메뉴 건너뛰기




Volumn 8, Issue 3, 1999, Pages 233-246

Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids

Author keywords

Confocal microscopy; Cytochrome P450; Hepatocyte; Spheroid

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450; ETHOXYRESORUFIN;

EID: 0032801247     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1177/096368979900800304     Document Type: Article
Times cited : (74)

References (46)
  • 1
    • 0024340802 scopus 로고
    • Ultrastructure of multicellular spheroids formed in the primary culture of adult rat hepatocytes
    • Asano, K.; Koide, N.; Tsuji, T. Ultrastructure of multicellular spheroids formed in the primary culture of adult rat hepatocytes. J. Clin. Electr. Microsc. 22:243-252-1989.
    • (1989) J. Clin. Electr. Microsc. , vol.22
    • Asano, K.1    Koide, N.2    Tsuji, T.3
  • 2
    • 0024121578 scopus 로고
    • Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes
    • Ben-Ze'ev, A.; Robinson, G. S.; Bucher, N. L.; Farmer, S. R. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc. Natl. Acad. Sci. USA 85:2161-2165; 1988.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2161-2165
    • Ben-Ze'ev, A.1    Robinson, G.S.2    Bucher, N.L.3    Farmer, S.R.4
  • 3
    • 0023090714 scopus 로고
    • Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver
    • Bissell, D.; Arenson, D.; Maher, J.; Roll, F. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 79:801-812; 1987.
    • (1987) J. Clin. Invest. , vol.79 , pp. 801-812
    • Bissell, D.1    Arenson, D.2    Maher, J.3    Roll, F.4
  • 4
    • 0022357068 scopus 로고
    • Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
    • Burke, M. D.; Thompson, S.; Elcombe, C. R.; Halpert, J.; Haaparanta, T.; Mayer, R. T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34:3337-3345; 1985.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3337-3345
    • Burke, M.D.1    Thompson, S.2    Elcombe, C.R.3    Halpert, J.4    Haaparanta, T.5    Mayer, R.T.6
  • 5
    • 0028106482 scopus 로고
    • Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
    • Burke, M. D.; Thompson, S.; Weaver, R. J.; Wolf, C. R.; Mayer, R. T. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem. Pharmacol. 48:923-936; 1994.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 923-936
    • Burke, M.D.1    Thompson, S.2    Weaver, R.J.3    Wolf, C.R.4    Mayer, R.T.5
  • 6
    • 0025987629 scopus 로고
    • A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes
    • Corlu, A.; Kneip, B.; Lhadi, C.; Leray, G.; Glaise, D.; Baffet, G.; Bourel, D.; Guguen-Guillouzo, C. A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes. J. Cell Biol. 115:505-515; 1991.
    • (1991) J. Cell Biol. , vol.115 , pp. 505-515
    • Corlu, A.1    Kneip, B.2    Lhadi, C.3    Leray, G.4    Glaise, D.5    Baffet, G.6    Bourel, D.7    Guguen-Guillouzo, C.8
  • 7
    • 0025866909 scopus 로고
    • Modulation of 3′azido-3′deoxythymidine catabolism by probenecid and ac etaminophen in freshly isolated rat hepatocytes
    • Cretton, E. M.; Sommadossi, J.-P. Modulation of 3′azido-3′deoxythymidine catabolism by probenecid and ac etaminophen in freshly isolated rat hepatocytes. Biochem. Pharmacol. 42:1475-1480; 1991.
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 1475-1480
    • Cretton, E.M.1    Sommadossi, J.-P.2
  • 8
    • 0023907035 scopus 로고
    • Long-term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity
    • Dich, J.; Vind, C.; Grunnet, N. Long-term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity. Hepatology 8:39-45; 1988.
    • (1988) Hepatology , vol.8 , pp. 39-45
    • Dich, J.1    Vind, C.2    Grunnet, N.3
  • 9
    • 0027275495 scopus 로고
    • A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates
    • Donato, M. T.; Gomez-Lechon, M. J.; Castell, J. V. A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates. Anal. Biochem. 213:29-33; 1993.
    • (1993) Anal. Biochem. , vol.213 , pp. 29-33
    • Donato, M.T.1    Gomez-Lechon, M.J.2    Castell, J.V.3
  • 10
    • 0025320692 scopus 로고
    • Variation in drug-metabolizing enzyme activities during the growth of human Hep G2 hepatoma cells
    • Doostdar, H.; Demoz, A.; Burke, M. D.; Melvin, W. T.; Grant, M. H. Variation in drug-metabolizing enzyme activities during the growth of human Hep G2 hepatoma cells. Xenobiotica 20:435-441; 1990.
    • (1990) Xenobiotica , vol.20 , pp. 435-441
    • Doostdar, H.1    Demoz, A.2    Burke, M.D.3    Melvin, W.T.4    Grant, M.H.5
  • 11
    • 0021364171 scopus 로고
    • Hepatocyte proliferation in vitro: Its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix
    • Enat, R.; Jefferson, D.; Ruiz-Opazo, N.; Gatmaitan, Z.; Leinwand, L.; Reid, L. Hepatocyte proliferation in vitro: Its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix. Proc. Natl. Acad. Sci. USA 81:1411-1415; 1984.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 1411-1415
    • Enat, R.1    Jefferson, D.2    Ruiz-Opazo, N.3    Gatmaitan, Z.4    Leinwand, L.5    Reid, L.6
  • 13
    • 0022852734 scopus 로고
    • Strain differences in the maintenance of cytochrome P-450 and mixed-function-oxidase activities in cultured rat hepatocytes
    • Grant, M. H.; Smith, S. J.; Burke, M. D. Strain differences in the maintenance of cytochrome P-450 and mixed-function-oxidase activities in cultured rat hepatocytes. Biochem. J. 239:785-788; 1986.
    • (1986) Biochem. J. , vol.239 , pp. 785-788
    • Grant, M.H.1    Smith, S.J.2    Burke, M.D.3
  • 14
    • 0020660763 scopus 로고
    • Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type
    • Guguen-Guillouzo, C.; Clement, B.; Baffet, G.; Beaumont, C.; Morel-Chang, E.; Glaise, D.; Guillouzo, A. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp. Cell Res. 143:47-54; 1983.
    • (1983) Exp. Cell Res. , vol.143 , pp. 47-54
    • Guguen-Guillouzo, C.1    Clement, B.2    Baffet, G.3    Beaumont, C.4    Morel-Chang, E.5    Glaise, D.6    Guillouzo, A.7
  • 16
    • 0028328474 scopus 로고
    • The primary and secondary metabolism of aflatoxin B1 by rat hepatocytes cultured on Matrigel
    • Judah, D. J.; Davies, R.; Hayes, J. D.; McLellan, L. I.; Neal, G. E. The primary and secondary metabolism of aflatoxin B1 by rat hepatocytes cultured on Matrigel. Toxicol. Appl. Pharmacol. 125:27-33; 1994.
    • (1994) Toxicol. Appl. Pharmacol. , vol.125 , pp. 27-33
    • Judah, D.J.1    Davies, R.2    Hayes, J.D.3    McLellan, L.I.4    Neal, G.E.5
  • 17
    • 0025135443 scopus 로고
    • Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments
    • Koide, N.; Sakaguchi, K.; Koide, Y.; Asano, K.; Kawaguchi, M.; Matsushima, H.; Takenami, T.; Shinji, T.; Mori, M.; Tsuji, T. Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments. Exp. Cell Res. 186:227-235; 1990.
    • (1990) Exp. Cell Res. , vol.186 , pp. 227-235
    • Koide, N.1    Sakaguchi, K.2    Koide, Y.3    Asano, K.4    Kawaguchi, M.5    Matsushima, H.6    Takenami, T.7    Shinji, T.8    Mori, M.9    Tsuji, T.10
  • 18
    • 0024366784 scopus 로고
    • Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans
    • Koide, N.; Shinji, T.; Tanabe, T.; Asano, K.; Kawaguchi, M.; Sakaguchi, K.; Koide, Y.; Mori, M.; Tsuji, T. Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans. Biochem. Biophys. Res. Commun. 161:385-391; 1989.
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 385-391
    • Koide, N.1    Shinji, T.2    Tanabe, T.3    Asano, K.4    Kawaguchi, M.5    Sakaguchi, K.6    Koide, Y.7    Mori, M.8    Tsuji, T.9
  • 19
    • 0022204028 scopus 로고
    • Spheroidal aggregate culture of rat liver cells: Histotypic reorganization, biomatrix deposition, and maintenance of functional activities
    • Landry, J.; Bernier, D.; Ouellet, C.; Goyette, R.; Marceau, N. Spheroidal aggregate culture of rat liver cells: Histotypic reorganization, biomatrix deposition, and maintenance of functional activities. J. Cell Biol. 101: 914-923; 1985.
    • (1985) J. Cell Biol. , vol.101 , pp. 914-923
    • Landry, J.1    Bernier, D.2    Ouellet, C.3    Goyette, R.4    Marceau, N.5
  • 20
    • 0029064234 scopus 로고
    • Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix
    • Mooney, D. J.; Langer, R.; Ingber, D. E. Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix. J. Cell Sci. 108:2311-2320; 1995.
    • (1995) J. Cell Sci. , vol.108 , pp. 2311-2320
    • Mooney, D.J.1    Langer, R.2    Ingber, D.E.3
  • 21
    • 0022982255 scopus 로고
    • Long-term maintenance of hepatocyte functional activity in co-culture: Requirements for sinusoidal endothelial cells and dexamethasone
    • Morin, O.; Normand, C. Long-term maintenance of hepatocyte functional activity in co-culture: Requirements for sinusoidal endothelial cells and dexamethasone. J. Cell Physiol. 129:103-110; 1986.
    • (1986) J. Cell Physiol. , vol.129 , pp. 103-110
    • Morin, O.1    Normand, C.2
  • 22
    • 0028306522 scopus 로고
    • Reversion of altered phenotype in primary cultured rat hepatocytes after intrahepatic and intrasplenic transplantation
    • Nishikawa, Y.; Ohta, T.; Ogawa, K.; Nagase, S. Reversion of altered phenotype in primary cultured rat hepatocytes after intrahepatic and intrasplenic transplantation. Lab. Invest. 70:925-932; 1994.
    • (1994) Lab. Invest. , vol.70 , pp. 925-932
    • Nishikawa, Y.1    Ohta, T.2    Ogawa, K.3    Nagase, S.4
  • 23
    • 0026661502 scopus 로고
    • Hepatocyte culture systems for artificial liver support: Implications for critical care medicine (bioartificial liver support)
    • Nyberg, S. L.; Shatford, R. A.; Hu, W.-S.; Payne, W. D.; Cerra, F. B. Hepatocyte culture systems for artificial liver support: Implications for critical care medicine (bioartificial liver support). Crit. Care Med. 20:1157-1168; 1992.
    • (1992) Crit. Care Med. , vol.20 , pp. 1157-1168
    • Nyberg, S.L.1    Shatford, R.A.2    Hu, W.-S.3    Payne, W.D.4    Cerra, F.B.5
  • 24
    • 0027017650 scopus 로고
    • Primary culture of rat hepatocytes entrapped in cylindrical collagen gels: An in vitro system with application to the bioartificial liver
    • Nyberg, S. L.; Shatford, R. A.; Payne, W. D.; Hu, W. S.; Cerra, F. B. Primary culture of rat hepatocytes entrapped in cylindrical collagen gels: An in vitro system with application to the bioartificial liver. Cytotechnology 10: 205-215; 1992.
    • (1992) Cytotechnology , vol.10 , pp. 205-215
    • Nyberg, S.L.1    Shatford, R.A.2    Payne, W.D.3    Hu, W.S.4    Cerra, F.B.5
  • 26
    • 0022472879 scopus 로고
    • Induction of drug-metabolizing enzymes: Mechanisms and consequences
    • Okey, A. B.; Roberts, E. A.; Harper, P. A.; Denison, M. S. Induction of drug-metabolizing enzymes: Mechanisms and consequences. Clin. Biochem. 19:132-141; 1986.
    • (1986) Clin. Biochem. , vol.19 , pp. 132-141
    • Okey, A.B.1    Roberts, E.A.2    Harper, P.A.3    Denison, M.S.4
  • 27
    • 0029944038 scopus 로고    scopus 로고
    • Transplatation of xenogeneic hepatocytes: Three-dimensionally cultured hepatocyte (spheroid) transplantation into the spleen
    • Ota, K.; Saito, S.; Hamasaki, K.; Tanaka, N.; Orita, K. Transplatation of xenogeneic hepatocytes: Three-dimensionally cultured hepatocyte (spheroid) transplantation into the spleen. Transplant. Proc. 28:1430-1432; 1996.
    • (1996) Transplant. Proc. , vol.28 , pp. 1430-1432
    • Ota, K.1    Saito, S.2    Hamasaki, K.3    Tanaka, N.4    Orita, K.5
  • 29
    • 0029945884 scopus 로고    scopus 로고
    • Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids
    • Peshwa, M. V.; Wu, F. J.; Sharp, H. L.; Cerra, F. B.; Hu, W.-S. Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids. In Vitro Cell. Dev. Biol. 32A:197-203; 1996.
    • (1996) Vitro Cell. Dev. Biol. , vol.32 A , pp. 197-203
    • Peshwa, M.V.1    Wu, F.J.2    Sharp, H.L.3    Cerra, F.B.4    Hu, W.-S.5
  • 30
    • 0027481679 scopus 로고
    • Inducibility of enzyme activities associated with the cytochrome P-450 1A family, ethoxyresorufin O-deethylase, and methoxyresorufin O-demethylase in human hepatocyte lines derived from normal liver tissue
    • Roberts, E. A.; Zhang, W. X.; Yang, S.; Lipa, J. Inducibility of enzyme activities associated with the cytochrome P-450 1A family, ethoxyresorufin O-deethylase, and methoxyresorufin O-demethylase in human hepatocyte lines derived from normal liver tissue. Drug Metab. Dispos. 21:56-61; 1993.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 56-61
    • Roberts, E.A.1    Zhang, W.X.2    Yang, S.3    Lipa, J.4
  • 31
    • 0025492387 scopus 로고
    • A two-compartment cell entrapment bioreactor with three different holding times for cells, high and low molecular weight compounds
    • Scholz, M.; Hu, W.-S. A two-compartment cell entrapment bioreactor with three different holding times for cells, high and low molecular weight compounds. Cytotechnology 4:127-137; 1991.
    • (1991) Cytotechnology , vol.4 , pp. 127-137
    • Scholz, M.1    Hu, W.-S.2
  • 33
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen, P. Preparation of isolated rat liver cells. Methods Cell Biol. 13:29-83; 1976.
    • (1976) Methods Cell Biol. , vol.13 , pp. 29-83
    • Seglen, P.1
  • 35
    • 0027443236 scopus 로고
    • Direct determination of functional activity of cytochrome P-4501A1 and NADPH DT-diaphorase in hepatoma cell lines using noninvasive scanning laser cytometry
    • Sidhu, J. S.; Kavangh, T. J.; Reilly, M. T.; Omiecinski, C. J. Direct determination of functional activity of cytochrome P-4501A1 and NADPH DT-diaphorase in hepatoma cell lines using noninvasive scanning laser cytometry. J. Toxicol. Environ. Health 40:177-194; 1993.
    • (1993) J. Toxicol. Environ. Health , vol.40 , pp. 177-194
    • Sidhu, J.S.1    Kavangh, T.J.2    Reilly, M.T.3    Omiecinski, C.J.4
  • 38
    • 0025113615 scopus 로고
    • Induction of cytochrome P-450 and 5-aminolevulinate synthease activities in cultured rat hepatoyctes
    • Sinclair, P. R.; Bement, W. J.; Haugen, S. A.; Sinclair, J. F.; Guzelian, P. S. Induction of cytochrome P-450 and 5-aminolevulinate synthease activities in cultured rat hepatoyctes. Cancer Res. 50:5219-5224; 1990.
    • (1990) Cancer Res. , vol.50 , pp. 5219-5224
    • Sinclair, P.R.1    Bement, W.J.2    Haugen, S.A.3    Sinclair, J.F.4    Guzelian, P.S.5
  • 41
    • 0026682542 scopus 로고
    • Receptor-mediated formation of multilayer aggregates of primary cultured adult rat hepatocytes on lactose-substituted polystyrene
    • Tobe, S.; Takei, Y.; Kobayashi, K.; Akaike, T. Receptor-mediated formation of multilayer aggregates of primary cultured adult rat hepatocytes on lactose-substituted polystyrene. Biochem. Biophys. Res. Commun. 184:225-230; 1992.
    • (1992) Biochem. Biophys. Res. Commun. , vol.184 , pp. 225-230
    • Tobe, S.1    Takei, Y.2    Kobayashi, K.3    Akaike, T.4
  • 42
    • 0025310545 scopus 로고
    • Long-term culture of rat liver cell spheroids in hormonally defined media
    • Tong, J. Z.; Bernard, O.; Alvarez, F. Long-term culture of rat liver cell spheroids in hormonally defined media. Exp. Cell Res. 189:87-92; 1990.
    • (1990) Exp. Cell Res. , vol.189 , pp. 87-92
    • Tong, J.Z.1    Bernard, O.2    Alvarez, F.3
  • 45
    • 85016542937 scopus 로고
    • Entrapment of hepatocyte spheroids in a hollow fiber bioreactor as a potential bioartificial liver
    • Wu, F. J.; Peshwa, M. V.; Cerra, F. B.; Hu, W.-S. Entrapment of hepatocyte spheroids in a hollow fiber bioreactor as a potential bioartificial liver. Tissue Eng. 1:29-40; 1995.
    • (1995) Tissue Eng. , vol.1 , pp. 29-40
    • Wu, F.J.1    Peshwa, M.V.2    Cerra, F.B.3    Hu, W.-S.4
  • 46
    • 0027220660 scopus 로고
    • Importance of cell aggregation for expression of liver functions and regeneration demonstrated with primary cultured hepatocytes
    • Yuasa, C.; Tomita, Y.; Shono, M.; Ishimura, K.; Ichihara, A. Importance of cell aggregation for expression of liver functions and regeneration demonstrated with primary cultured hepatocytes. J. Cell Physiol. 156:522-530; 1993.
    • (1993) J. Cell Physiol. , vol.156 , pp. 522-530
    • Yuasa, C.1    Tomita, Y.2    Shono, M.3    Ishimura, K.4    Ichihara, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.