메뉴 건너뛰기




Volumn 14, Issue 6, 2011, Pages 651-660

5′-Adenosine monophosphate-activated protein kinase-mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; LIPOFUSCIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; RAPAMYCIN; RESVERATROL; VASCULOTROPIN INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; STILBENE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

EID: 83755186590     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1220     Document Type: Article
Times cited : (39)

References (91)
  • 2
    • 70349469696 scopus 로고    scopus 로고
    • Antiangiogenic approaches to age-related macular degeneration today
    • Bressler NM. Antiangiogenic approaches to age-related macular degeneration today. Ophthalmology 2009;116:15-23.
    • (2009) Ophthalmology , vol.116 , pp. 15-23
    • Bressler, N.M.1
  • 3
    • 65549162660 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration
    • Ciulla TA, Rosenfeld PJ. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 2009;20:158-165.
    • (2009) Curr Opin Ophthalmol , vol.20 , pp. 158-165
    • Ciulla, T.A.1    Rosenfeld, P.J.2
  • 5
    • 33144459399 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of age-related macular degeneration
    • DOI 10.1016/j.survophthal.2005.12.001, PII S0039625705002067
    • Donoso LA, Kim D, Frost A, Callahan A, Hageman G. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Opthalmol 2006;91:137-152. (Pubitemid 43269939)
    • (2006) Survey of Ophthalmology , vol.51 , Issue.2 , pp. 137-152
    • Donoso, L.A.1    Kim, D.2    Frost, A.3    Callahan, A.4    Hageman, G.5
  • 6
    • 33746373850 scopus 로고    scopus 로고
    • Age-related macular degeneration (AMD): Pathogenesis and therapy
    • Nowak JZ. Age-related macular degeneration (AMD) pathogenesis and therapy. Pharmacol Report 2006;58:353-363. (Pubitemid 44111070)
    • (2006) Pharmacological Reports , vol.58 , Issue.3 , pp. 353-363
    • Nowak, J.Z.1
  • 8
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009;34:259-269.
    • (2009) Mol Cell , vol.34 , pp. 259-269
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3    Dikic, I.4
  • 9
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • DOI 10.1101/gad.1599207
    • Mizushima N. Autophagy: Process and function. Genes Dev 2009;21:2861-2873. (Pubitemid 350133435)
    • (2007) Genes and Development , vol.21 , Issue.22 , pp. 2861-2873
    • Mizushima, N.1
  • 10
    • 62949091373 scopus 로고    scopus 로고
    • Autophagy: A lysosomal degradation pathway with a central role in health and disease
    • Eskelinen EL, Saftig P. Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biphys Acta 2008;1793:664-673.
    • (2008) Biochim Biphys Acta , vol.1793 , pp. 664-673
    • Eskelinen, E.L.1    Saftig, P.2
  • 11
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • Yang Z, Klionsky DJ. Eaten alive: A history of macroautophagy. Nature Cell Biol 2010;12:814-822.
    • (2010) Nature Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 12
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • DOI 10.1016/S1534-5807(04)00099-1, PII S1534580704000991
    • Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 2004;6:463-477. (Pubitemid 38456176)
    • (2004) Developmental Cell , vol.6 , Issue.4 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 13
    • 37349003177 scopus 로고    scopus 로고
    • The role of autophagy in age-related neurodegeneration
    • DOI 10.1159/000109761
    • McCray BA, Taylor JP. The role of autophagy in age-related neurodegeneration. Neurosignals 2008;16:75-84. (Pubitemid 350308323)
    • (2008) NeuroSignals , vol.16 , Issue.1 , pp. 75-84
    • McCray, B.A.1    Taylor, J.P.2
  • 14
    • 69049088683 scopus 로고    scopus 로고
    • Regulatory role of HIF-1a in the pathogenesis of age-related macular degeneration (AMD)
    • Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. Regulatory role of HIF-1a in the pathogenesis of age-related macular degeneration (AMD). Ageing Res Rev 2009;8:349-358.
    • (2009) Ageing Res Rev , vol.8 , pp. 349-358
    • Arjamaa, O.1    Nikinmaa, M.2    Salminen, A.3    Kaarniranta, K.4
  • 15
    • 60949098753 scopus 로고    scopus 로고
    • Heat shock proteins as gatekeepers of proteolytic pathways Implications for age-related macular degeneration (AMD)
    • Kaarniranta K, Salminen A, Eskelinen EL, Kopitz J. Heat shock proteins as gatekeepers of proteolytic pathways Implications for age-related macular degeneration (AMD). Ageing Res Rev 2009;8:128-139.
    • (2009) Ageing Res Rev , vol.8 , pp. 128-139
    • Kaarniranta, K.1    Salminen, A.2    Eskelinen, E.L.3    Kopitz, J.4
  • 16
    • 65549139675 scopus 로고    scopus 로고
    • Regulation of the aging process in autophagy
    • Salminen A, Kaarniranta K. Regulation of the aging process in autophagy. Trends Mol Med 2009;15:217-224.
    • (2009) Trends Mol Med , vol.15 , pp. 217-224
    • Salminen, A.1    Kaarniranta, K.2
  • 19
    • 58349109733 scopus 로고    scopus 로고
    • Autophagy and exosomes in the aged retinal pigment epithelium: Possible relevance to drusen formation and agerelated macular degeneration
    • Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, Neufeld AH. Autophagy and exosomes in the aged retinal pigment epithelium: Possible relevance to drusen formation and agerelated macular degeneration. PLoS One 2009;24:e4160.
    • (2009) PLoS One , vol.24
    • Wang, A.L.1    Lukas, T.J.2    Yuan, M.3    Du, N.4    Tso, M.O.5    Neufeld, A.H.6
  • 20
    • 77952829285 scopus 로고    scopus 로고
    • Autophagy hot topic in AMD
    • Kaarniranta K. Autophagy hot topic in AMD. Acta Ophthalmol 2010;88:387-388.
    • (2010) Acta Ophthalmol , vol.88 , pp. 387-388
    • Kaarniranta, K.1
  • 21
    • 4344660368 scopus 로고    scopus 로고
    • The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
    • DOI 10.1016/j.biocel.2004.05.007, PII S1357272504002006
    • Bergamini E, Cavallini G, Donati A, Gori Z. The role of macroautophagy in the ageing process, anti-ageing intervention and age-related diseases. Int J Biochem Cell Biol 2004;36:2392-2404. (Pubitemid 39119754)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.12 , pp. 2392-2404
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 22
    • 77957349477 scopus 로고    scopus 로고
    • AMP-activated protein kinase and its downstream transcriptional pathways
    • Canto A, Auwerx J. AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci 2010;67:3407-3423.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3407-3423
    • Canto, A.1    Auwerx, J.2
  • 23
    • 34250891313 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A universal regulator of autophagy?
    • Hayer-Hansen M, Jaattela M. AMP-activated protein kinase: A universal regulator of autophagy? Autophagy 2007 3 381-283.
    • (2007) Autophagy , vol.3 , pp. 381-283
    • Haer-Hansen, M.1    Jattela, M.2
  • 24
    • 78851472160 scopus 로고    scopus 로고
    • Resveratrol in cardiovascular health and disease
    • Petrovski G, Gurusamy N, Das DK. Resveratrol in cardiovascular health and disease. Ann NY Acad Sci 2011;1215:22-33.
    • (2011) Ann NY Acad Sci , vol.1215 , pp. 22-33
    • Petrovski, G.1    Gurusamy, N.2    Das, D.K.3
  • 25
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • DOI 10.1038/nrm2249, PII NRM2249
    • Hardie DG. AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007;8:774-785. (Pubitemid 47462132)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 774-785
    • Hardie, D.G.1
  • 26
    • 43749106701 scopus 로고    scopus 로고
    • A2 but not a1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments
    • Qin S, De Vries GW. a2 but not a1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments. J Biol Chem 2008;283:6744-6751.
    • (2008) J Biol Chem , vol.283 , pp. 6744-6751
    • Qin, S.1    De Vries, G.W.2
  • 27
    • 78649472949 scopus 로고    scopus 로고
    • Differential roles of AMPKa1 and AMPKa2 in regulating 4-HNE-induced RPE cell death and permeability
    • Qin S, Rodrigues GA. Differential roles of AMPKa1 and AMPKa2 in regulating 4-HNE-induced RPE cell death and permeability. Exp Eye Res 2010;91:818-824.
    • (2010) Exp Eye Res , vol.91 , pp. 818-824
    • Qin, S.1    Rodrigues, G.A.2
  • 28
    • 56449117024 scopus 로고    scopus 로고
    • AMPK: A metabolic gauge regulating whole-body energy homeostasis
    • Lage R, Dieáguez C, Vidal-Puig A, Loápez M. AMPK: A metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 2008;14:539-549.
    • (2008) Trends Mol Med , vol.14 , pp. 539-549
    • Lage, R.1    Dieáguez, C.2    Vidal-Puig, A.3    Loápez, M.4
  • 29
    • 0035282062 scopus 로고    scopus 로고
    • Post-translational modifications of the -1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
    • DOI 10.1042/0264-6021:3540275
    • Warden SM, Richardson C, O'Donnell J, Stapleton D, Kemp BE, Witters LA. Post-translational modifications of the b-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J 2001;354:275-283. (Pubitemid 32209863)
    • (2001) Biochemical Journal , vol.354 , Issue.2 , pp. 275-283
    • Warden, S.M.1    Richardson, C.2    O'Donnell Jr., J.3    Stapleton, D.4    Kemp, B.E.5    Witters, L.A.6
  • 32
    • 0032508564 scopus 로고    scopus 로고
    • 6-mercaptopurine riboside. Evidence for involvement of AMP-activated protein kinase
    • DOI 10.1074/jbc.273.37.23758
    • Samari HR, Seglen PO. Inhibition of hepatocytic autophagy by adenosine, aminoimdazole-4-carboxyamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem 1998;273: 23758-23763. (Pubitemid 28435708)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.37 , pp. 23758-23763
    • Samari, H.R.1    Seglen, P.O.2
  • 35
    • 18044393806 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle
    • DOI 10.1161/01.RES.0000163633.10240.3b
    • Ouchi N, Shibata R, Walsh K. AMP.activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res 2005;96:838-846. (Pubitemid 40604967)
    • (2005) Circulation Research , vol.96 , Issue.8 , pp. 838-846
    • Ouchi, N.1    Shibata, R.2    Walsh, K.3
  • 36
    • 77953768762 scopus 로고    scopus 로고
    • AMPKalpha1 deletion shortens erythrocyte life span in mice: Role of oxidative stress
    • Wang S, Dale GL, Song P, Viollet B, Zou MH. AMPKalpha1 deletion shortens erythrocyte life span in mice: Role of oxidative stress. J Biol Chem 2010;25:19976-19985.
    • (2010) J Biol Chem , vol.25 , pp. 19976-19985
    • Wang, S.1    Dale, G.L.2    Song, P.3    Viollet, B.4    Zou, M.H.5
  • 37
    • 0141706665 scopus 로고    scopus 로고
    • Activation of 5-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: Role of peroxynitrite
    • DOI 10.1074/jbc.M300215200
    • Zou M-H, Hou X-Y, Shi C-M, Kirkpatick S, Liu F, Goldman MH, Cohen RA. Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol. Chem 2003;278: 34003-34010. (Pubitemid 37553236)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 34003-34010
    • Zou, M.-H.1    Hou, X.-Y.2    Shi, C.-M.3    Kirkpatick, S.4    Liu, F.5    Goldman, M.H.6    Cohen, R.A.7
  • 40
    • 0029591929 scopus 로고
    • Accumulation of lipofuscin within retinal pigment epithelial cells results in enhanced sensitivity to photooxidation
    • Brunk UT, Wihlmark U, Wrigstad A, Roberg K, Nilsson SE. Accumulation of lipofuscin within retinal pigment epithelial cells results in enhanced sensitivity to photooxidation. Gerontology 1995;41:201-212. (Pubitemid 26019917)
    • (1995) Gerontology , vol.41 , Issue.SUPPL. 2 , pp. 201-212
    • Brunk, U.T.1    Wihlmark, U.2    Wrigstad, A.3    Roberg, K.4    Nilsson, S.-E.5
  • 41
    • 10044255422 scopus 로고    scopus 로고
    • Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration
    • DOI 10.1016/j.biochi.2004.09.029, PII S0300908404001816, Recent Advances in Lipid Metabolism and Related Disorders
    • Kopitz J, Holz FG, Kaemmerer E, Schutt F. Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie 2004;86:825-831. (Pubitemid 39602762)
    • (2004) Biochimie , vol.86 , Issue.11 , pp. 825-831
    • Kopitz, J.1    Holz, F.G.2    Kaemmerer, E.3    Schutt, F.4
  • 42
    • 2442648066 scopus 로고    scopus 로고
    • Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
    • Bergmann M, Schu tt F, Holz FG, Kopitz J. Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J 2004; 18:562-564.
    • (2004) FASEB J , vol.18 , pp. 562-564
    • Bergmann, M.1    Schut, F.2    Holz, F.G.3    Kopitz, J.4
  • 43
    • 18044366931 scopus 로고    scopus 로고
    • RPE lipofuscin and its role in retinal pathobiology
    • DOI 10.1016/j.exer.2005.01.007
    • Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 2005;80:595-606. (Pubitemid 40602960)
    • (2005) Experimental Eye Research , vol.80 , Issue.5 , pp. 595-606
    • Sparrow, J.R.1    Boulton, M.2
  • 47
    • 78649690159 scopus 로고    scopus 로고
    • Does autophagy take a front seat in lifespan extension?
    • Petrovski G, Das DK. Does autophagy take a front seat in lifespan extension? J Cell Mol Med 2010 14 2543-2551.
    • (2010) J Cell Mol Med , vol.14 , pp. 2543-2551
    • Petrovski, G.1    Das, D.K.2
  • 48
    • 73849101809 scopus 로고    scopus 로고
    • Key factors in mTOR regulation
    • Bai X, Jiang Y. Key factors in mTOR regulation. Cell Mol Life Sci 2010;67:239-253.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 239-253
    • Bai, X.1    Jiang, Y.2
  • 49
    • 0025869741 scopus 로고
    • Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus
    • Lane WS, Galat A, Harding MW, Schreiber SL. Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. J Protein Chem 1991;10:151-160.
    • (1991) J Protein Chem , vol.10 , pp. 151-160
    • Lane, W.S.1    Galat, A.2    Harding, M.W.3    Schreiber, S.L.4
  • 50
    • 33750072949 scopus 로고    scopus 로고
    • MTOR and cancer therapy
    • DOI 10.1038/sj.onc.1209886, PII 1209886
    • Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006;25:6436-6446. (Pubitemid 44582287)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 52
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829-1834. (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 54
  • 56
    • 78649956469 scopus 로고    scopus 로고
    • MTORC2 regulates neutrophil chemotaxis in a cAMP-and RhoA-dependent fashion
    • Liu L, Das S, Losert W, Parent CA. mTORC2 regulates neutrophil chemotaxis in a cAMP-and RhoA-dependent fashion. Dev Cell 2010;19:845-857.
    • (2010) Dev Cell , vol.19 , pp. 845-857
    • Liu, L.1    Das, S.2    Losert, W.3    Parent, C.A.4
  • 57
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • DOI 10.1128/MCB.25.14.5834-5845.2005
    • Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 2005;25:5834-5845. (Pubitemid 40946541)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.14 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 58
    • 78149262655 scopus 로고    scopus 로고
    • Endoplastic reticulum stress in age-related macular degeneration: Trigger for neovascularization
    • Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E, Kaarniranta K. Endoplastic reticulum stress in age-related macular degeneration: Trigger for neovascularization. Mol Med 2010;16:535-542.
    • (2010) Mol Med , vol.16 , pp. 535-542
    • Salminen, A.1    Kauppinen, A.2    Jmt, H.3    Toropainen, E.4    Kaarniranta, K.5
  • 60
    • 77958138056 scopus 로고    scopus 로고
    • Altered mTOR signaling in senescent retinal pigment epithelium
    • Chen Y, Wang J, Cai J, Sternberg P. Altered mTOR signaling in senescent retinal pigment epithelium. Invest Ophthalmol Vis Sci 2010;51:5314-5319.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 5314-5319
    • Chen, Y.1    Wang, J.2    Cai, J.3    Sternberg, P.4
  • 64
    • 79955545737 scopus 로고    scopus 로고
    • Mature peripheral RPE cells have an intrinsic capacity to proliferate; A potential regulatory mechanism for age-related cell loss
    • Kokkinopoulos I, Shahabi G, Colman A, Jeffery G. Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss. PloS ONE 2011;6:e18921.
    • (2011) PloS ONE , vol.6
    • Kokkinopoulos, I.1    Shahabi, G.2    Colman, A.3    Jeffery, G.4
  • 66
  • 68
    • 58149473473 scopus 로고    scopus 로고
    • Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg-13-independent mechanism
    • Chan EY, Longatti A, McKnight NC, Tooze SA. Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg-13-independent mechanism. Mol Cell Biol 2009;29:157-171.
    • (2009) Mol Cell Biol , vol.29 , pp. 157-171
    • Chan, E.Y.1    Longatti, A.2    McKnight, N.C.3    Tooze, S.A.4
  • 69
    • 66449083078 scopus 로고    scopus 로고
    • ULK1 ATG 13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009;284:12297-12305.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam Du, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 72
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature Cell Biol 2011;13:132-141.
    • (2011) Nature Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 73
    • 78149476877 scopus 로고    scopus 로고
    • The association of AMPK with ULK1 regulates autophagy
    • Lee JW, Park S, Takahashi Y, Wang H-G. The association of AMPK with ULK 1 regulates autophagy, PLoS One 2010 5 e15394.
    • (2010) PLoS One , vol.5
    • Lee, J.W.1    Park, S.2    Takahashi, Y.3    Wang, H.-G.4
  • 74
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: From internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ. Exosome: From internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 2000;113: 3365-3374.
    • (2000) J Cell Sci , vol.113 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3    Stoorvogel, W.4    Geuze, H.J.5
  • 75
    • 43149120419 scopus 로고    scopus 로고
    • Exosome function: From tumor immunology to pathogen biology
    • DOI 10.1111/j.1600-0854.2008.00734.x
    • Schorey JS, Bhatnagar S. Exosome function: From tumor immunology to pathogen biology. Traffic 2008;9:871-881. (Pubitemid 351639493)
    • (2008) Traffic , vol.9 , Issue.6 , pp. 871-881
    • Schorey, J.S.1    Bhatnagar, S.2
  • 76
    • 0028073143 scopus 로고
    • Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
    • DOI 10.1016/0014-5793(94)01006-4
    • Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett 1994;353: 33-36. (Pubitemid 24312538)
    • (1994) FEBS Letters , vol.353 , Issue.1 , pp. 33-36
    • Sullivan, J.E.1
  • 77
    • 77956875005 scopus 로고    scopus 로고
    • 2010 AMPKinduced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
    • Leclerc GM, Leclerc GJ, Fu G, Barredo JC. 2010. AMPKinduced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. J Mol Signal 2010;5:15.
    • (2010) J Mol Signal , vol.5 , pp. 15
    • Leclerc, G.M.1    Leclerc, G.J.2    Fu, G.3    Barredo, J.C.4
  • 78
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • DOI 10.1158/0008-5472.CAN-06-4447
    • Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007;67:6745-6752. (Pubitemid 47105521)
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3    Lum, J.J.4    DeBerardinis, R.J.5    Zhao, F.6    Viollet, B.7    Thompson, C.B.8
  • 79
    • 79953193036 scopus 로고    scopus 로고
    • Sensing of energy and nutrients by AMPactivated protein kinase
    • Hardie DG. Sensing of energy and nutrients by AMPactivated protein kinase. Am J Clin Nutr 2011;93(Suppl): 891S-816S.
    • (2011) Am J Clin Nutr , vol.93 , Issue.SUPPL.
    • Hardie, D.G.1
  • 82
    • 49649105189 scopus 로고    scopus 로고
    • Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
    • Stahl A, Paschek L, Martin G, Gross NJ, Feltgen N, Hansen LL, Agostini HT. Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro. FEBS Lett 2008:582:3097-3102.
    • (2008) FEBS Lett , vol.582 , pp. 3097-3102
    • Stahl, A.1    Paschek, L.2    Martin, G.3    Gross, N.J.4    Feltgen, N.5    Hansen, L.L.6    Agostini, H.T.7
  • 83
    • 79955970932 scopus 로고    scopus 로고
    • Differential effects of rapamycin on rods and cones during light-induced stress in albino mice
    • Kunchithapautham K, Coughlin B, Lemasters JJ, Rohrer B. Differential effects of rapamycin on rods and cones during light-induced stress in albino mice. Invest Ophthalmol Vis Sci 2011;52:2967-2975.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2967-2975
    • Kunchithapautham, K.1    Coughlin, B.2    Lemasters, J.J.3    Rohrer, B.4
  • 85
    • 77954600273 scopus 로고    scopus 로고
    • Resveratrol regulates pathological angiogenesis by a eukaryotic elongation factor-2-kinase-reguated pathway
    • Khan AA, Dace DS, Ryazanov AG, Kelly J, Apte RS. Resveratrol regulates pathological angiogenesis by a eukaryotic elongation factor-2-kinase-reguated pathway. Am J Pathol 2010;177:481-492.
    • (2010) Am J Pathol , vol.177 , pp. 481-492
    • Khan, A.A.1    Dace, D.S.2    Ryazanov, A.G.3    Kelly, J.4    Apte, R.S.5
  • 86
    • 78649436142 scopus 로고    scopus 로고
    • Dose-dependency of resveratrol in providing health benefits
    • Mukherjee S, Dudley JI, Das DK. Dose-dependency of resveratrol in providing health benefits. Dose Response 2010,8:478-500.
    • (2010) Dose Response , vol.8 , pp. 478-500
    • Mukherjee, S.1    Dudley, J.I.2    Das, D.K.3
  • 87
    • 77954200118 scopus 로고    scopus 로고
    • Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage
    • Sheu SJ, Liu NC, Chen JL. Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage. J Ocul Pharmacol Ther 2010;26:231-236.
    • (2010) J Ocul Pharmacol Ther , vol.26 , pp. 231-236
    • Sheu, S.J.1    Liu, N.C.2    Chen, J.L.3
  • 88
    • 13444269361 scopus 로고    scopus 로고
    • Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition
    • DOI 10.1016/j.cbi.2004.11.003
    • King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 2005;151:143-149. (Pubitemid 40208564)
    • (2005) Chemico-Biological Interactions , vol.151 , Issue.2 , pp. 143-149
    • King, R.E.1    Kent, K.D.2    Bomser, J.A.3
  • 91
    • 41349084391 scopus 로고    scopus 로고
    • Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells
    • DOI 10.1007/s12263-007-0069-7
    • Hwang JT, Kwon DY, Park OJ, Kim MS. Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells. Genes Nutr 2008;2:323-326. (Pubitemid 351447706)
    • (2008) Genes and Nutrition , vol.2 , Issue.4 , pp. 323-326
    • Hwang, J.-T.1    Kwon, D.Y.2    Park, O.J.3    Kim, M.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.