894.
    • (2006) J Clin Oncol , vol.24 , pp. 3887-3894
    • Rucker, F.G.1    Bullinger, L.2    Schwaenen, C.3
  • 25
    • 10744230697 scopus 로고    scopus 로고
    • A pilot study of highthroughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
    • Ley TJ, Minx PJ, Walter MJ, et al. A pilot study of highthroughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A 2003; 100: 14275-14280.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14275-14280
    • Ley, T.J.1    Minx, P.J.2    Walter, M.J.3
  • 26
    • 34547676848 scopus 로고    scopus 로고
    • Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias
    • Falini B, Nicoletti I, Bolli N, et al. Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Hematologica 2007; 92: 519-532.
    • (2007) Hematologica , vol.92 , pp. 519-532
    • Falini, B.1    Nicoletti, I.2    Bolli, N.3
  • 27
  • 28
    • 19944427850 scopus 로고    scopus 로고
    • Gimema Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B, Mecucci C, Tiacci E, et al. Gimema Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352; 254-266.
    • (2005) N Engl J Med , vol.352 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 29
    • 58149240890 scopus 로고    scopus 로고
    • Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia: Results from AMLSG Trial AML HD98B
    • Schlenk RF, Dohner K, Kneba M, et al. Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia: Results from AMLSG Trial AML HD98B. Haematologica 2009; 94: 54-60.
    • (2009) Haematologica , vol.94 , pp. 54-60
    • Schlenk, R.F.1    Dohner, K.2    Kneba, M.3
  • 30
  • 31
    • 33846876123 scopus 로고    scopus 로고
    • Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biological and clinical features
    • Falini B, Nicoletti I, Martelli MF, et al. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biological and clinical features. Blood 2007; 109: 874-885.
    • (2007) Blood , vol.109 , pp. 874-885
    • Falini, B.1    Nicoletti, I.2    Martelli, M.F.3
  • 32
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S, Schoch C, Kern W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 2005; 106: 3733-3739.
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 33
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C, Koch S, Creutzig E, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 2006; 107: 4011-4020.
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3
  • 34
    • 77449140390 scopus 로고    scopus 로고
    • Favorable Prognostic Impact of NPM1 Mutations in Older Patients With Cytogenetically Normal De Novo Acute Myeloid Leukemia and Associated Gene- and MicroRNA-Expression Signatures: A Cancer and Leukemia Group B Study
    • Becker H, Marcucci G, Maharry K, et al. Favorable Prognostic Impact of NPM1 Mutations in Older Patients With Cytogenetically Normal De Novo Acute Myeloid Leukemia and Associated Gene- and MicroRNA-Expression Signatures: A Cancer and Leukemia Group B Study. J Clin Oncol 2010; 596-604.
    • (2010) J Clin Oncol , pp. 596-604
    • Becker, H.1    Marcucci, G.2    Maharry, K.3
  • 35
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111: 2776.
    • (2008) Blood , vol.111 , pp. 2776
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 36
    • 77952578145 scopus 로고    scopus 로고
    • Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
    • Falini B, Macijewski K, Weiss T, et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood 2010; 115: 3776-3786.
    • (2010) Blood , vol.115 , pp. 3776-3786
    • Falini, B.1    Macijewski, K.2    Weiss, T.3
  • 37
    • 77956553248 scopus 로고    scopus 로고
    • A novel prognostic model in elderly patients with acute myeloid leukemia-results of 909 patients entered into the prospective AML96 trial
    • Rollig C, Thiede C, Gramatzki M, et al. A novel prognostic model in elderly patients with acute myeloid leukemia-results of 909 patients entered into the prospective AML96 trial. Blood 2006; 116: 971-978.
    • (2006) Blood , vol.116 , pp. 971-978
    • Rollig, C.1    Thiede, C.2    Gramatzki, M.3
  • 38
    • 34047108206 scopus 로고    scopus 로고
    • Nucleophosmin acts as a novel AP2 alphabinding transcriptional corepressor during cell differentiation
    • Liu H, Tan BC, Tseng KH, et al. Nucleophosmin acts as a novel AP2 alphabinding transcriptional corepressor during cell differentiation. EMBO Rep 2007; 8: 394-400.
    • (2007) EMBO Rep , vol.8 , pp. 394-400
    • Liu, H.1    Tan, B.C.2    Tseng, K.H.3
  • 39
    • 4944232789 scopus 로고    scopus 로고
    • Phase III study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemia
    • Schlenk RF, Frohling S, Hartmann F, et al. Phase III study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemia. Leukemia 2008; 18: 1798-1803.
    • (2008) Leukemia , vol.18 , pp. 1798-1803
    • Schlenk, R.F.1    Frohling, S.2    Hartmann, F.3
  • 40
    • 58149240890 scopus 로고    scopus 로고
    • Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia: Results from AMLSG Trial AML HD98B
    • Schlenk RF, Dohner K, Kneba M, et al. Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia: Results from AMLSG Trial AML HD98B. Haematologica 2009; 94: 54-60.
    • (2009) Haematologica , vol.94 , pp. 54-60
    • Schlenk, R.F.1    Dohner, K.2    Kneba, M.3
  • 41
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A Cancer and Leukemia Group B study
    • Whitman SP, Archer KJ, Feng L, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A Cancer and Leukemia Group B study. Cancer Res 2001; 61: 7233-7239.
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 42
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002; 99: 4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 43
    • 33744455709 scopus 로고    scopus 로고
    • Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    • Kiyoi H, Naoe T. Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation. Int J Hematol 2006; 83: 301-308.
    • (2006) Int J Hematol , vol.83 , pp. 301-308
    • Kiyoi, H.1    Naoe, T.2
  • 44
    • 80052231301 scopus 로고    scopus 로고
    • FLT3 Inhibition as Therapy in Acute Myeloid Leukemia: A Record of Trials and Tribulations
    • Fathi AT, Chabner BA. FLT3 Inhibition as Therapy in Acute Myeloid Leukemia: A Record of Trials and Tribulations. Oncologist 2011; 16: 1162-1174.
    • (2011) Oncologist , vol.16 , pp. 1162-1174
    • Fathi, A.T.1    Chabner, B.A.2
  • 45
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003; 3: 650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 46
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001; 98: 1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 47
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
    • Frohling S, Schlenk RF, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 2002; 100: 4372-4380.
    • (2002) Blood , vol.100 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3
  • 48
    • 0036975615 scopus 로고    scopus 로고
    • Variable prognostic value of FLT3 internal tandem duplications in patients with de novo AML and a normal karyotype, t(15;17), t(8;21) or inv(16)
    • Kainz B, Heintel D, Marculescu R, et al. Variable prognostic value of FLT3 internal tandem duplications in patients with de novo AML and a normal karyotype, t(15;17), t(8;21) or inv(16). Hematol J 2002; 3: 283-289.
    • (2002) Hematol J , vol.3 , pp. 283-289
    • Kainz, B.1    Heintel, D.2    Marculescu, R.3
  • 49
    • 10744222892 scopus 로고    scopus 로고
    • Internal tandem duplications of Flt3 gene (Flt3/ITD) predicts a poor post-remission outcome in adult patients with acute non-promyelocytic leukemia
    • Ciolli S, Vannucchi AM, Leoni F, et al. Internal tandem duplications of Flt3 gene (Flt3/ITD) predicts a poor post-remission outcome in adult patients with acute non-promyelocytic leukemia. Leuk Lymphoma 2004; 45: 73-78.
    • (2004) Leuk Lymphoma , vol.45 , pp. 73-78
    • Ciolli, S.1    Vannucchi, A.M.2    Leoni, F.3
  • 50
    • 14644438570 scopus 로고    scopus 로고
    • Risk assessment in patients with acute myeloid leukemia and a normal karyotype
    • Bienz M, Ludwig M, Leibundgut EO, et al. Risk assessment in patients with acute myeloid leukemia and a normal karyotype. Clin Cancer Res 2005; 11: 1416-1424.
    • (2005) Clin Cancer Res , vol.11 , pp. 1416-1424
    • Bienz, M.1    Ludwig, M.2    Leibundgut, E.O.3
  • 51
    • 10744230464 scopus 로고    scopus 로고
    • Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
    • Ozeki K, Kiyoi H, Hirose Y, et al. Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Blood 2004; 103: 1901-1908.
    • (2004) Blood , vol.103 , pp. 1901-1908
    • Ozeki, K.1    Kiyoi, H.2    Hirose, Y.3
  • 52
    • 70350504884 scopus 로고    scopus 로고
    • Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
    • Kayser S, Schlenk R, Correa Londono M, et al. Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood 2009; 114: 12.
    • (2009) Blood , vol.114 , pp. 12
    • Kayser, S.1    Schlenk, R.2    Correa Londono, M.3
  • 53
    • 27744451026 scopus 로고    scopus 로고
    • No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): An analysis of 1135 patients, excluding acute prolyelocytic leukemia, from the UK MRC AML10 and 12 trials
    • Gale RE, Hills R, Kottaridis PD, et al. No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): An analysis of 1135 patients, excluding acute prolyelocytic leukemia, from the UK MRC AML10 and 12 trials. Blood 2005; 106: 3658-3665.
    • (2005) Blood , vol.106 , pp. 3658-3665
    • Gale, R.E.1    Hills, R.2    Kottaridis, P.D.3
  • 54
    • 79959362348 scopus 로고    scopus 로고
    • Comparison of autologous stem cell transplantation versus consolidation chemotherapy for patients with cytogenetically normal acute myeloid leukemia (CN-AML) and FLT3ITD
    • Harshabad Singh, Lillian L.Werner, Salma Asali, et al. Comparison of autologous stem cell transplantation versus consolidation chemotherapy for patients with cytogenetically normal acute myeloid leukemia (CN-AML) and FLT3ITD. Am J Hematol 2011; 86: 625-627.
    • (2011) Am J Hematol , vol.86 , pp. 625-627
    • Harshabad, S.1    Lillian, L.2    Werner, S.A.3
  • 55
    • 23744444913 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis
    • Yanada M, Matsuo K, Suzuki T, et al. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis. Leukemia 2005; 19: 1345-1349.
    • (2005) Leukemia , vol.19 , pp. 1345-1349
    • Yanada, M.1    Matsuo, K.2    Suzuki, T.3
  • 56
    • 34548029756 scopus 로고    scopus 로고
    • FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
    • Mead AJ, Linch DC, Hills RK, et al. FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia. Blood 2007; 110: 1262-1270.
    • (2007) Blood , vol.110 , pp. 1262-1270
    • Mead, A.J.1    Linch, D.C.2    Hills, R.K.3
  • 57
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (CEBPalpha), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (CEBPalpha), in acute myeloid leukemia. Nat Genet 2001; 3: 263-270.
    • (2001) Nat Genet , vol.3 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3
  • 58
    • 0037591396 scopus 로고    scopus 로고
    • Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML
    • Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, Meijer J, et al. Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol J 2003; 4: 31-40.
    • (2003) Hematol J , vol.4 , pp. 31-40
    • Barjesteh van Waalwijk van Doorn-Khosrovani, S.1    Erpelinck, C.2    Meijer, J.3
  • 59
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters B, Löwenberg B, Erpelinck-Verschueren C, et al. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood 2009; 113: 3088-3091.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.1    Löwenberg, B.2    Erpelinck-Verschueren, C.3
  • 60
    • 79952122978 scopus 로고    scopus 로고
    • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: Further evidence for CEBPA double mutant AML as a distinctive disease entity
    • Taskesen E, Bullinger L, Corbacioglu A, et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: Further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 2011; 117: 2469-2475.
    • (2011) Blood , vol.117 , pp. 2469-2475
    • Taskesen, E.1    Bullinger, L.2    Corbacioglu, A.3
  • 61
    • 77954921625 scopus 로고    scopus 로고
    • Prognostic Significance of CEBPA Mutations in a Large Cohort of Younger Adult Patients With Acute Myeloid Leukemia: Impact of Double CEBPA Mutations and the Interaction With FLT3 and NPM1 Mutations
    • Green C, Koo K, Hills R, et al. Prognostic Significance of CEBPA Mutations in a Large Cohort of Younger Adult Patients With Acute Myeloid Leukemia: Impact of Double CEBPA Mutations and the Interaction With FLT3 and NPM1 Mutations. J Clin Oncol 2010; 28: 2739-2747.
    • (2010) J Clin Oncol , vol.28 , pp. 2739-2747
    • Green, C.1    Koo, K.2    Hills, R.3
  • 62
    • 77953047175 scopus 로고    scopus 로고
    • C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogenetics
    • Lu Y, Chen W, Chen W, et al. C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogenetics. Am J Hematol 2010; 85: 426-430.
    • (2010) Am J Hematol , vol.85 , pp. 426-430
    • Lu, Y.1    Chen, W.2    Chen, W.3
  • 63
    • 34250011216 scopus 로고    scopus 로고
    • Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: A Cancer and Leukemia Group B study
    • Whitman SP, Ruppert AS, Marcucci G, et al. Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: A Cancer and Leukemia Group B study. Blood 2007; 109: 5164-5167.
    • (2007) Blood , vol.109 , pp. 5164-5167
    • Whitman, S.P.1    Ruppert, A.S.2    Marcucci, G.3
  • 64
    • 0032522974 scopus 로고    scopus 로고
    • Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance
    • King-Underwood L, Pritchard-Jones K. Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 1998; 91: 2961-2968.
    • (1998) Blood , vol.91 , pp. 2961-2968
    • King-Underwood, L.1    Pritchard-Jones, K.2
  • 65
    • 0030891372 scopus 로고    scopus 로고
    • A clinical overview of WT1 gene mutations
    • Little M, Wells C. A clinical overview of WT1 gene mutations. Hum Mutat 1997; 9: 209-225.
    • (1997) Hum Mutat , vol.9 , pp. 209-225
    • Little, M.1    Wells, C.2
  • 66
    • 7044262957 scopus 로고    scopus 로고
    • Frequency and heritability of WT1 mutations in nonsyndromic Wilms' tumor patients: A UK Children's Cancer Study Group Study
    • Little SE, Hanks SP, King-Underwood L, et al. Frequency and heritability of WT1 mutations in nonsyndromic Wilms' tumor patients: A UK Children's Cancer Study Group Study. J Clin Oncol 2004; 22: 4140-4146.
    • (2004) J Clin Oncol , vol.22 , pp. 4140-4146
    • Little, S.E.1    Hanks, S.P.2    King-Underwood, L.3
  • 67
    • 34250784012 scopus 로고    scopus 로고
    • The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis
    • Ariyaratana S, Loeb DM. The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis. Expert Rev Mol Med 2007; 9: 1-17.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-17
    • Ariyaratana, S.1    Loeb, D.M.2
  • 69
    • 56749098118 scopus 로고    scopus 로고
    • Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party
    • Virappane P, Gale R, Hills R, et al. Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008; 26: 5429-5435.
    • (2008) J Clin Oncol , vol.26 , pp. 5429-5435
    • Virappane, P.1    Gale, R.2    Hills, R.3
  • 70
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Paschka P, Marcucci G, Ruppert AS, et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study. J Clin Oncol 2008; 26: 4595-4602.
    • (2008) J Clin Oncol , vol.26 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 71
    • 77954671159 scopus 로고    scopus 로고
    • WT1 mutation in 470 adult patients with acute myeloid leukemia: Stability during disease evolution and implication of its incorporation into a survival scoring system
    • Hou H, Huang T, Lin L, et al. WT1 mutation in 470 adult patients with acute myeloid leukemia: Stability during disease evolution and implication of its incorporation into a survival scoring system. Blood 2010; 115: 5222-5231.
    • (2010) Blood , vol.115 , pp. 5222-5231
    • Hou, H.1    Huang, T.2    Lin, L.3
  • 72
    • 77449122409 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the mutational hotspot of WT1 predicts favorable outcome in patients with cytogenetically normal acute myeloid leukemia
    • Damm F, Heuser M, Morgan M, et al. Single nucleotide polymorphism in the mutational hotspot of WT1 predicts favorable outcome in patients with cytogenetically normal acute myeloid leukemia. J Clin Oncol 2011; 28: 578-585.
    • (2011) J Clin Oncol , vol.28 , pp. 578-585
    • Damm, F.1    Heuser, M.2    Morgan, M.3
  • 73
    • 33646575624 scopus 로고    scopus 로고
    • Implication of NRAS mutations in AML: A study of 2502 patients
    • Bacher U, Haferlach T, Schoch C, et al. Implication of NRAS mutations in AML: A study of 2502 patients. Blood 2006; 107: 3847-3853.
    • (2006) Blood , vol.107 , pp. 3847-3853
    • Bacher, U.1    Haferlach, T.2    Schoch, C.3
  • 74
    • 24744449132 scopus 로고    scopus 로고
    • RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence out-come in patients younger than 60 years
    • Bowen DT, Frew ME, Hills R, et al. RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence out-come in patients younger than 60 years. Blood 2005; 106: 2113-2119.
    • (2005) Blood , vol.106 , pp. 2113-2119
    • Bowen, D.T.1    Frew, M.E.2    Hills, R.3
  • 75
    • 53749099948 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: A Cancer and Leukemia Group B study
    • Neubauer A, Maharry K, Mrozek K, et al. Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: A Cancer and Leukemia Group B study. J Clin Oncol 2008; 26: 4603-4609.
    • (2008) J Clin Oncol , vol.26 , pp. 4603-4609
    • Neubauer, A.1    Maharry, K.2    Mrozek, K.3
  • 76
    • 7944237790 scopus 로고    scopus 로고
    • Role of NADP-- dependent isocitrate dehydrogenase (NADP--ICDH) on cellular defence against oxidative injury by gammarays
    • Lee SH, Jo SH, Lee SM, et al. Role of NADP-- dependent isocitrate dehydrogenase (NADP--ICDH) on cellular defence against oxidative injury by gammarays. Int J Radiat Biol 2004; 80: 635-642.
    • (2004) Int J Radiat Biol , vol.80 , pp. 635-642
    • Lee, S.H.1    Jo, S.H.2    Lee, S.M.3
  • 77
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361: 1058-1066.
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 78
    • 77950968519 scopus 로고    scopus 로고
    • Distinct clinical and biological characteristics in adult acute myeloid leukemia bearing isocitrate dehydrogenase 1 (IDH1) mutation
    • Chou WC, Hou HA, Chen CY, et al. Distinct clinical and biological characteristics in adult acute myeloid leukemia bearing isocitrate dehydrogenase 1 (IDH1) mutation. Blood 2010; 115: 2749-2754.
    • (2010) Blood , vol.115 , pp. 2749-2754
    • Chou, W.C.1    Hou, H.A.2    Chen, C.Y.3
  • 79
    • 77952481300 scopus 로고    scopus 로고
    • Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor
    • Wagner K, Damm F, Göhring G, et al. Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor. J Clin Oncol 2010; 28: 2356-2364.
    • (2010) J Clin Oncol , vol.28 , pp. 2356-2364
    • Wagner, K.1    Damm, F.2    Göhring, G.3
  • 80
    • 77952424259 scopus 로고    scopus 로고
    • Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study
    • Ho PA, Alonzo TA, Kopecky KJ, et al. Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study. Leukemia 2010; 24: 909-913.
    • (2010) Leukemia , vol.24 , pp. 909-913
    • Ho, P.A.1    Alonzo, T.A.2    Kopecky, K.J.3
  • 81
    • 77957771067 scopus 로고    scopus 로고
    • IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
    • Schnittger S, Haferlach C, Ulke M, et al. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 2010; 116: 5486-5496.
    • (2010) Blood , vol.116 , pp. 5486-5496
    • Schnittger, S.1    Haferlach, C.2    Ulke, M.3
  • 82
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
    • Marcucci G, Maharry K, Wu Y, et al. IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study. J Clin Oncol 2010; 28: 2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.3
  • 83
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group
    • Boissel N, Nibourel O, Renneville A, et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group. J Clin Oncol 2010; 28: 3717-3723.
    • (2010) J Clin Oncol , vol.28 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3
  • 84
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
    • Paschka P, Schlenk R, Gaidzik V, et al. IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication. J Clin Oncol 2010; 28: 3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.2    Gaidzik, V.3
  • 85
    • 77957192661 scopus 로고    scopus 로고
    • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
    • Abbas S, Lugthart S, Kavelaars FG, et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value. Blood 2010; 116: 2122-2126.
    • (2010) Blood , vol.116 , pp. 2122-2126
    • Abbas, S.1    Lugthart, S.2    Kavelaars, F.G.3
  • 86
    • 77957759961 scopus 로고    scopus 로고
    • The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    • Green CL, Evans CM, Hills RK, et al. The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. Blood 2010; 116: 2779-2782.
    • (2010) Blood , vol.116 , pp. 2779-2782
    • Green, C.L.1    Evans, C.M.2    Hills, R.K.3
  • 87
    • 79751530369 scopus 로고    scopus 로고
    • The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia
    • Chou WC, Lei WC, Ko BS, et al. The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. Leukemia 2011; 25: 246-253.
    • (2011) Leukemia , vol.25 , pp. 246-253
    • Chou, W.C.1    Lei, W.C.2    Ko, B.S.3
  • 88
    • 77956050251 scopus 로고    scopus 로고
    • Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
    • Thol F, Damm F, Wagner K, et al. Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood 2010; 116: 614-616.
    • (2010) Blood , vol.116 , pp. 614-616
    • Thol, F.1    Damm, F.2    Wagner, K.3
  • 89
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations depends on the location of the mutation
    • Green CL, Evans CM, Zhao L, et al. The prognostic significance of IDH2 mutations depends on the location of the mutation. Blood 2011; 118: 409-412.
    • (2011) Blood , vol.118 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3
  • 90
    • 78650983952 scopus 로고    scopus 로고
    • Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
    • Lugthart S, Figueroa ME, Bindels E, et al. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood 2011; 117: 234-241.
    • (2011) Blood , vol.117 , pp. 234-241
    • Lugthart, S.1    Figueroa, M.E.2    Bindels, E.3
  • 91
    • 55549101623 scopus 로고    scopus 로고
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    • Ley TJ, Mardis ER, Ding L, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008; 456: 66-72.
    • (2008) Nature , vol.456 , pp. 66-72
    • Ley, T.J.1    Mardis, E.R.2    Ding, L.3
  • 92
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A Mutations in Acute Myeloid Leukemia
    • Ley T, Ding L, Walter M, et al. DNMT3A Mutations in Acute Myeloid Leukemia. N Engl J Med 2010; 363: 2424-2433.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.1    Ding, L.2    Walter, M.3
  • 93
    • 79960735923 scopus 로고    scopus 로고
    • Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
    • Thol F, Damm F, Lüdeking A, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol 2011; 29: 2889-2896.
    • (2011) J Clin Oncol , vol.29 , pp. 2889-2896
    • Thol, F.1    Damm, F.2    Lüdeking, A.3
  • 94
    • 67650924270 scopus 로고    scopus 로고
    • Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
    • Tefferi A, Lim KH, Abdel-Wahab O, et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia 2009; 23: 1343-1345.
    • (2009) Leukemia , vol.23 , pp. 1343-1345
    • Tefferi, A.1    Lim, K.H.2    Abdel-Wahab, O.3
  • 95
    • 77956513784 scopus 로고    scopus 로고
    • Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission
    • Nibourel O, Kosmider O, Cheok M, et al. Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission. Blood 2010; 116: 1132-1135.
    • (2010) Blood , vol.116 , pp. 1132-1135
    • Nibourel, O.1    Kosmider, O.2    Cheok, M.3
  • 96
    • 79954428737 scopus 로고    scopus 로고
    • TET2 Mutations Improve the New European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
    • Metzeler KH, Maharry K, Radmacher MD, et al. TET2 Mutations Improve the New European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study. J Clin Oncol 2011; 29: 1373-1381.
    • (2011) J Clin Oncol , vol.29 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3
  • 97
    • 80053620171 scopus 로고    scopus 로고
    • TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
    • Aug 9. [Epub ahead of print].
    • Chou WC, Chou SC, Liu CY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood 2011 Aug 9. [Epub ahead of print].
    • (2011) Blood
    • Chou, W.C.1    Chou, S.C.2    Liu, C.Y.3
  • 98
    • 0142195934 scopus 로고    scopus 로고
    • BAALC, a novel marker of human hematopoietic progenitor cells
    • Baldus CD, Tanner SM, Kusewitt DF, et al. BAALC, a novel marker of human hematopoietic progenitor cells. Exp Hematol 2003; 31: 1051-1056.
    • (2003) Exp Hematol , vol.31 , pp. 1051-1056
    • Baldus, C.D.1    Tanner, S.M.2    Kusewitt, D.F.3
  • 99
    • 33644866304 scopus 로고    scopus 로고
    • BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: Prognostic implications
    • Baldus CD, Thiede C, Soucek S, et al. BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: Prognostic implications. J Clin Oncol 2006; 24: 790-797.
    • (2006) J Clin Oncol , vol.24 , pp. 790-797
    • Baldus, C.D.1    Thiede, C.2    Soucek, S.3
  • 100
    • 0041440085 scopus 로고    scopus 로고
    • BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: A Cancer and Leukemia Group B study
    • Baldus CD, Tanner SM, Ruppert AS, et al. BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: A Cancer and Leukemia Group B study. Blood 2003; 102: 1613-1618.
    • (2003) Blood , vol.102 , pp. 1613-1618
    • Baldus, C.D.1    Tanner, S.M.2    Ruppert, A.S.3
  • 101
    • 14644438570 scopus 로고    scopus 로고
    • Risk assessment in patients with acute myeloid leukemia and a normal karyotype
    • Beinz M, Ludwig M, Leibundgut EO, et al. Risk assessment in patients with acute myeloid leukemia and a normal karyotype. Clin Cancer Res 2005; 11: 1416-1424.
    • (2005) Clin Cancer Res , vol.11 , pp. 1416-1424
    • Beinz, M.1    Ludwig, M.2    Leibundgut, E.O.3
  • 102
    • 45949110015 scopus 로고    scopus 로고
    • High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: A Cancer and Leukemia Group B (CALGB) study
    • Langer C, Radmacher MD, Ruppert AS, et al. High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: A Cancer and Leukemia Group B (CALGB) study. Blood 2008; 111: 5371-5379.
    • (2008) Blood , vol.111 , pp. 5371-5379
    • Langer, C.1    Radmacher, M.D.2    Ruppert, A.S.3
  • 103
    • 78650426052 scopus 로고    scopus 로고
    • BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA-expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Schwind S, Marcucci G, Maharry K, et al. BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA-expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. Blood 2011; 116: 5660-5669.
    • (2011) Blood , vol.116 , pp. 5660-5669
    • Schwind, S.1    Marcucci, G.2    Maharry, K.3
  • 104
    • 77950565905 scopus 로고    scopus 로고
    • BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML)
    • Santamaría C, Chillón MC, García-Sanz R, et al. BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML). Ann Hematol 2010; 89: 453-458.
    • (2010) Ann Hematol , vol.89 , pp. 453-458
    • Santamaría, C.1    Chillón, M.C.2    García-Sanz, R.3
  • 105
    • 0028307384 scopus 로고
    • A second Ewing's sarcoma translocation t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
    • Sorensen PH, Lessnick SL, Lopez-Terrada D, et al. A second Ewing's sarcoma translocation t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 1994; 6: 146-151.
    • (1994) Nat Genet , vol.6 , pp. 146-151
    • Sorensen, P.H.1    Lessnick, S.L.2    Lopez-Terrada, D.3
  • 106
    • 0025616597 scopus 로고
    • ETS family of genes in leukemia and Down syndrome
    • Papas TS, Watson DK, Sacchi N, et al. ETS family of genes in leukemia and Down syndrome. Am J Med Genet Suppl 1990; 7: 251-261.
    • (1990) Am J Med Genet Suppl , vol.7 , pp. 251-261
    • Papas, T.S.1    Watson, D.K.2    Sacchi, N.3
  • 107
    • 24744468832 scopus 로고    scopus 로고
    • The proto-oncogene ERG in megakaryoblastic leukemias
    • Rainis L, Toki T, Pimanda JE, et al. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res 2005; 65: 7596-7602.
    • (2005) Cancer Res , vol.65 , pp. 7596-7602
    • Rainis, L.1    Toki, T.2    Pimanda, J.E.3
  • 108
    • 34548234969 scopus 로고    scopus 로고
    • High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Whitman P, et al. High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol 2007; 25: 3337-3343.
    • (2007) J Clin Oncol , vol.25 , pp. 3337-3343
    • Marcucci, G.1    Maharry, K.2    Whitman, P.3
  • 109
    • 77649096189 scopus 로고    scopus 로고
    • ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: A comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays
    • Metzeler KH, Dufour A, Benthaus T, et al. ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: A comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. J Clin Oncol 2009; 27: 5031-5038.
    • (2009) J Clin Oncol , vol.27 , pp. 5031-5038
    • Metzeler, K.H.1    Dufour, A.2    Benthaus, T.3
  • 110
    • 0037421957 scopus 로고    scopus 로고
    • The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription
    • Van Wely KHM, Molijn AC, Buijs A, et al. The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. Oncogene 2003; 22: 699-709.
    • (2003) Oncogene , vol.22 , pp. 699-709
    • Van Wely, K.H.M.1    Molijn, A.C.2    Buijs, A.3
  • 111
    • 24344468192 scopus 로고    scopus 로고
    • The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation
    • Sutton ALM, Zhang X, Ellison TI, et al. The 1, 25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. Mol Endocrinol 2005; 19: 2234 - 2244.
    • (2005) Mol Endocrinol , vol.19 , pp. 2234-2244
    • Sutton, A.L.M.1    Zhang, X.2    Ellison, T.I.3
  • 112
    • 33845263501 scopus 로고    scopus 로고
    • High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics
    • Heuser M, Beutel G, Krauter J, et al. High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Blood 2006; 108: 3898-3905.
    • (2006) Blood , vol.108 , pp. 3898-3905
    • Heuser, M.1    Beutel, G.2    Krauter, J.3
  • 113
    • 67650312343 scopus 로고    scopus 로고
    • Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Langer C, Marcucci G, Holland KB, et al. Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study. J Clin Oncol 2009; 27: 3198-3204.
    • (2009) J Clin Oncol , vol.27 , pp. 3198-3204
    • Langer, C.1    Marcucci, G.2    Holland, K.B.3
  • 114
    • 34548841921 scopus 로고    scopus 로고
    • MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML
    • Heuser M, Argiropoulos B, Florian Kuchenbauer F, et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood 2007; 110: 1639-1647.
    • (2007) Blood , vol.110 , pp. 1639-1647
    • Heuser, M.1    Argiropoulos, B.2    Florian Kuchenbauer, F.3
  • 115
    • 0028942107 scopus 로고
    • A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells
    • Tse W, Zhu W, Chen HS, Cohen A. A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. Blood 1995; 85: 650-656.
    • (1995) Blood , vol.85 , pp. 650-656
    • Tse, W.1    Zhu, W.2    Chen, H.S.3    Cohen, A.4
  • 116
    • 8644234805 scopus 로고    scopus 로고
    • AF1q, a fusion partner with MLL, has restricted expression in the normal bone marrow cell hierarchy
    • Tse W, Hu ZB, Geng DJ, et al. AF1q, a fusion partner with MLL, has restricted expression in the normal bone marrow cell hierarchy. Blood 1998; 92: 2437.
    • (1998) Blood , vol.92 , pp. 2437
    • Tse, W.1    Hu, Z.B.2    Geng, D.J.3
  • 117
    • 8644238287 scopus 로고    scopus 로고
    • Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia
    • Tse W, Meshinchi S, Alonzo TA, et al. Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia. Blood 2004; 104: 3058-3063.
    • (2004) Blood , vol.104 , pp. 3058-3063
    • Tse, W.1    Meshinchi, S.2    Alonzo, T.A.3
  • 118
    • 12744279347 scopus 로고    scopus 로고
    • Increased AF1q gene expression in high-risk myelodysplastic syndrome
    • Tse W, Joachim DH, Stirewalt D, et al. Increased AF1q gene expression in high-risk myelodysplastic syndrome. Br J Haematol 2005; 128: 218-220.
    • (2005) Br J Haematol , vol.128 , pp. 218-220
    • Tse, W.1    Joachim, D.H.2    Stirewalt, D.3
  • 119
    • 65649120444 scopus 로고    scopus 로고
    • Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics
    • Strunk CJ, Platzbecker U, Thiede C, et al. Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics. Am J Hematol 2009; 84: 308-309.
    • (2009) Am J Hematol , vol.84 , pp. 308-309
    • Strunk, C.J.1    Platzbecker, U.2    Thiede, C.3
  • 120
    • 0023678897 scopus 로고
    • Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines
    • Morishita K, Parker DS, Mucenski ML, et al. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 1988; 54: 831-840.
    • (1988) Cell , vol.54 , pp. 831-840
    • Morishita, K.1    Parker, D.S.2    Mucenski, M.L.3
  • 121
    • 85047694750 scopus 로고    scopus 로고
    • EVI1 induces myelodysplastic syndrome in mice
    • Buonamici S, Li D, Chi Y, et al. EVI1 induces myelodysplastic syndrome in mice. J Clin Invest 2004; 114: 713-719.
    • (2004) J Clin Invest , vol.114 , pp. 713-719
    • Buonamici, S.1    Li, D.2    Chi, Y.3
  • 122
    • 0037305621 scopus 로고    scopus 로고
    • High EVI1 expression predicts poor survival in acute myeloid leukemia: A study of 319 de novo AML patients
    • Van Waalwijk van Doorn-Khosrovani SB, Erpelinck C, van Putten WL, et al. High EVI1 expression predicts poor survival in acute myeloid leukemia: A study of 319 de novo AML patients. Blood 2003; 101: 837-845.
    • (2003) Blood , vol.101 , pp. 837-845
    • Van Waalwijk van Doorn-Khosrovani, S.B.1    Erpelinck, C.2    van Putten, W.L.3
  • 123
    • 42949122111 scopus 로고    scopus 로고
    • High EVI1 levels predict adverse outcome in acute myeloid leukemia: Prevalence of EVI1 over-expression and chromosome 3q26 abnormalities underestimated
    • Lugthart S, Van Drunen E, Van Norden Y, et al. High EVI1 levels predict adverse outcome in acute myeloid leukemia: Prevalence of EVI1 over-expression and chromosome 3q26 abnormalities underestimated. Blood 2008; 11: 4329-4337.
    • (2008) Blood , vol.11 , pp. 4329-4337
    • Lugthart, S.1    Van Drunen, E.2    Van Norden, Y.3
  • 124
    • 67651046996 scopus 로고    scopus 로고
    • Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemia
    • Santamaria CM, Chillon MC, Garcia-Sanz R, et al. Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemia. Blood 2009; 114: 148-152.
    • (2009) Blood , vol.114 , pp. 148-152
    • Santamaria, C.M.1    Chillon, M.C.2    Garcia-Sanz, R.3
  • 125
    • 77951641594 scopus 로고    scopus 로고
    • High EVEN Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities
    • Groschel S, Lugthart S, Schlenk RF, et al. High EVEN Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities. J Colin Onslow 2010; 28: 2101-2107.
    • (2010) J Colin Onslow , vol.28 , pp. 2101-2107
    • Groschel, S.1    Lugthart, S.2    Schlenk, R.F.3
  • 126
    • 0025238437 scopus 로고
    • The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
    • Benezra R, Davis RL, Lockshon D, et al. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins. Cell 1990; 61: 49-59.
    • (1990) Cell , vol.61 , pp. 49-59
    • Benezra, R.1    Davis, R.L.2    Lockshon, D.3
  • 127
    • 0034471262 scopus 로고    scopus 로고
    • ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
    • Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2002; 113: 3897-3905.
    • (2002) J Cell Sci , vol.113 , pp. 3897-3905
    • Norton, J.D.1
  • 128
    • 0034161969 scopus 로고    scopus 로고
    • A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells
    • Lin CQ, Singh J, Murata K, et al. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 2000; 60: 1332-1340.
    • (2000) Cancer Res , vol.60 , pp. 1332-1340
    • Lin, C.Q.1    Singh, J.2    Murata, K.3
  • 129
    • 0036093103 scopus 로고    scopus 로고
    • Over expression of ID-1 in prostate cancer
    • Ouyang XS, Wang X, Lee DT, et al. Over expression of ID-1 in prostate cancer. J Urol 2002; 167: 2598-2602.
    • (2002) J Urol , vol.167 , pp. 2598-2602
    • Ouyang, X.S.1    Wang, X.2    Lee, D.T.3
  • 130
    • 0345686714 scopus 로고    scopus 로고
    • Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
    • Fong S, Itahana Y, Sumida T, et al. Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A 2003; 100: 13543-13548.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13543-13548
    • Fong, S.1    Itahana, Y.2    Sumida, T.3
  • 131
    • 0345669748 scopus 로고    scopus 로고
    • Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer
    • Schoppmann SF, Schindl M, Bayer G, et al. Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer. Int J Cancer 2003; 104: 677-682.
    • (2003) Int J Cancer , vol.104 , pp. 677-682
    • Schoppmann, S.F.1    Schindl, M.2    Bayer, G.3
  • 132
    • 70449495051 scopus 로고    scopus 로고
    • High Id1 expression is associated with poor prognosis in 237 patients with acute myeloid leukemia
    • Tang R, Hirsch P, Fava F, et al. High Id1 expression is associated with poor prognosis in 237 patients with acute myeloid leukemia. Blood 2009; 114: 2993-3000.
    • (2009) Blood , vol.114 , pp. 2993-3000
    • Tang, R.1    Hirsch, P.2    Fava, F.3
  • 133
    • 52649174782 scopus 로고    scopus 로고
    • Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells
    • Tam WF, Gu TL, Chen J, et al. Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells. Blood 2008; 112: 1981-1992.
    • (2008) Blood , vol.112 , pp. 1981-1992
    • Tam, W.F.1    Gu, T.L.2    Chen, J.3
  • 134
    • 58549114892 scopus 로고    scopus 로고
    • The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia
    • Al-Mawali A, Gillis D, Lewis I, et al. The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia. Am J Clin Pathol 2009; 131: 16-26.
    • (2009) Am J Clin Pathol , vol.131 , pp. 16-26
    • Al-Mawali, A.1    Gillis, D.2    Lewis, I.3
  • 135
    • 0038446666 scopus 로고    scopus 로고
    • Quantitative real-time RT-PCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia: Assessment of prognostic significance in adult patients from intergroup protocol 0129
    • Gallagher RE, Yeap BY, Bi W, et al. Quantitative real-time RT-PCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia: Assessment of prognostic significance in adult patients from intergroup protocol 0129. Blood 2003; 101: 2521-2528.
    • (2003) Blood , vol.101 , pp. 2521-2528
    • Gallagher, R.E.1    Yeap, B.Y.2    Bi, W.3
  • 136
    • 0642368568 scopus 로고    scopus 로고
    • Prognostic value of minimal residual disease quantification by real-time reverse transcriptase polymerase chain reaction in patients with core binding factor leukemias
    • Krauter J, Gorlich K, Ottmann O, et al. Prognostic value of minimal residual disease quantification by real-time reverse transcriptase polymerase chain reaction in patients with core binding factor leukemias. J Clin Oncol 2003; 21: 4413-4422.
    • (2003) J Clin Oncol , vol.21 , pp. 4413-4422
    • Krauter, J.1    Gorlich, K.2    Ottmann, O.3
  • 137
    • 70349579540 scopus 로고    scopus 로고
    • Minimal residual disease levels assessed by NPM1 mutation specific RQ-PCR provide important prognostic information in AML
    • Schnittger S, Kern W, Tschulik C, et al. Minimal residual disease levels assessed by NPM1 mutation specific RQ-PCR provide important prognostic information in AML. Blood 2009; 114: 2220-2231.
    • (2009) Blood , vol.114 , pp. 2220-2231
    • Schnittger, S.1    Kern, W.2    Tschulik, C.3
  • 138
    • 79960127726 scopus 로고    scopus 로고
    • Monitoring of Minimal Residual Disease in NPM1-Mutated Acute Myeloid Leukemia: A Study From the German-Austrian Acute Myeloid Leukemia Study Group
    • Krönke J, Schlenk RF, Jensen KO, et al. Monitoring of Minimal Residual Disease in NPM1-Mutated Acute Myeloid Leukemia: A Study From the German-Austrian Acute Myeloid Leukemia Study Group. J Clin Oncol 2011; 29: 2709-2716.
    • (2011) J Clin Oncol , vol.29 , pp. 2709-2716
    • Krönke, J.1    Schlenk, R.F.2    Jensen, K.O.3
  • 139
    • 57549101876 scopus 로고    scopus 로고
    • Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation
    • Bacher U, Badbaran A, Fehse B, et al. Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation. J Exp Hematol 2009; 37: 135-142.
    • (2009) J Exp Hematol , vol.37 , pp. 135-142
    • Bacher, U.1    Badbaran, A.2    Fehse, B.3
  • 140
    • 70449726860 scopus 로고    scopus 로고
    • Real-time quantitative PCR detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: An European LeukemiaNet Study
    • Cilloni D, Renneville A, Hermitte F, et al. Real-time quantitative PCR detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: An European LeukemiaNet Study. J Clin Oncol 2009; 27: 5195-5201.
    • (2009) J Clin Oncol , vol.27 , pp. 5195-5201
    • Cilloni, D.1    Renneville, A.2    Hermitte, F.3
  • 141
    • 58549105899 scopus 로고    scopus 로고
    • Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease
    • Qin Y, Zhu H, Jiang B, et al. Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. Leuk Res 2009; 33: 384-390.
    • (2009) Leuk Res , vol.33 , pp. 384-390
    • Qin, Y.1    Zhu, H.2    Jiang, B.3
  • 142
    • 20344390504 scopus 로고    scopus 로고
    • Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia
    • Scholl S, Loncarevic IF, Krause C, et al. Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia. Leuk Res 2005; 29: 849-853.
    • (2005) Leuk Res , vol.29 , pp. 849-853
    • Scholl, S.1    Loncarevic, I.F.2    Krause, C.3
  • 143
    • 79953847289 scopus 로고    scopus 로고
    • Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information
    • Chou WC, Hou HA, Liu CY, et al. Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information. Ann Oncol 2011; 22: 696-704.
    • (2011) Ann Oncol , vol.22 , pp. 696-704
    • Chou, W.C.1    Hou, H.A.2    Liu, C.Y.3
  • 144
    • 0036785393 scopus 로고    scopus 로고
    • Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
    • Kottaridis PD, Gale RE, Langabeer SE, et al. Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood 2002; 100: 2393-2398.
    • (2002) Blood , vol.100 , pp. 2393-2398
    • Kottaridis, P.D.1    Gale, R.E.2    Langabeer, S.E.3
  • 145
    • 0036786289 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse
    • Shih LY, Huang CF, Wu JH, et al. Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse. Blood 2002; 100: 2387-2392.
    • (2002) Blood , vol.100 , pp. 2387-2392
    • Shih, L.Y.1    Huang, C.F.2    Wu, J.H.3
  • 146
    • 0242329735 scopus 로고    scopus 로고
    • Evidence for allelic evolution of CEBPalpha mutations in acute myeloid leukemia
    • Tiesmeier J, Czwalinna A, Muller-Tidow C, et al. Evidence for allelic evolution of CEBPalpha mutations in acute myeloid leukemia. Br J Haematol 2003; 123: 413-419.
    • (2003) Br J Haematol , vol.123 , pp. 413-419
    • Tiesmeier, J.1    Czwalinna, A.2    Muller-Tidow, C.3
  • 147
    • 33644643303 scopus 로고    scopus 로고
    • Development of quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia
    • Smith LL, Pearce D, Smith ML, et al. Development of quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia. Br J Haematol 2006; 133: 103-105.
    • (2006) Br J Haematol , vol.133 , pp. 103-105
    • Smith, L.L.1    Pearce, D.2    Smith, M.L.3
  • 148
    • 0030871371 scopus 로고    scopus 로고
    • Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript
    • Kong XT, Ida K, Ichikawa H, et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood 1997; 90: 1192-1199.
    • (1997) Blood , vol.90 , pp. 1192-1199
    • Kong, X.T.1    Ida, K.2    Ichikawa, H.3
  • 149
    • 79960973763 scopus 로고    scopus 로고
    • Risk-stratification of intermediate-risk acute myeloid leukemia: Integrative analysis of a multitude of gene mutation and expression markers
    • Rockova V, Abbas S, Wouters BJ, et al. Risk-stratification of intermediate-risk acute myeloid leukemia: Integrative analysis of a multitude of gene mutation and expression markers. Blood 2011; 118: 1069-1076.
    • (2011) Blood , vol.118 , pp. 1069-1076
    • Rockova, V.1    Abbas, S.2    Wouters, B.J.3
  • 150
    • 79955973367 scopus 로고    scopus 로고
    • Integrative prognostic risk score in acute myeloid leukemia with normal karyotype
    • 117
    • Damm F, Heuser M, Morgan M, et al. Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood 2011; 28;117: 4561-4568.
    • (2011) Blood , vol.28 , pp. 4561-4568
    • Damm, F.1    Heuser, M.2    Morgan, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.