The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Madera, Rachel F ^a   Wang, Jennifer P ^a   Libraty, Daniel H ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; BIOLOGICAL FACTOR; INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; POLYINOSINIC POLYCYTIDYLIC ACID; RESIQUIMOD; RNA LIKE IMMUNE RESPONSE MODIFIER; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; IMIDAZOLE DERIVATIVE; IMMUNOLOGICAL ADJUVANT; RNA;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD4+ TH1 CELL; CELL STIMULATION; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG DESIGN; GENE EXPRESSION; IN VITRO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PROTEIN SECRETION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; TIME;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; IMIDAZOLES; INTERFERON TYPE I; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; MICE; MYELOID DIFFERENTIATION FACTOR 88; POLY I-C; RNA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TH1 CELLS; TIME FACTORS;

EID: 83655212415     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029412     Document Type: Article

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