A clinical overview of Wt1 gene mutations

Human Mutation

Volumn 9, Issue 3, 1997, Pages 209-225

  Little, Melissa ^a   Wells, Christine ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Denys Drash syndrome; tumour suppressor; WAGR syndrome; Wilms' tumour; WT1

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; CHILDHOOD CANCER; DENYS DRASH SYNDROME; GENE MUTATION; GENETIC PREDISPOSITION; GENITAL MALFORMATION; GRANULOSA CELL TUMOR; HUMAN; MESOTHELIOMA; NEPHROBLASTOMA; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

ALLELES; BECKWITH-WIEDEMANN SYNDROME; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 11; CRYPTORCHIDISM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GENES, WILMS TUMOR; HUMANS; KIDNEY NEOPLASMS; MALE; MENTAL RETARDATION; MUTATION; NEOPLASMS; NEPHROTIC SYNDROME; PSEUDOHERMAPHRODITISM; WAGR SYNDROME; X CHROMOSOME;

EID: 0030891372     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1004(1997)9:3<209::AID-HUMU2>3.0.CO;2-2     Document Type: Review

References (3)

1. Akasaka Y, Kikuchi H, Nagai T, Hiraoka N, Kato S, Hata J (1993) A point mutation found in the WT1 gene in a sporadic Wilms tumour without genitourinary abnormalities is identical with the most frequent point mutation in Denys-Drash syndrome. FEES 317:39-43.
2. Webb N, Lewis M, Williamson K, van Heyningen V, Bruce J, Lendon M, Postlethwaite R (1995) Do children with diffuse mesangial sclerosis in association with mutations of the Wilms' tumour suppressor gene (WT1) require bilateral nephrectomy? Pediatr Nephrol 9:252-253.
3. Wilmore HR White OF, Howell RT, Brown KW (1994) Germline and somatic abnormalities of chromosome 7 in Wilms' tumor. Cancer Genet Cytogenet 77:93-98.