Allosteric regulation of the cofactor-dependent serine protease coagulation factor VIIa

Trends in Cardiovascular Medicine

Volumn 8, Issue 8, 1998, Pages 350-356

  Ruf, Wolfram ^a   Dickinson, Craig D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7A; SERINE PROTEINASE;

ALLOSTERISM; BINDING SITE; BLOOD CLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0031649079     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(98)00031-0     Document Type: Article

References (41)

1. Banner DW, D'Arcy A, Chène C, et al.: 1996. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380:41-46.
2. Bharadwaj D, Iino M, Kontoyianni M, Smith KJ, Foster DC, Kisiel W: 1996. Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. J Biol Chem 271:30,685-30,691.
3. Bode W, Schwager P, Huber R: 1978. The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A-resolution. J Mol Biol 118:99-112.
4. Bode W, Mayr I, Baumann U, Huber R, Stone SR, Hofsteenge J: 1989. The refined 1.9 Å crystal structure of human α-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J 8: 3467-3475.
5. Bode W, Huber R, Rydel TJ, Tulinsky A: 1992. X-ray crystal structures of human α-thrombin and of the human thrombin-hirudin complex. In Berliner LJ, ed. Thrombin: Structure and Function. New York, Plenum Press, pp. 3-61.
6. a toward flurogenic peptides containing the activation site sequences of bovine factor IX and factor X. Biochemistry 22:1021-1029.
7. +-induced allosteric regulation of catalytic activity in serine proteases. Proc Natl Acad Sci USA 93:10,653-10,656.
8. + binding site of thrombin. J Biol Chem 270:22,089-22,092.
9. Di Cera E, Dang QD, Ayala YM: 1997. Molecular mechanisms of thrombin function. Cell Mol Life Sci 53:701-730.
10. Dickinson CD, Ruf W: 1997. Active site modification of factor VIIa affects interactions of the protease domain with tissue factor. J Biol Chem 272:19,875-19,879.
11. Dickinson CD, Kelly CR, Ruf W: 1996. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. Proc Natl Acad Sci USA 93:14,379-14,384.
12. Dickinson CD, Shobe J, Ruf W: 1998. Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor VIIa. J Mol Biol 277:959-971.
13. Ferrin TE, Huang CC, Jarvis LE, Langridge R: 1988. The MIDAS display system. J Mol Graph 6:13-27.
14. Higashi S, Nishimura H, Aita K, Iwanaga S: 1994. Identification of regions of bovine factor VII essential for binding to tissue factor. J Biol Chem 269:18,891-18,898.
15. Higashi S, Matsumoto N, Iwanaga S: 1996. Molecular mechanism of tissue factor-mediated acceleration of factor VIIa activity. J Biol Chem 271:26,569-26,574.
16. Higashi S, Matsumoto N, Iwanaga S: 1997. Conformation of factor VIIa stabilized by a labile disulfide bond (Cys-310-Cys-329) in the protease domain is essential for interaction with tissue factor. J Biol Chem 272:25,724-25,730.
17. Huang M, Syed R, Stura EA, et al.: 1998. The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF-5G9 complex. J Mol Biol 275:873-894.
18. 166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J Biol Chem 271:21,752-21,757.
19. Huber R, Bode W: 1978. Structural basis of the activation and action of trypsin. Acc Chem Res 11:114-122.
20. 44 regulates catalytic function of the bound protease factor VIIa. Biochem J 315:145-151.
21. Kraulis PJ: 1991. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Cryst 24:946-950.
22. Krishnaswamy S, Betz A: 1997. Exosites determine macromolecular substrate recognition by prothrombinase. Biochemistry 36:12,080-12,086.
23. Le Bonniec BF, Esmon CT: 1991. Glu-192->Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. Proc Natl Acad Sci USA 88:7371-7375.
24. Liu L-W, Vu T-KH, Esmon CT, Coughlin SR: 1991. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem 266:16,977-16,980.
25. 304->Trp). Evidence that a region in the catalytic domain of factor VII is important for the association with tissue factor. J Biol Chem 269:7355-7363.
26. Merritt EA, Murphy MEP: 1994. RASTER3D version 2.0: a program for photorealistic molecular graphics. Acta Cryst D50:869-873.
27. O'Brien DP, Gale, KM, Anderson, JS, et al.: 1991. Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male. Blood 78:132-140.
28. Payne MA, Neuenschwander PF, Johnson AE, Morrissey JH: 1996. Effect of soluble tissue factor on the kinetic mechanism of factor VIIa: Enhancement of p-guanidinobenzoate substrate hydrolysis. Biochemistry 35:7100-7106.
29. Rao LVM, Ruf W: 1995. Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor-VIIa with Xa-tissue factor pathway inhibitor. Biochemistry 34:10,867-10,871.
30. 290 is required for efficient activation of the macromolecular substrate factor X. Biochemistry 33:11,631-11,636.
31. Ruf W, Edgington TS: 1991. An anti-tissue factor monoclonal antibody which inhibits TF: VIIa complex is a potent anticoagulant in plasma. Thromb Haemost 66:529-533.
32. Ruf W, Edgington TS: 1994. Structural biology of tissue factor, the initiator of thrombogenesis in vivo. FASEB J 8:385-390.
33. Ruf W, Mueller BM: 1996. Tissue factor in cancer angiogenesis and metastasis. Curr Opin Hematol 3:379-384.
34. Ruf W, Kalnik MW, Lund-Hansen T, Edgington TS: 1991a. Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J Biol Chem 266: 15,719-15,725.
35. Ruf W, Rehemtulla A, Morrissey JH, Edgington TS: 1991b. Phospholipid independent and dependent interactions required for tissue factor receptor and cofactor function. J Biol Chem 266:2158-2166.
36. Ruf W, Miles DJ, Rehemtulla A, Edgington TS: 1992. Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. J Biol Chem 267:6375-6381.
37. Schechter I, Berger A: 1967. On the size of the active site in proteases. I. Papain. Biochem Biophys Res Commun 27:157-162.
38. Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A. 1994. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci 3:2254-2271.
39. Walker RK, Krishnaswamy S: 1993. The influence of factor Va on the active site of factor Xa. J Biol Chem 268:13,920-13,929.
40. →Lys) and its functional consequences in a hereditary factor X deficiency (factor X "Vorarlberg"). J Biol Chem 265:11,982-11,989.
41. Ye J, Esmon NL, Esmon CT, Johnson AE: 1991. The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. J Biol Chem 266: 23,016-23,021.