-
1
-
-
0034001130
-
Treatment of severe depression
-
Thase ME. Treatment of severe depression. J Clin Psychiatry 2000;61:17-25 (Pubitemid 30124146)
-
(2000)
Journal of Clinical Psychiatry
, vol.61
, Issue.SUPPL. 1
, pp. 17-25
-
-
Thase, M.E.1
-
2
-
-
77954905955
-
Imaging genetics of mood disorders
-
Scharinger C, Rabl U, Sitte HH, Pezawas L. Imaging genetics of mood disorders. Neuroimage 2010;53(3):810-21
-
(2010)
Neuroimage
, vol.53
, Issue.3
, pp. 810-21
-
-
Scharinger, C.1
Rabl, U.2
Sitte, H.H.3
Pezawas, L.4
-
3
-
-
34247509796
-
Epigenetic regulation in psychiatric disorders
-
DOI 10.1038/nrn2132, PII NRN2132
-
Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007;8(5):355-67 (Pubitemid 46652469)
-
(2007)
Nature Reviews Neuroscience
, vol.8
, Issue.5
, pp. 355-367
-
-
Tsankova, N.1
Renthal, W.2
Kumar, A.3
Nestler, E.J.4
-
4
-
-
0036267888
-
The discovery of chemical neurotransmitters
-
DOI 10.1006/brcg.2001.1487
-
Valenstein ES. The discovery of chemical neurotransmitters. Brain Cogn 2002;49(1):73-95 (Pubitemid 34587765)
-
(2002)
Brain and Cognition
, vol.49
, Issue.1
, pp. 73-95
-
-
Valenstein, E.S.1
-
5
-
-
0346366732
-
Quantitative analysis of sponsorship bias in economic studies of antidepressants
-
DOI 10.1192/bjp.183.6.498
-
Baker CB, Johnsrud MT, Crismon ML, et al. Quantitative analysis of sponsorship bias in economic studies of antidepressants. Br J Psychiatry 2003;183:498-506 (Pubitemid 37533195)
-
(2003)
British Journal of Psychiatry
, vol.183
, Issue.DEC.
, pp. 498-506
-
-
Baker, C.B.1
Johnsrud, M.T.2
Crismon, M.L.3
Rosenheck, R.A.4
Woods, S.W.5
-
6
-
-
14844298782
-
Is mood chemistry?
-
DOI 1038/nrn1629
-
Castren E. Is mood chemistry? Nat Rev Neurosci 2005;6:241-6 (Pubitemid 40342418)
-
(2005)
Nature Reviews Neuroscience
, vol.6
, Issue.3
, pp. 241-246
-
-
Castren, E.1
-
7
-
-
39149087067
-
Strategies and tactics for optimizing the hit-to-lead process and beyond - A computational chemistry perspective
-
Manly CJ, Chandrasekhar J, Ochterski JW, et al. Strategies and tactics for optimizing the hit-to-lead process and beyond - a computational chemistry perspective. Drug Discov Today 2008;13(3-4):99-109
-
(2008)
Drug Discov Today
, vol.13
, Issue.3-4
, pp. 99-109
-
-
Manly, C.J.1
Chandrasekhar, J.2
Ochterski, J.W.3
-
8
-
-
33750576990
-
The role of serendipity in drug discovery
-
Ban TA. The role of serendipity in drug discovery. Dialogues Clin Neurosci 2006;8(3):335-44 (Pubitemid 44682750)
-
(2006)
Dialogues in Clinical Neuroscience
, vol.8
, Issue.3
, pp. 335-344
-
-
Ban, T.A.1
-
9
-
-
34447555813
-
Tricyclic antidepressant pharmacology and therapeutic drug interactions updated
-
DOI 10.1038/sj.bjp.0707253, PII 0707253
-
Gillman PK. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol 2007;151(6):737-48 (Pubitemid 47075311)
-
(2007)
British Journal of Pharmacology
, vol.151
, Issue.6
, pp. 737-748
-
-
Gillman, P.K.1
-
10
-
-
34548547156
-
Triple uptake inhibitors: Therapeutic potential in depression and beyond
-
Chen Z, Skolnick P. Triple uptake inhibitors: Therapeutic potential in depression and beyond. Expert Opin Investing Drugs 2007;16(9):1365-76
-
(2007)
Expert Opin Investing Drugs
, vol.16
, Issue.9
, pp. 1365-76
-
-
Chen, Z.1
Skolnick, P.2
-
11
-
-
77953673853
-
A concise total synthesis of (r)-fluoxetine, a potent and selective serotonin reuptake inhibitor
-
Fatima dA, Lapis A, Pilli R. A concise total synthesis of (r)-fluoxetine, a potent and selective serotonin reuptake inhibitor. J Mex Chem Soc 2005;49(2):257-61
-
(2005)
J Mex Chem Soc
, vol.49
, Issue.2
, pp. 257-61
-
-
Fatima, D.A.1
Lapis, A.2
Pilli, R.3
-
12
-
-
76749150603
-
St. John's wort components and the brain: Uptake, concentrations reached and the mechanisms underlying pharmacological effects
-
Caccia S, Gobbi M. St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects. Curr Drug Metab 2009;10(9):1055-65
-
(2009)
Curr Drug Metab
, vol.10
, Issue.9
, pp. 1055-65
-
-
Caccia, S.1
Gobbi, M.2
-
14
-
-
0037051930
-
Effect of hypericum perforatum (St John's wort) in major depressive disorder
-
Hypericum Depression Trial Study Group
-
Hypericum Depression Trial Study Group. Effect of hypericum perforatum (St John's wort) in major depressive disorder. JAMA 2002;287(14):1807-14
-
(2002)
JAMA
, vol.287
, Issue.14
, pp. 1807-14
-
-
-
15
-
-
78649417094
-
Do specificy dietary constituents and supplements affect mental energy? Review of evidence
-
Gorby HE, Brownawell AM, Falk MC. Do specificy dietary constituents and supplements affect mental energy? Review of evidence. Nutr Rev 2010;68:697-718
-
(2010)
Nutr Rev
, vol.68
, pp. 697-718
-
-
Gorby, H.E.1
Brownawell, A.M.2
Falk, M.C.3
-
16
-
-
42949131239
-
Psychological effects of dietary components of tea: Caffenine and l-theanine
-
Janet B. Psychological effects of dietary components of tea: caffenine and l-theanine. Nutr Rev 2008;66:82-90
-
(2008)
Nutr Rev
, vol.66
, pp. 82-90
-
-
Janet, B.1
-
17
-
-
0032852074
-
Chocolate Food or drug?
-
Bruinsma K, Taren DL. Chocolate: Food or drug? J Am Diet Assoc 1999;99(10):1249-56
-
(1999)
J Am Diet Assoc
, vol.99
, Issue.10
, pp. 1249-56
-
-
Bruinsma, K.1
Taren, D.L.2
-
19
-
-
0006704184
-
Aroma-chology: A status review
-
Jellinek JS. Aroma-chology: a status review. Perfum Flavor 1994;19:25-49
-
(1994)
Perfum Flavor
, vol.19
, pp. 25-49
-
-
Jellinek, J.S.1
-
20
-
-
79955640798
-
Novel psychological and neurophysiological significance of beer aromas. Part i: Measurement of changes in human emotions during the smelling of hop and ester aromas using a measurement system for brainwaves
-
Kaneda H, Kojima H, Watari J. Novel psychological and neurophysiological significance of beer aromas. Part i: Measurement of changes in human emotions during the smelling of hop and ester aromas using a measurement system for brainwaves. J Am Soc Brew Chem 2011;69(2):67-74
-
(2011)
J Am Soc Brew Chem
, vol.69
, Issue.2
, pp. 67-74
-
-
Kaneda, H.1
Kojima, H.2
Watari, J.3
-
21
-
-
79955595425
-
Novel psychological and neurophysiological significance of beer aromas. Part ii: Effects of beer aromas on brainwaves related to changes in human emotions
-
Kaneda H, Kojima H, Watari J. Novel psychological and neurophysiological significance of beer aromas. Part ii: Effects of beer aromas on brainwaves related to changes in human emotions. J Am Soc Brew Chem 2011;69(2):75-80
-
J Am Soc Brew Chem 2011
, vol.69
, Issue.2
, pp. 75-80
-
-
Kaneda, H.1
Kojima, H.2
Watari, J.3
-
22
-
-
84862192766
-
Chembl: A large-scale bioactivity database for drug discovery
-
Published online: September, doi: 10.1093/nar/gkr777
-
Gaulton A, Bellis LJ, Bento AP, et al. Chembl: a large-scale bioactivity database for drug discovery. Nucleic Acids Res 2011. Published online: September 23, 2011; doi: 10.1093/nar/gkr777
-
(2011)
Nucleic Acids Res
, vol.23
, pp. 2011
-
-
Gaulton, A.1
Bellis, L.J.2
Bento, A.P.3
-
23
-
-
0038658852
-
The gras process
-
Burdock GA. The gras process. Food Tech 2003;57:17
-
(2003)
Food Tech
, vol.57
, pp. 17
-
-
Burdock, G.A.1
-
24
-
-
58149175157
-
Superscent - A database of flavors and scents
-
Dunkel M, Schmidt U, Struck S, et al. Superscent - a database of flavors and scents. Nucleic Acids Res 2009;37(Database):D291-D4
-
(2009)
Nucleic Acids Res
, vol.37
, Issue.DATABASE
-
-
Dunkel, M.1
Schmidt, U.2
Struck, S.3
-
26
-
-
27144435943
-
In silico predictions of blood-brain barrier penetration: Considerations to "keep in mind"
-
DOI 10.1124/jpet.104.075705
-
Goodwin JT. In silico predictions of blood-brain barrier penetration: considerations to "keep in mind". J Pharmacol Exp Ther 2005;315(2):477-83 (Pubitemid 41500710)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.315
, Issue.2
, pp. 477-483
-
-
Goodwin, J.T.1
Clark, D.E.2
-
27
-
-
25844495011
-
Medicinal chemical properties of successful central nervous system drugs
-
DOI 10.1602/neurorx.2.4.541
-
Pajouhesh H, Lenz GR. Medicinal chemical properties of successful central nervous sytem drugs. NeuroRx 2005;2:541-53 (Pubitemid 41393264)
-
(2005)
NeuroRx
, vol.2
, Issue.4
, pp. 541-553
-
-
Pajouhesh, H.1
Lenz, G.R.2
-
28
-
-
0032714220
-
Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs
-
DOI 10.1023/A:1015040217741
-
Kelder J, Grootenhuis PDJ, Bayada DM, et al. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs. Pharm Res 1999;16(10):1514-19 (Pubitemid 29510546)
-
(1999)
Pharmaceutical Research
, vol.16
, Issue.10
, pp. 1514-1519
-
-
Kelder, J.1
Grootenhuis, P.D.J.2
Bayada, D.M.3
Delbressine, L.P.C.4
Ploemen, J.-P.5
-
29
-
-
0032410164
-
Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors
-
van de Waterbeemd H, Camenisch G, Folkers G, et al. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J Drug Target 1998;6(2):151-65 (Pubitemid 29033982)
-
(1998)
Journal of Drug Targeting
, vol.6
, Issue.2
, pp. 151-165
-
-
Van De Waterbeemd, H.1
Camenisch, G.2
Folkers, G.3
Chretien, J.R.4
Raevsky, O.A.5
-
30
-
-
83455262686
-
-
Drug absorption studies, In: Ehrhardt C, Kim K-J, editors, Springer; US
-
Garg P, Verma J, Roy N. In silico modeling for blood-brain barrier permeability predictions. In: Ehrhardt C, Kim K-J, editors. Drug absorption studies. Springer; US: 2008. p. 510-56
-
(2008)
Silico Modeling for Blood-brain Barrier Permeability Predictions
, pp. 510-556
-
-
Garg, P.1
Verma, J.2
Roy, N.3
-
31
-
-
67650299761
-
Quantifying biogenic bias in screening libraries
-
Hert J, Irwin JJ, Laggner C, et al. Quantifying biogenic bias in screening libraries. Nat Chem Biol 2009;5(7):479-83
-
(2009)
Nat Chem Biol
, vol.5
, Issue.7
, pp. 479-83
-
-
Hert, J.1
Irwin, J.J.2
Laggner, C.3
-
32
-
-
44449159422
-
Quantifying the relationships among drug classes
-
DOI 10.1021/ci8000259
-
Hert J, Keiser MJ, Irwin JJ, et al. Quantifying the relationships among drug classes. J Chem Inf Model 2008;48(4):755-65 (Pubitemid 351757743)
-
(2008)
Journal of Chemical Information and Modeling
, vol.48
, Issue.4
, pp. 755-765
-
-
Hert, J.1
Keiser, M.J.2
Irwin, J.J.3
Oprea, T.I.4
Shoichet, B.K.5
-
33
-
-
0036662353
-
Using molecular equivalence numbers to visually explore structural features that distinguish chemical libraries
-
DOI 10.1021/ci025535l
-
Xu YJ, Johnson M. Using molecular equivalence numbers to visually explore structural features that distinguish chemical libraries. J Chem Inf Comput Sci 2002;42(4):912-26 (Pubitemid 35355241)
-
(2002)
Journal of Chemical Information and Computer Sciences
, vol.42
, Issue.4
, pp. 912-926
-
-
Xu, Y.-J.1
Johnson, M.2
-
35
-
-
0037330091
-
A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder
-
Amsterdam JD. A double-blind, placebo-controlled trial of the safety and efficacy of selegline transdermal system without dietary restriction in patients with major depressive disorder. J Clin Psychiatry 2003;64(2):208-14 (Pubitemid 36268325)
-
(2003)
Journal of Clinical Psychiatry
, vol.64
, Issue.2
, pp. 208-214
-
-
Amsterdam, J.D.1
-
36
-
-
44449117421
-
Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors
-
DOI 10.1073/pnas.0710626105
-
Son SY, Ma A, Kondou Y, et al. Structure of human monoamine oxidase a at 2.2-angstrom resolution: the control of opening the entry for substrates/inhibitors. Proc Natl Acad Sci USA 2008;105(15):5739-44 (Pubitemid 351758442)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.15
, pp. 5739-5744
-
-
Son, S.-Y.1
Ma, J.2
Kondou, Y.3
Yoshimura, M.4
Yamashita, E.5
Tsukihara, T.6
-
37
-
-
78049530845
-
Potentiation of ligand binding through cooperative effects in monoamine oxidase B
-
Bonivento D, Milczek EM, McDonald GR, et al. Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J Biol Chem 2010;285(47):36849-56
-
(2010)
J Biol Chem
, vol.285
, Issue.47
, pp. 36849-36856
-
-
Bonivento, D.1
Milczek, E.M.2
McDonald, G.R.3
-
38
-
-
79953279070
-
Exploration of new scaffolds as potential mao-A inhibitors using pharmacophore and 3D-QSAR based in silico screening
-
Shelke SM, Bhosale SH, Dash RC, et al. Exploration of new scaffolds as potential mao-a inhibitors using pharmacophore and 3D-QSAR based in silico screening. Bioorg Med Chem Lett 2011;21(8):2419-24
-
(2011)
Bioorg Med Chem Lett
, vol.21
, Issue.8
, pp. 2419-2424
-
-
Shelke, S.M.1
Bhosale, S.H.2
Dash, R.C.3
-
39
-
-
0028183017
-
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
-
Hoyer D, Clarke DE, Fozard JR, et al. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonine) Pharmacol Rev. 1994;46(2):157-203 (Pubitemid 24185150)
-
(1994)
Pharmacological Reviews
, vol.46
, Issue.2
, pp. 157-203
-
-
Hoyer, D.1
Clarke, D.E.2
Fozard, J.R.3
Hartig, P.R.4
Martin, G.R.5
Mylecharane, E.J.6
Saxena, P.R.7
Humphrey, P.P.A.8
-
40
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
DOI 10.1126/science.289.5480.739
-
Palczewski K, Kumasaka T, Hori T, et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 2000;289(5480):739-45 (Pubitemid 30650186)
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
41
-
-
79953234218
-
Crystal structure of metarhodopsin ii
-
Choe HW, Kim YJ, Park JH, et al. Crystal structure of metarhodopsin ii. Nature 2011;471(7340):651-U137
-
(2011)
Nature
, vol.471
, Issue.7340
-
-
Choe, H.W.1
Kim, Y.J.2
Park, J.H.3
-
42
-
-
38749131545
-
New G-protein-coupled receptor crystal structures: Insights and limitations
-
Kobilka B, Schertler GFX. New G-protein-coupled receptor crystal structures: insights and limitations. Trends Pharmacol Sci 2008;29(2):79-83
-
(2008)
Trends Pharmacol Sci
, vol.29
, Issue.2
, pp. 79-83
-
-
Kobilka, B.1
Schertler, G.F.X.2
-
43
-
-
56749103466
-
The 2.6 angstrom crystal structure of a human a(2a) adenosine receptor bound to an antagonist
-
Jaakola VP, Griffith MT, Hanson MA, et al. The 2.6 angstrom crystal structure of a human a(2a) adenosine receptor bound to an antagonist. Science 2008;322(5905):1211-17
-
(2008)
Science
, vol.322
, Issue.5905
, pp. 1211-17
-
-
Jaakola, V.P.1
Griffith, M.T.2
Hanson, M.A.3
-
44
-
-
33845505655
-
Curvature and Hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes
-
DOI 10.1529/biophysj.106.082776
-
Botelho AV, Huber T, Sakmar TP, Brown MF. Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes. Biophys J 2006;91(12):4464-77 (Pubitemid 44911035)
-
(2006)
Biophysical Journal
, vol.91
, Issue.12
, pp. 4464-4477
-
-
Botelho, A.V.1
Huber, T.2
Sakmar, T.P.3
Brown, M.F.4
-
45
-
-
34548495357
-
Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations
-
DOI 10.1016/j.jmb.2007.06.047, PII S002228360700842X
-
Lau PW, Grossfield A, Feller SE, et al. Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations. J Mol Biol 2007;372(4):906-17 (Pubitemid 47371253)
-
(2007)
Journal of Molecular Biology
, vol.372
, Issue.4
, pp. 906-917
-
-
Lau, P.-W.1
Grossfield, A.2
Feller, S.E.3
Pitman, M.C.4
Brown, M.F.5
-
46
-
-
47049084133
-
Internal hydration increases during activation of the G-protein-coupled receptor rhodopsin
-
Grossfield A, Pitman MC, Feller SE, et al. Internal hydration increases during activation of the G-protein-coupled receptor rhodopsin. J Mol Biol 2008;381(2):478-86
-
(2008)
J Mol Biol
, vol.381
, Issue.2
, pp. 478-86
-
-
Grossfield, A.1
Pitman, M.C.2
Feller, S.E.3
-
47
-
-
33845926317
-
Retinal counterion switch mechanism in vision evaluated by molecular simulations
-
DOI 10.1021/ja0671971
-
Martinez-Mayorga K, Pitman MC, Grossfield A, et al. Retinal counterion switch mechanism in vision evaluated by molecular simulations. J Am Chem Soc 2006;128:16502-3 (Pubitemid 46032720)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.51
, pp. 16502-16503
-
-
Martinez-Mayorga, K.1
Pitman, M.C.2
Grossfield, A.3
Feller, S.E.4
Brown, M.F.5
-
48
-
-
72949087747
-
Molecular modeling and docking studies of human 5-hydroxytryptamine 2A (5-HT2a) receptor for the identification of hotspots for ligand binding
-
Kanagarajadurai K, Malini M, Bhattacharya A, et al. Molecular modeling and docking studies of human 5-hydroxytryptamine 2A (5-HT2a) receptor for the identification of hotspots for ligand binding. Mol BioSyst 2009;5(12):1877-88
-
(2009)
Mol BioSyst
, vol.5
, Issue.12
, pp. 1877-88
-
-
Kanagarajadurai, K.1
Malini, M.2
Bhattacharya, A.3
-
49
-
-
79952125277
-
Predicted structures and dynamics for agonists and antagonists bound to serotonin 5-HT2b and 5-HT2c receptors
-
Kim SK, Li YY, Abrol R, et al. Predicted structures and dynamics for agonists and antagonists bound to serotonin 5-HT2b and 5-HT2c receptors. J Chem Inf Model 2011;51(2):420-33
-
J Chem Inf Model 2011
, vol.51
, Issue.2
, pp. 420-33
-
-
Kim, S.K.1
Li, Y.Y.2
Abrol, R.3
-
50
-
-
0023645034
-
Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins
-
Cornette JL, Cease KB, Margalit H, et al. Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins. J Mol Biol 1987;195(3):659-85
-
(1987)
J Mol Biol
, vol.195
, Issue.3
, pp. 659-85
-
-
Cornette, J.L.1
Cease, K.B.2
Margalit, H.3
-
51
-
-
4444274752
-
PREDICT modeling and in-silico screening for G-protein coupled receptors
-
DOI 10.1002/prot.20195
-
Shacham S, Marantz Y, Bar-Haim S, et al. Predict modeling and in-silico screening for G-protein coupled receptors. Proteins 2004;57(1):51-86 (Pubitemid 39195884)
-
(2004)
Proteins: Structure, Function and Genetics
, vol.57
, Issue.1
, pp. 51-86
-
-
Shacham, S.1
Marantz, Y.2
Bar-Haim, S.3
Kalid, O.4
Warshaviak, D.5
Avisar, N.6
Inbal, B.7
Heifetz, A.8
Fichman, M.9
Topf, M.10
Naor, Z.11
Noiman, S.12
Becker, O.M.13
-
52
-
-
0036790954
-
Prediction of structure and function of G protein-coupled receptors
-
Vaidehi N, Floriano WB, Trabanino R, et al. Prediction of structure and function of G protein-coupled receptors. Proc Natl Acad Sci USA 2002;99(20):12622-7
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.20
, pp. 12622-7
-
-
Vaidehi, N.1
Floriano, W.B.2
Trabanino, R.3
-
53
-
-
77349102450
-
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5- phenyl- and 5-spiroimidazolidine- 2,4-dione derivatives. Novel 5-ht1a receptor agonist with potential antidepressant and anxiolytic activity
-
Czopek A, Byrtus H, Kolaczkowski M, et al. Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5- phenyl- and 5-spiroimidazolidine- 2,4-dione derivatives. Novel 5-ht1a receptor agonist with potential antidepressant and anxiolytic activity. Eur J Med Chem 2010;45(4):1295-303
-
Eur J Med Chem 2010
, vol.45
, Issue.4
, pp. 1295-303
-
-
Czopek, A.1
Byrtus, H.2
Kolaczkowski, M.3
-
54
-
-
33744832614
-
1A agonist (PRX-00023) for the treatment of anxiety and depression
-
DOI 10.1021/jm0508641
-
Becker OM, Dhanoa DS, Marantz Y, et al. An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1a agonist (prx-00023) for the treatment of anxiety and depression. J Med Chem 2006;49(11):3116-35 (Pubitemid 43830511)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.11
, pp. 3116-3135
-
-
Becker, O.M.1
Dhanoa, D.S.2
Marantz, Y.3
Chen, D.4
Shacham, S.5
Cheruku, S.6
Heifetz, A.7
Mohanty, P.8
Fichman, M.9
Sharadendu, A.10
Nudelman, R.11
Kauffman, M.12
Noiman, S.13
-
55
-
-
80054795187
-
GPCR agonist binding revealed by modeling and crystallography
-
Katritch V, Abagyan R. GPCR agonist binding revealed by modeling and crystallography. Trends Pharmacol Sci 2011;32:637-43
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 637-43
-
-
Katritch, V.1
Abagyan, R.2
-
56
-
-
67349282342
-
Antidepressant specificity of serotonin transporter suggested by three leut-ssri structures
-
Zhou Z, Zhen J, Karpowich NK, et al. Antidepressant specificity of serotonin transporter suggested by three leut-ssri structures. Nat Struct Mol Biol 2009;16(6):652-U96
-
(2009)
Nat Struct Mol Biol
, vol.16
, Issue.6
-
-
Zhou, Z.1
Zhen, J.2
Karpowich, N.K.3
-
57
-
-
0035195373
-
A putative three-dimensional arrangement of the human serotonin transporter transmembrane helices: A tool to aid experimental studies
-
DOI 10.1016/S1093-3263(01)00112-7, PII S1093326301001127
-
Ravna AW, Edvardsen O. A putative three-dimensional arrangement of the human serotonin transporter transmembrane helices: a tool to aid experimental studies. J Mol Graph Model 2001;20(2):133-44 (Pubitemid 33135510)
-
(2001)
Journal of Molecular Graphics and Modelling
, vol.20
, Issue.2
, pp. 133-144
-
-
Ravna, A.W.1
Edvardsen, O.2
-
58
-
-
65649109333
-
Location of the antidepressant binding site in the serotonin transporter. Importance of Ser-438 in recognition of citalopram and tricyclic antidepressants
-
Andersen J, Taboureau O, Hansen KB, et al. Location of the antidepressant binding site in the serotonin transporter. Importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. J Biol Chem 2009;284(15):10276-84
-
(2009)
J Biol Chem
, vol.284
, Issue.15
, pp. 10276-84
-
-
Andersen, J.1
Taboureau, O.2
Hansen, K.B.3
-
59
-
-
77950887681
-
Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter
-
Sinning S, Musgaard M, Jensen M, et al. Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter. J Biol Chem 2010;285(11):8363-74
-
(2010)
J Biol Chem
, vol.285
, Issue.11
, pp. 8363-74
-
-
Sinning, S.1
Musgaard, M.2
Jensen, M.3
-
60
-
-
68949176654
-
Structure and localisation of drug binding sites on neurotransmitter transporters
-
Ravna AW, Sylte I, Dahl SG. Structure and localisation of drug binding sites on neurotransmitter transporters. J Mol Model 2009;15(10):1155-64
-
(2009)
J Mol Model
, vol.15
, Issue.10
, pp. 1155-64
-
-
Ravna, A.W.1
Sylte, I.2
Dahl, S.G.3
-
61
-
-
24644470065
-
--dependent neurotransmitter transporters
-
DOI 10.1038/nature03978
-
Yamashita A, Singh SK, Kawate T, et al. Crystal structure of a bacterial homologue of na+/cl-dependent neurotransmitter transporters. Nature 2005;437(7056):215-23 (Pubitemid 41294479)
-
(2005)
Nature
, vol.437
, Issue.7056
, pp. 215-223
-
-
Yamashita, A.1
Singh, S.K.2
Kawate, T.3
Jin, Y.4
Gouaux, E.5
-
62
-
-
36549031819
-
How dopamine transporter interacts with dopamine: Insights from molecular modeling and simulation
-
DOI 10.1529/biophysj.107.110924
-
Huang X, Zhan CG. How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation. Biophys J 2007;93:3627-39 (Pubitemid 350190825)
-
(2007)
Biophysical Journal
, vol.93
, Issue.10
, pp. 3627-3639
-
-
Huang, X.1
Zhan, C.-G.2
-
63
-
-
2542633585
-
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: Evidence of unfavorable interactions proximal to the 3α-position of the piperidine ring
-
DOI 10.1021/jm0303296
-
Petukhov PA, Zhang JR, Wang CZ, et al. Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3 alpha-position of the piperidine ring. J Med Chem 2004;47(12):3009-18 (Pubitemid 38702698)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.12
, pp. 3009-3018
-
-
Petukhov, P.A.1
Zhang, J.2
Wang, C.Z.3
Ye, Y.P.4
Johnson, K.M.5
Kozikowski, A.P.6
-
64
-
-
27444437203
-
2 receptor antagonism with potent serotonin reuptake inhibition
-
DOI 10.1021/jm050148z
-
Smid P, Coolen H, Keizer HG, et al. Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-omega-(1H-indol-3-yl) alkyllpiperazines, novel potential antipsychotics combining potent dopamine D-2 receptor antagonism with potent serotonin reuptake inhibition. J Med Chem 2005;48(22):6855-69 (Pubitemid 41533107)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.22
, pp. 6855-6869
-
-
Smid, P.1
Coolen, H.K.A.C.2
Keizer, H.G.3
Van Hes, R.4
De Moes, J.-P.5
Den Hartog, A.P.6
Stork, B.7
Plekkenpol, R.H.8
Niemann, L.C.9
Stroomer, C.N.J.10
Tulp, M.Th.M.11
Van Stuivenberg, H.H.12
McCreary, A.C.13
Hesselink, M.B.14
Herremans, A.H.J.15
Kruse, C.G.16
-
65
-
-
33745865926
-
Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: A proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters
-
DOI 10.1021/jm0601699
-
Zhang SJ, Fernandez F, Hazeldine S, et al. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5- benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. J Med Chem 2006;49(14):4239-47 (Pubitemid 44036667)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.14
, pp. 4239-4247
-
-
Zhang, S.1
Fernandez, F.2
Hazeldine, S.3
Deschamps, J.4
Zhen, J.5
Reith, M.E.A.6
Dutta, A.K.7
-
66
-
-
80053327464
-
Multi-target structure activity relationships characterized by activity-difference maps and consensus similarity measure
-
Medina-Franco JL, Yongye AB, Perez-Villanueva J, et al. Multi-target structure activity relationships characterized by activity-difference maps and consensus similarity measure. J Chem Inf Model 2011;51(9):2427-39
-
(2011)
J Chem Inf Model
, vol.51
, Issue.9
, pp. 2427-39
-
-
Medina-Franco, J.L.1
Yongye, A.B.2
Perez-Villanueva, J.3
-
67
-
-
33845782959
-
Analysis of data fusion methods in virtual screening: Similarity and group fusion
-
DOI 10.1021/ci0496144
-
Whittle M, Gillet VJ, Willett P, et al. Analysis of data fusion methods in virtual screening: Similarity and group fusion. J Chem Inf Model 2006;46:2206-19 (Pubitemid 46008096)
-
(2006)
Journal of Chemical Information and Modeling
, vol.46
, Issue.6
, pp. 2206-2219
-
-
Whittle, M.1
Gillet, V.J.2
Willett, P.3
Loesel, J.4
-
68
-
-
74049133612
-
Optimal assignment methods for ligand-based virtual screening
-
Jahn A, Hinselmann G, Fechner N, Zell A. Optimal assignment methods for ligand-based virtual screening. J Chem 2009;1:14
-
(2009)
J Chem
, vol.1
, pp. 14
-
-
Jahn, A.1
Hinselmann, G.2
Fechner, N.3
Zell, A.4
-
69
-
-
30844443282
-
Molecular similarity and diversity in chemoinformatics: From theory to applications
-
DOI 10.1007/s11030-006-8697-1
-
Maldonado AG, Doucet JP, Petitjean M, Fan B-T. Molecular similarity and diversity in chemoinformatics: From theory to applications. Mol Divers 2006;1039:39-79 (Pubitemid 43102376)
-
(2006)
Molecular Diversity
, vol.10
, Issue.1
, pp. 39-79
-
-
Maldonado, A.G.1
Doucet, J.P.2
Petitjean, M.3
Fan, B.-T.4
-
70
-
-
34548289911
-
Free resources to assist structure-based virtual ligand screening experiments
-
DOI 10.2174/138920307781369391
-
Villoutreix BO, Renault N, Lagorce D, et al. Free resources to assist structure-based virtual ligand screening experiments. Curr Protein Pept Sci 2007;8(4):381-411 (Pubitemid 47321574)
-
(2007)
Current Protein and Peptide Science
, vol.8
, Issue.4
, pp. 381-411
-
-
Villoutreix, B.O.1
Renault, N.2
Lagorce, D.3
Sperandio, O.4
Montes, M.5
Miteva, M.A.6
-
71
-
-
77950058867
-
The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT7r antagonists
-
Kurczab R, Nowak M, Chilmonczyk Z, et al. The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT7r antagonists. Bioorg Med Chem Lett 2010;20(8):2465-8
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.8
, pp. 2465-8
-
-
Kurczab, R.1
Nowak, M.2
Chilmonczyk, Z.3
-
72
-
-
77649220192
-
Current trends in ligand-based virtual screening: Molecular representations, data mining methods, new application areas, and performance evaluation
-
Geppert H, Vogt M, Bajorath J Jr. Current trends in ligand-based virtual screening: Molecular representations, data mining methods, new application areas, and performance evaluation. J Chem Inf Model 2010;50(2):205-16
-
(2010)
J Chem Inf Model
, vol.50
, Issue.2
, pp. 205-16
-
-
Geppert, H.1
Vogt, M.2
Bajorath Jr., J.3
-
73
-
-
41049113277
-
Hierarchical structure-based virtual screening for drug design
-
Miteva M. Hierarchical structure-based virtual screening for drug design. Biotechnol Biotechnol Equine 2008;22:634-8 (Pubitemid 351422067)
-
(2008)
Biotechnology and Biotechnological Equipment
, vol.22
, Issue.1
, pp. 634-638
-
-
Miteva, M.1
-
74
-
-
66149105428
-
Beyond the virtual screening paradigm: Structure-based searching for new lead compounds
-
Schlosser J, Rarey M. Beyond the virtual screening paradigm: structure-based searching for new lead compounds. J Chem Inf Model 2009;49:800-9
-
(2009)
J Chem Inf Model
, vol.49
, pp. 800-9
-
-
Schlosser, J.1
Rarey, M.2
-
75
-
-
79952484009
-
Development of selective and reversible pyrazoline based MAO-B inhibitors: Virtual screening, synthesis and biological evaluation
-
Mishra N, Sasmal D. Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation. Bioorg Med Chem Lett 2011;21(7):1969-73
-
(2011)
Bioorg Med Chem Lett
, vol.21
, Issue.7
, pp. 1969-1973
-
-
Mishra, N.1
Sasmal, D.2
-
76
-
-
32344446616
-
A qsar model for in silico screening of MAO-A inhibitors. Prediction, syn
-
thesis, and biological assay of novel coumarins
-
Santana L, Uriarte E, Gonzalez-Diaz H, et al. A qsar model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins. J Med Chem 2006;49:1149-56
-
(2006)
J Med Chem
, vol.49
, pp. 1149-1156
-
-
Santana, L.1
Uriarte, E.2
Gonzalez-Diaz, H.3
-
77
-
-
70349820343
-
Application of rough set theory to high throughput screening data for rational selection of lead compounds
-
Koyama M, Hasegawa K, Arakawa M, Funatsu K. Application of rough set theory to high throughput screening data for rational selection of lead compounds. Chem Bio Inf J 2008;8:85-95
-
(2008)
Chem Bio Inf J
, vol.8
, pp. 85-95
-
-
Koyama, M.1
Hasegawa, K.2
Arakawa, M.3
Funatsu, K.4
-
78
-
-
66449114449
-
Identification of novel serotonin 2C receptor ligands by sequential virtual screening
-
Ahmed A, Choo H, Cho YS, et al. Identification of novel serotonin 2C receptor ligands by sequential virtual screening. Bioorg Med Chem 2009;17:4559-68
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 4559-4568
-
-
Ahmed, A.1
Choo, H.2
Cho, Y.S.3
-
79
-
-
40649084840
-
Pharmacophore design and database searching for selective monoamine neurotransmitter transporter ligands
-
DOI 10.1016/j.jmgm.2007.10.003, PII S1093326307001519
-
MacDougall IJA, Griffith R. Pharmacophore design and database searching for selective monoamine neurotransmitter transporter ligands. J Mol Graph Model 2008;26(7):1113-24 (Pubitemid 351374850)
-
(2008)
Journal of Molecular Graphics and Modelling
, vol.26
, Issue.7
, pp. 1113-1124
-
-
MacDougall, I.J.A.1
Griffith, R.2
-
80
-
-
68249090529
-
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling
-
Khanfar Ma, Asal BA, Mudit M, et al. The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: in vitro and in vivo activities and pharmacophore modeling. Bioorg Med Chem 2009;17:6032-9
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 6032-9
-
-
Khanfar, M.A.1
Asal, B.A.2
Mudit, M.3
-
81
-
-
57749094583
-
Identification of small molecules that inhibit GSK-3beta through virtual screening
-
Kang NS, Lee GN, Kim CH, et al. Identification of small molecules that inhibit GSK-3beta through virtual screening. Bioorg Med Chem Lett 2009;19:533-7
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 533-7
-
-
Kang, N.S.1
Lee, G.N.2
Kwon, C.H.3
-
82
-
-
64249091873
-
Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models
-
Vadivelan S, Sinha BN, Tajne S, Jagarlapudi SaRP. Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem 2009;44:2361-71
-
(2009)
Eur J Med Chem
, vol.44
, pp. 2361-71
-
-
Vadivelan, S.1
Sinha, B.N.2
Tajne, S.3
Jagarlapudi, S.A.R.P.4
-
83
-
-
33244481311
-
Screening for new antidepressant leads of multiple activities by support vector machines
-
DOI 10.1021/ci050301y
-
Lepp Z, Kinoshita T, Chuman H. Screening for new antidepressant leads of multiple activities by support vector machines. J Chem Inf Model 2006;46:158-67 (Pubitemid 43282111)
-
(2006)
Journal of Chemical Information and Modeling
, vol.46
, Issue.1
, pp. 158-167
-
-
Lepp, Z.1
Kinoshita, T.2
Chuman, H.3
-
84
-
-
77949489371
-
Synthesis and pharmacological evaluation of novel fused thiophene derivatives as 5-HT2a receptor antagonists: Molecular modeling study
-
El-Kerdawy MM, El-Bendary ER, Abdel-Aziz AAM, et al. Synthesis and pharmacological evaluation of novel fused thiophene derivatives as 5-HT2a receptor antagonists: Molecular modeling study. Eur J Med Chem 2010;45(5):1805-20
-
(2010)
Eur J Med Chem
, vol.45
, Issue.5
, pp. 1805-1820
-
-
El-Kerdawy, M.M.1
El-Bendary, E.R.2
Abdel-Aziz, A.A.M.3
-
85
-
-
33745125776
-
2C inhibitors: Synthesis and biological evaluation
-
DOI 10.1016/j.bmcl.2006.05.034, PII S0960894X06005762
-
Micheli F, Pasquarello A, Tedesco G, et al. Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2c inhibitors: Synthesis and biological evaluation. Bioorg Med Chem Lett 2006;16(15):3906-12 (Pubitemid 43903229)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.15
, pp. 3906-3912
-
-
Micheli, F.1
Pasquarello, A.2
Tedesco, G.3
Hamprecht, D.4
Bonanomi, G.5
Checchia, A.6
Jaxa-Chamiec, A.7
Damiani, F.8
Davalli, S.9
Donati, D.10
Gallotti, C.11
Petrone, M.12
Rinaldi, M.13
Riley, G.14
Terreni, S.15
Wood, M.16
-
86
-
-
77649189967
-
Pharmacophore-based 3D QSAR studies on a series of high affinity 5-HT1a receptor ligands
-
Weber KC, Salum LB, Honorio KM, et al. Pharmacophore-based 3D QSAR studies on a series of high affinity 5-HT1a receptor ligands. Eur J Med Chem 2010;45(4):1508-14
-
(2010)
Eur J Med Chem
, vol.45
, Issue.4
, pp. 1508-14
-
-
Weber, K.C.1
Salum, L.B.2
Honorio, K.M.3
-
87
-
-
46449097898
-
Qsar study on dual 5-HT1a and 5-HT1b antagonists: An insight into the structural requirement for antidepressant activity
-
Dessalew N. Qsar study on dual 5-HT1a and 5-HT1b antagonists: an insight into the structural requirement for antidepressant activity. Arch Pharm 2008;341(5):314-22
-
(2008)
Arch Pharm
, vol.341
, Issue.5
, pp. 314-22
-
-
Dessalew, N.1
-
88
-
-
80053295985
-
Discovery of novel selective serotonin reuptake inhibitors through development of a protein-based pharmacophore
-
Manepalli S, Geffert LM, Surratt CK, Madura JD. Discovery of novel selective serotonin reuptake inhibitors through development of a protein-based pharmacophore. J Chem Inf Model 2011;51(9):2417-26
-
(2011)
J Chem Inf Model
, vol.51
, Issue.9
, pp. 2417-26
-
-
Manepalli, S.1
Geffert, L.M.2
Surratt, C.K.3
Madura, J.D.4
-
89
-
-
76249105122
-
Mutational mapping and modeling of the binding site for (s)-citalopram in the human serotonin transporter
-
Andersen J, Olsen L, Hansen KB, et al. Mutational mapping and modeling of the binding site for (s)-citalopram in the human serotonin transporter. J Biol Chem 2010;285(3):2051-63
-
J Biol Chem 2010
, vol.285
, Issue.3
, pp. 2051-63
-
-
Andersen, J.1
Olsen, L.2
Hansen, K.B.3
-
90
-
-
79551598571
-
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter
-
Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS ONE 2011;6(1):e16350
-
(2011)
PLoS ONE
, vol.6
, Issue.1
-
-
Shan, J.1
Javitch, J.A.2
Shi, L.3
Weinstein, H.4
-
91
-
-
46049086729
-
The binding sites for cocaine and dopamine in the dopamine transporter overlap
-
Beuming T, Kniazeff J, Bergmann ML, et al. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci 2008;11(7):780-9
-
(2008)
Nat Neurosci
, vol.11
, Issue.7
, pp. 780-9
-
-
Beuming, T.1
Kniazeff, J.2
Bergmann, M.L.3
-
92
-
-
79957808687
-
Interaction of tyrosine 151 in norepinephrine transporter with the 2beta group of cocaine analog RTI-113
-
Hill ER, Huang X, Zhan CG, et al. Interaction of tyrosine 151 in norepinephrine transporter with the 2beta group of cocaine analog RTI-113. Neuropharmacology 2011;61(1-2):112-20
-
(2011)
Neuropharmacology
, vol.61
, Issue.1-2
, pp. 112-20
-
-
Hill, E.R.1
Huang, X.2
Zhan, C.G.3
-
93
-
-
80053167954
-
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter NET
-
Schlessinger A, Geier E, Fan H, et al. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci USA 2011;108(38):15810-15
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.38
, pp. 15810-15
-
-
Schlessinger, A.1
Geier, E.2
Fan, H.3
-
94
-
-
77954753254
-
Interaction of selective serotonin reuptake inhibitors with neuronal nicotinic acetylcholine receptors
-
Arias HR, Feuerbach D, Targowska-Duda KM, et al. Interaction of selective serotonin reuptake inhibitors with neuronal nicotinic acetylcholine receptors. Biochemistry (Mosc) 2010;49(27):5734-42
-
(2010)
Biochemistry (Mosc)
, vol.49
, Issue.27
, pp. 5734-42
-
-
Arias, H.R.1
Feuerbach, D.2
Targowska-Duda, K.M.3
-
95
-
-
77249089718
-
Different interaction between tricyclic antidepressants and mecamylamine with the human alpha3beta4 nicotinic acetylcholine receptor ion channel
-
Arias HR, Targowska-Duda KM, Feuerbach D, et al. Different interaction between tricyclic antidepressants and mecamylamine with the human alpha3beta4 nicotinic acetylcholine receptor ion channel. Neurochem Int 2010;56(4):642-9
-
(2010)
Neurochem Int
, vol.56
, Issue.4
, pp. 642-9
-
-
Arias, H.R.1
Targowska-Duda, K.M.2
Feuerbach, D.3
-
96
-
-
55749104893
-
Identifying the binding site(s) for antidepressants on the torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies
-
Sanghvi M, Hamouda AK, Jozwiak K, et al. Identifying the binding site(s) for antidepressants on the torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies. Biochim Biophys Acta 2008;1778(12):2690-9
-
(2008)
Biochim Biophys Acta
, vol.1778
, Issue.12
, pp. 2690-9
-
-
Sanghvi, M.1
Hamouda, A.K.2
Jozwiak, K.3
-
97
-
-
56749170908
-
Dihydropyrrole 2,3-d pyridine derivatives as novel corticotropin- releasing factor-1 antagonists: Mapping of the receptor binding pocket by in silico docking studies
-
Di Fabio R, Arban R, Bernasconi G, et al. Dihydropyrrole 2,3-d pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: Mapping of the receptor binding pocket by in silico docking studies. J Med Chem 2008;51(22):7273-86
-
(2008)
J Med Chem
, vol.51
, Issue.22
, pp. 7273-86
-
-
Di Fabio, R.1
Arban, R.2
Bernasconi, G.3
-
98
-
-
34247558494
-
Dihydropyridopyrazinones and dihydropteridinones as corticotropin- releasing factor-1 receptor antagonists: Structure-activity relationships and computational modeling
-
DOI 10.1021/jm0611410
-
Dzierba CD, Tebben AJ, Wilde RG, et al. Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling. J Med Chem 2007;50(9):2269-72 (Pubitemid 46683082)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.9
, pp. 2269-2272
-
-
Dzierba, C.D.1
Tebben, A.J.2
Wilde, R.G.3
Takvorian, A.G.4
Rafalski, M.5
Kasireddy-Polam, P.6
Klaczkiewicz, J.D.7
Pechulis, A.D.8
Davis, A.L.9
Sweet, M.P.10
Woo, A.M.11
Yang, Z.12
Ebeltoft, S.M.13
Molski, T.F.14
Zhang, G.15
Zaczek, R.C.16
Trainor, G.L.17
Combs, A.P.18
Gilligan, P.J.19
-
99
-
-
73449099919
-
3D-QSAR study of corticotropin-releasing factor 1 antagonists and pharmacophore-based drug design
-
Ye Y, Liao Q, Wei J, Gao Q. 3D-QSAR study of corticotropin-releasing factor 1 antagonists and pharmacophore-based drug design. Neurochem Int 2010;56(1):107-17
-
(2010)
Neurochem Int
, vol.56
, Issue.1
, pp. 107-17
-
-
Ye, Y.1
Liao, Q.2
Wei, J.3
Gao, Q.4
-
101
-
-
78149283474
-
3D-QSAR homology modeling and molecular docking studies on spiropiperidines analogues as agonists of nociceptin/orphanin FQ receptor
-
Liu M, He L, Hu X, et al. 3D-QSAR, homology modeling, and molecular docking studies on spiropiperidines analogues as agonists of nociceptin/orphanin FQ receptor. Bioorg Med Chem Lett 2010;20(23):7004-10
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.23
, pp. 7004-10
-
-
Liu, M.1
He, L.2
Hu, X.3
-
102
-
-
66849091683
-
Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel
-
Furutani K, Ohno Y, Inanobe A, et al. Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel. Mol Pharmacol 2009;75(6):1287-95
-
(2009)
Mol Pharmacol
, vol.75
, Issue.6
, pp. 1287-95
-
-
Furutani, K.1
Ohno, Y.2
Inanobe, A.3
-
103
-
-
45749124873
-
Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: Modulation at the N-portion of biphenyl-3-yl alkylcarbamates
-
DOI 10.1021/jm701631z
-
Mor M, Lodola A, Rivara S, et al. Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. J Med Chem 2008;51(12):3487-98 (Pubitemid 351875005)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.12
, pp. 3487-3498
-
-
Mor, M.1
Lodola, A.2
Rivara, S.3
Vacondio, F.4
Duranti, A.5
Tontini, A.6
Sanchini, S.7
Piersanti, G.8
Clapper, J.R.9
King, A.R.10
Tarzia, G.11
Piomelli, D.12
-
104
-
-
34250892426
-
3 antagonists
-
DOI 10.1002/qsar.200610144
-
Narkhede SS, Degani MS. Pharmacophore refinement and 3D-QSAR studies of histamine H3 antagonists. QSAR Comb Sci 2007;26(6):744-53 (Pubitemid 46984720)
-
(2007)
QSAR and Combinatorial Science
, vol.26
, Issue.6
, pp. 744-753
-
-
Narkhede, S.S.1
Degani, M.S.2
-
105
-
-
34547552521
-
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
-
DOI 10.1016/j.bmcl.2007.06.036, PII S0960894X07007172
-
Ray NC, Clark RD, Clark DE, et al. Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators. Bioorg Med Chem Lett 2007;17(17):4901-5 (Pubitemid 47187687)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.17
, pp. 4901-4905
-
-
Ray, N.C.1
Clark, R.D.2
Clark, D.E.3
Williams, K.4
Hickin, H.G.5
Crackett, P.H.6
Dyke, H.J.7
Lockey, P.M.8
Wong, M.9
Devos, R.10
White, A.11
Belanoff, J.K.12
-
106
-
-
77955432319
-
Synthesis, antidepressant evaluation and qsar studies of novel 2-(5H-[1,2,4]triazino[5,6-b] indol-3-ylthio)-n-(substituted phenyl) acetamides
-
Shelke SM, Bhosale SH. Synthesis, antidepressant evaluation and qsar studies of novel 2-(5H-[1,2,4]triazino[5,6-b] indol-3-ylthio)-n-(substituted phenyl) acetamides. Bioorg Med Chem Lett 2010;20(15):4661-4
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.15
, pp. 4661-4664
-
-
Shelke, S.M.1
Bhosale, S.H.2
-
107
-
-
54949110164
-
QSRR study of psychiatric drugs using classification and regression trees combined with adaptive neuro-ruzzy inference system
-
Jalali-Heravi M, Shahbazikhah P, Ghadiri-Bidhendi A. QSRR study of psychiatric drugs using classification and regression trees combined with adaptive neuro-ruzzy inference system. QSRR Comb Sci 2008;27(6):729-39
-
(2008)
QSRR Comb Sci
, vol.27
, Issue.6
, pp. 729-39
-
-
Jalali-Heravi, M.1
Shahbazikhah, P.2
Ghadiri-Bidhendi, A.3
-
108
-
-
22844437445
-
High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy
-
DOI 10.1107/S0907444905004038
-
Gill R, Mohammed F, Badyal R, et al. High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy. Acta Crystallogr D Biol Crystallogr 2005;61(Pt 5):545-55 (Pubitemid 44336726)
-
(2005)
Acta Crystallographica Section D: Biological Crystallography
, vol.61
, Issue.5
, pp. 545-555
-
-
Gill, R.1
Mohammed, F.2
Badyal, R.3
Coates, L.4
Erskine, P.5
Thompson, D.6
Cooper, J.7
Gore, M.8
Wood, S.9
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