Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber

Toxicology and Applied Pharmacology

Volumn 249, Issue 2, 2010, Pages 140-147

  Shen, Chong ^a   Zhang, Guoliang ^b   Meng, Qin ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Cell function; Drug adsorption; Gel entrapped hepatocytes; Hepatotoxicity; Hollow fiber

Indexed keywords

AMIODARONE; AZATHIOPRINE; CHLOROQUINE; CLOZAPINE; COLLAGEN GEL; COPOLYMER; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; PARACETAMOL; POLYSULFONE G POLY(ETHYLENE GLYCOL); RIFAMPICIN; SALICYLIC ACID; TETRACYCLINE; UNCLASSIFIED DRUG;

ADSORPTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HOLLOW FIBER; HYDROPHOBICITY; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MALE; MONOLAYER CULTURE; NONHUMAN; RAT; RELIABILITY;

ADSORPTION; ANIMALS; CELLS, CULTURED; COLLAGEN; CYTOCHROME P-450 ENZYME SYSTEM; DRUG TOXICITY; GELS; HEPATOCYTES; MALE; MEMBRANES, ARTIFICIAL; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; TOXICITY TESTS;

EID: 77958155396     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.08.028     Document Type: Article

References (44)

1. Beken S., Tytgat T., Pahernik S., Koebe H.G., Vercruysse A., Rogiers V. Cell morphology, albumin secretion and glutathione S-transferase expression in collagen gel sandwich and immobilization cultures of rat hepatocytes. Toxicol. In Vitro 1997, 11:409-416.
2. Cheung C., Yu A.M., Ward J.M., Krausz K.W., Akiyama T.E., Feigenbaum L., Gonzalez F.J. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab. Dispos. 2005, 33:449-457.
3. Damme B., Darmer D., Pankow D. Induction of hepatic cytochrome P4502E1 in rats by acetylsalicylic acid or sodium salicylate. Toxicology 1996, 106:99-103.
4. de Lara R., Benavente J. Use of hydrodynamic and electrical measurements to determine protein fouling mechanisms for microfiltration membranes with different structures and materials. Sep. Purif. Technol. 2009, 66:517-524.
5. deSmet K., Callaerts A., Vercruysse A., Rogiers V. Effect of phenobarbital on 7-ethoxycoumarin-O-deethylase and microsomal epoxide hydrase activities in collagen gel cultures of rat hepatocytes. Toxicol. In Vitro 1997, 11:459-463.
6. Diekmann S., Bader A., Schmitmeier S. Present and future developments in hepatic tissue engineering for liver support systems-State of the art and future developments of hepatic cell culture techniques for the use in liver support systems. Cytotechnology 2006, 50:163-179.
7. Dong J.Q., Smith P.C. Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes. Drug Metab. Dispos. 2009, 37:2314-2322.
8. Du Y., Chia S.M., Han R., Chang S., Tang H., Yu H. 3D hepatocyte monolayer on hybrid RGD/galactose substratum. Biomaterials 2006, 27:5669-5680.
9. Ehsani N., Parkkinen S., Nystrom M. Fractionation of natural and model egg-white protein solutions with modified and unmodified polysulfone UF membranes. J. Membr. Sci. 1997, 123:105-119.
10. Farkas D., Tannenbaum S.R. Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. Toxicol. Sci. 2005, 85:927-934.
11. Gardiner T.H., Lewis J.M., Shore P.A. Distribution of clozapine in the rat: localization in lung. J. Pharmacol. Exp. Ther. 1978, 206:151-157.
12. He X.C., Yu H.Y., Tang Z.Q., Liu L.Q., Yan M.G., Gu J.S., Wei X.W. Reducing protein fouling of a polypropylene microporous membrane by CO2 plasma surface modification. Desalination 2009, 244:80-89.
13. Khetani S.R., Bhatia S.N. Microscale culture of human liver cells for drug development. Nat. Biotech. 2008, 26:120-126.
14. Liu Y., Koops G.H., Strathmann H. Characterization of morphology controlled polyethersulfone hollow fiber membranes by the addition of polyethylene glycol to the dope and bore liquid solution. J. Membr. Sci. 2003, 223:187-199.
15. Lu Y., Meng Q., Zhang G., Bei X. Clozapine-induced hepatotoxicity in rat hepatocytes by gel entrapment and monolayer culture. Toxicol. In Vitro 2008, 22:1754-1760.
16. Mahlicli F.Y., Altinkaya S.A. The effects of urease immobilization on the transport characteristics and protein adsorption capacity of cellulose acetate based hemodialysis membranes. J. Mater. Sci. 2009, 20:2167-2179.
17. Marion T.L., Leslie E.M., Brouwer K.L.R. Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. Mol. Pharmacol. 2007, 4:911-918.
18. Meng Q. Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity. Expert Opin. Drug Metab. Toxicol. 2010, 6:1-14.
19. Meng Q., Zhang G., Shen C., Qiu H. Sensitivities of gel entrapped hepatocytes in hollow fibers to hepatotoxic drug. Toxicol. Lett. 2006, 166:19-26.
20. Meng Q., Ru J., Zhang G., Shen C., Schmitmeier S., Bader A. Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. Toxicol. Lett. 2007, 168:140-147.
21. Nakazawa K., Izumi Y., Mori R. Morphological and functional studies of rat hepatocytes on a hydrophobic or hydrophilic polydimethylsiloxane surface. Acta Biomater. 2009, 5:613-620.
22. Namekawa K., Fukuda M., Matsuda M., Yagi Y., Yamamoto K.I., Sakai K. Nanotechnological characterization of human serum albumin adsorption on wet synthetic polymer dialysis membrane surfaces. ASAIO J. 2009, 55:236-242.
23. Napolitano A.P., Dean D.M., Man A.J., Youssef J., Ho D.N., Rago A.P., Lech M.P., Morgan J.R. Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels. Biotechniques 2007, 43(494):496-500.
24. Nyberg S.L., Shatford R.A., Payne W.D., Hu W.S., Cerra F.B. Primary culture of rat hepatocytes entrapped in cylindrical collagen gels-an invitro system with application to the bioartificial liver-rat hepatocytes cultured in cylindrical collagen gels. Cytotechnology 1992, 10:205-215.
25. Nyberg S.L., Shatford R.A., Peshwa M.V., White J.G., Cerra F.B., Hu W.S. Evaluation of a hepatocyte-entrapment hollow fiber bioreactor-a potential bioartificial liver. Biotechnol. Bioeng. 1993, 41:194-203.
26. Oswald S., Grube M., Siegmund W., Kroemer H.K. Transporter-mediated uptake into cellular compartments. Xenobiotica 2007, 37:1171-1195.
27. Palmgren J.J., Monkkonen J., Korjamo T., Hassinen A., Auriola S. Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions. Eur. J. Pharm. Biopharm. 2006, 64:369-378.
28. Park J.Y., Acar M.H., Akthakul A., Kuhlman W., Mayes A.M. Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes. Biomaterials 2006, 27:856-865.
29. Shatford R.A., Nyberg S.L., Meier S.J., White J.G., Payne W.D., Hu W.S., Cerra F.B. Hepatocyte function in a hollow fiber bioreactor: a potential bioartificial liver. J. Surg. Res. 1992, 53:549-557.
30. Shen C., Zhang G., Meng Q. Evaluation of amiodarone-induced phospholipidosis by in vitro system of 3D cultured rat hepatocytes in gel entrapment. Biochem. Eng. J 2010, 49:308-316.
31. Su Y.L., Cheng W., Li C., Jiang Z.Y. Preparation of antifouling ultrafiltration membranes with poly(ethylene glycol)-graft-polyacrylonitrile copolymers. J. Membr. Sci. 2009, 329:246-252.
32. Tassaneeyakul W., Veronese M.E., Birkett D.J., Miners J.O. High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes. J. Chromatogr. 1993, 616:73-78.
33. Tremblay P.L., Berthod F., Germain L., Auger F.A. In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue. J. Pharm. Exp. Ther. 2005, 315:510-516.
34. Tsuruoka S., Yamamoto H., Ioka T., Ando H., Saito T., Fujimura A. Adsorption of oxacalcitriol by polysulphone haemodialyser in patients with secondary hyperparathyroidism. Br. J. Clin. Pharmacol. 2004, 58:488-495.
35. Unger J.K., Kuehlein G., Schroers A., Gerlach J.C., Rossaint R. Adsorption of xenobiotics to plastic tubing incorporated into dynamic in vitro systems used in pharmacological research-limits and progress. Biomaterials 2001, 22:2031-2037.
36. Wang H.Z., Chang C.H., Lin C.P., Tsai M.C. Using MTT viability assay to test the cytotoxicity of antibiotics and steroid to cultured porcine corneal endothelial cells. J. Ocul. Pharmacol. Ther. 1996, 12:35-43.
37. Wang Y.H., Jones D.R., Hall S.D. Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab. Dispos. 2005, 33:664-671.
38. Weigelt B., Bissell M.J. Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin. Cancer Biol. 2008, 18:311-321.
39. Wu F.J., Peshwa M.V., Cerra F.B., Hu W.S. Entrapment of hepatocyte spheroids in a hollow fiber bioreactor as a potential bioartificial liver. Tissue Eng. 1995, 1:29-40.
40. Wu D.Q., Zhang G.L., Shen C., Zhao Q., Li H., Meng Q. Evaluation of diffusion in gel entrapment cell culture within hollow fibers. World J. Gastroenterol. 2005, 11:1599-1604.
41. Wyss P.A., Moor M.J., Bickel M.H. Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats. J. Pharmacol. Exp. Ther. 1990, 254:502-507.
42. Yin J., Meng Q., Zhang G., Sun Y. Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture. Chem. Biol. Interact. 2009, 180:368-375.
43. Zhan J., Liu Z., Wang B.G., Ding F.X. Modification of a membrane surface charge by a low temperature plasma induced grafting reaction and its application to reduce membrane fouling. Sep. Sci. Tech. 2004, 39:2977-2995.
44. Zhang M.G., Nguyen Q.T., Ping Z.H. Hydrophilic modification of poly (vinylidene fluoride) microporous membrane. J. Membr. Sci. 2009, 327:78-86.