Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: Evidence of unfavorable interactions proximal to the 3α-position of the piperidine ring

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 3009-3018

  Petukhov, Pavel A ^a,c   Zhang, Jianrong ^c   Wang, Cheng Z ^b   Ye, Yan Ping ^b   Johnson, Kenneth M ^b   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENE; COCAINE DERIVATIVE; DOPAMINE TRANSPORTER; LIGAND; NORADRENALIN TRANSPORTER; PIPERIDINE DERIVATIVE; SEROTONIN TRANSPORTER;

ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; BINDING SITE; COCAINE DEPENDENCE; DEPRESSION; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; BRAIN; CARRIER PROTEINS; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PIPERIDINES; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 2542633585     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0303296     Document Type: Article

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