-
1
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., and Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest 108 (2001) 1167-1174
-
(2001)
J. Clin. Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
-
2
-
-
9144271181
-
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
-
Zang M., Zuccollo A., Hou X., Nagata D., Walsh K., Herscovitz H., Brecher P., Ruderman N.B., and Cohen R.A. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J. Biol. Chem. 279 (2004) 47898-47905
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47898-47905
-
-
Zang, M.1
Zuccollo, A.2
Hou, X.3
Nagata, D.4
Walsh, K.5
Herscovitz, H.6
Brecher, P.7
Ruderman, N.B.8
Cohen, R.A.9
-
3
-
-
20844451123
-
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn B.B., Alquier T., Carling D., and Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1 (2005) 15-25
-
(2005)
Cell Metab.
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
4
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Muller C., Carling D., and Kahn B.B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Muller, C.5
Carling, D.6
Kahn, B.B.7
-
5
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., and Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8 (2002) 1288-1295
-
(2002)
Nat. Med.
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
Eto, K.11
Akanuma, Y.12
Froguel, P.13
Foufelle, F.14
Ferre, P.15
Carling, D.16
Kimura, S.17
Nagai, R.18
Kahn, B.B.19
Kadowaki, T.20
more..
-
6
-
-
0035937174
-
Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia
-
Lee Y., Wang M.Y., Kakuma T., Wang Z.W., Babcock E., McCorkle K., Higa M., Zhou Y.T., and Unger R.H. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J. Biol. Chem. 276 (2001) 5629-5635
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5629-5635
-
-
Lee, Y.1
Wang, M.Y.2
Kakuma, T.3
Wang, Z.W.4
Babcock, E.5
McCorkle, K.6
Higa, M.7
Zhou, Y.T.8
Unger, R.H.9
-
7
-
-
0012785395
-
Metformin reverses fatty liver disease in obese, leptin-deficient mice
-
Lin H.Z., Yang S.Q., Chuckaree C., Kuhajda F., Ronnet G., and Diehl A.M. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat. Med. 6 (2000) 998-1003
-
(2000)
Nat. Med.
, vol.6
, pp. 998-1003
-
-
Lin, H.Z.1
Yang, S.Q.2
Chuckaree, C.3
Kuhajda, F.4
Ronnet, G.5
Diehl, A.M.6
-
8
-
-
19144365586
-
A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
-
Bugianesi E., Gentilcore E., Manini R., Natale S., Vanni E., Villanova N., David E., Rizzetto M., and Marchesini G. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am. J. Gastroenterol. 100 (2005) 1082-1090
-
(2005)
Am. J. Gastroenterol.
, vol.100
, pp. 1082-1090
-
-
Bugianesi, E.1
Gentilcore, E.2
Manini, R.3
Natale, S.4
Vanni, E.5
Villanova, N.6
David, E.7
Rizzetto, M.8
Marchesini, G.9
-
9
-
-
0025336153
-
Lipoprotein assembly and secretion by hepatocytes
-
Vance J.E., and Vance D.E. Lipoprotein assembly and secretion by hepatocytes. Annu. Rev. Nutr. 10 (1990) 337-356
-
(1990)
Annu. Rev. Nutr.
, vol.10
, pp. 337-356
-
-
Vance, J.E.1
Vance, D.E.2
-
10
-
-
0035339354
-
Sustained stimulation of exocytosis triggers continuous membrane retrieval in rat pituitary somatotrophs
-
Kilic G., Angleson J.K., Cochilla A.J., Nussinovitch I., and Betz W.J. Sustained stimulation of exocytosis triggers continuous membrane retrieval in rat pituitary somatotrophs. J. Physiol. 532 (2001) 771-783
-
(2001)
J. Physiol.
, vol.532
, pp. 771-783
-
-
Kilic, G.1
Angleson, J.K.2
Cochilla, A.J.3
Nussinovitch, I.4
Betz, W.J.5
-
11
-
-
14944354652
-
Inhibition of cellular responses to insulin in a rat liver cell line. A role for PKC in insulin resistance
-
Puljak L., Pagliassotti M.J., Wei Y., Qadri I., Parameswara V., Esser V., Fitz J.G., and Kilic G. Inhibition of cellular responses to insulin in a rat liver cell line. A role for PKC in insulin resistance. J. Physiol. 563 (2005) 471-482
-
(2005)
J. Physiol.
, vol.563
, pp. 471-482
-
-
Puljak, L.1
Pagliassotti, M.J.2
Wei, Y.3
Qadri, I.4
Parameswara, V.5
Esser, V.6
Fitz, J.G.7
Kilic, G.8
-
12
-
-
0035920235
-
Insulin stimulates membrane conductance in a liver cell line: evidence for insertion of ion channels through a phosphoinositide 3-kinase-dependent mechanism
-
Kilic G., Doctor R.B., and Fitz J.G. Insulin stimulates membrane conductance in a liver cell line: evidence for insertion of ion channels through a phosphoinositide 3-kinase-dependent mechanism. J. Biol. Chem. 276 (2001) 26762-26768
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26762-26768
-
-
Kilic, G.1
Doctor, R.B.2
Fitz, J.G.3
-
14
-
-
0029972449
-
Simultaneous independent measurement of endocytosis and exocytosis
-
Smith C.B., and Betz W.J. Simultaneous independent measurement of endocytosis and exocytosis. Nature 380 (1996) 531-534
-
(1996)
Nature
, vol.380
, pp. 531-534
-
-
Smith, C.B.1
Betz, W.J.2
-
15
-
-
0035997019
-
Exocytosis in bovine chromaffin cells: studies with patch-clamp capacitance and FM1-43 fluorescence
-
Kilic G. Exocytosis in bovine chromaffin cells: studies with patch-clamp capacitance and FM1-43 fluorescence. Biophys. J. 83 (2002) 849-857
-
(2002)
Biophys. J.
, vol.83
, pp. 849-857
-
-
Kilic, G.1
-
16
-
-
0023858306
-
Patch-clamp techniques for time-resolved capacitance measurements in single cells
-
Lindau M., and Neher E. Patch-clamp techniques for time-resolved capacitance measurements in single cells. Pflugers Arch. 411 (1988) 137-146
-
(1988)
Pflugers Arch.
, vol.411
, pp. 137-146
-
-
Lindau, M.1
Neher, E.2
-
17
-
-
0038643426
-
Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice
-
Letteron P., Sutton A., Mansouri A., Fromenty B., and Pessayre D. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology 38 (2003) 133-140
-
(2003)
Hepatology
, vol.38
, pp. 133-140
-
-
Letteron, P.1
Sutton, A.2
Mansouri, A.3
Fromenty, B.4
Pessayre, D.5
-
18
-
-
0141818124
-
Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion
-
Gilham D., Ho S., Rasouli M., Martres P., Vance D.E., and Lehner R. Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion. FASEB J. 17 (2003) 1685-1687
-
(2003)
FASEB J.
, vol.17
, pp. 1685-1687
-
-
Gilham, D.1
Ho, S.2
Rasouli, M.3
Martres, P.4
Vance, D.E.5
Lehner, R.6
-
19
-
-
0034708682
-
Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model
-
Taghibiglou C., Carpentier A., Van Iderstine S.C., Chen B., Rudy D., Aiton A., Lewis G.F., and Adeli K. Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J. Biol. Chem. 275 (2000) 8416-8425
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8416-8425
-
-
Taghibiglou, C.1
Carpentier, A.2
Van Iderstine, S.C.3
Chen, B.4
Rudy, D.5
Aiton, A.6
Lewis, G.F.7
Adeli, K.8
-
20
-
-
70449158340
-
A simple method for the isolation and purification of total lipides from animal tissues
-
Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226 (1957) 497-509
-
(1957)
J. Biol. Chem.
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
-
21
-
-
23944445556
-
Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells
-
Ho S.S., and Pal S. Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. Atherosclerosis 182 (2005) 29-36
-
(2005)
Atherosclerosis
, vol.182
, pp. 29-36
-
-
Ho, S.S.1
Pal, S.2
-
22
-
-
33845993219
-
Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited
-
Basso F., Freeman L.A., Ko C., Joyce C., Amar M.J., Shamburek R.D., Tansey T., Thomas F., Wu J., Paigen B., Remaley A.T., Santamarina-Fojo S., and Brewer Jr. H.B. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J. Lipid Res. 48 (2007) 114-126
-
(2007)
J. Lipid Res.
, vol.48
, pp. 114-126
-
-
Basso, F.1
Freeman, L.A.2
Ko, C.3
Joyce, C.4
Amar, M.J.5
Shamburek, R.D.6
Tansey, T.7
Thomas, F.8
Wu, J.9
Paigen, B.10
Remaley, A.T.11
Santamarina-Fojo, S.12
Brewer Jr., H.B.13
-
23
-
-
0021816546
-
Spectrofluorometric studies of the lipid probe, Nile red
-
Greenspan P., and Fowler S.D. Spectrofluorometric studies of the lipid probe, Nile red. J. Lipid Res. 26 (1985) 781-789
-
(1985)
J. Lipid Res.
, vol.26
, pp. 781-789
-
-
Greenspan, P.1
Fowler, S.D.2
-
24
-
-
33847006599
-
The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
-
Cha J.Y., and Repa J.J. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282 (2007) 743-751
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 743-751
-
-
Cha, J.Y.1
Repa, J.J.2
-
25
-
-
0017738601
-
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
-
McGarry J.D., Mannaerts G.P., and Foster D.W. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest 60 (1977) 265-270
-
(1977)
J. Clin. Invest
, vol.60
, pp. 265-270
-
-
McGarry, J.D.1
Mannaerts, G.P.2
Foster, D.W.3
-
26
-
-
0018092729
-
Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment
-
Mannaerts G.P., Thomas J., Debeer L.J., McGarry J.D., and Foster D.W. Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment. Biochim. Biophys. Acta 529 (1978) 201-211
-
(1978)
Biochim. Biophys. Acta
, vol.529
, pp. 201-211
-
-
Mannaerts, G.P.1
Thomas, J.2
Debeer, L.J.3
McGarry, J.D.4
Foster, D.W.5
-
27
-
-
85047689953
-
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
-
Corton J.M., Gillespie J.G., Hawley S.A., and Hardie D.G. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?. Eur. J. Biochem. 229 (1995) 558-565
-
(1995)
Eur. J. Biochem.
, vol.229
, pp. 558-565
-
-
Corton, J.M.1
Gillespie, J.G.2
Hawley, S.A.3
Hardie, D.G.4
-
28
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
Browning J.D., and Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest 114 (2004) 147-152
-
(2004)
J. Clin. Invest
, vol.114
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
29
-
-
0025310576
-
Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver
-
Clarke P.R., and Hardie D.G. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J. 9 (1990) 2439-2446
-
(1990)
EMBO J.
, vol.9
, pp. 2439-2446
-
-
Clarke, P.R.1
Hardie, D.G.2
-
30
-
-
3042551249
-
Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation
-
Perdomo G., Commerford S.R., Richard A.M., Adams S.H., Corkey B.E., O'Doherty R.M., and Brown N.F. Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J. Biol. Chem. 279 (2004) 27177-27186
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 27177-27186
-
-
Perdomo, G.1
Commerford, S.R.2
Richard, A.M.3
Adams, S.H.4
Corkey, B.E.5
O'Doherty, R.M.6
Brown, N.F.7
-
31
-
-
12744280700
-
Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion
-
Herrero L., Rubi B., Sebastian D., Serra D., Asins G., Maechler P., Prentki M., and Hegardt F.G. Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion. Diabetes 54 (2005) 462-471
-
(2005)
Diabetes
, vol.54
, pp. 462-471
-
-
Herrero, L.1
Rubi, B.2
Sebastian, D.3
Serra, D.4
Asins, G.5
Maechler, P.6
Prentki, M.7
Hegardt, F.G.8
-
32
-
-
3142670354
-
Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial
-
Nair S., Diehl A.M., Wiseman M., Farr Jr. G.H., and Perrillo R.P. Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial. Aliment. Pharmacol. Ther. 20 (2004) 23-28
-
(2004)
Aliment. Pharmacol. Ther.
, vol.20
, pp. 23-28
-
-
Nair, S.1
Diehl, A.M.2
Wiseman, M.3
Farr Jr., G.H.4
Perrillo, R.P.5
-
34
-
-
0023270025
-
Use of Nile red for the rapid in situ quantitation of lipids on thin-layer chromatograms
-
Fowler S.D., Brown W.J., Warfel J., and Greenspan P. Use of Nile red for the rapid in situ quantitation of lipids on thin-layer chromatograms. J. Lipid Res. 28 (1987) 1225-1232
-
(1987)
J. Lipid Res.
, vol.28
, pp. 1225-1232
-
-
Fowler, S.D.1
Brown, W.J.2
Warfel, J.3
Greenspan, P.4
-
35
-
-
0031568242
-
Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism
-
Velasco G., Geelen M.J., and Guzman M. Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism. Arch. Biochem. Biophys. 337 (1997) 169-175
-
(1997)
Arch. Biochem. Biophys.
, vol.337
, pp. 169-175
-
-
Velasco, G.1
Geelen, M.J.2
Guzman, M.3
-
36
-
-
0033559856
-
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
-
Muoio D.M., Seefeld K., Witters L.A., and Coleman R.A. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J. 338 Pt 3 (1999) 783-791
-
(1999)
Biochem J.
, vol.338
, Issue.PART 3
, pp. 783-791
-
-
Muoio, D.M.1
Seefeld, K.2
Witters, L.A.3
Coleman, R.A.4
-
37
-
-
0025727192
-
Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B
-
Dixon J.L., Furukawa S., and Ginsberg H.N. Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. J. Biol. Chem. 266 (1991) 5080-5086
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 5080-5086
-
-
Dixon, J.L.1
Furukawa, S.2
Ginsberg, H.N.3
-
38
-
-
3242656203
-
Triacylglycerol hydrolase: role in intracellular lipid metabolism
-
Dolinsky V.W., Gilham D., Alam M., Vance D.E., and Lehner R. Triacylglycerol hydrolase: role in intracellular lipid metabolism. Cell Mol. Life Sci. 61 (2004) 1633-1651
-
(2004)
Cell Mol. Life Sci.
, vol.61
, pp. 1633-1651
-
-
Dolinsky, V.W.1
Gilham, D.2
Alam, M.3
Vance, D.E.4
Lehner, R.5
|