-
1
-
-
79959208615
-
Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
-
Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Age-related macular degeneration (AMD): Alzheimer's disease in the eye? J Alzheimers Dis 2011 24 615-631.
-
(2011)
J Alzheimers Dis
, vol.24
, pp. 615-631
-
-
Kaarniranta, K.1
Salminen, A.2
Haapasalo, A.3
Soininen, H.4
Hiltunen, M.5
-
2
-
-
70349469696
-
Antiangiogenic approaches to age-related macular degeneration today
-
Bressler NM. Antiangiogenic approaches to age-related macular degeneration today. Ophthalmology 2009;116:15-23.
-
(2009)
Ophthalmology
, vol.116
, pp. 15-23
-
-
Bressler, N.M.1
-
3
-
-
65549162660
-
Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration
-
Ciulla TA, Rosenfeld PJ. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 2009;20:158-165.
-
(2009)
Curr Opin Ophthalmol
, vol.20
, pp. 158-165
-
-
Ciulla, T.A.1
Rosenfeld, P.J.2
-
4
-
-
77955604125
-
Mechanisms of protein aggregation in the retinal pigment epithelial cells
-
Kaarniranta K, Hyttinen JMT, Ryhanen T, Viiri J, Paimela T, Toropainen E, Sorri I, Salminen A. Mechanisms of protein aggregation in the retinal pigment epithelial cells. Front Biosci (Elite Ed) 2010;2:1374-1384.
-
(2010)
Front Biosci (Elite Ed)
, vol.2
, pp. 1374-1384
-
-
Kaarniranta, K.1
Jmt, H.2
Ryhanen, T.3
Viiri, J.4
Paimela, T.5
Toropainen, E.6
Sorri, I.7
Salminen, A.8
-
5
-
-
33144459399
-
The role of inflammation in the pathogenesis of age-related macular degeneration
-
DOI 10.1016/j.survophthal.2005.12.001, PII S0039625705002067
-
Donoso LA, Kim D, Frost A, Callahan A, Hageman G. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Opthalmol 2006;91:137-152. (Pubitemid 43269939)
-
(2006)
Survey of Ophthalmology
, vol.51
, Issue.2
, pp. 137-152
-
-
Donoso, L.A.1
Kim, D.2
Frost, A.3
Callahan, A.4
Hageman, G.5
-
6
-
-
33746373850
-
Age-related macular degeneration (AMD): Pathogenesis and therapy
-
Nowak JZ. Age-related macular degeneration (AMD) pathogenesis and therapy. Pharmacol Report 2006;58:353-363. (Pubitemid 44111070)
-
(2006)
Pharmacological Reports
, vol.58
, Issue.3
, pp. 353-363
-
-
Nowak, J.Z.1
-
9
-
-
36249025723
-
Autophagy: Process and function
-
DOI 10.1101/gad.1599207
-
Mizushima N. Autophagy: Process and function. Genes Dev 2009;21:2861-2873. (Pubitemid 350133435)
-
(2007)
Genes and Development
, vol.21
, Issue.22
, pp. 2861-2873
-
-
Mizushima, N.1
-
10
-
-
62949091373
-
Autophagy: A lysosomal degradation pathway with a central role in health and disease
-
Eskelinen EL, Saftig P. Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biphys Acta 2008;1793:664-673.
-
(2008)
Biochim Biphys Acta
, vol.1793
, pp. 664-673
-
-
Eskelinen, E.L.1
Saftig, P.2
-
11
-
-
77956404377
-
Eaten alive: A history of macroautophagy
-
Yang Z, Klionsky DJ. Eaten alive: A history of macroautophagy. Nature Cell Biol 2010;12:814-822.
-
(2010)
Nature Cell Biol
, vol.12
, pp. 814-822
-
-
Yang, Z.1
Klionsky, D.J.2
-
12
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
DOI 10.1016/S1534-5807(04)00099-1, PII S1534580704000991
-
Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 2004;6:463-477. (Pubitemid 38456176)
-
(2004)
Developmental Cell
, vol.6
, Issue.4
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
13
-
-
37349003177
-
The role of autophagy in age-related neurodegeneration
-
DOI 10.1159/000109761
-
McCray BA, Taylor JP. The role of autophagy in age-related neurodegeneration. Neurosignals 2008;16:75-84. (Pubitemid 350308323)
-
(2008)
NeuroSignals
, vol.16
, Issue.1
, pp. 75-84
-
-
McCray, B.A.1
Taylor, J.P.2
-
14
-
-
69049088683
-
Regulatory role of HIF-1a in the pathogenesis of age-related macular degeneration (AMD)
-
Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. Regulatory role of HIF-1a in the pathogenesis of age-related macular degeneration (AMD). Ageing Res Rev 2009;8:349-358.
-
(2009)
Ageing Res Rev
, vol.8
, pp. 349-358
-
-
Arjamaa, O.1
Nikinmaa, M.2
Salminen, A.3
Kaarniranta, K.4
-
15
-
-
60949098753
-
Heat shock proteins as gatekeepers of proteolytic pathways Implications for age-related macular degeneration (AMD)
-
Kaarniranta K, Salminen A, Eskelinen EL, Kopitz J. Heat shock proteins as gatekeepers of proteolytic pathways Implications for age-related macular degeneration (AMD). Ageing Res Rev 2009;8:128-139.
-
(2009)
Ageing Res Rev
, vol.8
, pp. 128-139
-
-
Kaarniranta, K.1
Salminen, A.2
Eskelinen, E.L.3
Kopitz, J.4
-
16
-
-
65549139675
-
Regulation of the aging process in autophagy
-
Salminen A, Kaarniranta K. Regulation of the aging process in autophagy. Trends Mol Med 2009;15:217-224.
-
(2009)
Trends Mol Med
, vol.15
, pp. 217-224
-
-
Salminen, A.1
Kaarniranta, K.2
-
17
-
-
77449157041
-
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells
-
Ryhanen T, Hyttinen JMT, Kopitz J, Rilla K, Kuusisto E, Mannermaa E, Viiri J, Holmberg CI, Immonen I, Meri S, Parkkinen J, Eskelinen EL, Uusitalo H, Salminen A, Karniranta K. Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med 2009;13:3616-3631.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 3616-3631
-
-
Ryhaen, T.1
Jmt, H.2
Kopitz, J.3
Rilla, K.4
Kuusisto, E.5
Mannermaa, E.6
Viiri, J.7
Holmberg, C.I.8
Immonen, I.9
Meri, S.10
Parkkinen, J.11
Eskelinen, E.L.12
Uusitalo, H.13
Salminen, A.14
Karniranta, K.15
-
18
-
-
77955601582
-
P62/sequestosome 1 as a regulator of proteasome inhibitorinduced autophagy in human retinal pigment epithelial cells
-
Viiri J, Hyttinen JMT, Ryhanen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A, Kaarniranta K. p62/sequestosome 1 as a regulator of proteasome inhibitorinduced autophagy in human retinal pigment epithelial cells. Mol Vis 2010;16:1399-1414.
-
(2010)
Mol Vis
, vol.16
, pp. 1399-1414
-
-
Viiri, J.1
Jmt, H.2
Ryhanen, T.3
Rilla, K.4
Paimela, T.5
Kuusisto, E.6
Siitonen, A.7
Urtti, A.8
Salminen, A.9
Kaarniranta, K.10
-
19
-
-
58349109733
-
Autophagy and exosomes in the aged retinal pigment epithelium: Possible relevance to drusen formation and agerelated macular degeneration
-
Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, Neufeld AH. Autophagy and exosomes in the aged retinal pigment epithelium: Possible relevance to drusen formation and agerelated macular degeneration. PLoS One 2009;24:e4160.
-
(2009)
PLoS One
, vol.24
-
-
Wang, A.L.1
Lukas, T.J.2
Yuan, M.3
Du, N.4
Tso, M.O.5
Neufeld, A.H.6
-
20
-
-
77952829285
-
Autophagy hot topic in AMD
-
Kaarniranta K. Autophagy hot topic in AMD. Acta Ophthalmol 2010;88:387-388.
-
(2010)
Acta Ophthalmol
, vol.88
, pp. 387-388
-
-
Kaarniranta, K.1
-
21
-
-
4344660368
-
The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
-
DOI 10.1016/j.biocel.2004.05.007, PII S1357272504002006
-
Bergamini E, Cavallini G, Donati A, Gori Z. The role of macroautophagy in the ageing process, anti-ageing intervention and age-related diseases. Int J Biochem Cell Biol 2004;36:2392-2404. (Pubitemid 39119754)
-
(2004)
International Journal of Biochemistry and Cell Biology
, vol.36
, Issue.12
, pp. 2392-2404
-
-
Bergamini, E.1
Cavallini, G.2
Donati, A.3
Gori, Z.4
-
22
-
-
77957349477
-
AMP-activated protein kinase and its downstream transcriptional pathways
-
Canto A, Auwerx J. AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci 2010;67:3407-3423.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 3407-3423
-
-
Canto, A.1
Auwerx, J.2
-
23
-
-
34250891313
-
AMP-activated protein kinase: A universal regulator of autophagy?
-
Hayer-Hansen M, Jaattela M. AMP-activated protein kinase: A universal regulator of autophagy? Autophagy 2007 3 381-283.
-
(2007)
Autophagy
, vol.3
, pp. 381-283
-
-
Haer-Hansen, M.1
Jattela, M.2
-
24
-
-
78851472160
-
Resveratrol in cardiovascular health and disease
-
Petrovski G, Gurusamy N, Das DK. Resveratrol in cardiovascular health and disease. Ann NY Acad Sci 2011;1215:22-33.
-
(2011)
Ann NY Acad Sci
, vol.1215
, pp. 22-33
-
-
Petrovski, G.1
Gurusamy, N.2
Das, D.K.3
-
25
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
-
DOI 10.1038/nrm2249, PII NRM2249
-
Hardie DG. AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007;8:774-785. (Pubitemid 47462132)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.10
, pp. 774-785
-
-
Hardie, D.G.1
-
26
-
-
43749106701
-
A2 but not a1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments
-
Qin S, De Vries GW. a2 but not a1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments. J Biol Chem 2008;283:6744-6751.
-
(2008)
J Biol Chem
, vol.283
, pp. 6744-6751
-
-
Qin, S.1
De Vries, G.W.2
-
27
-
-
78649472949
-
Differential roles of AMPKa1 and AMPKa2 in regulating 4-HNE-induced RPE cell death and permeability
-
Qin S, Rodrigues GA. Differential roles of AMPKa1 and AMPKa2 in regulating 4-HNE-induced RPE cell death and permeability. Exp Eye Res 2010;91:818-824.
-
(2010)
Exp Eye Res
, vol.91
, pp. 818-824
-
-
Qin, S.1
Rodrigues, G.A.2
-
28
-
-
56449117024
-
AMPK: A metabolic gauge regulating whole-body energy homeostasis
-
Lage R, Dieáguez C, Vidal-Puig A, Loápez M. AMPK: A metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 2008;14:539-549.
-
(2008)
Trends Mol Med
, vol.14
, pp. 539-549
-
-
Lage, R.1
Dieáguez, C.2
Vidal-Puig, A.3
Loápez, M.4
-
29
-
-
0035282062
-
Post-translational modifications of the -1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
-
DOI 10.1042/0264-6021:3540275
-
Warden SM, Richardson C, O'Donnell J, Stapleton D, Kemp BE, Witters LA. Post-translational modifications of the b-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J 2001;354:275-283. (Pubitemid 32209863)
-
(2001)
Biochemical Journal
, vol.354
, Issue.2
, pp. 275-283
-
-
Warden, S.M.1
Richardson, C.2
O'Donnell Jr., J.3
Stapleton, D.4
Kemp, B.E.5
Witters, L.A.6
-
30
-
-
33845924783
-
AMP-activated protein kinase and the regulation of autophagic proteolysis
-
DOI 10.1074/jbc.M605488200
-
Meley D, Bauvy C, Houben-Weerts JH, Dubbelhuis PF, Helmond MT, Codogno P, Meijer AJ. AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem 2006;281:34870-34879. (Pubitemid 46036526)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.46
, pp. 34870-34879
-
-
Meley, D.1
Bauvy, C.2
Houben-Weerts, J.H.P.M.3
Dubbelhuis, P.F.4
Helmond, M.T.J.5
Codogno, P.6
Meijer, A.J.7
-
31
-
-
33947250696
-
kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
-
DOI 10.1038/ncb1537, PII NCB1537
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007;9:218-224. (Pubitemid 46420865)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.2
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.-X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
Kondo, S.7
Dumont, D.J.8
Gutterman, J.U.9
Walker, C.L.10
Slingerland, J.M.11
Mills, G.B.12
-
32
-
-
0032508564
-
6-mercaptopurine riboside. Evidence for involvement of AMP-activated protein kinase
-
DOI 10.1074/jbc.273.37.23758
-
Samari HR, Seglen PO. Inhibition of hepatocytic autophagy by adenosine, aminoimdazole-4-carboxyamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem 1998;273: 23758-23763. (Pubitemid 28435708)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.37
, pp. 23758-23763
-
-
Samari, H.R.1
Seglen, P.O.2
-
33
-
-
41249091730
-
Role of AMP-activated protein kinase in autophagy and proteasome function
-
Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, Sanz P. Role of AMP-activated protein kinase in autophagy and proteasome function. Biochem Biophys Res Commun 2008;369:964-968.
-
(2008)
Biochem Biophys Res Commun
, vol.369
, pp. 964-968
-
-
Viana, R.1
Aguado, C.2
Esteban, I.3
Moreno, D.4
Viollet, B.5
Knecht, E.6
Sanz, P.7
-
34
-
-
77749233738
-
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
-
Alexander A, Cai S-L, Kim J, Nanez A, Sahin M, MacLean K H, Inoki K, Guan K-L, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci USA 2010;107:4153-4158.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4153-4158
-
-
Alexander, A.1
Cai, S.-L.2
Kim, J.3
Nanez, A.4
Sahin, M.5
MacLean, K.H.6
Inoki, K.7
Guan, K.-L.8
Shen, J.9
Person, M.D.10
Kusewitt, D.11
Mills, G.B.12
Kastan, M.B.13
Walker, C.L.14
-
35
-
-
18044393806
-
AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle
-
DOI 10.1161/01.RES.0000163633.10240.3b
-
Ouchi N, Shibata R, Walsh K. AMP.activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res 2005;96:838-846. (Pubitemid 40604967)
-
(2005)
Circulation Research
, vol.96
, Issue.8
, pp. 838-846
-
-
Ouchi, N.1
Shibata, R.2
Walsh, K.3
-
36
-
-
77953768762
-
AMPKalpha1 deletion shortens erythrocyte life span in mice: Role of oxidative stress
-
Wang S, Dale GL, Song P, Viollet B, Zou MH. AMPKalpha1 deletion shortens erythrocyte life span in mice: Role of oxidative stress. J Biol Chem 2010;25:19976-19985.
-
(2010)
J Biol Chem
, vol.25
, pp. 19976-19985
-
-
Wang, S.1
Dale, G.L.2
Song, P.3
Viollet, B.4
Zou, M.H.5
-
37
-
-
0141706665
-
Activation of 5-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: Role of peroxynitrite
-
DOI 10.1074/jbc.M300215200
-
Zou M-H, Hou X-Y, Shi C-M, Kirkpatick S, Liu F, Goldman MH, Cohen RA. Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol. Chem 2003;278: 34003-34010. (Pubitemid 37553236)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.36
, pp. 34003-34010
-
-
Zou, M.-H.1
Hou, X.-Y.2
Shi, C.-M.3
Kirkpatick, S.4
Liu, F.5
Goldman, M.H.6
Cohen, R.A.7
-
38
-
-
77449100323
-
AMP-activated protein kinase attenuates nitric oxide-induced cell death
-
Meares GP, Hughes KJ, Jaimes KF, Salvatori AS, Rhodes CJ, Corbett JA. AMP-activated protein kinase attenuates nitric oxide-induced cell death. J Biol Chem 2010;285:3191-3200.
-
(2010)
J Biol Chem
, vol.285
, pp. 3191-3200
-
-
Meares, G.P.1
Hughes, K.J.2
Jaimes, K.F.3
Salvatori, A.S.4
Rhodes, C.J.5
Corbett, J.A.6
-
39
-
-
64449087671
-
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
-
Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budlinger GR, Chandel NS. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Rad Biol Med 2009;46:1386-1391.
-
(2009)
Free Rad Biol Med
, vol.46
, pp. 1386-1391
-
-
Emerling, B.M.1
Weinberg, F.2
Snyder, C.3
Burgess, Z.4
Mutlu, G.M.5
Viollet, B.6
Budlinger, G.R.7
Chandel, N.S.8
-
40
-
-
0029591929
-
Accumulation of lipofuscin within retinal pigment epithelial cells results in enhanced sensitivity to photooxidation
-
Brunk UT, Wihlmark U, Wrigstad A, Roberg K, Nilsson SE. Accumulation of lipofuscin within retinal pigment epithelial cells results in enhanced sensitivity to photooxidation. Gerontology 1995;41:201-212. (Pubitemid 26019917)
-
(1995)
Gerontology
, vol.41
, Issue.SUPPL. 2
, pp. 201-212
-
-
Brunk, U.T.1
Wihlmark, U.2
Wrigstad, A.3
Roberg, K.4
Nilsson, S.-E.5
-
41
-
-
10044255422
-
Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration
-
DOI 10.1016/j.biochi.2004.09.029, PII S0300908404001816, Recent Advances in Lipid Metabolism and Related Disorders
-
Kopitz J, Holz FG, Kaemmerer E, Schutt F. Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie 2004;86:825-831. (Pubitemid 39602762)
-
(2004)
Biochimie
, vol.86
, Issue.11
, pp. 825-831
-
-
Kopitz, J.1
Holz, F.G.2
Kaemmerer, E.3
Schutt, F.4
-
42
-
-
2442648066
-
Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
-
Bergmann M, Schu tt F, Holz FG, Kopitz J. Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J 2004; 18:562-564.
-
(2004)
FASEB J
, vol.18
, pp. 562-564
-
-
Bergmann, M.1
Schut, F.2
Holz, F.G.3
Kopitz, J.4
-
43
-
-
18044366931
-
RPE lipofuscin and its role in retinal pathobiology
-
DOI 10.1016/j.exer.2005.01.007
-
Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 2005;80:595-606. (Pubitemid 40602960)
-
(2005)
Experimental Eye Research
, vol.80
, Issue.5
, pp. 595-606
-
-
Sparrow, J.R.1
Boulton, M.2
-
44
-
-
35348944706
-
Iron homeostasis and toxicity in retinal degeneration
-
DOI 10.1016/j.preteyeres.2007.07.004, PII S1350946207000547
-
He X, Hahn P, Iacovelli J, Wong R, King C, Bhisitkul R, Massaro-Giordano M, Dunaief JL. Iron homeostasis and toxicity in retinal degeneration. Prog Retin Eye Res 2007;26: 649-673. (Pubitemid 47615564)
-
(2007)
Progress in Retinal and Eye Research
, vol.26
, Issue.6
, pp. 649-673
-
-
He, X.1
Hahn, P.2
Iacovelli, J.3
Wong, R.4
King, C.5
Bhisitkul, R.6
Massaro-Giordano, M.7
Dunaief, J.L.8
-
47
-
-
78649690159
-
Does autophagy take a front seat in lifespan extension?
-
Petrovski G, Das DK. Does autophagy take a front seat in lifespan extension? J Cell Mol Med 2010 14 2543-2551.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 2543-2551
-
-
Petrovski, G.1
Das, D.K.2
-
48
-
-
73849101809
-
Key factors in mTOR regulation
-
Bai X, Jiang Y. Key factors in mTOR regulation. Cell Mol Life Sci 2010;67:239-253.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 239-253
-
-
Bai, X.1
Jiang, Y.2
-
49
-
-
0025869741
-
Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus
-
Lane WS, Galat A, Harding MW, Schreiber SL. Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. J Protein Chem 1991;10:151-160.
-
(1991)
J Protein Chem
, vol.10
, pp. 151-160
-
-
Lane, W.S.1
Galat, A.2
Harding, M.W.3
Schreiber, S.L.4
-
50
-
-
33750072949
-
MTOR and cancer therapy
-
DOI 10.1038/sj.onc.1209886, PII 1209886
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006;25:6436-6446. (Pubitemid 44582287)
-
(2006)
Oncogene
, vol.25
, Issue.48
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
52
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
DOI 10.1101/gad.1110003
-
Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829-1834. (Pubitemid 36944560)
-
(2003)
Genes and Development
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
53
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008;30: 214-226. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
54
-
-
77950501014
-
MTOR regulation of autophagy
-
Jung CH, Ro S-H, Cao J, Otto NM, Kim D-H. mTOR regulation of autophagy. FEBS Lett 2010;584:1287-1295.
-
(2010)
FEBS Lett
, vol.584
, pp. 1287-1295
-
-
Ro, S.-H.1
Cao, J.2
Otto, N.M.3
Kim, D.-H.4
-
55
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
DOI 10.1101/gad.1256804
-
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WGl. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004;18: 2893-2904. (Pubitemid 39602308)
-
(2004)
Genes and Development
, vol.18
, Issue.23
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
56
-
-
78649956469
-
MTORC2 regulates neutrophil chemotaxis in a cAMP-and RhoA-dependent fashion
-
Liu L, Das S, Losert W, Parent CA. mTORC2 regulates neutrophil chemotaxis in a cAMP-and RhoA-dependent fashion. Dev Cell 2010;19:845-857.
-
(2010)
Dev Cell
, vol.19
, pp. 845-857
-
-
Liu, L.1
Das, S.2
Losert, W.3
Parent, C.A.4
-
57
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
DOI 10.1128/MCB.25.14.5834-5845.2005
-
Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 2005;25:5834-5845. (Pubitemid 40946541)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.14
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
58
-
-
78149262655
-
Endoplastic reticulum stress in age-related macular degeneration: Trigger for neovascularization
-
Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E, Kaarniranta K. Endoplastic reticulum stress in age-related macular degeneration: Trigger for neovascularization. Mol Med 2010;16:535-542.
-
(2010)
Mol Med
, vol.16
, pp. 535-542
-
-
Salminen, A.1
Kauppinen, A.2
Jmt, H.3
Toropainen, E.4
Kaarniranta, K.5
-
61
-
-
78650928867
-
MTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
-
Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M, Bok D, Dunaief JL, LaVail MM, Vollrath D. mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin Invest 2011;121: 369-383.
-
(2011)
J Clin Invest
, vol.121
, pp. 369-383
-
-
Zhao, C.1
Yasumura, D.2
Li, X.3
Matthes, M.4
Lloyd, M.5
Nielsen, G.6
Ahern, K.7
Snyder, M.8
Bok, D.9
Dunaief, J.L.10
Lavail, M.M.11
Vollrath, D.12
-
62
-
-
79951899224
-
CCR3 and choroidal neovascularization
-
Li Y, Huang D, Xia X, Wang Z, Luo L, Wen R. CCR3 and choroidal neovascularization. PLoS One 2011;6:e17106.
-
(2011)
PLoS One
, vol.6
-
-
Li, Y.1
Huang, D.2
Xia, X.3
Wang, Z.4
Luo, L.5
Wen, R.6
-
63
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
DOI 10.1038/nm0202-128
-
Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Fiegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK. Rapamycin inhibits primary and metastatic tumor growth by angiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002;8:128-135. (Pubitemid 34155123)
-
(2002)
Nature Medicine
, vol.8
, Issue.2
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
Jauch, K.-W.11
Geissler, E.K.12
-
64
-
-
79955545737
-
Mature peripheral RPE cells have an intrinsic capacity to proliferate; A potential regulatory mechanism for age-related cell loss
-
Kokkinopoulos I, Shahabi G, Colman A, Jeffery G. Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss. PloS ONE 2011;6:e18921.
-
(2011)
PloS ONE
, vol.6
-
-
Kokkinopoulos, I.1
Shahabi, G.2
Colman, A.3
Jeffery, G.4
-
65
-
-
0034683568
-
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
-
Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000;150:1507-1513.
-
(2000)
J Cell Biol
, vol.150
, pp. 1507-1513
-
-
Kamada, Y.1
Funakoshi, T.2
Shintani, T.3
Nagano, K.4
Ohsumi, M.5
Ohsumi, Y.6
-
66
-
-
65249176304
-
ULK-Atg13-FIP complexes mediate mTOR signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro S-H, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009;20:1992-2003.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jun, C.B.1
Ro, S.-H.2
Kim, Y.M.3
Otto, N.M.4
Cao, J.5
Kundu, M.6
Kim, D.H.7
-
67
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex mediates mTOR signaling and is essential for autophagy
-
Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex mediates mTOR signaling and is essential for autophagy. Mol Biol Cell 2009;284:1981-1991.
-
(2009)
Mol Biol Cell
, vol.284
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
Iemura, S.7
Natsume, T.8
Takehana, K.9
Yamada, N.10
Guan, J.L.11
Oshiro, N.12
Mizushima, N.13
-
68
-
-
58149473473
-
Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg-13-independent mechanism
-
Chan EY, Longatti A, McKnight NC, Tooze SA. Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg-13-independent mechanism. Mol Cell Biol 2009;29:157-171.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 157-171
-
-
Chan, E.Y.1
Longatti, A.2
McKnight, N.C.3
Tooze, S.A.4
-
69
-
-
66449083078
-
ULK1 ATG 13.FIP200 complex mediates mTOR signaling and is essential for autophagy
-
Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009;284:12297-12305.
-
(2009)
J Biol Chem
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam Du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
70
-
-
38049098543
-
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
-
Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 2007;282:37298-37303.
-
(2007)
J Biol Chem
, vol.282
, pp. 37298-37303
-
-
Hanada, T.1
Noda, N.N.2
Satomi, Y.3
Ichimura, Y.4
Fujioka, Y.5
Takao, T.6
Inagaki, F.7
Ohsumi, Y.8
-
71
-
-
57549094368
-
The Atg8 conjugation system is indispensable for the proper development of autophagic isolation membranes in mice
-
Sou YS, Waguri S, Iwata J, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M. The Atg8 conjugation system is indispensable for the proper development of autophagic isolation membranes in mice. Mol Biol Cell 2007;19:4762-4775.
-
(2007)
Mol Biol Cell
, vol.19
, pp. 4762-4775
-
-
Sou, Y.S.1
Waguri, S.2
Iwata, J.3
Ueno, T.4
Fujimura, T.5
Hara, T.6
Sawada, N.7
Yamada, A.8
Mizushima, N.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Komatsu, M.13
-
72
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature Cell Biol 2011;13:132-141.
-
(2011)
Nature Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
74
-
-
0033767690
-
Exosome: From internal vesicle of the multivesicular body to intercellular signaling device
-
Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ. Exosome: From internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 2000;113: 3365-3374.
-
(2000)
J Cell Sci
, vol.113
, pp. 3365-3374
-
-
Denzer, K.1
Kleijmeer, M.J.2
Heijnen, H.F.3
Stoorvogel, W.4
Geuze, H.J.5
-
75
-
-
43149120419
-
Exosome function: From tumor immunology to pathogen biology
-
DOI 10.1111/j.1600-0854.2008.00734.x
-
Schorey JS, Bhatnagar S. Exosome function: From tumor immunology to pathogen biology. Traffic 2008;9:871-881. (Pubitemid 351639493)
-
(2008)
Traffic
, vol.9
, Issue.6
, pp. 871-881
-
-
Schorey, J.S.1
Bhatnagar, S.2
-
76
-
-
0028073143
-
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
-
DOI 10.1016/0014-5793(94)01006-4
-
Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett 1994;353: 33-36. (Pubitemid 24312538)
-
(1994)
FEBS Letters
, vol.353
, Issue.1
, pp. 33-36
-
-
Sullivan, J.E.1
-
77
-
-
77956875005
-
2010 AMPKinduced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
-
Leclerc GM, Leclerc GJ, Fu G, Barredo JC. 2010. AMPKinduced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. J Mol Signal 2010;5:15.
-
(2010)
J Mol Signal
, vol.5
, pp. 15
-
-
Leclerc, G.M.1
Leclerc, G.J.2
Fu, G.3
Barredo, J.C.4
-
78
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
DOI 10.1158/0008-5472.CAN-06-4447
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007;67:6745-6752. (Pubitemid 47105521)
-
(2007)
Cancer Research
, vol.67
, Issue.14
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
DeBerardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
79
-
-
79953193036
-
Sensing of energy and nutrients by AMPactivated protein kinase
-
Hardie DG. Sensing of energy and nutrients by AMPactivated protein kinase. Am J Clin Nutr 2011;93(Suppl): 891S-816S.
-
(2011)
Am J Clin Nutr
, vol.93
, Issue.SUPPL.
-
-
Hardie, D.G.1
-
80
-
-
44749094644
-
Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line
-
Puljak L, Parameswara V, Dolovcak S, Waldrop SL, Emmett D, Esser V, Fitz JG, Kilic G. Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. Exp Cell Res 2008;314:2100-2109.
-
(2008)
Exp Cell Res
, vol.314
, pp. 2100-2109
-
-
Puljak, L.1
Parameswara, V.2
Dolovcak, S.3
Waldrop, S.L.4
Emmett, D.5
Esser, V.6
Fitz, J.G.7
Kilic, G.8
-
81
-
-
25444435486
-
Systemic rapamycin inhibits retinal and choroidal neovascularization in mice
-
Dejneka NS, Kuroki AM, Fosnot J, Tang W, Tolentino MJ, Bennett J. Systemic rapamycin inhibits retinal and choroidal neovascularizaion in mice. Mol Vision 2004;10:964-972. (Pubitemid 41358195)
-
(2004)
Molecular Vision
, vol.10
, pp. 964-972
-
-
Dejneka, N.S.1
Kuroki, A.M.2
Fosnot, J.3
Tang, W.4
Tolentino, M.J.5
Bennett, J.6
-
82
-
-
49649105189
-
Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
-
Stahl A, Paschek L, Martin G, Gross NJ, Feltgen N, Hansen LL, Agostini HT. Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro. FEBS Lett 2008:582:3097-3102.
-
(2008)
FEBS Lett
, vol.582
, pp. 3097-3102
-
-
Stahl, A.1
Paschek, L.2
Martin, G.3
Gross, N.J.4
Feltgen, N.5
Hansen, L.L.6
Agostini, H.T.7
-
84
-
-
77957369366
-
Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation
-
Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation. Am J Pathol 2010;177:1725-1731.
-
(2010)
Am J Pathol
, vol.177
, pp. 1725-1731
-
-
Kubota, S.1
Kurihara, T.2
Ebinuma, M.3
Kubota, M.4
Yuki, K.5
Sasaki, M.6
Noda, K.7
Ozawa, Y.8
Oike, Y.9
Ishida, S.10
Tsubota, K.11
-
85
-
-
77954600273
-
Resveratrol regulates pathological angiogenesis by a eukaryotic elongation factor-2-kinase-reguated pathway
-
Khan AA, Dace DS, Ryazanov AG, Kelly J, Apte RS. Resveratrol regulates pathological angiogenesis by a eukaryotic elongation factor-2-kinase-reguated pathway. Am J Pathol 2010;177:481-492.
-
(2010)
Am J Pathol
, vol.177
, pp. 481-492
-
-
Khan, A.A.1
Dace, D.S.2
Ryazanov, A.G.3
Kelly, J.4
Apte, R.S.5
-
86
-
-
78649436142
-
Dose-dependency of resveratrol in providing health benefits
-
Mukherjee S, Dudley JI, Das DK. Dose-dependency of resveratrol in providing health benefits. Dose Response 2010,8:478-500.
-
(2010)
Dose Response
, vol.8
, pp. 478-500
-
-
Mukherjee, S.1
Dudley, J.I.2
Das, D.K.3
-
87
-
-
77954200118
-
Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage
-
Sheu SJ, Liu NC, Chen JL. Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage. J Ocul Pharmacol Ther 2010;26:231-236.
-
(2010)
J Ocul Pharmacol Ther
, vol.26
, pp. 231-236
-
-
Sheu, S.J.1
Liu, N.C.2
Chen, J.L.3
-
88
-
-
13444269361
-
Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition
-
DOI 10.1016/j.cbi.2004.11.003
-
King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 2005;151:143-149. (Pubitemid 40208564)
-
(2005)
Chemico-Biological Interactions
, vol.151
, Issue.2
, pp. 143-149
-
-
King, R.E.1
Kent, K.D.2
Bomser, J.A.3
-
90
-
-
77950575506
-
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
-
Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzi MG, Davies P, Marambaud P. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem 2010;285:9100-9113.
-
(2010)
J Biol Chem
, vol.285
, pp. 9100-9113
-
-
Vingtdeux, V.1
Giliberto, L.2
Zhao, H.3
Chandakkar, P.4
Wu, Q.5
Simon, J.E.6
Janle, E.M.7
Lobo, J.8
Ferruzi, M.G.9
Davies, P.10
Marambaud, P.11
-
91
-
-
41349084391
-
Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells
-
DOI 10.1007/s12263-007-0069-7
-
Hwang JT, Kwon DY, Park OJ, Kim MS. Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells. Genes Nutr 2008;2:323-326. (Pubitemid 351447706)
-
(2008)
Genes and Nutrition
, vol.2
, Issue.4
, pp. 323-326
-
-
Hwang, J.-T.1
Kwon, D.Y.2
Park, O.J.3
Kim, M.S.4
|