The dynamics and mechanisms of interleukin-1α and β nuclear import

Traffic

Volumn 10, Issue 1, 2009, Pages 16-25

  Luheshi, Nadia M ^a   Rothwell, Nancy J ^a   Brough, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

FRAP; Interleukin 1; Microglia; Nuclear import; Ran

Indexed keywords

BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; RAN PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BLEACHING; CELL MEMBRANE TRANSPORT; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOSOL; FLUORESCENCE; HUMAN; HUMAN CELL; INFLAMMATION; MICROGLIA; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; MICE; MICROGLIA; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 58149187865     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2008.00840.x     Document Type: Article

References (35)

1. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87: 2095-2147.
2. Mosley B, Urdal DL, Prickett KS, Larsen A, Cosman D, Conlon PJ, Gillis S, Dower SK. The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem 1987; 262: 2941-2944.
3. Kavita U, Mizel SB. Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease. J Biol Chem 1995; 270: 27758-27765.
4. Subramaniam S, Stansberg C, Cunningham C. The interleukin 1 receptor family. Dev Comp Immunol 2004; 28: 415-428.
5. Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). Cytokine 2005; 31: 153-160.
6. Maier JA, Statuto M, Ragnotti G. Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells. Mol Cell Biol 1994; 14: 1845-1851.
7. Merhi-Soussi F, Berti M, Wehrle-Haller B, Gabay C. Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1alpha precursor on cell motility. Cytokine 2005; 32: 163-170.
8. McMahon GA, Garfinkel S, Prudovsky I, Hu X, Maciag T. Intracellular precursor interleukin (IL)-1alpha, but not mature IL-1alpha, is able to regulate human endothelial cell migration in vitro. J Biol Chem 1997; 272: 28202-28205.
9. Stevenson FT, Turck J, Locksley RM, Lovett DH. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Proc Natl Acad Sci U S A 1997; 94: 508-513.
10. Pollock AS, Turck J, Lovett DH. The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells. FASEB J 2003; 17: 203-213.
11. Cheng W, Shivshankar P, Zhong Y, Chen D, Li Z, Zhong G. Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor. Infect Immun 2008; 76: 942-951.
12. Stewart M. Molecular mechanism of the nuclear protein import cycle. Nat Rev Mol Cell Biol 2007; 8: 195-208.
13. Palacios I, Weis K, Klebe C, Mattaj IW, Dingwall C. RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J Cell Biol 1996; 133: 485-494.
14. Wessendorf JH, Garfinkel S, Zhan X, Brown S, Maciag T. Identification of a nuclear localization sequence within the structure of the human interleukin-1 alpha precursor. J Biol Chem 1993; 268: 22100-22104.
15. Gorlich D, Kutay U. Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 1999; 15: 607-660.
16. Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G, Rothwell N. Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J Neurosci 2002; 22: 38-43.
17. Lippincott-Schwartz J, Snapp E, Kenworthy A. Studying protein dynamics in living cells. Nat Rev Mol Cell Biol 2001; 2: 444-456.
18. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001; 2: 734-744.
19. Stevenson FT, Torrano F, Locksley RM, Lovett DH. Interleukin 1: The patterns of translation and intracellular distribution support alternative secretory mechanisms. J Cell Physiol 1992; 152: 223-231.
20. Kawaguchi Y, Nishimagi E, Tochimoto A, Kawamoto M, Katsumata Y, Soejima M, Kanno T, Kamatani N, Hara M. Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1 alpha in systemic sclerosis fibroblasts. Proc Natl Acad Sci U S A 2006; 103: 14501-14506.
21. Schultz K, Murthy V, Tatro JB, Beasley D. Endogenous Interleukin-1{alpha} promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2007; 292: H2927-H2934.
22. Burysek L, Houstek J. Multifactorial induction of gene expression and nuclear localization of mouse interleukin 1 alpha. Cytokine 1996; 8: 460-467.
23. Brough D, Rothwell NJ. Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. J Cell Sci 2007; 120: 772-781.
24. Grenfell S, Smithers N, Witham S, Shaw A, Graber P, Solari R. Analysis of mutations in the putative nuclear localization sequence of interleukin-1 beta. Biochem J 1991; 280: 111-116.
25. Kalderon D, Roberts BL, Richardson WD, Smith AE. A short amino acid sequence able to specify nuclear location. Cell 1984; 39: 499-509.
26. Stacey DW, Allfrey VG. Microinjection studies of protein transit across the nuclear envelope of human cells. Exp Cell Res 1984; 154: 283-292.
27. Wang R, Brattain MG. The maximal size of protein to diffuse through the nuclear pore is larger than 60kDa. FEBS Lett 2007; 581: 3164-3170.
28. Seibel NM, Eljouni J, Nalaskowski MM, Hampe W. Nuclear localization of enhanced green fluorescent protein homomultimers. Anal Biochem 2007; 368: 95-99.
29. Brough D, Bhatti F, Irvine RF. Mobility of proteins associated with the plasma membrane by interaction with inositol lipids. J Cell Sci 2005; 118: 3019-3025.
30. Klebe C, Bischoff FR, Ponstingl H, Wittinghofer A. Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry 1995; 34: 639-647.
31. Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, Bouche G, Girard JP. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A 2007; 104: 282-287.
32. Sharma S, Kulk N, Nold MF, Graf R, Kim SH, Reinhardt D, Dinarello CA, Bufler P. The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol 2008; 180: 5477-5482.
33. Werman A, Werman-Venkert R, White R, Lee JK, Werman B, Krelin Y, Voronov E, Dinarello CA, Apte RN. The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A 2004; 101: 2434-2439.
34. Snapp E, Altan N, Lippincott-Schwartz J. Measuring protein mobility by photobleaching GFP-chimeras in living cells. In: Bonifacino M, Dasso J, Harford J, Lippincott-Schwartz J, Yamada M, editors. Current Protocols in Cell Biology. New York: John Wiley & Sons; 2003; Chapter 21:UNit 21.1.
35. Brough D, Le Feuvre RA, Iwakura Y, Rothwell NJ. Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Mol Cell Neurosci 2002; 19: 272-280.