Ca2+ binding to the first epidermal growth factor-like domain of factor VIIa increases amidolytic activity and tissue factor affinity

Journal of Biological Chemistry

Volumn 272, Issue 32, 1997, Pages 19919-19924

  Persson, Egon ^a   Olsen, Ole H ^a   Østergaard, Anette ^a   Nielsen, Lars S ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7A; CALCIUM BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; SERINE PROTEINASE; ASPARTIC ACID; BLOOD CLOTTING FACTOR 10; CALCIUM; THROMBOPLASTIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BLOOD CLOTTING; ENZYME ACTIVITY; LIPID ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SITE DIRECTED MUTAGENESIS; AFFINITY CHROMATOGRAPHY; CHEMICAL STRUCTURE; GENETICS; HUMAN; KINETICS; METABOLISM; PROTEIN CONFORMATION;

ASPARTIC ACID; BINDING SITES; CALCIUM; CHROMATOGRAPHY, AFFINITY; EPIDERMAL GROWTH FACTOR; FACTOR VIIA; FACTOR X; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; THROMBOPLASTIN;

EID: 0030609859     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.32.19919     Document Type: Article

References (57)

1. Furie, B., and Furie, B. C. (1988) Cell 53, 505-518
2. Stenflo, J. (1991) Blood 78, 1637-1651
3. Öhlin, A.-K., Linse, S., and Stenflo, J. (1988) J. Biol. Chem. 263, 7411-7417
4. Persson, E., Selander, M., Linse, S., Drakenberg, T., Öhlin, A.-K., and Stenflo, J. (1989) J. Biol. Chem. 264, 16897-16904
5. Huang, L. H., Ke, X.-H., Sweeney, W., and Tam, J. P. (1989) Biochem. Biophys. Res. Commun. 160, 133-139
6. Handford, P. A., Baron, M., Mayhew, M., Willis, A., Beesley, T., Brownlee, G. G., and Campbell, I. D. (1990) EMBO J. 9, 475-480
7. Schiødt, J., Harrit, N., Christensen, U., and Petersen, L. C. (1992) FEBS Lett. 306, 265-268
8. Selander-Sunnerhagen, M., Ullner, M., Persson, E., Teleman, O., Stenflo, J., and Drakenberg, T. (1992) J. Biol. Chem. 267, 19642-19649
9. Rao, Z., Handford, P., Mayhew, M., Knott, V., Brownlee, G. G., and Stuart, D. (1995) Cell 82, 131-141
10. Persson, E., Hogg, P. J., and Stenflo, J. (1993) J. Biol. Chem. 268, 22531-22539
11. Persson, E., Björk, I., and Stenflo, J. (1991) J. Biol. Chem. 266, 2444-2452
12. Valcarce, C., Selander-Sunnerhagen, M., Tämlitz, A.-M., Drakenberg, T., Björk, I., and Stenflo, J. (1993) J. Biol. Chem. 268, 26673-26678
13. Banner, D. W., D'Arcy, A., Chène, C., Winkler, F. K., Guha, A., Konigsberg, W. H., Nemerson, Y., and Kirchhofer, D. (1996) Nature 380, 41-46
14. Sabharwal, A. K., Birktoft, J. J., Gorka, J., Wildgoose, P., Petersen, L. C., and Bajaj, S. P. (1995) J. Biol. Chem. 270, 15523-15530
15. Wildgoose, P., Foster, D., Schiødt, J., Wiberg, F. C., Birktoft, J. J., and Petersen, L. C. (1993) Biochemistry 32, 114-119
16. Handford, P. A., Mayhew, M., Baron, M., Winship, P. R., Campbell, I. D., and Brownlee, G. G. (1991) Nature 351, 164-167
17. Mayhew, M., Handford, P., Baron, M., Tse, A. G. D., Campbell, I. D., and Brownlee, G. G. (1992) Protein Eng. 5, 489-494
18. Thim, L., Bjoern, S., Christensen, M., Nicolaisen, E. M., Lund-Hansen, T., Pedersen, A., and Hedner, U. (1988) Biochemistry 27, 7785-7793
19. Persson, E., and Nielsen, L. S. (1996) FEBS Lett. 385, 241-243
20. Neuenschwander, P. F., and Morrissey, J. H. (1994) J. Biol. Chem. 269, 8007-8013
21. Stone, M. J., Ruf, W., Miles, D. J., Edgington, T. S., and Wright, P. E. (1995) Biochem. J. 310, 605-614
22. Freskgård, P.-O., Olsen, O. H., and Persson, E. (1996) Protein Sci. 5, 1531-1540
23. Rao, L. V. M., Williams, T., and Rapaport, S. I. (1996) Blood 87, 3738-3748
24. Laemmli, U. K. (1970) Nature 227, 680-685
25. Du, Z. J., Regier, D. A., and Desrosiers, R. C. (1995) BioTechniques 18, 376-378
26. Persson, E., and Petersen, L. C. (1995) Eur. J. Biochem. 234, 293-300
27. Persson, E. (1996) Haemostasis 26, Suppl. 1, 31-34
28. Sunnerhagen, M., Olah, G. A., Stenflo, J., Forsén, S., Drakenberg, T., and Trewhella, J. (1996) Biochemistry 35, 11547-11559
29. Soriano-Garcia, M., Padmanabhan, K., de Vos, A. M., and Tulinsky, A. (1992) Biochemistry 31, 2554-2566
30. Muller, Y. A., Ultsch, M. H., Kelley, R. F., and de Vos, A. M. (1994) Biochemistry 33, 10864-10870
31. Lawson, J. H., Butenas, S., and Mann, K. G. (1992) J. Biol. Chem. 267, 4834-4843
32. Higashi, S., Nishimura, H., Fujii, S., Takada, K., and Iwanaga, S. (1992) J. Biol. Chem. 267, 17990-17996
33. O'Brien, D. P., Kemball-Cook, G., Hutchinson, A. M., Martin, D. M. A., Johnson, D. J. D., Byfield, P. G. H., Takamiya, O., Tuddenham, E. G. D., and McVey, J. H. (1994) Biochemistry 33, 14162-14169
34. Waxman, E., Ross, J. B. A., Laue, T. M., Guha, A., Thiruvikraman, S. V., Lin, T. C., Konigsberg, W. H., and Nemerson, Y. (1992) Biochemistry 31, 3998-4003
35. Toomey, J. R., Smith, K. J., and Stafford, D. W. (1991) J. Biol. Chem. 266, 19198-19202
36. Clarke, B. J., Ofusu, F. A., Sridhara, S., Bona, R. D., Rickles, F. R., and Blajchman, M. A. (1992) FEBS Lett. 298, 206-210
37. Chang, J.-Y., Stafford, D. W., and Straight, D. L. (1995) Biochemistry 34, 12227-12232
38. Butenas, S., Ribarik, N., and Mann, K. G. (1993) Biochemistry 32, 6531-6538
39. Lenting, P. J., Christophe, O. D., ter Maat, H., Rees, D. J. G., and Mertens, K. (1996) J. Biol. Chem. 271, 25332-25337
40. Nemerson, Y., and Gentry, R. (1986) Biochemistry 25, 4020-4033
41. Dickinson, C. D., Kelly, C. R., and Ruf, W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14379-14384
42. Davis, L. M., McGraw, R. A., Ware, J. L., Roberts, H. R., and Stafford, D. W. (1987) Blood 69, 140-143
43. Rees, D. J. G., Jones, I. M., Handford, P. A., Walter, S. J., Esnouf, M. P., Smith, K. J., and Brownlee, G. G. (1988) EMBO J. 7, 2053-2061
44. Green, P. M., Bentley, D. R., Mibashan, R. S., Nilsson, I. M., and Giannelli, F. (1989) EMBO J. 8, 1067-1072
45. McCord, D. M., Monroe, D. M., Smith, K. J., and Roberts, H. R. (1990) J. Biol. Chem. 265, 10250-10254
46. Winship, P. R., and Dragon, A. C. (1991) Br. J. Haematol. 77, 102-109
47. Walter, J., Pabinger-Fasching, I., and Watzke, H. H. (1994) Thromb. Haemostasis 72, 74-77
48. Öhlin, A.-K., Björk, I., and Stenflo, J. (1990) Biochemistry 29, 644-651
49. Astermark, J., Björk, I., Öhlin, A.-K., and Stenflo, J. (1991) J. Biol. Chem. 266, 2430-2437
50. Vysotchin, A., Medved, L. V., and Ingham, K. C. (1993) J. Biol. Chem. 268, 8436-8446
51. Medved, L. V., Vysotchin, A., and Ingham, K. C. (1994) Biochemistry 33, 478-485
52. Valcarce, C., Holmgren, A., and Stenflo, J. (1994) J. Biol. Chem. 269, 26011-26016
53. Persson, E., and Stenflo, J. (1992) FEBS Lett. 314, 5-9
54. McCallum, C. D., Hapak, R. C., Neuenschwander, P. F., Morrissey, J. H., and Johnson, A. E. (1996) J. Biol. Chem. 271, 28168-28175
55. Nicolaisen, E. M., Petersen, L. C., Thim, L., Jacobsen, J. K., Christensen, M., and Hedner, U. (1992) FEBS Lett. 306, 157-160
56. Nicolaisen, E. M., Thim, L., Jacobsen, J. K., Nielsen, P. F., Mollerup, I., Jørgensen, T., and Hedner, U. (1993) FEBS Lett. 317, 245-249
57. Anderssen, T., Halvorsen, H., Bajaj, S. P., and Østerud, B. (1993) Thromb. Haemostasis 70, 414-417