The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 6032-6039

  Khanfar, Mohammad A ^a   Asal, Bilal Abu ^a   Mudit, Mudit ^a   Kaddoumi, Amal ^a   El Sayed, Khalid A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Alzheimer's disease; Cancer; Marine natural products; Molecular modeling; Pharmacophore modeling; Phenylmethylene hydantoins; Synthase kinase 3 (GSK 3 )inhibitors; Type 2 diabetes

Indexed keywords

5 (4 (ETHYLTHIO)BENZYLIDENE)HYDANTOIN; 5 (4 HYDROXYBENZYLIDENE)HYDANTOIN; BENZENE DERIVATIVE; CARBENE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR; HYDANTOIN DERIVATIVE; NATURAL PRODUCT; PHENYLMETHYLENEHYDANTOIN DERIVATIVE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER MODEL; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; GLYCOGEN LIVER LEVEL; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RAT; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; HYDANTOINS; MICE; MODELS, CHEMICAL; PORIFERA; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

HEMIMYCALE ARABICA; MUS;

EID: 68249090529     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.054     Document Type: Article

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