A novel 3D liver organoid system for elucidation of hepatic glucose metabolism

Biotechnology and Bioengineering

Volumn 109, Issue 2, 2012, Pages 595-604

  Lu, Yanhua ^a   Zhang, Guoliang ^b   Shen, Chong ^a   Uygun, Korkut ^c   Yarmush, Martin L ^c,d   Meng, Qin ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

3D organoid culture; Glucose metabolism; Hollow fiber bioreactor; Rat hepatocytes

Indexed keywords

CULTURE METHODS; CULTURING CELLS; DEXAMETHASONES; GLUCONEOGENESIS; GLUCOSE CONSUMPTION; GLUCOSE METABOLISM; HEPATOCYTES; HOLLOW FIBER BIOREACTOR; HOLLOW FIBER REACTORS; IN-VITRO; IN-VIVO; KEY ENZYMES; LIVER-SPECIFIC FUNCTIONS; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOLAYER CULTURE; ORGANOIDS; RAT HEPATOCYTES; REACTIVE OXYGEN SPECIES; SELF-ASSEMBLE; STRESS CONDITION; THREE-DIMENSIONAL (3D); TIGHT JUNCTIONS;

CELL CULTURE; CELL MEMBRANES; GENE EXPRESSION; GLUCOSE; METABOLISM; MONOLAYERS; PHYSIOLOGY;

THREE DIMENSIONAL;

GLUCOSE; GLYCOGEN; INSULIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); DOWN REGULATION; DRUG SCREENING; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLYCOGENOLYSIS; HEPATOBILIARY SYSTEM; HORMONE RESPONSE; LIPID STORAGE; LIVER CELL CULTURE; LIVER FUNCTION; LIVER METABOLISM; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOLAYER CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; GENE EXPRESSION REGULATION; GLUCOSE; HEPATOCYTES; INSULIN; LIVER; MALE; MODELS, BIOLOGICAL; ORGANOIDS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 83555165223     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23349     Document Type: Article

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