Prevention of β strand movement into a zymogen-like position does not confer higher activity to coagulation factor VIIa

Biochemistry

Volumn 43, Issue 44, 2004, Pages 14096-14103

  Olsen, Ole H ^a   Nielsen, Per F ^a   Persson, Egon ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COAGULATION; CONFORMATIONS; ENZYME KINETICS; MUTAGENESIS; SUBSTRATES; TISSUE;

CHYMOTRIPSIN; MUTATION; PEPTIDE BONDS; TISSUE FACTOR (TF);

ENZYMES;

BLOOD CLOTTING FACTOR 7A; ENZYME PRECURSOR; MUTANT PROTEIN; THROMBOPLASTIN; TRYPSIN; TRYPSINOGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; REGULATORY MECHANISM;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHROMOGENIC COMPOUNDS; CRICETINAE; CYSTEINE; ENZYME ACTIVATION; ENZYME PRECURSORS; FACTOR VIIA; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; THERMODYNAMICS; THROMBOPLASTIN; TRANSFECTION; VALINE; VARIATION (GENETICS);

EID: 8344226974     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048721o     Document Type: Article

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