Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor

Journal of Biological Chemistry

Volumn 272, Issue 18, 1997, Pages 11863-11868

  Sørensen, Brit Binow ^a   Persson, Egon ^a   Freskgård, Per Ola ^a   Kjalke, Marianne ^a   Ezban, Mirella ^a   Williams, Todd ^b   Rao, L Vijaya Mohan ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7A;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; THROMBOGENESIS;

AMINO ACID CHLOROMETHYL KETONES; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CELL MEMBRANE; CIRCULAR DICHROISM; FACTOR VIIA; FIBRIN; HUMANS; KINETICS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; THROMBOPLASTIN; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0030991982     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.18.11863     Document Type: Article

References (30)

1. Rapaport, S. I., and Rao, L. V. M. (1995) Thromb. Haemostasis 74, 7-17
2. Drake, T. A., Morrissey, J. H., and Edgington, T. S. (1989) Am. J. Pathol. 134, 1087-1097
3. Fleck, R. A., Rao, L. V. M., Rapaport, S. I., and Varki, N. (1990) Thromb. Res. 59, 421-437
4. Rivers, R. P. A., Hathaway, W. E., and Weston, W. L. (1975) Br. J. Haematol. 30, 311-316
5. Drake, T. A., Cheng, J., Chang, A., and Taylor, F. B., Jr. (1993) Am. J. Pathol. 142, 1458-1470
6. Zhang, Y., Deng, Y., Wendt, T., Liliensiek, B., Bierhaus, A., Greten, J., He, W., Chen, B., Hach-Wunderle, V., Waldherr, R., Ziegler, R., Mannel, D., Stern, D. M., and Nawroth, P. P. (1996) J. Clin. Invest. 97, 2213-2224
7. Østerud, B. (1995) Blood Coagul. & Fibrinolysis 6, Suppl. 1, S20-S25
8. Muller, Y. A., Ultsch, M. H., Kelley, R. F., and de Vos, A. M. (1994) Biochemistry 33, 10864-10870
9. Harlos, K., Martin, D. M. A., O'Brien, D. P., Jones, E. Y., Stuart, D. I., Polikarpov, I., Miller, A., Tuddenham, E. G. D., and Boys, C. W. G. (1994) Nature 370, 662-666
10. Banner, D. W., D'Arcy, A., Chène, C., Winkler, F. K., Guha, A., Konigsberg, W. H., Nemerson, Y., and Kirchhofer, D. (1996) Nature 380, 41-46
11. Jang, Y. S., Guzman, L. A., Lincoff, A. M., Gottsaunerwolf, M., Forudi, F., Hart, C. E., Courtman, D. W., Ezban, M., Ellis, S. G., and Topol, E. J. (1995) Circulation 92, 3041-3050
12. Harker, L. A., Hanson, S. R., Wilcox, J. N., and Kelly, A. B. (1996) Haemostatis 26, Suppl. 1, 76-82
13. Wildgoose, P., Bregengard, C., and Nordfang, O. (1993) Thromb. Haemostasis 69, 780
14. Ørvim, U., Barstad, R. M., Örning, L., Petersen, L. B., Ezban, M., Hedner, U., and Sakariassen, K. S. (1995) Thromb. Haemostasis 73, 1185
15. Kirchhofer, D., Tschopp, T. B., and Baumgartner, H. R. (1995) Arterioscler. Thromb. 15, 1098-1106
16. Oliver, J. A., Hoffman, M., Monroe, D. M., Ezban, M., Hedner, U., and Roberts, H. R. (1995) Blood 86, 77a
17. Sakai, T., Lund-Hansen, T., Paborsky, L., Pedersen, A. H., and Kisiel, W. (1989) J. Biol. Chem. 264, 9980-9988
18. Thim, L., Christensen, M., Nicolaisen, E. M., Lund-Hansen, T., Pedersen, A. H., and Hedner, U. (1988) Biochemistry 27, 7785-7793
19. Nicolaisen, E. M., Petersen, L. C., Thim, L., Jacobsen, J. K., Christensen, M., and Hedner, U. (1992) FEBS Lett. 306, 157-160
20. Bajaj, S. P., Rapaport, S. I., and Prodanos, C. (1981) Prep. Biochem. 11, 397-412
21. Rao, L. V. M., Robinson, T., and Hoang, A. D. (1992) Thromb. Haemostasis 67, 654-659
22. Rao, L. V. M. (1988) Thromb. Res. 51, 373-384
23. Freskgård, P-O., Olsen, O. H., and Persson, E. (1996) Protein Sci. 5, 1531-1540
24. Higashi, S., Matsumoto, N., and Iwanaga, S. (1996) J. Biol. Chem. 271, 26569-26574
25. Rao, L. V. M., Williams, T., and Rapaport, S. I. (1996) Blood 87, 3738-3748
26. Le, D. T., Rapaport, S. I., and Rao, L. V. M. (1992) J. Biol. Chem. 267, 15447-15454
27. Rao, L. V. M., Nordfang, O., Hoang, A. D., and Pendurthi, U. R. (1995) Blood 85, 121-129
28. Persson, E. (1996) Haemostasis 26, Suppl. 1, 31-34
29. Fair, D. S., and MacDonald, M. J. (1987) J. Biol. Chem. 262, 11692-11698
30. Bach, R., Gentry, R., and Nemerson, Y. (1986) Biochemistry 25, 4007-4020