MDA5 and MAVS mediate type I interferon responses to coxsackie B virus

Journal of Virology

Volumn 84, Issue 1, 2010, Pages 254-260

  Wang, Jennifer P ^a   Cerny, Anna ^a   Asher, Damon R ^a   Kurt Jones, Evelyn A ^a   Bronson, Roderick T ^b   Finberg, Robert W ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS B; COXSACKIE VIRUS INFECTION; CYTOKINE PRODUCTION; HISTOPATHOLOGY; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTERFERON PRODUCTION; KNOCKOUT MOUSE; LIVER NECROSIS; MORTALITY; MOUSE; NONHUMAN; PANCREAS NECROSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; COXSACKIEVIRUS INFECTIONS; CYTOKINES; DEAD-BOX RNA HELICASES; ENTEROVIRUS B, HUMAN; IMMUNITY, INNATE; INTERFERON TYPE I; MICE; MICE, KNOCKOUT; VIRAL LOAD;

COXSACKIEVIRUS; ENTEROVIRUS; HUMAN ENTEROVIRUS B; MUS;

EID: 72849147111     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00631-09     Document Type: Article

References (34)

1. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-150. (Pubitemid 28361303)
2. Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413:732-738. (Pubitemid 33009951)
3. Asher, D. R., A. M. Cerny, and R. W. Finberg. 2005. The erythrocyte viral trap: transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infection. Proc. Natl. Acad. Sci. USA 102:12897-12902.
4. Barral, P. M., J. M. Morrison, J. Drahos, P. Gupta, D. Sarkar, P. B. Fisher, and V. R. Racaniello. 2007. MDA-5 is cleaved in poliovirus-infected cells. J. Virol. 81:3677-3684.
5. Bergelson, J. M., J. A. Cunningham, G. Droguett, E. A. Kurt-Jones, A. Krithivas, J. S. Hong, M. S. Horwitz, R. L. Crowell, and R. W. Finberg. 1997. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
6. Deonarain, R., D. Cerullo, K. Fuse, P. P. Liu, and E. N. Fish. 2004. Protective role for interferon-beta in coxsackievirus B3 infection. Circulation 110: 3540-3543. (Pubitemid 39612568)
7. Dotta, F., S. Censini, A. G. van Halteren, L. Marselli, M. Masini, S. Dionisi, F. Mosca, U. Boggi, A. O. Muda, S. D. Prato, J. F. Elliott, A. Covacci, R. Rappuoli, B. O. Roep, and P. Marchetti. 2007. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc. Natl. Acad. Sci. USA 104:5115-5120.
8. Elfaitouri, A., A. K. Berg, G. Frisk, H. Yin, T. Tuvemo, and J. Blomberg. 2007. Recent enterovirus infection in type 1 diabetes: evidence with a novel IgM method. J. Med. Virol. 79:1861-1867.
9. Giarratana, N., G. Penna, S. Amuchastegui, R. Mariani, K. C. Daniel, and L. Adorini. 2004. A vitamin D analog downregulates proinflammatory chemokine production by pancreatic islets inhibiting T-cell recruitment and type 1 diabetes development. J. Immunol. 173:2280-2287. (Pubitemid 39063083)
10. Gitlin, L., W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R. A. Flavell, M. S. Diamond, and M. Colonna. 2006. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. USA 103:8459-8464.
11. Hardarson, H. S., J. S. Baker, Z. Yang, E. Purevjav, C. H. Huang, L. Alexopoulou, N. Li, R. A. Flavell, N. E. Bowles, and J. G. Vallejo. 2007. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. Am. J. Physiol. Heart Circ. Physiol. 292: H251-H258.
12. Honda, K., S. Sakaguchi, C. Nakajima, A. Watanabe, H. Yanai, M. Matsumoto, T. Ohteki, T. Kaisho, A. Takaoka, S. Akira, T. Seya, and T. Taniguchi. 2003. Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. USA 100:10872-10877.
13. Hornung, V., J. Ellegast, S. Kim, K. Brzozka, A. Jung, H. Kato, H. Poeck, S. Akira, K. K. Conzelmann, M. Schlee, S. Endres, and G. Hartmann. 2006. 5′-Triphosphate RNA is the ligand for RIG-I. Science 314:994-997.
14. Hultcrantz, M., M. H. Huhn, M. Wolf, A. Olsson, S. Jacobson, B. R. Williams, O. Korsgren, and M. Flodstrom-Tullberg. 2007. Interferons induce an antiviral state in human pancreatic islet cells. Virology 367:92-101. (Pubitemid 47418925)
15. Kato, H., O. Takeuchi, S. Sato, M. Yoneyama, M. Yamamoto, K. Matsui, S. Uematsu, A. Jung, T. Kawai, K. J. Ishii, O. Yamaguchi, K. Otsu, T. Tsujimura, C. S. Koh, C. Reis e Sousa, Y. Matsuura, T. Fujita, and S. Akira. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-105.
16. Kawai, T., K. Takahashi, S. Sato, C. Coban, H. Kumar, H. Kato, K. J. Ishii, O. Takeuchi, and S. Akira. 2005. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6:981-988.
17. Kolumam, G. A., S. Thomas, L. J. Thompson, J. Sprent, and K. Murali- Krishna. 2006. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202:637-650.
18. Le Goffic, R., V. Balloy, M. Lagranderie, L. Alexopoulou, N. Escriou, R. Flavell, M. Chignard, and M. Si-Tahar. 2006. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog. 2:e53.
19. McCartney, S. A., L. B. Thackray, L. Gitlin, S. Gilfillan, H. W. Virgin, and M. Colonna. 2008. MDA-5 recognition of a murine norovirus. PLoS Pathog. 4:e1000108.
20. Mena, I., C. Fischer, J. R. Gebhard, C. M. Perry, S. Harkins, and J. L. Whitton. 2000. Coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and immunopathology. Virology 271:276-288. (Pubitemid 30461306)
21. Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J. Tschopp. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167-1172. (Pubitemid 41509355)
22. Nejentsev, S., N. Walker, D. Riches, M. Egholm, and J. A. Todd. 2009. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324:387-389.
23. Richer, M. J., D. J. Lavallee, I. Shanina, and M. S. Horwitz. 2009. Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. PLoS ONE 4:e4127.
24. Roivainen, M., S. Rasilainen, P. Ylipaasto, R. Nissinen, J. Ustinov, L. Bouwens, D. L. Eizirik, T. Hovi, and T. Otonkoski. 2000. Mechanisms of coxsackievirus- induced damage to human pancreatic beta-cells. J. Clin. Endocrinol. Metab. 85:432-440.
25. Salazar-Mather, T. P., C. A. Lewis, and C. A. Biron. 2002. Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver. J. Clin. Investig. 110:321-330.
26. Seth, R. B., L. Sun, C. K. Ea, and Z. J. Chen. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3. Cell 122:669-682.
27. Smyth, D. J., J. D. Cooper, R. Bailey, S. Field, O. Burren, L. J. Smink, C. Guja, C. Ionescu-Tirgoviste, B. Widmer, D. B. Dunger, D. A. Savage, N. M. Walker, D. G. Clayton, and J. A. Todd. 2006. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat. Genet. 38:617-619.
28. Triantafilou, K., G. Orthopoulos, E. Vakakis, M. A. Ahmed, D. T. Golenbock, P. M. Lepper, and M. Triantafilou. 2005. Human cardiac inflammatory responses triggered by coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cell Microbiol. 7:1117-1126. (Pubitemid 41030937)
29. Vercammen, E., J. Staal, and R. Beyaert. 2008. Sensing of viral infection and activation of innate immunity by Toll-like receptor 3. Clin. Microbiol. Rev. 21:13-25.
30. Wang, J. P., D. R. Asher, M. Chan, E. A. Kurt-Jones, and R. W. Finberg. 2007. Cutting edge: antibody-mediated TLR7-dependent recognition of viral RNA. J. Immunol. 178:3363-3367.
31. Wang, T., T. Town, L. Alexopoulou, J. F. Anderson, E. Fikrig, and R. A. Flavell. 2004. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 10:1366-1373.
32. Wessely, R., K. Klingel, K. U. Knowlton, and R. Kandolf. 2001. Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation 103:756-761. (Pubitemid 32144207)
33. Xu, L. G., Y. Y. Wang, K. J. Han, L. Y. Li, Z. Zhai, and H. B. Shu. 2005. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19:727-740.
34. Yin, H., A. K. Berg, T. Tuvemo, and G. Frisk. 2002. Enterovirus RNA is found in peripheral blood mononuclear cells in a majority of type 1 diabetic children at onset. Diabetes 51:1964-1971. (Pubitemid 34564312)