메뉴 건너뛰기




Volumn 106, Issue 6, 2005, Pages 2113-2119

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DAUNORUBICIN; ETOPOSIDE; MITOXANTRONE; RETINOIC ACID; TIOGUANINE;

EID: 24744449132     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2005-03-0867     Document Type: Article
Times cited : (207)

References (45)
  • 1
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 2
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 3
    • 0035383812 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells
    • Ning ZQ, Li J, Arceci RJ. Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells. Blood. 2001;97:3559-3567.
    • (2001) Blood , vol.97 , pp. 3559-3567
    • Ning, Z.Q.1    Li, J.2    Arceci, R.J.3
  • 4
    • 0027979146 scopus 로고
    • Loss of the normal nf1 allele from the bone-marrow of children with type-1 neurofibromatosis and malignant myeloid disorders
    • Shannon KM, Oconnell P, Martin GA, et al. Loss of the normal nf1 allele from the bone-marrow of children with type-1 neurofibromatosis and malignant myeloid disorders. New Engl J Med. 1994; 330:597-601.
    • (1994) New Engl J Med , vol.330 , pp. 597-601
    • Shannon, K.M.1    Oconnell, P.2    Martin, G.A.3
  • 5
    • 0030972025 scopus 로고    scopus 로고
    • Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells
    • Towatari M, Iida H, Tanimoto M, et al. Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia. 1997; 11:479-484.
    • (1997) Leukemia , vol.11 , pp. 479-484
    • Towatari, M.1    Iida, H.2    Tanimoto, M.3
  • 6
    • 0011134388 scopus 로고
    • RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes
    • Janssen JW, Steenvoorden AC, Lyons J, et al. RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci U S A. 1987;84:9228-9232.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9228-9232
    • Janssen, J.W.1    Steenvoorden, A.C.2    Lyons, J.3
  • 7
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3
  • 8
    • 0028214608 scopus 로고
    • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
    • Neubauer A, Dodge RK, George SL, et al. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood. 1994;83:1603-1611.
    • (1994) Blood , vol.83 , pp. 1603-1611
    • Neubauer, A.1    Dodge, R.K.2    George, S.L.3
  • 9
    • 0027155193 scopus 로고
    • Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia
    • Kubo K, Naoe T, Kiyoi H, et al. Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia. Jpn J Cancer Res. 1993;84:379-387.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 379-387
    • Kubo, K.1    Naoe, T.2    Kiyoi, H.3
  • 10
    • 0025240615 scopus 로고
    • The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing
    • Ahuja HG, Foti A, Bar Eli M, Cline MJ. The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing. Blood. 1990;75:1684-1690.
    • (1990) Blood , vol.75 , pp. 1684-1690
    • Ahuja, H.G.1    Foti, A.2    Bar Eli, M.3    Cline, M.J.4
  • 11
    • 0024990090 scopus 로고
    • N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance
    • Radich JP, Kopecky KJ, Willman CL, et al. N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance. Blood. 1990;76:801-807.
    • (1990) Blood , vol.76 , pp. 801-807
    • Radich, J.P.1    Kopecky, K.J.2    Willman, C.L.3
  • 12
    • 0035383768 scopus 로고    scopus 로고
    • FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    • 200t
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood. 200t; 97:3589-3595.
    • Blood , vol.97 , pp. 3589-3595
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 13
    • 0027181645 scopus 로고
    • N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome
    • Paquette RL, Landaw EM, Pierre RV, et al. N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome. Blood. 1993;82:590-599.
    • (1993) Blood , vol.82 , pp. 590-599
    • Paquette, R.L.1    Landaw, E.M.2    Pierre, R.V.3
  • 14
    • 0034492376 scopus 로고    scopus 로고
    • Short report: Oncogene mutation and prognosis in the myelodysplastic syndromes
    • Padua RA, West RR. Short report: oncogene mutation and prognosis in the myelodysplastic syndromes. Br J Haematol. 2000;111:873-874.
    • (2000) Br J Haematol , vol.111 , pp. 873-874
    • Padua, R.A.1    West, R.R.2
  • 16
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial: The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial: the Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92:2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 17
    • 0030895252 scopus 로고    scopus 로고
    • Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia: Results of the Medical Research Council's 10th AML trial (MRC AML10)
    • Hann IM, Stevens RF, Goldstone AH, et al. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia: results of the Medical Research Council's 10th AML trial (MRC AML10). Blood. 1997;89:2311-2318.
    • (1997) Blood , vol.89 , pp. 2311-2318
    • Hann, I.M.1    Stevens, R.F.2    Goldstone, A.H.3
  • 18
    • 0008381951 scopus 로고    scopus 로고
    • A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial: United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties
    • Wheatley K, Burnett AK, Goldstone AH, et al. A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial: United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties. Br J Haematol. 1999;107: 69-79.
    • (1999) Br J Haematol , vol.107 , pp. 69-79
    • Wheatley, K.1    Burnett, A.K.2    Goldstone, A.H.3
  • 19
    • 0034988112 scopus 로고    scopus 로고
    • Comparison of 'sequential' versus 'standard' chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): Results of the UK Medical Research Council AML-R trial
    • Liu Yin JA, Wheatley K, Rees JK, Burnett AK. Comparison of 'sequential' versus 'standard' chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): results of the UK Medical Research Council AML-R trial. Br J Haematol. 2001;113:713-726.
    • (2001) Br J Haematol , vol.113 , pp. 713-726
    • Liu Yin, J.A.1    Wheatley, K.2    Rees, J.K.3    Burnett, A.K.4
  • 20
    • 0038446667 scopus 로고    scopus 로고
    • CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication
    • Bowen DT, Frew ME, Rollinson S, et al. CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication. Blood. 2003;101:2770-2774.
    • (2003) Blood , vol.101 , pp. 2770-2774
    • Bowen, D.T.1    Frew, M.E.2    Rollinson, S.3
  • 21
    • 18244369274 scopus 로고    scopus 로고
    • A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis
    • Nishikawa T, Maemura K, Hirata I, et al. A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis. Clin Chim Acta. 2002;318:107-112.
    • (2002) Clin Chim Acta , vol.318 , pp. 107-112
    • Nishikawa, T.1    Maemura, K.2    Hirata, I.3
  • 22
    • 0027141064 scopus 로고
    • Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method
    • Lin SY, Chen PH, Wang CK, et al. Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method. Am J Clin Pathol. 1993;100:686-689.
    • (1993) Am J Clin Pathol , vol.100 , pp. 686-689
    • Lin, S.Y.1    Chen, P.H.2    Wang, C.K.3
  • 23
    • 0031822452 scopus 로고    scopus 로고
    • Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix
    • O'Leary JJ, Landers RJ, Silva I, et al. Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix. J Clin Pathol. 1998;51:576-582.
    • (1998) J Clin Pathol , vol.51 , pp. 576-582
    • O'Leary, J.J.1    Landers, R.J.2    Silva, I.3
  • 25
    • 0028114788 scopus 로고
    • The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia
    • Coghlan DW, Morley AA, Matthews JP, Bishop JF. The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia. Leukemia. 1994;8:1682-1687.
    • (1994) Leukemia , vol.8 , pp. 1682-1687
    • Coghlan, D.W.1    Morley, A.A.2    Matthews, J.P.3    Bishop, J.F.4
  • 26
    • 9144253166 scopus 로고    scopus 로고
    • Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia
    • Ritter M, Kim TD, Lisske P, et al. Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia. Haematologica. 2004;89:1397-1399.
    • (2004) Haematologica , vol.89 , pp. 1397-1399
    • Ritter, M.1    Kim, T.D.2    Lisske, P.3
  • 27
    • 0842328518 scopus 로고    scopus 로고
    • Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16)
    • Valk PJ, Bowen DT, Frew ME, et al. Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16) [letter]. Haematologica. 2004;89:106.
    • (2004) Haematologica , vol.89 , pp. 106
    • Valk, P.J.1    Bowen, D.T.2    Frew, M.E.3
  • 28
    • 0026500545 scopus 로고
    • Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): Implications for the role of N-ras mutation in AML pathogenesis
    • Basney A, Gill R, Levi S, et al. Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): implications for the role of N-ras mutation in AML pathogenesis. Blood. 1992;79:981-989.
    • (1992) Blood , vol.79 , pp. 981-989
    • Basney, A.1    Gill, R.2    Levi, S.3
  • 29
    • 0034999807 scopus 로고    scopus 로고
    • Denaturing high-performance liquid chromatography: A review
    • Xiao W, Oefner PJ. Denaturing high-performance liquid chromatography: a review. Hum Mutat. 2001;17:439-474.
    • (2001) Hum Mutat , vol.17 , pp. 439-474
    • Xiao, W.1    Oefner, P.J.2
  • 30
    • 12644273250 scopus 로고    scopus 로고
    • Biochemical characterization of a novel KRAS insertion mutation from a human leukemia
    • Bollag G, Adler F, elMasry N, et al. Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. J Biol Chem. 1996; 271:32491-32494.
    • (1996) J Biol Chem , vol.271 , pp. 32491-32494
    • Bollag, G.1    Adler, F.2    Elmasry, N.3
  • 31
    • 0023687430 scopus 로고
    • RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation
    • Padua RA, Carter G, Hughes D, et al. RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation. Leukemia. 1988;2:503-510.
    • (1988) Leukemia , vol.2 , pp. 503-510
    • Padua, R.A.1    Carter, G.2    Hughes, D.3
  • 32
    • 0034114254 scopus 로고    scopus 로고
    • Oncogenic base substitution mutations in circulating leukocytes of normal individuals
    • Wilson VL, Yin X, Thompson B, et al. Oncogenic base substitution mutations in circulating leukocytes of normal individuals. Cancer Res. 2000;60: 1830-1834.
    • (2000) Cancer Res , vol.60 , pp. 1830-1834
    • Wilson, V.L.1    Yin, X.2    Thompson, B.3
  • 33
    • 0025276219 scopus 로고
    • Ras mutations in patients following cytotoxic therapy for lymphoma
    • Carter G, Hughes DC, Clark RE, et al. Ras mutations in patients following cytotoxic therapy for lymphoma. Oncogene. 1990;5:411-416.
    • (1990) Oncogene , vol.5 , pp. 411-416
    • Carter, G.1    Hughes, D.C.2    Clark, R.E.3
  • 34
    • 0029819604 scopus 로고    scopus 로고
    • Activating mutations of N- And K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group Phase III Trial
    • Liu P, Leong T, Quam L, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood. 1996;88:2699-2706.
    • (1996) Blood , vol.88 , pp. 2699-2706
    • Liu, P.1    Leong, T.2    Quam, L.3
  • 35
    • 0025942816 scopus 로고
    • Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors
    • Capella G, Cronauer-Mitra S, Pienado MA, Perucho M. Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect. 1991;93:125-131.
    • (1991) Environ Health Perspect , vol.93 , pp. 125-131
    • Capella, G.1    Cronauer-Mitra, S.2    Pienado, M.A.3    Perucho, M.4
  • 36
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to a mutations in K-ras in colorectal tumorigenesis
    • Esteller M, Toyota M, Sanchez-Cespedes M, et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res. 2000;60:2368-2371.
    • (2000) Cancer Res , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3
  • 37
    • 0023934849 scopus 로고
    • Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes
    • Lyons J, Janssen JW, Bartram C, Layton M, Mufti GJ. Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes. Blood. 1988;71: 1707-1712.
    • (1988) Blood , vol.71 , pp. 1707-1712
    • Lyons, J.1    Janssen, J.W.2    Bartram, C.3    Layton, M.4    Mufti, G.J.5
  • 38
    • 0028218281 scopus 로고
    • Retroviral-mediated gene transfer of a mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation
    • Maher J, Colonna F, Baker D, Luzzatto L, Roberts I. Retroviral-mediated gene transfer of a mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation. Exp Hematol. 1994;22:8-12.
    • (1994) Exp Hematol , vol.22 , pp. 8-12
    • Maher, J.1    Colonna, F.2    Baker, D.3    Luzzatto, L.4    Roberts, I.5
  • 39
    • 0023615744 scopus 로고
    • Expression of ras proto-oncogene proteins in normal human tissues
    • Furth ME, Aldrich TH, Cordon-Cardo C. Expression of ras proto-oncogene proteins in normal human tissues. Oncogene. 1987;1:47-58.
    • (1987) Oncogene , vol.1 , pp. 47-58
    • Furth, M.E.1    Aldrich, T.H.2    Cordon-Cardo, C.3
  • 40
    • 0032936416 scopus 로고    scopus 로고
    • Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation
    • Iida M, Towatari M, Nakao A, et al. Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation. Leukemia. 1999;13:585-589.
    • (1999) Leukemia , vol.13 , pp. 585-589
    • Iida, M.1    Towatari, M.2    Nakao, A.3
  • 41
    • 0030980641 scopus 로고    scopus 로고
    • Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
    • Irani K, Xia Y, Zweier JL, et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science. 1997;275:1649-1652.
    • (1997) Science , vol.275 , pp. 1649-1652
    • Irani, K.1    Xia, Y.2    Zweier, J.L.3
  • 42
    • 0033559734 scopus 로고    scopus 로고
    • Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice
    • MacKenzie KL, Dolnikov A, Millington M, Shounan Y, Symonds G. Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. Blood. 1999;93: 2043-2056.
    • (1999) Blood , vol.93 , pp. 2043-2056
    • MacKenzie, K.L.1    Dolnikov, A.2    Millington, M.3    Shounan, Y.4    Symonds, G.5
  • 43
    • 0032701282 scopus 로고    scopus 로고
    • Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors
    • Darley RL, Burnett AK. Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors. Exp Hematol. 1999;27:1599-1608.
    • (1999) Exp Hematol , vol.27 , pp. 1599-1608
    • Darley, R.L.1    Burnett, A.K.2
  • 44
    • 0036178826 scopus 로고    scopus 로고
    • Prospects for anti-ras drugs
    • Ahmadian MR. Prospects for anti-ras drugs. Br J Haematol. 2002;116:511-518.
    • (2002) Br J Haematol , vol.116 , pp. 511-518
    • Ahmadian, M.R.1
  • 45
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
    • Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood. 2001;97:3361-3369.
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.