Influence of the γ-carboxyglutamic acid-rich domain and hydrophobic stack of factor vila on tissue factor binding

Pathophysiology of Haemostasis and Thrombosis

Volumn 26, Issue , 1996, Pages 31-34

  Persson, Egon ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Amidolytic activity; Extrinsic pathway; Factor VIla; Gla domain; Hydrophobic stack; Surface plasmon resonance; Tissue factor

Indexed keywords

4 CARBOXYGLUTAMIC ACID; BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN;

BLOOD CLOTTING; CONFERENCE PAPER; HUMAN; PRIORITY JOURNAL;

1-CARBOXYGLUTAMIC ACID; AMINO ACID SEQUENCE; ANIMALS; BLOOD COAGULATION TESTS; CELLS, CULTURED; CRICETINAE; FACTOR VIIA; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY; THROMBOPLASTIN; WATER;

EID: 0029915869     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217237     Document Type: Article

References (11)

1. Ruf W, Kalnik MW. Lund-Hansen T, Edgington TS: Characterization of factor VII association with tissue factor in solution. J Biol Chem 1991;266:15719-15725.
2. Higashi S, Nishimura H. Fujii S, Ta-kada K, Iwanaga S: Tissue factor potentiates the factor Vila-catalyzed hydrolysis of an ester substrate. J Biol Chem 1992;267:17990-17996.
3. Higashi S, Nishimura H, Aita K, Iwanaga S: Identification of regions of bovine factor VII essential for binding to tissue factor. J Biol Chem 1994;269:18891-18898.
4. Neuenschwander PF, Morrissey JH: Roles of the membrane-interactive regions of factor Vila and tissue factor. J Biol Chem 1994,269:8007-8013.
5. Petersen LC, Schiodt J, Christensen U: Involvement of the hydrophobic stack residues 39-44 of factor Vila in tissue factor interactions. FEBS Lett 1994;347:73-79.
6. 2t binding sites in the y-carboxyglutamic acid-containing domain of factor Vila. Eur J Biochem, in press.
7. Kelley RF: Thermodynamicsofprotein-protein interaction studied by using BIAcore and single-site mutagenesis. Methods 1994;6:111-120.
8. O'Brien DP, Kemball-Cook G, Hutchinson AM. Martin DMA, Johnson DJD, Byfield PGH, Ta-kamiya O, Tuddenham EGD. McVey JH: Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVI1-R79Q). Biochemistry 1994;33:14162-14169.
9. Banner DW, D'Arcy A, Chene C, Vilbois F. Konigsberg WH, Guha A, Nemerson Y, Kirchhofer D: The crystal structure of the complex of human factor Vila with human soluble tissue factor (abstract 1084). Thromb Haemost 1995,73:1183.
10. Wildgoosc P. Jorgensen T, Komiya-ma Y, Nakagaki T, Pedersen A, Ki-siel W: The role of phospholipids and the factor VII Gla domain in the interaction of factor VII with tissue factor. Thromb Haemost 1992:67: 679-685.
11. Martin DMA, O'Brien DP, Tuddenham EGD, Byfield PGH: Synthesis and characterization of wild-type and variant y-carboxyglutamic acid-containing domains of factor VII. Biochemistry 1993:32:13949-13955.