Similar Molecular Interactions of Factor VII and Factor VIIa with the Tissue Factor Region that Allosterically Regulates Enzyme Activity

Biochemistry

Volumn 43, Issue 5, 2004, Pages 1223-1229

  Kelley, Robert F ^a   Yang, Jihong ^a   Eigenbrot, Charles ^a   Moran, Paul ^a   Peek, Mark ^a   Lipari, Michael T ^a   Kirchhofer, Daniel ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL ACTIVATION; COAGULATION; CONFORMATIONS; MOLECULAR STRUCTURE; SURFACE PLASMON RESONANCE;

MOLECULAR INTERACTIONS;

ENZYMES;

BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; ENZYME PRECURSOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR 1; EPIDERMAL GROWTH FACTOR 2; MONOCLONAL ANTIBODY; PROTEINASE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DISSOCIATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME REGULATION; MEASUREMENT; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME PRECURSORS; FACTOR VII; FACTOR VIIA; FACTOR X; HUMANS; HYDROLYSIS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SOLUBILITY; SURFACE PLASMON RESONANCE; THROMBOPLASTIN;

EID: 0842283889     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035738i     Document Type: Article

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